Homo sapiens (cDNA) (huge0)
Gene : KIAA0028
DDBJ : KIAA0028
Swiss-Prot:SYLM_HUMAN RecName: Full=Probable leucyl-tRNA synthetase, mitochondrial; EC=6.1.1.4;AltName: Full=Leucine--tRNA ligase; Short=LeuRS;Flags: Precursor;
Homologs Archaea 65/68 : Bacteria 911/915 : Eukaryota 195/199 : Viruses 0/175 --->[See Alignment]
a.27.1
b.51.1
c.26.1


















:904 amino acids



































































































































:SECSTR
























































































































:PSIPRED







:DISOPRED


:BLT:PDB 60->893 2bteA PDBj e-133 36.9 %


:RPS:PDB 58->902 2bteA PDBj e-132 36.9 %


:RPS:SCOP 58->287 1h3nA3 c.26.1.1 * 6e-46 45.0 %


:RPS:SCOP 282->434 1h3nA2 b.51.1.1 * 3e-18 21.2 %


:RPS:SCOP 445->682 1h3nA3 c.26.1.1 * 8e-49 51.3 %


:RPS:SCOP 700->888 1rqgA1 a.27.1.1 * 2e-13 13.3 %


:HMM:SCOP 51->683 1h3nA3 c.26.1.1 * 1e-131 32.3 %


:HMM:SCOP 692->836 1h3nA1 a.27.1.1 * 1.7e-17 35.2 %


:RPS:PFM 64->677 PF00133 * tRNA-synt_1 1e-50 37.7 %


:HMM:PFM 62->319 PF00133 * tRNA-synt_1 8e-28 30.5 203/601


:HMM:PFM 445->602 PF00133 * tRNA-synt_1 6.1e-11 23.8 143/601


:HMM:PFM 639->679 PF00133 * tRNA-synt_1 5e-10 39.0 41/601


:HMM:PFM 727->850 PF08264 * Anticodon_1 1.4e-15 27.0 115/152
:BLT:SWISS 2->904 SYLM_HUMAN 0.0 100.0 %


