RPS-BLAST 2.2.16 [Mar-25-2007]

Database: 95pdb09Oct16_0000; 95pdb09Oct16_0001; 95pdb09Oct16_0002;
95pdb09Oct16_0003 
           66,450 sequences; 15,983,541 total letters

Searching..................................................done

Query= ACF55106.1 spne4 sulB GIB00761CH01 "dihydrofolate synthetase"
         (440 letters)



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

2am1A [x.x.x] UDP-N-ACETYLMURAMOYLALANINE-D-GLUTAMYL-LYSINE-D-        159   1e-41
1e8cB [c.98.1 - c.72.2 - c.59.1] UDP-N-ACETYLMURAMOYLALANYL-D-GL...   140   9e-36
1e8cA [c.98.1 - c.72.2 - c.59.1] UDP-N-ACETYLMURAMOYLALANYL-D-GL...   137   4e-35
2cb4A [x.x.x] MOSQUITOCIDAL TOXIN                                     108   3e-26
3eagA [x.x.x] UDP-N-ACETYLMURAMATE:L-ALANYL-GAMMA-D-GLUTAMYL-         100   9e-24
1eehA [c.5.1 - c.72.2 - c.59.1] UDP-N-ACETYLMURAMOYL-L-ALANINE:D...    91   6e-21
1e0dA [c.5.1 - c.72.2 - c.59.1] UDP-N-ACETYLMURAMOYLALANINE--D-G...    61   5e-12
2atmA [x.x.x] HYALURONOGLUCOSAMINIDASE                                 58   6e-11

>2am1A [x.x.x] UDP-N-ACETYLMURAMOYLALANINE-D-GLUTAMYL-LYSINE-D-
          Length = 442

 Score =  159 bits (403), Expect = 1e-41
 Identities = 51/420 (12%), Positives = 115/420 (27%), Gaps = 72/420 (17%)

Query: 21  GLERMVELLALRGNPHLKLKVLHIGGTNGKGSTIAFLKKMLEKLGLRVGVFSSPYLIHYT 80
            +    + LA        + V  + G+NGK +T      +  +              +Y 
Sbjct: 81  DVLTAFQSLASYYLEKTTVDVFAVTGSNGKTTTKDLAHLLSTRYKT------YKTQGNYN 134

Query: 81  DQISINGESISEARLEALMADYQSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDVAI 140
           ++I +    +                                            +  V  
Sbjct: 135 NEIGLPYTVLHPEG---------------------------------------TEKLVLE 155

Query: 141 MEVGMGGLLDSTNVCQPILTGITTIGLDHVALLGDTLEAIAEQKAGIIKQGMPLVTGRIA 200
            +  +G +   + + +P    +T +G  H+A        IA+ K         L+     
Sbjct: 156 GQDHLGDIHLLSELARPKTAIVTLVGEAHLAFFK-DRSEIAKGKQIADGASGSLLLAPAD 214

Query: 201 PEALTVIDRIAEEKDAPRLAYGTDYQVRHQESVVTGEVFDYTSAVRQGRFQTSLLGLYQI 260
           P     +       D   + +G   ++   + V   +   + +   +      + G Y  
Sbjct: 215 PIVEDYL-----PIDKKVVRFGQGAELEITDLVERKDSLTFKANFLEQALDLPVTGKYNA 269

Query: 261 ENAGMAIALLDTFCQEDGRELASNDFLGQALEETSW-PGRLEIV--SRDPLMILDGAHNP 317
            NA  +   L        +E  S + +  A +       R E    +    ++ D  +  
Sbjct: 270 TNAIASYVAL--------QEGVSEEQIRLAFQHLELTRNRTEWKKAANGADILSDVYNAN 321

Query: 318 HAIKALLVTLQERFADHHKEILFTC-------IKTKALEDMLDLLGAMPDTELTLTHFAD 370
              K +L T     A+   + +             +    +L L   + D  +       
Sbjct: 322 PTAKLILETFSAIPANEGGKKIAVLADKELGDQSVQLHNQILSLSPDVLDIVIFYGEDIA 381

