BLASTP 2.2.16 [Mar-25-2007]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= CIRT_01234 cimm2 CIRG_01232 Broad_Institute ""
(388 letters)
Database: sws57.9x
510,076 sequences; 179,409,320 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
ALKBH_SCHPO RecName: Full=Alkylated DNA repair protein alkB homo... 159 5e-41
ALKB_DICDI RecName: Full=Alpha-ketoglutarate-dependent dioxygena... 98 1e-22
ALKB1_HUMAN RecName: Full=Alkylated DNA repair protein alkB homo... 90 4e-20
ALKB1_MOUSE RecName: Full=Alkylated DNA repair protein alkB homo... 88 1e-19
ALKBH_ARATH RecName: Full=Alkylated DNA repair protein alkB homo... 80 2e-17
ALKB_CAUCR RecName: Full=Alpha-ketoglutarate-dependent dioxygena... 59 5e-11
ALKB_CAUCN RecName: Full=Alpha-ketoglutarate-dependent dioxygena... 59 5e-11
ALKB_ECOLI RecName: Full=Alpha-ketoglutarate-dependent dioxygena... 50 3e-08
YLW2_SCHPO RecName: Full=Uncharacterized protein P8A3.02c; 45 1e-06
ALKB_SALTY RecName: Full=Alpha-ketoglutarate-dependent dioxygena... 44 2e-06
ALKB8_XENTR RecName: Full=Alkylated DNA repair protein alkB homo... 42 1e-05
ALKB8_MOUSE RecName: Full=Alkylated DNA repair protein alkB homo... 42 1e-05
ALKB8_MACFA RecName: Full=Alkylated DNA repair protein alkB homo... 41 2e-05
ALKB8_BOVIN RecName: Full=Alkylated DNA repair protein alkB homo... 41 2e-05
ZN750_HUMAN RecName: Full=Protein ZNF750; 38 1e-04
ALKB8_HUMAN RecName: Full=Alkylated DNA repair protein alkB homo... 37 2e-04
>ALKBH_SCHPO RecName: Full=Alkylated DNA repair protein alkB
homolog;
Length = 297
Score = 159 bits (401), Expect = 5e-41
Identities = 86/181 (47%), Positives = 116/181 (64%), Gaps = 19/181 (10%)
Query: 202 RPLSIQAALNSKLRWITLGGQYNWTTKEYP-PGPPPAFPSDISTLLHSIFPETT------ 254
+PL++ ++ KLRW+TLG QY+WTTKEYP P P FP D+ + + E+T
Sbjct: 123 KPLTVDRLVHKKLRWVTLGEQYDWTTKEYPDPSKSPGFPKDLGDFVEKVVKESTDFLHWK 182
Query: 255 AEAAIVNLYSPGDTLNPHRDVSEECDT-GLISISLGCHALFLVG-HGNGDSCAVIRLRSG 312
AEAAIVN YSPGDTL+ H D SEE T LIS+S+G ++L+G + + +RL SG
Sbjct: 183 AEAAIVNFYSPGDTLSAHIDESEEDLTLPLISLSMGLDCIYLIGTESRSEKPSALRLHSG 242
Query: 313 DAVYMTGASRFAWHAVPKIIPSTCPDWLKTWPGGGDVPDEDSQRWWGWMAGKRVNLNVRQ 372
D V MTG SR A+HAVPKIIP++ P++L T ++ W GW++ KRVN NVRQ
Sbjct: 243 DVVIMTGTSRKAFHAVPKIIPNSTPNYLLT----------GNKAWDGWISRKRVNFNVRQ 292
Query: 373 M 373
+
Sbjct: 293 V 293
>ALKB_DICDI RecName: Full=Alpha-ketoglutarate-dependent dioxygenase
alkB; EC=1.14.11.-;AltName: Full=Alkylated DNA
repair protein alkB;
Length = 393
Score = 98.2 bits (243), Expect = 1e-22
Identities = 73/211 (34%), Positives = 100/211 (47%), Gaps = 18/211 (8%)
