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Homo sapiens (cDNA) (huge0)
Gene : KIAA0012
DDBJ      :             KIAA0012
Swiss-Prot:TLR1_HUMAN   RecName: Full=Toll-like receptor 1;AltName: Full=Toll/interleukin-1 receptor-like protein;         Short=TIL;AltName: CD_antigen=CD281;Flags: Precursor;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  61/199 : Viruses  0/175   --->[See Alignment]
c.10.2c.23.2
:789 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   28->559 2z7xB PDBj 0.0 92.1 %
:BLT:PDB   628->788 1fyvA PDBj 2e-90 100.0 %
:RPS:PDB   98->174 1dceA PDBj 3e-08 17.9 %
:RPS:PDB   209->321 3a24A PDBj 7e-04 16.7 %
:RPS:PDB   355->534 1dceA PDBj 3e-12 14.9 %
:RPS:SCOP  32->169 2ifgA3  c.10.2.7 * 2e-07 15.4 %
:RPS:SCOP  357->580 1gwbA  c.10.2.7 * 8e-13 21.6 %
:RPS:SCOP  628->788 1fyvA  c.23.2.1 * 5e-69 98.8 %
:HMM:SCOP  32->546 1jl5A_ c.10.2.6 * 1.2e-45 33.3 %
:HMM:SCOP  628->783 1fyvA_ c.23.2.1 * 1.2e-45 37.8 %
:RPS:PFM   643->778 PF01582 * TIR 1e-25 48.8 %
:HMM:PFM   642->777 PF01582 * TIR 6.2e-41 35.6 135/141  
:HMM:PFM   98->113 PF00560 * LRR_1 0.00046 50.0 16/22  
:HMM:PFM   557->580 PF01463 * LRRCT 1.8e-05 43.5 23/25  
:BLT:SWISS 4->789 TLR1_HUMAN 0.0 99.9 %
:TM
:REPEAT 2|8->172|205->363
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0012 GT:ORG huge0 GT:GENE KIAA0012 GT:PRODUCT KIAA0012 GT:DATABASE huge2038 LENGTH 789 SQ:AASEQ CSKMTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNTIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAKK SW:ID TLR1_HUMAN SW:DE RecName: Full=Toll-like receptor 1;AltName: Full=Toll/interleukin-1 receptor-like protein; Short=TIL;AltName: CD_antigen=CD281;Flags: Precursor; SW:GN Name=TLR1; Synonyms=KIAA0012; SW:KW 3D-structure; Cell membrane; Complete proteome; Cytoplasmic vesicle;Direct protein sequencing; Disulfide bond; Glycoprotein;Immune response; Inflammatory response; Innate immunity;Leucine-rich repeat; Membrane; Polymorphism; Receptor; Repeat; Signal;Transmembrane. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 4->789|TLR1_HUMAN|0.0|99.9|786/786| GO:SWS:NREP 7 GO:SWS GO:0005886|"GO:plasma membrane"|Cell membrane| GO:SWS GO:0031410|"GO:cytoplasmic vesicle"|Cytoplasmic vesicle| GO:SWS GO:0006954|"GO:inflammatory response"|Inflammatory response| GO:SWS GO:0045087|"GO:innate immune response"|Innate immunity| GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0004872|"GO:receptor activity"|Receptor| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| TM:NTM 2 TM:REGION 7->29| TM:REGION 580->602| NREPEAT 1 REPEAT 2|8->172|205->363| SEG 66->80|sdilslsklriliis| SEG 427->438|sllslnmssnil| SEG 587->601|vtivatmlvlavtvt| BL:PDB:NREP 2 BL:PDB:REP 28->559|2z7xB|0.0|92.1|507/520| BL:PDB:REP 628->788|1fyvA|2e-90|100.0|159/159| RP:PDB:NREP 3 RP:PDB:REP 98->174|1dceA|3e-08|17.9|77/566| RP:PDB:REP 