Query: 371 SRATDESVLKEAAKSRNLSYQDWHDFLE--QNLTDKKEEKQTVRIVTGSLYFLSQVRAYL 428
             A   S             +D   F +  + + +       + ++ GS   L+++   L
Sbjct: 382 QLAQLASQFPIGHVYYFKKTEDQDQFEDLVKQVKESLGAHDQI-LLKGSNSNLAKLVESL 440


>1e8cB [c.98.1 - c.72.2 - c.59.1]
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-
          Length = 484

 Score =  140 bits (353), Expect = 9e-36
 Identities = 46/396 (11%), Positives = 99/396 (25%), Gaps = 64/396 (16%)

Query: 41  VLHIGGTNGKGSTIAFLKKMLEKLGLRVGVFSSPYLIHYTDQISINGESISEARLEALMA 100
           +       G+ S +  +   L    +     +                            
Sbjct: 123 LAQWSQLLGEISAVGTVGNGLLGKVIPTENTT---------------------------- 154

Query: 101 DYQSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDVAIMEVGMGGLLDSTNV-CQPIL 159
                                 +          +Q      EV   GL+       +   
Sbjct: 155 -------------------GSAVDVQHELAGLVDQGATFCAEVSSHGLVQHRVAALKFAA 195

Query: 160 TGITTIGLDHVALLGDTLEAIAEQKAGIIKQGMPLVTGRIAPEALTVIDRIAEEK----- 214
           +  T +  DH+   GD     A         G  ++           + ++ +       
Sbjct: 196 SVFTNLSRDHLDYHGDEHYEAAWLLYSEHHCGQAIINADD-EVGRRWLAKLPDAVAVSED 254

Query: 215 DAPRLAYGTDYQVRHQESVVTGEVFDYTSAVRQGRFQTSLLGLYQIENAGMAIALLDTFC 274
                 +G   +        +G    ++S+        S LG + + N  +A+A L    
Sbjct: 255 HINPNCHGRWLKATEVNYHDSGATIRFSSSW-GDGEIESHLGAFNVSNLLLALATLLAL- 312

Query: 275 QEDGRELASNDFLGQALEETSW-PGRLEIVSR-DPLMILDGAHNPHAIKALLVTLQERFA 332
              G  LA    L +         GR    +   P +++D AH P A++  L   +   A
Sbjct: 313 ---GYPLAD---LLKTAARLQPVCGREVFTAPGKPTVVVDYAHTPDALEKALQAARLHCA 366

Query: 333 DHHKEILFTCIKTKALEDMLDLLGAMPDTELTLTHFADSRATDESVLKEAAKSRNLSYQD 392
                +          +  L  +         +T          +++ +     +  +  
Sbjct: 367 GKLWCVFGCGGDRDKGKRPLGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGLDAGHAK 426

Query: 393 WHDFLEQNLTDKKEEKQTVRIVTGSLYFLSQVRAYL 428
                E      + ++  V +V G  +   Q+    
Sbjct: 427 VEGRAEAVTCAVQAKENDVVLVAGKGHEDYQIVGNQ 462


>1e8cA [c.98.1 - c.72.2 - c.59.1]
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-
          Length = 482

 Score =  137 bits (347), Expect = 4e-35
 Identities = 49/413 (11%), Positives = 104/413 (25%), Gaps = 64/413 (15%)

Query: 24  RMVELLALRGNPHLKLKVLHIGGTNGKGSTIAFLKKMLEKLGLRVGVFSSPYLIHYTDQI 83
           R+V +    G       +       G+ S +  +   L    +     +           
Sbjct: 105 RLVGVTGTNGKTTTTQLLAQWSQLLGEISAVGTVGNGLLGKVIPTENTT----------- 153

Query: 84  SINGESISEARLEALMADYQSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDVAIMEV 143
                                                  +          +Q      EV
Sbjct: 154 ------------------------------------GSAVDVQHELAGLVDQGATFCAEV 177