:PROS 92->103|PS00178|AA_TRNA_LIGASE_I
SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0028
GT:ORG huge0
GT:GENE KIAA0028
GT:PRODUCT KIAA0028
GT:DATABASE huge2038
LENGTH 904
SQ:AASEQ RMASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQMAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFLVQD
SW:ID SYLM_HUMAN
SW:DE RecName: Full=Probable leucyl-tRNA synthetase, mitochondrial; EC=6.1.1.4;AltName: Full=Leucine--tRNA ligase; Short=LeuRS;Flags: Precursor;
SW:GN Name=LARS2; Synonyms=KIAA0028;
SW:KW Acetylation; Aminoacyl-tRNA synthetase; ATP-binding;Complete proteome; Ligase; Mitochondrion; Nucleotide-binding;Polymorphism; Protein biosynthesis; Transit peptide.
SW:EXACT F
SW:FUNC +
BL:SWS:NREP 1
BL:SWS:REP 2->904|SYLM_HUMAN|0.0|100.0|903/903|
GO:SWS:NREP 6
GO:SWS GO:0004812|"GO:aminoacyl-tRNA ligase activity"|Aminoacyl-tRNA synthetase|
GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding|
GO:SWS GO:0016874|"GO:ligase activity"|Ligase|
GO:SWS GO:0005739|"GO:mitochondrion"|Mitochondrion|
GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding|
GO:SWS GO:0006412|"GO:translation"|Protein biosynthesis|
PROS 92->103|PS00178|AA_TRNA_LIGASE_I|PDOC00161|
BL:PDB:NREP 1
BL:PDB:REP 60->893|2bteA|e-133|36.9|805/876|
RP:PDB:NREP 1
RP:PDB:REP 58->902|2bteA|e-132|36.9|818/876|
RP:PFM:NREP 1
RP:PFM:REP 64->677|PF00133|1e-50|37.7|501/593|tRNA-synt_1|
HM:PFM:NREP 4
HM:PFM:REP 62->319|PF00133|8e-28|30.5|203/601|tRNA-synt_1|
HM:PFM:REP 445->602|PF00133|6.1e-11|23.8|143/601|tRNA-synt_1|
HM:PFM:REP 639->679|PF00133|5e-10|39.0|41/601|tRNA-synt_1|
HM:PFM:REP 727->850|PF08264|1.4e-15|27.0|115/152|Anticodon_1|
GO:PFM:NREP 6
GO:PFM GO:0000166|"GO:nucleotide binding"|PF00133|IPR002300|
GO:PFM GO:0004812|"GO:aminoacyl-tRNA ligase activity"|PF00133|IPR002300|
GO:PFM GO:0005524|"GO:ATP binding"|PF00133|IPR002300|
GO:PFM GO:0005737|"GO:cytoplasm"|PF00133|IPR002300|
GO:PFM GO:0006412|"GO:translation"|PF00133|IPR002300|
GO:PFM GO:0006418|"GO:tRNA aminoacylation for protein translation"|PF00133|IPR002300|
RP:SCP:NREP 4
RP:SCP:REP 58->287|1h3nA3|6e-46|45.0|230/494|c.26.1.1|
RP:SCP:REP 282->434|1h3nA2|3e-18|21.2|151/192|b.51.1.1|
RP:SCP:REP 445->682|1h3nA3|8e-49|51.3|238/494|c.26.1.1|
RP:SCP:REP 700->888|1rqgA1|2e-13|13.3|173/210|a.27.1.1|
HM:SCP:REP 51->683|1h3nA3|1e-131|32.3|465/495|c.26.1.1|1/1|Nucleotidylyl transferase|
HM:SCP:REP 692->836|1h3nA1|1.7e-17|35.2|125/128|a.27.1.1|1/1|Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases|
OP:NHOMO 3133
OP:NHOMOORG 1171
OP:PATTERN 33333233233333424122221443343423333333333334323332234333333331--22-1 3321222222222232222-23222322222232223244211223111112121113113332222222213332224323334443222322222222222222222222222222222222233311232323233233332323333333333223222323333332333333323232222233234444443444344444344443344444434443333333223333333333333343333334444434443333444332223334442222322333333333333322323333333322333222343333333333323233332333334222334233444454443343333122222232223333443344444433333333333-3333433223323223223332333332323333332232222222222232322333333322232221222222222222222432332222222222232332222233332222222223322222222223333332222222222222222322222222333232112133333333233334123122111111111111111112121122222222222222222222222222222222212222213222223222222222222222-22322222222222222222222222222222222222222222222222221222222222222222322222222222223222222222222222222322222222222222222222222222222222222222222222222222222222222222222232222121112123232344334-43433234443433222223233333333333 2211444-41121121223222322232212223322444334222324442331132122223223313342324414441222234---22212111111133313637485738233225476462dl627553332842522532261263454349H24442724244354134b4442353562353434323 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
STR:NPRED 896
STR:RPRED 99.1
SQ:SECSTR #####THGGccEEEEGGGGccTTccHHHHHHHHHHHcccTTTEEEEEEEccEEEEEEHHHHHHHHHHHHHHcccccccccTTcEEEEEEccccccccccHHHHHHHHHHHHHHHHHHHTTcEEEcccccccccHHHHHHHHHTTccHHHHHHHHHHHHHHHHHHTTccccGGGcccTTcHHHHHHHHHHHHHHHHTTcEEEEEEEEEEETTTTEEEcGGGcTTccccccTTcccEEEEEEEEEEcGGGGHHHHHHTTTTccccHHHHHHHHHHHccEEEEEEEEEcccHccccccEEEEEEccGGGGGGccEEEEcTTcTHHHHcccHHHHHHHHHHHHHHEEEEEEEEcTTTccEEEEEEcTTccTTcTTcEEEEcGGGcHHHHHHHHHTTccccccEcccccccccEcccGGGTTccHHHHHHHHHHHHHHHTcEEEEEEccccccccEEcccccccccEEEETTTEEEEcccTTcccccccHHHHccccccGGGGcHHHHEEEccccccEEEccccEEcHHHHTTTHHHHTTcTTcccccccHHHHHHHccccEEEEcGGGTTTHHHHHHHHHHHHHHTTcccccccccccEEcccEEEcEEEEEcccEEEHHHHHHTTcEEEEcTTccEEEEEcccccTTTTccccHHHHHHHccHHHHHHHHHccccTTccEEEcHHHHHHHHHHHHHHHHHHHHHHTHHHEcHHHTcccccccTTccTHHHHHHHHHHHHHHHHHHHHHHTTcHHHHHHHHHHHHHHHHHHHHHccHccHHHHHHHHHHHHHHTTTcHHHHHHHHHTTHHHHHHHHHHHHccccGGGTccccccHHHcHccccEEEEEEETTEEEEEEEEcccccccHHHHHHHHTTccccHHHHHcccccEEEEETT#TEEEEEc##
DISOP:02AL 1-3,12-31,36-51,634-645|
PSIPRED cHHHHHHHHcccHHHHHHHHHHccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHcccccccccccccEEEEEcccccccccccHHHHHHHHHHHHHHHHHHHcccEEEcccccccccHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHcccEEEccccEEcccHHHHHHHHHHHHHHHHcccEEcccEEEEccccccccccHHHHHHccccccccccEEcccccEEEEEcccHHHHHHHHHHccccccccHHHccccccccEEEEccccccccccccccEEEEEEccccccccccEEEEccccHHHHHHHcccHHHHHHHHcccccccccccccccccccccEEEEcccccccccccEEEccccccccccHHHHHcccEEEEEEEcccccEEEEccHHHccccHHHHHHHHHHHHHHccccccEEEEEccccEEEccccccEEccEEEEccccEEEEEHHHccHHHHHHHHHcccccccHHHccccccccccccccccccccccccEEEcccHHHHHHcccccccccccHHHHHccccccEEEccHHHHHHHHHHHHHHHHHHHHcccccccccHHHHEHHcEEEcHHccccccccccHHHHHccccccHHHHHHHHHcccccHHHHHccccccHHHHHHHcccHHHHHHHHHHccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccEEEcccccccHHHHcHHHHHHHHEEEccccEEEEEccccccccHHHHHHHHHccHHHHHHHccccEEEEEEEccccEEEEEEcc
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