Query: 187 DDPTRTFSPKDATVHRPLSIQAALNSKLRWITLGGQYNWTTKEYPPGPPPAFPSDISTLL 246
+ PTR PL L KL W TLG QY WT + Y FP D+ L+
Sbjct: 192 EQPTRPLDKNG----EPLPTYRQLLDKLAWSTLGYQYQWTPRLYSEEFYEEFPDDLQELV 247
Query: 247 HSI-----FPETTAEAAIVNLYSPGDTLNPHRDVSE-ECDTGLISISLGCHALFLVGHGN 300
I F AEAA VN YS + H D +E E + +ISIS G A+FL+G
Sbjct: 248 QKIAIATKFDPYVAEAATVNFYSEDSIMGGHLDDAEQEMEKPIISISFGSTAVFLMGAET 307
Query: 301 GDSCAV-IRLRSGDAVYMTGASRFAWHAVPKIIPSTCPDWLKTWPGGGDVPDEDSQRWWG 359
D V + +RSGD V M G SR+ +H V KI+ ++ L + D+D +
Sbjct: 308 RDIAPVPLFIRSGDIVIMGGRSRYCYHGVAKIVENSFDLGLI-----DENDDQDLKYKIQ 362
Query: 360 WMAGK--RVNLNVRQMFQSPPTNPAALGEND 388
W+ K RVN+N RQ+F+ P + +N+
Sbjct: 363 WLKEKNRRVNINTRQVFKVPKLGGKLINKNE 393
>ALKB1_HUMAN RecName: Full=Alkylated DNA repair protein alkB homolog
1;
Length = 389
Score = 89.7 bits (221), Expect = 4e-20
Identities = 71/206 (34%), Positives = 99/206 (48%), Gaps = 25/206 (12%)
Query: 196 KDATVHRPLSIQAALNSKLRWITLGGQYNWTTKEYPPGPPPAFPSDISTLLHSI-----F 250
K+AT RP S L KLRW+T+G YNW +K+Y FPSD+ L + F
Sbjct: 154 KEATKRRPRS----LLEKLRWVTVGYHYNWDSKKYSADHYTPFPSDLGFLSEQVAAACGF 209
Query: 251 PETTAEAAIVNLYSPGDTLNPHRDVSE-ECDTGLISISLGCHALFLVGHGNGDSC-AVIR 308
+ AEA I+N Y TL H D SE + L+S S G A+FL+G D +
Sbjct: 210 EDFRAEAGILNYYRLDSTLGIHVDRSELDHSKPLLSFSFGQSAIFLLGGLQRDEAPTAMF 269
Query: 309 LRSGDAVYMTGASRFAWHAVPKIIPST----CPDWLKTWPGGGDVPD---------EDSQ 355
+ SGD + M+G SR HAVP+++P+ P L+ P +P ED Q
Sbjct: 270 MHSGDIMIMSGFSRLLNHAVPRVLPNPEGEGLPHCLEA-PLPAVLPRDSMVEPCSMEDWQ 328
Query: 356 RWWGWMAGKRVNLNVRQMFQSPPTNP 381
++ RVN+ VRQ+ + P
Sbjct: 329 VCASYLKTARVNMTVRQVLATDQNFP 354
>ALKB1_MOUSE RecName: Full=Alkylated DNA repair protein alkB homolog
1;
Length = 389
Score = 88.2 bits (217), Expect = 1e-19
Identities = 74/216 (34%), Positives = 101/216 (46%), Gaps = 28/216 (12%)
Query: 196 KDATVHRPLSIQAALNSKLRWITLGGQYNWTTKEYPPGPPPAFPSDISTLLHSI-----F 250
K+ T RP S L +LRW+TLG YNW +K+Y FPSD++ L + F
Sbjct: 154 KEVTKRRPRS----LLERLRWVTLGYHYNWDSKKYSADHYTPFPSDLAFLSEQVATACGF 209
Query: 251 PETTAEAAIVNLYSPGDTLNPHRDVSE-ECDTGLISISLGCHALFLVGHGNGDSC-AVIR 308
AEA I+N Y TL H D SE + L+S S G A+FL+G D +
Sbjct: 210 QGFQAEAGILNYYRLDSTLGIHVDRSELDHSKPLLSFSFGQSAIFLLGGLKRDEAPTAMF 269
Query: 309 LRSGDAVYMTGASRFAWHAVPKIIP----STCPDWLKTWPGGGDVPD---------EDSQ 355
+ SGD + M+G SR HAVP+++P P L+T P +P ED Q
Sbjct: 270 MHSGDIMVMSGFSRLLNHAVPRVLPHPDGECLPHCLET-PLPAVLPSNSLVEPCSVEDWQ 328
Query: 356 RWWGWMAGKRVNLNVRQMF---QSPPTNPAALGEND 388
++ RVN+ VRQ+ Q P P + D
Sbjct: 329 VCATYLRTARVNMTVRQVLATGQDFPLEPVEETKRD 364
>ALKBH_ARATH RecName: Full=Alkylated DNA repair protein alkB
homolog;
Length = 345
Score = 80.5 bits (197), Expect = 2e-17