Query: 144 GMGGLLDSTN-VCQPILTGITTIGLDHVALLGDTLEAIAEQKAGIIKQGMPLVTGRIAPE 202
              GL+       +   +  T +  DH+   GD     A         G  ++       
Sbjct: 178 SSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDEHYEAAWLLYSEHHCGQAIINADD-EV 236

Query: 203 ALTVIDRIAEEK-----DAPRLAYGTDYQVRHQESVVTGEVFDYTSAVRQGRFQTSLLGL 257
               + ++ +             +G   +        +G    ++S+        S LG 
Sbjct: 237 GRRWLAKLPDAVAVSEDHINPNCHGRWLKATEVNYHDSGATIRFSSSW-GDGEIESHLGA 295

Query: 258 YQIENAGMAIALLDTFCQEDGRELASNDFLGQALEETSW-PGRLEIVSR-DPLMILDGAH 315
           + + N  +A+A L       G  LA    L +         GR    +   P +++D AH
Sbjct: 296 FNVSNLLLALATLLAL----GYPLAD---LLKTAARLQPVCGREVFTAPGKPTVVVDYAH 348

Query: 316 NPHAIKALLVTLQERFADHHKEILFTCIKTKALEDMLDLLGAMPDTELTLTHFADSRATD 375
            P A++  L   +   A     +          +  L  +         +T         
Sbjct: 349 TPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLGAIAEEFADVAVVTDDNPRTEEP 408

Query: 376 ESVLKEAAKSRNLSYQDWHDFLEQNLTDKKEEKQTVRIVTGSLYFLSQVRAYL 428
            +++ +     +  +       E      + ++  V +V G  +   Q+    
Sbjct: 409 RAIINDILAGLDAGHAKVEGRAEAVTCAVQAKENDVVLVAGKGHEDYQIVGNQ 461


>2cb4A [x.x.x] MOSQUITOCIDAL TOXIN
          Length = 253

 Score =  108 bits (271), Expect = 3e-26
 Identities = 13/301 (4%), Positives = 37/301 (12%), Gaps = 72/301 (23%)

Query: 34  NPHLKLKVLHIGGTNGKGSTIAFLKKMLEKLGLRVGVFSSPYLIHYTDQISINGESISEA 93
           N         I   +      + L +++                                
Sbjct: 1   NS--PKDNTWIQAASLTWLDSSLLYQLISTRIPSFASP---------------------- 36

Query: 94  RLEALMADYQSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDVAIMEVGM---GGLLD 150
                                         T  +         +  ++         +  
Sbjct: 37  -----------------------NGLHREQTIDSNTGQIQIDNEHRLLRWDRRPPNDIFL 73

Query: 151 STNVCQPILTGITTIGLDHVALLGDTLEAIAEQKAGIIKQGMPLVTGRIAPEALTVIDRI 210
           +  + +     ++ +   H+         +      I           +  E        
Sbjct: 74  NGFIPRVTNQNLSPVEDTHLLNY------LRTNSPSIFVSTTRARYNNLGLEITPWTPHS 127

Query: 211 AEEKDAPRLAYGTDYQVR-----HQESVVTGEVFDYTSAVRQGRFQTSLLGLYQIENAGM 265
           A      R        +       +           T               Y       
Sbjct: 128 ANNNIIYRYEIFAPGGIDINASFSRNHNPFPNEDQITFPGGIRPEFIRSTYEYHNGEIVR 187

Query: 266 AIALLDTFCQEDGRELASNDFLGQALEETSW-PGRLEIVSRDPLMILDGAHNPHAIKALL 324
                +           S           S                     +        
Sbjct: 188 IWINPNFIN-------PSTLNDVSGPSNISKVFWHENHS---EGNNDSYNQDFDFAPNGE 237

Query: 325 V 325
           +
Sbjct: 238 I 238


>3eagA [x.x.x] UDP-N-ACETYLMURAMATE:L-ALANYL-GAMMA-D-GLUTAMYL-
          Length = 316

