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Caenorhabditis elegans (nematode) (cele0)
Gene : B0334.8
DDBJ      :             Gonadotropin-releasing hormone receptor like protein
Swiss-Prot:AGE1_CAEEL   RecName: Full=Phosphatidylinositol 3-kinase age-1;         Short=PtdIns-3-kinase age-1;         Short=PI3-kinase age-1;         Short=PI3K age-1;         EC=2.7.1.137;AltName: Full=Aging alteration protein 1;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  195/199 : Viruses  0/175   --->[See Alignment]
a.118.1b.7.1d.144.1d.15.1
:1182 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   106->1179 3hhmA PDBj 7e-96 30.8 %
:RPS:PDB   357->1177 1e7vA PDBj 5e-49 28.5 %
:RPS:SCOP  179->370 1e7uA3  d.15.1.5 * 8e-21 15.9 %
:RPS:SCOP  420->568 1e7uA2  b.7.1.1 * 6e-10 23.4 %
:RPS:SCOP  613->788 1e7uA1  a.118.1.6 * 3e-35 31.9 %
:RPS:SCOP  791->872 1e7uA4  d.144.1.4 * 6e-07 28.4 %
:HMM:SCOP  175->371 1e8yA3 d.15.1.5 * 2.3e-34 25.0 %
:HMM:SCOP  425->569 1e8yA2 b.7.1.1 * 1.3e-35 26.9 %
:HMM:SCOP  585->790 1e8yA1 a.118.1.6 * 3.2e-37 32.1 %
:HMM:SCOP  790->1180 1e8yA4 d.144.1.4 * 3.1e-76 28.8 %
:RPS:PFM   446->554 PF00792 * PI3K_C2 3e-07 35.6 %
:RPS:PFM   627->796 PF00613 * PI3Ka 2e-19 34.6 %
:RPS:PFM   892->1122 PF00454 * PI3_PI4_kinase 3e-17 38.7 %
:HMM:PFM   886->1129 PF00454 * PI3_PI4_kinase 3.5e-46 29.7 229/235  
:HMM:PFM   242->360 PF00794 * PI3K_rbd 1e-32 37.5 104/107  
:HMM:PFM   626->793 PF00613 * PI3Ka 3.9e-29 33.1 157/185  
:HMM:PFM   98->176 PF02192 * PI3K_p85B 3.4e-26 28.9 76/78  
:HMM:PFM   447->578 PF00792 * PI3K_C2 5.6e-28 27.9 129/141  
:BLT:SWISS 1->1182 AGE1_CAEEL 0.0 100.0 %
:PROS 889->903|PS00915|PI3_4_KINASE_1
:PROS 1016->1036|PS00916|PI3_4_KINASE_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links DAD WormBase Abbreviations Back to title page
GT:ID CAB57914.2 GT:GENE B0334.8 GT:PRODUCT Gonadotropin-releasing hormone receptor like protein GT:ORG cele0 GT:DATABASE WS208 WP:CE CE43431 WP:PRODUCT Gonadotropin-releasing hormone receptor like protein WP:LOCUS WBGene00000090 GB:PROTEIN_ID CAB57914.2 LENGTH 1182 SQ:AASEQ MSMGRSPSTTFRSRTGSHGARDLIAGHGRNSRRISQMHVNILHPQLQTMVEQWQMRERPSLETENGKGSLLLENEGVADIITMCPFGEVISVVFPWFLANVRTSLEIKLSDFKHQLFELIAPMKWGTYSVKPQDYVFRQLNNFGEIEVIFNDDQPLSKLELHGTFPMLFLYQPDGINRDKELMSDISHCLGYSLDKLEESLDEELRQFRASLWARTKKTCLTRGLEGTSHYAFPEEQYLCVGESCPKDLESKVKAAKLSYQMFWRKRKAEINGVCEKMMKIQIEFNPNETPKSLLHTFLYEMRKLDVYDTDDPADEGWFLQLAGRTTFVTNPDVKLTSYDGVRSELESYRCPGFVVRRQSLVLKDYCRPKPLYEPHYVRAHERKLALDVLSVSIDSTPKQSKNSDMVMTDFRPTASLKQVSLWDLDANLMIRPVNISGFDFPADVDMYVRIEFSVYVGTLTLASKSTTKVNAQFAKWNKEMYTFDLYMKDMPPSAVLSIRVLYGKVKLKSEEFEVGWVNMSLTDWRDELRQGQFLFHLWAPEPTANRSRIGENGARIGTNAAVTIEISSYGGRVRMPSQGQYTYLVKHRSTWTETLNIMGDDYESCIRDPGYKKLQMLVKKHESGIVLEEDEQRHVWMWRRYIQKQEPDLLIVLSELAFVWTDRENFSELYVMLEKWKPPSVAAALTLLGKRCTDRVIRKFAVEKLNEQLSPVTFHLFILPLIQALKYEPRAQSEVGMMLLTRALCDYRIGHRLFWLLRAEIARLRDCDLKSEEYRRISLLMEAYLRGNEEHIKIITRQVDMVDELTRISTLVKGMPKDVATMKLRDELRSISHKMENMDSPLDPVYKLGEMIIDKAIVLGSAKRPLMLHWKNKNPKSDLHLPFCAMIFKNGDDLRQDMLVLQVLEVMDNIWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFMNKWIRKQCGIEDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMTVIRSGKSVDGNSHELQKFKTLCVEAYEVMWNNRDLFVSLFTLMLGMELPELSTKADLDHLKKTLFCNGESKEEARKFFAGIYEEAFNGSWSTKTNWLFHAVKHY