Identities = 58/177 (32%), Positives = 87/177 (49%), Gaps = 12/177 (6%)
Query: 208 AALNSKLRWITLGGQYNWTTKEYPPG-PPPAFPSDISTLL--HSIFP-----ETTAEAAI 259
+ L KLRW TLG Q++W+ + Y P P + L H+ E E AI
Sbjct: 171 SVLLRKLRWSTLGLQFDWSKRNYDVSLPHNNIPDALCQLAKTHAAIAMPDGEEFRPEGAI 230
Query: 260 VNLYSPGDTLNPHRDVSE-ECDTGLISISLGCHALFLVG-HGNGDSCAVIRLRSGDAVYM 317
VN + GDTL H D E + ++S+SLGC A+FL+G D + LRSGD V M
Sbjct: 231 VNYFGIGDTLGGHLDDMEADWSKPIVSMSLGCKAIFLLGGKSKDDPPHAMYLRSGDVVLM 290
Query: 318 TGASRFAWHAVPKIIPSTCPDWLKTWPGGGDVPDEDSQRWWGWMAGKRVNLNVRQMF 374
G +R +H +P+I T + ++ E + ++ R+N+N+RQ+F
Sbjct: 291 AGEARECFHGIPRIF--TGEENADIGALESELSHESGHFFAEYIKTSRININIRQVF 345
>ALKB_CAUCR RecName: Full=Alpha-ketoglutarate-dependent dioxygenase
alkB homolog; EC=1.14.11.-;
Length = 220
Score = 59.3 bits (142), Expect = 5e-11
Identities = 47/146 (32%), Positives = 70/146 (47%), Gaps = 10/146 (6%)
Query: 193 FSPKDATVHRPLSIQAALNSKLRWITLGGQYNWTTKEYPPGPP-PAFPS---DISTLLHS 248
FS +P+S+ L W + Y + + G P P P D+ T+L
Sbjct: 54 FSNYRTAYGKPMSVAMTALGSLGWTSDARGYRYVDRHPETGRPWPDMPPALLDLWTVLGD 113
Query: 249 IFPETTAEAAIVNLYSPGDTLNPHRDVSEECDTG--LISISLGCHALFLVGHGNG-DSCA 305
PET ++ +VNLY G + H+D +E D ++SISLG A+F +G N D
Sbjct: 114 --PETPPDSCLVNLYRDGARMGLHQD-RDEADPRFPVLSISLGDTAVFRIGGVNRKDPTR 170
Query: 306 VIRLRSGDAVYMTGASRFAWHAVPKI 331
+RL SGD + G +R A+H V +I
Sbjct: 171 SLRLASGDVCRLLGPARLAFHGVDRI 196
>ALKB_CAUCN RecName: Full=Alpha-ketoglutarate-dependent dioxygenase
alkB homolog; EC=1.14.11.-;
Length = 220
Score = 59.3 bits (142), Expect = 5e-11
Identities = 47/146 (32%), Positives = 70/146 (47%), Gaps = 10/146 (6%)
Query: 193 FSPKDATVHRPLSIQAALNSKLRWITLGGQYNWTTKEYPPGPP-PAFPS---DISTLLHS 248
FS +P+S+ L W + Y + + G P P P D+ T+L
Sbjct: 54 FSNYRTAYGKPMSVAMTALGSLGWTSDARGYRYVDRHPETGRPWPDMPPALLDLWTVLGD 113
Query: 249 IFPETTAEAAIVNLYSPGDTLNPHRDVSEECDTG--LISISLGCHALFLVGHGNG-DSCA 305
PET ++ +VNLY G + H+D +E D ++SISLG A+F +G N D
Sbjct: 114 --PETPPDSCLVNLYRDGARMGLHQD-RDEADPRFPVLSISLGDTAVFRIGGVNRKDPTR 170
Query: 306 VIRLRSGDAVYMTGASRFAWHAVPKI 331
+RL SGD + G +R A+H V +I
Sbjct: 171 SLRLASGDVCRLLGPARLAFHGVDRI 196
>ALKB_ECOLI RecName: Full=Alpha-ketoglutarate-dependent dioxygenase
alkB; EC=1.14.11.-;AltName: Full=Alkylated DNA
repair protein alkB;
Length = 216
Score = 50.1 bits (118), Expect = 3e-08
Identities = 37/125 (29%), Positives = 53/125 (42%), Gaps = 17/125 (13%)
Query: 221 GQYNWTTKE----YPPGPP------PAFPSDISTLLHSI-----FPETTAEAAIVNLYSP 265
G WTT Y P P PA P L +P+ +A ++N Y+P
Sbjct: 65 GHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAP 124
Query: 266 GDTLNPHRDVSE-ECDTGLISISLGCHALFLVGH-GNGDSCAVIRLRSGDAVYMTGASRF 323