 Score =  100 bits (249), Expect = 9e-24
 Identities = 35/281 (12%), Positives = 71/281 (25%), Gaps = 45/281 (16%)

Query: 19  HFGLERMVELLALRGNPHLKLKVLHIGGTNGKGSTIAFLKKMLEKLGLRVGVFSSPYLIH 78
           + GL  +     L  N      VL + GT+GK +T +    +    GL  G        +
Sbjct: 81  NLGLPYISGPQWLSENVLHHHWVLGVAGTHGKTTTASLAWVLE-YAGLAPGFLIGGVPEN 139

Query: 79  YTDQISINGESISEARLEALMADYQSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDV 138
           +     +      +   ++                                +F    ++ 
Sbjct: 140 FGVSARLPQTPRQDPNSQS-------------------------------PFFV---IEA 165

Query: 139 AIMEVGMGGLLDSTNVCQPILTGITTIGLDHVALLGDTLEAIAEQKAGIIKQGMPLVTGR 198
              +             +P    +  +  DH  +    L AI  Q   +++         
Sbjct: 166 DEYDTAFFDKRSKFVHYRPRTAVLNNLEFDHADIFA-DLGAIQTQFHYLVRTVPSEGLIV 224

Query: 199 IAPEALTVIDRIAEEKDAPRLAYGTDYQVRHQESVVTGEVFDYTSAVRQGRFQTSLLGLY 258
                 ++ D + +    P   +GT++  +  E+   G          +   +       
Sbjct: 225 CNGRQQSLQDTLDKGCWTPVEKFGTEHGWQAGEANADGSFDVLLDG--KTAGRVKWDLGR 282

Query: 259 QIENAGMAIALLDTFCQEDGRELASNDFLGQALEETSWPGR 299
              NA   IA                    +AL       R
Sbjct: 283 HNRNALAVIAAARHV-------GVDIQTACEALGAFKNVKR 316


>1eehA [c.5.1 - c.72.2 - c.59.1]
           UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE
          Length = 431

 Score = 90.9 bits (224), Expect = 6e-21
 Identities = 42/313 (13%), Positives = 82/313 (26%), Gaps = 35/313 (11%)

Query: 126 LAYDYFASEQVDVAIMEVGMGGLLDSTNVCQPILTGITTIGLDHVALLGDTLEAIAEQKA 185
           L       ++ ++ ++E+    L  +++  Q +   I  +  DH+      L+     K 
Sbjct: 141 LPALMLLDDECELYVLELSSFQLETTSS-LQAVAATILNVTEDHMDRYPFGLQQYRAAKL 199

Query: 186 GIIKQGMPLVTGRIAPEALTVIDRIAEEKDAPRLAYGTDYQVRHQESVVTGEVFDYTSAV 245
            I +     V                   D   +++G +                     
Sbjct: 200 RIYENAKVCVVNADDALT-----MPIRGADERCVSFGVN------MGDYHLTWLRVKGEK 248

Query: 246 RQGRFQTSLLGLYQIENAGMAIALLDTFCQEDGRELASNDFLGQALEE-TSWPGRLEIV- 303
                +  L G +   NA  A+AL D                 +AL   T  P R E+V 
Sbjct: 249 VLNVKEMKLSGQHNYTNALAALALADAAGL-------PRASSLKALTTFTGLPHRFEVVL 301

Query: 304 -SRDPLMILDGAHNPHAIKALLVTLQERFADHHKEILFTCI-KTKALEDMLDLLGAMPDT 361
                  I D         +    L     D    +L     K+     +   L      
Sbjct: 302 EHNGVRWINDSKATNVG--STEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVR 359

Query: 362 ELTLTHFADSRATDESVLKEAAKSRNLSYQDWHDFLEQNLTDKKEEKQTVRIVTGSLYFL 421
                        D + L           +     +       +     + +++ +   L
Sbjct: 360 LYCFG-------RDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGD--MVLLSPACASL 410

