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Homo sapiens (cDNA) (huge0)
Gene : KIAA0018
DDBJ      :             KIAA0018
Swiss-Prot:DHC24_HUMAN  RecName: Full=24-dehydrocholesterol reductase;         EC=1.3.1.-;AltName: Full=3-beta-hydroxysterol delta-24-reductase;AltName: Full=Seladin-1;AltName: Full=Diminuto/dwarf1 homolog;Flags: Precursor;

Homologs  Archaea  1/68 : Bacteria  44/915 : Eukaryota  123/199 : Viruses  0/175   --->[See Alignment]
d.145.1
:553 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   199->309 2exrA PDBj 9e-09 33.0 %
:RPS:PDB   110->532 3bw7A PDBj 1e-45 13.0 %
:RPS:SCOP  108->271 1w1oA2  d.145.1.1 * 2e-30 18.3 %
:HMM:SCOP  62->271 1w1oA2 d.145.1.1 * 3.4e-32 32.8 %
:RPS:PFM   155->237 PF01565 * FAD_binding_4 1e-08 43.4 %
:HMM:PFM   149->240 PF01565 * FAD_binding_4 5.7e-18 35.9 92/138  
:BLT:SWISS 38->553 DHC24_HUMAN 0.0 100.0 %
:TM
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0018 GT:ORG huge0 GT:GENE KIAA0018 GT:PRODUCT KIAA0018 GT:DATABASE huge2038 LENGTH 553 SQ:AASEQ DPGLPGLWATGAERARRGAGGSDRRREPAALTARRRTMEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH SW:ID DHC24_HUMAN SW:DE RecName: Full=24-dehydrocholesterol reductase; EC=1.3.1.-;AltName: Full=3-beta-hydroxysterol delta-24-reductase;AltName: Full=Seladin-1;AltName: Full=Diminuto/dwarf1 homolog;Flags: Precursor; SW:GN Name=DHCR24; Synonyms=KIAA0018; SW:KW Cholesterol biosynthesis; Complete proteome; Disease mutation;Endoplasmic reticulum; FAD; Golgi apparatus; Lipid synthesis;Membrane; Oxidoreductase; Phosphoprotein; Signal;Steroid biosynthesis; Sterol biosynthesis; Transmembrane. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 38->553|DHC24_HUMAN|0.0|100.0|516/516| GO:SWS:NREP 10 GO:SWS GO:0006695|"GO:cholesterol biosynthetic process"|Cholesterol biosynthesis| GO:SWS GO:0005783|"GO:endoplasmic reticulum"|Endoplasmic reticulum| GO:SWS GO:0005794|"GO:Golgi apparatus"|Golgi apparatus| GO:SWS GO:0008610|"GO:lipid biosynthetic process"|Lipid synthesis| GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| GO:SWS GO:0006694|"GO:steroid biosynthetic process"|Steroid biosynthesis| GO:SWS GO:0016126|"GO:sterol biosynthetic process"|Sterol biosynthesis| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| TM:NTM 2 TM:REGION 40->62| TM:REGION 74->96| SEG 9->26|atgaerarrgaggsdrrr| BL:PDB:NREP 1 BL:PDB:REP 199->309|2exrA|9e-09|33.0|103/483| RP:PDB:NREP 1 RP:PDB:REP 110->532|3bw7A|1e-45|13.0|416/497| RP:PFM:NREP 1 RP:PFM:REP 155->237|PF01565|1e-08|43.4|83/139|FAD_binding_4| HM:PFM:NREP 1 HM:PFM:REP 149->240|PF01565|5.7e-18|35.9|92/138|FAD_binding_4| GO:PFM:NREP 2 GO:PFM GO:0016491|"GO:oxidoreductase activity"|PF01565|IPR006094| GO:PFM GO:0050660|"GO:FAD binding"|PF01565|IPR006094| RP:SCP:NREP 1 RP:SCP:REP 108->271|1w1oA2|2e-30|18.3|164/206|d.145.1.1| HM:SCP:REP 62->271|1w1oA2|3.4e-32|32.8|195/206|d.145.1.1|1/1|FAD-binding domain| OP:NHOMO 284 OP:NHOMOORG 168 OP:PATTERN ------------------------------------------------1------------------- --------111-1111111-11111111111111112111------1-------------121--11---1-------------1-----------------------------------------1-------1---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1-------------------------------------------------------1----------------------------------------------------------------------------------------------------------------------------------------------------------------------1---------------------------------1--------------------------------------------------------------------------------------------------------------- ------1--------53541221525222333311132222222223233323212351111------------------------11---13----------1---21-5121111111111124111281111111111111-111111-131112124311153--2-3211----------2113422------1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 515 STR:RPRED 93.1 SQ:SECSTR ##################################HHTTTTccccccc###cHHHHHHHGGGccccGcccccGcGGccccccccccccccccccccGGGccccEccccHHHHHHHHHHHHHcTTccccEEEEccccccccTTccTTEGGGGGcccccccEEEcTTccEEEEETTccHHHHHHHHHTTTEEEccccccccccHHHHHTTccccTTHHHHccGGGcEEEEEEEETTccEEEEEccccHHHHHHHTTcTTccEEEEEEEEEEEEcccEEEEEEccHHHHHHHHHHHHcccccccccEEEEEEEEGGGHHHHHHTTccccHHHHHHHHHHHHHHTcEEcEEEEEEEEEEEcccTTHHHHHHHHHHHHHHTccccTTcEEEEEEEHHHHHTHHHHHHHHHHHTTHHHTTccccccccEEEEEEGGGHHHHHHHcccccTTTccccccEEEEEETcccccccccEEEEEEEccccccTTcHHHHHHHHHHHHHHHHHTTcccEEcccccccHHHHHHHHcHHHHHHHHHHHcTTccc#ccHHHHHHHHHT DISOP:02AL 1-2,17-27,551-554| PSIPRED ccccccccccccccccccccccccccccccHHHHHcccccHHcHHHHHHHHHcccccccEEEEEEEEEcEEEEccccccccccccHHcccccccEEEcccHHcccccHHHHHHHHHHHHHccccEEEEEcccccccccccccccccccEEEEEcccccEEEEccccEEEEEccccHHHHHHHHHHcccEEccccccccccHHHHHccccccccccccccHHHEEEEEEEEEccccEEEEcccccHHHHHHHHccccccEEEEEEEEEEEEcccEEEEEEEEcccHHHHHHHHHHHcccccccEEEEEEEccccEEEEEEEEccccccccccccccccccHHHHHHHHHHcccccccccccHHHHHccccccHHHHHHHHHHHccccHHHHHHHHHccHHHHHHHHHHHHHHHccccccccccEEEEEHHHHHHHHHHHHHccccccEEEEcEEccccccccccccccccEEEEEEEcccccccccHHHHHHHHHHHHHHHHccccHHHHHHHccHHHHHHHccccHHHHHHHHccccccccHHHHHHHccccc //