G L+ H+D E + ++S+SLG A+F G D + L GD V G SR
Sbjct: 125 GAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRL 184
Query: 324 AWHAV 328
+H +
Sbjct: 185 FYHGI 189
>YLW2_SCHPO RecName: Full=Uncharacterized protein P8A3.02c;
Length = 225
Score = 44.7 bits (104), Expect = 1e-06
Identities = 31/122 (25%), Positives = 58/122 (47%), Gaps = 15/122 (12%)
Query: 255 AEAAIVNLYSPGDTLNPHRDVSEECDTGLISISLGCHALFLVGHGNGDSCAVIRLRSGDA 314
AEA I+ +Y+PGD + PH+D+ E G+ S + + H + IRL G
Sbjct: 115 AEAIIMQVYNPGDGIIPHKDL-EMFGDGVAIFSFLSNTTMIFTHPELKLKSKIRLEKGSL 173
Query: 315 VYMTGASRFAWHAVPKIIPSTCPDWLKTWPGGGDVPDEDSQRWWGWMAGKRVNLNVRQMF 374
+ M+G +R+ W IP DW V ++ ++W +R+++ +R++
Sbjct: 174 LLMSGTARYDWF---HEIPFRAGDW---------VMNDGEEKWVS--RSQRLSVTMRRII 219
Query: 375 QS 376
++
Sbjct: 220 EN 221
>ALKB_SALTY RecName: Full=Alpha-ketoglutarate-dependent dioxygenase
alkB; EC=1.14.11.-;AltName: Full=Alkylated DNA
repair protein alkB;
Length = 216
Score = 44.3 bits (103), Expect = 2e-06
Identities = 34/125 (27%), Positives = 52/125 (41%), Gaps = 17/125 (13%)
Query: 221 GQYNWTTKEY----------PPGPPPAFPSDISTLLHSI-----FPETTAEAAIVNLYSP 265
G WTT + P PA P +++ + +A ++N Y+P
Sbjct: 65 GALGWTTDRHGYCYAVRDPLTDKPWPALPLSFASVCRQAAIAAGYASFQPDACLINRYAP 124
Query: 266 GDTLNPHRDVSE-ECDTGLISISLGCHALFLVGH-GNGDSCAVIRLRSGDAVYMTGASRF 323
G L+ H+D E + ++S+SLG A+F G D I L GD V G SR
Sbjct: 125 GAKLSLHQDKDEPDLRAPIVSVSLGVPAVFQFGGLRRSDPIQRILLEHGDIVVWGGESRL 184
Query: 324 AWHAV 328
+H +
Sbjct: 185 FYHGI 189
>ALKB8_XENTR RecName: Full=Alkylated DNA repair protein alkB homolog
8;
Length = 628
Score = 41.6 bits (96), Expect = 1e-05
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 260 VNLYSPGDTLNPHRDVSEECDTGLISISLGCHALFLVGHGNGDSCAVIRLRSGDAVYMTG 319
+N Y PG + PH D + ++S+SLG + H NG S + L + M+G
Sbjct: 224 INQYEPGQGIPPHVDTHSAFEDEILSLSLGAEIVMDFKHPNG-SVVPVMLPQRSLLIMSG 282
Query: 320 ASRFAW 325
SR+ W
Sbjct: 283 ESRYLW 288
>ALKB8_MOUSE RecName: Full=Alkylated DNA repair protein alkB homolog
8;
Length = 664
Score = 41.6 bits (96), Expect = 1e-05
Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 1/98 (1%)
Query: 228 KEYPPGPPPAFPSDISTLLHSIFPETTAEAAIVNLYSPGDTLNPHRDVSEECDTGLISIS 287
K P G P S + LL + + + +N Y PG + H D + +IS+S
Sbjct: 194 KPLPGGLPEVCSSILEKLLKEGYIKHKPDQLTINQYEPGHGIPAHIDTHSAFEDEIISLS 253
Query: 288 LGCHALFLVGHGNGDSCAVIRLRSGDAVYMTGASRFAW 325
LG + H G + V+ L + MTG SR+ W
Sbjct: 254 LGSAIVMDFKHPEGVTVQVM-LPRRSLLVMTGESRYLW 290
>ALKB8_MACFA RecName: Full=Alkylated DNA repair protein alkB homolog
8;
Length = 664
Score = 41.2 bits (95), Expect = 2e-05
Identities = 26/98 (26%), Positives = 42/98 (42%), Gaps = 1/98 (1%)