Query: 422 SQVRAYLMERKNE 434
            Q + +  +R NE
Sbjct: 411 DQFKNFE-QRGNE 422


>1e0dA [c.5.1 - c.72.2 - c.59.1]
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
          Length = 429

 Score = 61.3 bits (147), Expect = 5e-12
 Identities = 37/264 (14%), Positives = 67/264 (25%), Gaps = 30/264 (11%)

Query: 175 DTLEAIAEQKAGIIKQGMPLVTGRIAPEALTVIDRIAEEKDAPRLAYGTDYQVRHQESVV 234
             L+     K  I +     V        + + D          +++G +    H     
Sbjct: 183 FGLQQYRAAKLRIYENAKVCVVNADDALTMPIADERC-------VSFGVNMGDYHLNHQQ 235

Query: 235 TGEVFDYTSAVRQGRFQTSLLGLYQIENAGMAIALLDTFCQEDGRELASNDFLGQALEE- 293
                           +  L G +   NA  A+AL D                 +AL   
Sbjct: 236 GETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGL-------PRASSLKALTTF 288

Query: 294 TSWPGRLEIVSRDP---LMILDGAHNPHAIKALLVTLQERFADHHKEILFTCIKTKALED 350
           T  P R E+V        +    A N  + +A L  L      H   +L    K+     
Sbjct: 289 TGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLH--LLLGGDGKSADFSP 346

Query: 351 MLDLLGAMPDTELTLTHFADSRATDESVLKEAAKSRNLSYQDWHDFLEQNLTDKKEEKQT 410
           +   L                 A                 +     +       +     
Sbjct: 347 LARYLNGDNVRLYCFGRDGAQLA-------ALRPEVAEQTETMEQAMRLLAPRVQPGD-- 397

Query: 411 VRIVTGSLYFLSQVRAYLMERKNE 434
           + +++ +   L Q + +  +R NE
Sbjct: 398 MVLLSPACASLDQFKNF-EQRGNE 420


>2atmA [x.x.x] HYALURONOGLUCOSAMINIDASE
          Length = 323

 Score = 57.9 bits (139), Expect = 6e-11
 Identities = 6/203 (2%), Positives = 29/203 (14%), Gaps = 39/203 (19%)

Query: 162 ITTIGLDHVALLGDTLEAIAEQKAGIIKQGMP----------------LVTGRIAPEALT 205
              +            + +                              +      +   
Sbjct: 6   YWNVPTFMCHQYDLYFDEVT-NFNIKRNSKDDFQGDKIAIFYDPGEFPALLSLKDGKYKK 64

Query: 206 VIDRIAEEKDAPRLAYGTDYQVRHQESVVTGEVFD-YTSAVRQGRFQTSLLGLYQIENAG 264
               + +E +           +                    +  F+ +   +   +N  
Sbjct: 65  RNGGVPQEGNITIHLQKFIENLDKIYPNRNFSGIGVIDFERWRPIFRQNWGNMKIHKNFS 124

Query: 265 MAIALLDTFCQEDGRELASNDFLGQALEETSW-PGRLEIV-------------SRDPLMI 310
           + +       +       +     +A +                                
Sbjct: 125 IDLVR----NEHPT---WNKKIELEASKRFEKYARFFMEETLKLAKKTRKQADWGYYGYP 177

Query: 311 LDGAHNPHAIKALLVTLQERFAD 333
                +P+ +            D
Sbjct: 178 YCFNMSPNNLVPECDVTAMHEND 200


  Database: 95pdb09Oct16_0000
    Posted date:  Oct 27, 2009  4:27 PM
  Number of letters in database: 15,983,541
  Number of sequences in database:  66,450
  
Lambda     K      H
   0.324    0.138    0.394 

Gapped
Lambda     K      H
   0.267   0.0401    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 66450
Number of Hits to DB: 18,564,112
Number of extensions: 1118483
Number of successful extensions: 13300
Number of sequences better than 1.0e-03: 10
Number of HSP's gapped: 6009
Number of HSP's successfully gapped: 171
Length of database: 100,000
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)