SW:ID AGE1_CAEEL SW:DE RecName: Full=Phosphatidylinositol 3-kinase age-1; Short=PtdIns-3-kinase age-1; Short=PI3-kinase age-1; Short=PI3K age-1; EC=2.7.1.137;AltName: Full=Aging alteration protein 1; SW:GN Name=age-1; ORFNames=B0334.8; SW:KW ATP-binding; Complete proteome; Kinase; Nucleotide-binding;Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->1182|AGE1_CAEEL|0.0|100.0|1182/1182| GO:SWS:NREP 4 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0016301|"GO:kinase activity"|Kinase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 889->903|PS00915|PI3_4_KINASE_1|PDOC00710| PROS 1016->1036|PS00916|PI3_4_KINASE_2|PDOC00710| SEG 193->205|sldkleesldeel| SEG 978->988|edekkkskkds| BL:PDB:NREP 1 BL:PDB:REP 106->1179|3hhmA|7e-96|30.8|947/1032| RP:PDB:NREP 1 RP:PDB:REP 357->1177|1e7vA|5e-49|28.5|722/850| RP:PFM:NREP 3 RP:PFM:REP 446->554|PF00792|3e-07|35.6|104/128|PI3K_C2| RP:PFM:REP 627->796|PF00613|2e-19|34.6|159/182|PI3Ka| RP:PFM:REP 892->1122|PF00454|3e-17|38.7|199/227|PI3_PI4_kinase| HM:PFM:NREP 5 HM:PFM:REP 886->1129|PF00454|3.5e-46|29.7|229/235|PI3_PI4_kinase| HM:PFM:REP 242->360|PF00794|1e-32|37.5|104/107|PI3K_rbd| HM:PFM:REP 626->793|PF00613|3.9e-29|33.1|157/185|PI3Ka| HM:PFM:REP 98->176|PF02192|3.4e-26|28.9|76/78|PI3K_p85B| HM:PFM:REP 447->578|PF00792|5.6e-28|27.9|129/141|PI3K_C2| GO:PFM:NREP 6 GO:PFM GO:0005942|"GO:phosphoinositide 3-kinase complex"|PF00792|IPR002420| GO:PFM GO:0016303|"GO:1-phosphatidylinositol-3-kinase activity"|PF00792|IPR002420| GO:PFM GO:0046854|"GO:phosphoinositide phosphorylation"|PF00792|IPR002420| GO:PFM GO:0048015|"GO:phosphoinositide-mediated signaling"|PF00792|IPR002420| GO:PFM GO:0004428|"GO:inositol or phosphatidylinositol kinase activity"|PF00613|IPR001263| GO:PFM GO:0016773|"GO:phosphotransferase activity, alcohol group as acceptor"|PF00454|IPR000403| RP:SCP:NREP 4 RP:SCP:REP 179->370|1e7uA3|8e-21|15.9|164/168|d.15.1.5| RP:SCP:REP 420->568|1e7uA2|6e-10|23.4|141/149|b.7.1.1| RP:SCP:REP 613->788|1e7uA1|3e-35|31.9|166/196|a.118.1.6| RP:SCP:REP 791->872|1e7uA4|6e-07|28.4|81/359|d.144.1.4| HM:SCP:REP 175->371|1e8yA3|2.3e-34|25.0|176/0|d.15.1.5|1/1|Ubiquitin-like| HM:SCP:REP 425->569|1e8yA2|1.3e-35|26.9|145/166|b.7.1.1|1/1|C2 domain (Calcium/lipid-binding domain, CaLB)| HM:SCP:REP 585->790|1e8yA1|3.2e-37|32.1|196/0|a.118.1.6|1/1|ARM repeat| HM:SCP:REP 790->1180|1e8yA4|3.1e-76|28.8|358/0|d.144.1.4|1/1|Protein kinase-like (PK-like)| OP:NHOMO 1074 OP:NHOMOORG 195 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 2211BA41621243323331111111-11111111112221111113233233223333333233323-3224233323231222323-342322333311134333598AEFFIEDA788BB7NL797RwB-BAD7A89A9AD75988AE75G8CBA56DL466A3965878631322K2222333553661579884 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 1049 STR:RPRED 88.7 SQ:SECSTR #########################################################################################################TccHHHHHHHHHHHGGGcTTGGGcccGGGcEEEEEcTTccEEEEccTTccTTTccccc##cEEEEEccccccTTTTTTTHHHHHHTccTTTTTTcccHHHHHHHHHTHHHHHHHHHHHHTTHHHHHHcccc##ccccccccHHHHTTTcccEEEE#EEEEEEEEEEETTccHHHHHH#HHHHHHHHHTcccT###THHHHHHHHHGGG####EEEEETTcccccccc#ccGGGcHHHHHHHHHTcccEEEETccccEEEETTccccccccccGGGcHHHHHHHHHTcccEEEEEccccTTTTcccccGccccccccccccccEEEEEEEEEEccccccccccEEEEEEEEEETTEEEEEEccccEEcccEEEEEEEEEEEEETTTccTTcEEEEEEEccEEcEEEEccEEEEEccccccTTcccccEEEEEEcEEcccccccGGGGcccccTTTccEEccTTEccccGGGGcccccccTTTccEEEEEEccccccccccccccHHHHHHHHHHHTccccccccHHHHHHHHHHcHHHHTTcGGGHHHHHTTccccTTcHHHHHHHHHHTTccHcccHHHHHHHccTTcccHHHHHHHHHHHTTTccHHHHHHHHHHHHHHGGGccccccHHHHHHHHHHHTcHHHHHHHHHHHHHHHHHcTTTHcTTTHHHHHHHHHHHHHTcccHHHHHHHHHHHHHHHHHHHHHHHHTcccccccccHHHHHHHHHHHHHHHTETTEEEEEEEEEcGGGcEEcccccccEEEEEEEccTTccccccEEEEEEEEcccHHHHHHHHHHHHHHHHHHHHTTcccccccccEEEEETTEEEEEccccEEEHHHHHHHHTcccccccccHHHHHHHHHHHHccc###########ccTTcHTcGGHcccHHHHHHHHHHHHHHHHHHHHHHHHTTccccccTTEEEETTccEEEccccccccccccccccHHHHHHccccTTcccccccHHHHHcccHHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHccccccHHHHHHHHHHHTTTTccHHHHHHHHHHHHHHHHHHTTHHHHHHHHHcc### DISOP:02AL 1182-1183| PSIPRED cccccccccccccccccccHHHHHHcccccccEEEEEccEEccccccHHHHHHHHHccccccccccccEEEEEcccEEEEEEEccccEEEEEEEccccccccccccccHHHHHHHHHHHHHHcccHHHccccccEEEEEEcccccEEEEEccccccccccccccccEEEEEccccccHHHHHHHHHHHHHccccccccccccHHHHHHHHHHHHHHHHHHHHccccccHHHccccccccccccccccccccccccccEEEEEEEcccEEEEEEcccEEEEEEEEEcccccHHHHHHHHHHHHHHHccccccccccccEEEEEcccEEEEEccccccccHHHHHHHHHccccccEEEEEccccccccccccccccHHHHHHHHHHcccccccccHHHHHHHcccccccccccccccccccEEEEcccccccEEEEEcccccccccccEEEEEEEEEEEccEEccccccccccccccccccEEEEcccccccccHHHEEEEEEEEEcccccccccEEEEEEEEccccccEEEEccEEEEcccccccccccccccccccccccEEEEEEEcccccccccccHHHcccccccccccccccccccccccccccccHHHHHHHHHHcccccccccHHHHHHHHHHHHHHHcccHHHHHHHHccccccccHHHHHHHHHHHHHcccccHHHHHHHcccccccHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHccccccccHHHHHHHHHHccccccccccHHHHHcccccccccccccHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHccccccccccccEEEcccccccEEEEccccccEEEEEEccccccccccccEEEEEEEcccHHHHHHHHHHHHHHHHHHHHccccEEEEEEEEEEEccccEEEEEEcccHHHHHHHHHccccHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHcHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHHHccccccHHHEEEcccccEEEEEHHHHccccccccccccccccccccHHHHHHHcccccccccHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHccccccccccHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHccccEEHHHHHHHHHcc //