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Homo sapiens (cDNA) (huge0)
Gene : KIAA0006
DDBJ      :             KIAA0006
Swiss-Prot:ARHG6_HUMAN  RecName: Full=Rho guanine nucleotide exchange factor 6;AltName: Full=Rac/Cdc42 guanine nucleotide exchange factor 6;AltName: Full=PAK-interacting exchange factor alpha;AltName: Full=Alpha-Pix;AltName: Full=COOL-2;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  120/199 : Viruses  0/175   --->[See Alignment]
a.40.1a.87.1b.34.2b.55.1
:773 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->108 1wyrA PDBj 2e-59 100.0 %
:BLT:PDB   155->219 1ujyA PDBj 3e-35 98.5 %
:BLT:PDB   226->434 1by1A PDBj 1e-82 66.5 %
:BLT:PDB   427->548 1v61A PDBj 3e-58 85.2 %
:BLT:PDB   709->758 2w6bA PDBj 2e-14 71.4 %
:RPS:PDB   1->113 2d86A PDBj 6e-13 27.4 %
:RPS:PDB   155->217 2ak5B PDBj 4e-17 77.8 %
:RPS:PDB   226->429 1by1A PDBj 2e-32 67.2 %
:RPS:PDB   426->548 1aweA PDBj 1e-08 20.0 %
:RPS:SCOP  1->121 1ujoA  a.40.1.1 * 4e-18 24.4 %
:RPS:SCOP  128->222 1udlA  b.34.2.1 * 5e-20 34.0 %
:RPS:SCOP  226->433 1by1A  a.87.1.1 * 9e-40 66.8 %
:RPS:SCOP  427->545 1v61A  b.55.1.1 * 8e-10 85.7 %
:HMM:SCOP  1->130 1ujoA_ a.40.1.1 * 5.5e-24 37.6 %
:HMM:SCOP  157->263 1ng2A2 b.34.2.1 * 8e-22 29.9 %
:HMM:SCOP  226->429 1by1A_ a.87.1.1 * 2.5e-44 30.9 %
:HMM:SCOP  420->544 1v61A_ b.55.1.1 * 1.8e-35 37.6 %
:RPS:PFM   1->90 PF00307 * CH 2e-06 33.3 %
:RPS:PFM   161->211 PF07653 * SH3_2 2e-11 51.0 %
:RPS:PFM   243->414 PF00621 * RhoGEF 1e-23 35.7 %
:HMM:PFM   242->416 PF00621 * RhoGEF 5.8e-35 29.3 174/180  
:HMM:PFM   162->214 PF07653 * SH3_2 1.2e-18 43.4 53/55  
:HMM:PFM   1->102 PF00307 * CH 2.7e-14 28.4 95/109  
:HMM:PFM   458->544 PF00169 * PH 6.2e-13 24.1 87/104  
:HMM:PFM   710->749 PF06005 * DUF904 0.0002 36.4 33/72  
:BLT:SWISS 1->773 ARHG6_HUMAN 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0006 GT:ORG huge0 GT:GENE KIAA0006 GT:PRODUCT KIAA0006 GT:DATABASE huge2038 LENGTH 773 SQ:AASEQ EEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP SW:ID ARHG6_HUMAN SW:DE RecName: Full=Rho guanine nucleotide exchange factor 6;AltName: Full=Rac/Cdc42 guanine nucleotide exchange factor 6;AltName: Full=PAK-interacting exchange factor alpha;AltName: Full=Alpha-Pix;AltName: Full=COOL-2; SW:GN Name=ARHGEF6; Synonyms=COOL2, KIAA0006, PIXA; SW:KW 3D-structure; Acetylation; Alternative splicing; Complete proteome;Guanine-nucleotide releasing factor; Mental retardation;Phosphoprotein; Polymorphism; SH3 domain. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->773|ARHG6_HUMAN|0.0|100.0|773/776| GO:SWS:NREP 1 GO:SWS GO:0005085|"GO:guanyl-nucleotide exchange factor activity"|Guanine-nucleotide releasing factor| SEG 549->569|scsslsktsssscsahssfss| SEG 587->603|slsclrpapplrpsaal| SEG 686->697|llpeeekliiee| BL:PDB:NREP 5 BL:PDB:REP 1->108|1wyrA|2e-59|100.0|108/121| BL:PDB:REP 155->219|1ujyA|3e-35|98.5|65/76| BL:PDB:REP 226->434|1by1A|1e-82|66.5|209/209| BL:PDB:REP 427->548|1v61A|3e-58|85.2|122/132| BL:PDB:REP 709->758|2w6bA|2e-14|71.4|49/50| RP:PDB:NREP 4 RP:PDB:REP 1->113|2d86A|6e-13|27.4|113/143| RP:PDB:REP 155->217|2ak5B|4e-17|77.8|63/64| RP:PDB:REP 226->429|1by1A|2e-32|67.2|204/209| RP:PDB:REP 426->548|1aweA|1e-08|20.0|120/130| RP:PFM:NREP 