209->321|3a24A|7e-04|16.7|102/641| RP:PDB:REP 355->534|1dceA|3e-12|14.9|174/566| RP:PFM:NREP 1 RP:PFM:REP 643->778|PF01582|1e-25|48.8|129/133|TIR| HM:PFM:NREP 3 HM:PFM:REP 642->777|PF01582|6.2e-41|35.6|135/141|TIR| HM:PFM:REP 98->113|PF00560|0.00046|50.0|16/22|LRR_1| HM:PFM:REP 557->580|PF01463|1.8e-05|43.5|23/25|LRRCT| GO:PFM:NREP 4 GO:PFM GO:0004888|"GO:transmembrane receptor activity"|PF01582|IPR000157| GO:PFM GO:0007165|"GO:signal transduction"|PF01582|IPR000157| GO:PFM GO:0031224|"GO:intrinsic to membrane"|PF01582|IPR000157| GO:PFM GO:0045087|"GO:innate immune response"|PF01582|IPR000157| RP:SCP:NREP 3 RP:SCP:REP 32->169|2ifgA3|2e-07|15.4|138/156|c.10.2.7| RP:SCP:REP 357->580|1gwbA|8e-13|21.6|218/265|c.10.2.7| RP:SCP:REP 628->788|1fyvA|5e-69|98.8|161/161|c.23.2.1| HM:SCP:REP 32->546|1jl5A_|1.2e-45|33.3|291/0|c.10.2.6|1/1|L domain-like| HM:SCP:REP 628->783|1fyvA_|1.2e-45|37.8|156/0|c.23.2.1|1/1|Toll/Interleukin receptor TIR domain| OP:NHOMO 741 OP:NHOMOORG 61 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------*DFABMC5366687FB5G5MtC1CAF7776A79AF77487B688ADBBK-1-2pV45688A--5---------------------1--- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 715 STR:RPRED 90.6 SQ:SECSTR ###########################cccEEEcTTcccccccccccTTccEEEccccccccccTTTTTTcTTccEEEcccccccEEcTTTTTTcTTccEEEcccccccEEcTTTcTTccEEEcccccccEEcGcGGGTTcccccEEEcTTcccccccEEcTTccTTcTTccEEEccccccccccTTTTTTcccccEEEcTTccccccEEcTTTTTGGGGccccEEEcccccccEEcTTTTTTcTTccEEEccccccEEEEccccGGGTTcTTccEEEcccccEEEccTTTTTTcTTccEEEcTTccEEcccccccTTTTcccccEEEccccccccccTTTTTTcTTccEEEcccccccHHHHHHcHHHHHHHHHHHHHHcTTcHHHHHHHHcTTTTHHHHHHcTGGGHHHHHHHHHHHHHHcGGGHHHHHHHHHHHHHHHHHHHGGTTccEEEccccccccccGGGGGcTTccEEEcccccccccGGGTTcccccEEEcccccccccTTGGGGGcTTccEEEcTTcGGGGcccGGGGcGGcTTccEEEccccGGGGcTTHHHHHHHHcTTcccGGGcccc##############################################ccccTTccccccEEEEEEccGGGHHHHHHTHHHHHHTTTccEEcTTTTccTTccHHHHHHHHHHHEEEEEEEEcHHHHHHTcHHHHHHTTcccccccccccEEEEEcccccGGGccTTcHHHHHHHHTcccEEccccGGGccHHHHHHHHHHHcccccccc# DISOP:02AL 1-1,780-790| PSIPRED ccccHHHHHHHHHHHHHcccccccccccEEEEEccccccccccccccccEEEEEcccccccccccHHHcccccccEEEccccccccccHHHHcccccccEEEccccccccccccccccccEEEccccccccccccHHHcccccccEEEccccccccccccccccccHHHHHHHHHHccccccccccccccccccccEEEcccccccccccHHHccccccccccHHccccccccccccccHHHHccccHHHccccccccccccHHHHccccccccccEEEEcccccccccccccccccccccccccccccccccccccccccHHcccccccEEEEEcccccccccccccccccccEEEcccccccccccHHHHccccccEEEcccccccccccccHHHcccccccEEEcccccccccccHHHHcccccccEEEcccccccccccccccccccEEEccccccccccHHHHccccccEEEcccccccccccccccccccEEEccccccccccHHHHcccccccEEEcccccccccccHHHHHHHHHHcccEEcccccccEEEcccHHHcccEEEEEEHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccEEEEEEEccccHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHHHccEEEEEEcHHHHccHHHHHHHHHHHHHHHHHcccEEEEEEEcccccHHccHHHHHHHHHHccccEEEccccHHHHHHHHHHHHHHccccccccccc //