Query: 228 KEYPPGPPPAFPSDISTLLHSIFPETTAEAAIVNLYSPGDTLNPHRDVSEECDTGLISIS 287
K P G P S + L + + + +N Y PG + H D + ++S+S
Sbjct: 194 KPLPGGLPDICDSFLEKWLREGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLS 253
Query: 288 LGCHALFLVGHGNGDSCAVIRLRSGDAVYMTGASRFAW 325
LG + H +G + V+ L + MTG SR+ W
Sbjct: 254 LGSEIVMDFKHPDGTAVPVM-LPRRSLLVMTGESRYLW 290
>ALKB8_BOVIN RecName: Full=Alkylated DNA repair protein alkB homolog
8;
Length = 664
Score = 41.2 bits (95), Expect = 2e-05
Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 1/98 (1%)
Query: 228 KEYPPGPPPAFPSDISTLLHSIFPETTAEAAIVNLYSPGDTLNPHRDVSEECDTGLISIS 287
K P G P S + L F + + +N Y PG + H D + +IS+S
Sbjct: 194 KPLPGGLPDICESILEKWLKEGFIKHKPDQLTINQYEPGHGIPAHIDTHSAFEDEIISLS 253
Query: 288 LGCHALFLVGHGNGDSCAVIRLRSGDAVYMTGASRFAW 325
LG + H +G + V+ L + MTG SR+ W
Sbjct: 254 LGSEIVMDFKHPDGMTVPVM-LPCRSLLVMTGESRYLW 290
>ZN750_HUMAN RecName: Full=Protein ZNF750;
Length = 723
Score = 38.1 bits (87), Expect = 1e-04
Identities = 37/152 (24%), Positives = 57/152 (37%), Gaps = 21/152 (13%)
Query: 148 LHLHYDVSYPSPSSDANGASALKGTQQEACWSTNSSFFRDDPTRTFSPKDATVHRPLSIQ 207
LH P+P + AL+G + + + P +P+ +H P +
Sbjct: 132 LHRASPCKSPAPEAALGAQPALEGAARPSAFVPVGEHRLKGPDNAEAPETLALHNPTAKA 191
Query: 208 AALNSKLRWITLGGQYNWTTKEYPPGPPPAFPSDIST---------LLHSIFPETT---- 254
+ ++K + T G Y W K P PP FP IS+ +H PE
Sbjct: 192 VSFHTKSAFHTPG--YPW--KAGSPFLPPEFPHKISSTKGLGAISPYMHPTIPEYPPHFY 247
Query: 255 AEAAIVNLYSPGDTLNPHRDVSEECDTGLISI 286
E + +YSP S ECD L+S+
Sbjct: 248 TEHGLATIYSPYLLAGS----SPECDAPLLSV 275
>ALKB8_HUMAN RecName: Full=Alkylated DNA repair protein alkB homolog
8;
Length = 664
Score = 37.4 bits (85), Expect = 2e-04
Identities = 24/93 (25%), Positives = 40/93 (43%), Gaps = 1/93 (1%)
Query: 233 GPPPAFPSDISTLLHSIFPETTAEAAIVNLYSPGDTLNPHRDVSEECDTGLISISLGCHA 292
G P S + L + + + +N Y PG + H D + ++S+SLG
Sbjct: 199 GLPDICESFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSLGSEI 258
Query: 293 LFLVGHGNGDSCAVIRLRSGDAVYMTGASRFAW 325
+ H +G + V+ L + MTG SR+ W
Sbjct: 259 VMDFKHPDGIAVPVM-LPRRSLLVMTGESRYLW 290
Database: sws57.9x
Posted date: Nov 5, 2009 10:46 AM
Number of letters in database: 179,409,320
Number of sequences in database: 510,076
Lambda K H
0.325 0.138 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 510076
Number of Hits to DB: 13,886,376,990
Number of extensions: 555354028
Number of successful extensions: 1188594
Number of sequences better than 1.0e-03: 14726
Number of HSP's gapped: 1163231
Number of HSP's successfully gapped: 22136
Length of database: 100,000
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)