3 RP:PFM:REP 1->90|PF00307|2e-06|33.3|84/106|CH| RP:PFM:REP 161->211|PF07653|2e-11|51.0|51/53|SH3_2| RP:PFM:REP 243->414|PF00621|1e-23|35.7|171/179|RhoGEF| HM:PFM:NREP 5 HM:PFM:REP 242->416|PF00621|5.8e-35|29.3|174/180|RhoGEF| HM:PFM:REP 162->214|PF07653|1.2e-18|43.4|53/55|SH3_2| HM:PFM:REP 1->102|PF00307|2.7e-14|28.4|95/109|CH| HM:PFM:REP 458->544|PF00169|6.2e-13|24.1|87/104|PH| HM:PFM:REP 710->749|PF06005|0.0002|36.4|33/72|DUF904| GO:PFM:NREP 3 GO:PFM GO:0005089|"GO:Rho guanyl-nucleotide exchange factor activity"|PF00621|IPR000219| GO:PFM GO:0005622|"GO:intracellular"|PF00621|IPR000219| GO:PFM GO:0035023|"GO:regulation of Rho protein signal transduction"|PF00621|IPR000219| RP:SCP:NREP 4 RP:SCP:REP 1->121|1ujoA|4e-18|24.4|119/144|a.40.1.1| RP:SCP:REP 128->222|1udlA|5e-20|34.0|94/98|b.34.2.1| RP:SCP:REP 226->433|1by1A|9e-40|66.8|208/209|a.87.1.1| RP:SCP:REP 427->545|1v61A|8e-10|85.7|119/132|b.55.1.1| HM:SCP:REP 1->130|1ujoA_|5.5e-24|37.6|125/144|a.40.1.1|1/1|Calponin-homology domain, CH-domain| HM:SCP:REP 157->263|1ng2A2|8e-22|29.9|107/118|b.34.2.1|1/1|SH3-domain| HM:SCP:REP 226->429|1by1A_|2.5e-44|30.9|204/209|a.87.1.1|1/1|DBL homology domain (DH-domain)| HM:SCP:REP 420->544|1v61A_|1.8e-35|37.6|125/132|b.55.1.1|1/1|PH domain-like| OP:NHOMO 1823 OP:NHOMOORG 120 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----FE3-----338--2112111112---1-1---11---11-------------1-1-1-11111--1---11-1--1111111-2--2---2-1--12-2755-H23NbVUmZZD9GFHQH*wDi9**X9mRwDJBBYEJZGBLDDAYA8qFcPRN7BGB8883GB7K6B99--------------2--------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 597 STR:RPRED 77.2 SQ:SECSTR HHHHHHHHHHTTcccTTccTTTccHHHHHHHHHTcHHHHHHHHHHcTTcccGGGcccccHHHHHHHHHHHHHHHHHTTTTcccHHHHHTTccTHHHHHHHHHHTTcHHHHHHHHccEEEEcTTcHHHHHHHHHHTTcccccTTcEEEccHHHHHHHTccEEEEEccccccccTTcccccTTcEEEEEcccccEEEEEccccEEEEEGGGEEEcccccccHcccHHcTTccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHTTcTTccHHHHHHHHTTHHHHHHHHHHHHHHHHTTcccccGGGcccHHHHHHTHHHHHTHHHHHHHHHHHHHHHHHHHTcHHHHHHHHHHHHTccccHHHHHHHHHHHHHHHHHHHHHHHHTccTTcTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccHHHcccEEEEEEEEEEccccccEEEEEEEETTEEEEEEEcTTcTTcEEEcccEEEEEEEEEEEEETTcEEccEEEEEccccEEEEcccHHHHHHHHHHHHHHHHTTT################################################################################################################################################################HHHHHHHHHHHHHHHHHHHHHHH#HHHHHHHHHHHHHHHHHHHHHHHHcc############### DISOP:02AL 1-1,102-158,228-237,543-647,673-680,696-708,756-770,773-774| PSIPRED cHHHHHHHHHccccccccccccccHHHHHHHccccHHHHHHHHHHccccHHHcccccccHHHHHHHHHHHHHHHHHHcccccccccccccccccccHHHcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccEEEEEccccccccccccccHHcEEEEEEEccccEEEEEcccccccccccccccccccccccccccccccccccHHHHHHHHcHHHHHHccHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHHccHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHHcccccccHHHccHHHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccEEEEEEEEEEEcccccccEEEEEEEccEEEEEEEccccccEEEEccccHHHcEEEEccccccccEEEEEEccccEEEEEEEccHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHccccccccccccHHHccccccccHHHHHHHHEEEcccEEcccccccccccccccccccEEEcccccEEEEccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccccc //