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Homo sapiens (cDNA) (huge0)
Gene : KIAA0028
DDBJ      :             KIAA0028
Swiss-Prot:SYLM_HUMAN   RecName: Full=Probable leucyl-tRNA synthetase, mitochondrial;         EC=6.1.1.4;AltName: Full=Leucine--tRNA ligase;         Short=LeuRS;Flags: Precursor;

Homologs  Archaea  65/68 : Bacteria  911/915 : Eukaryota  195/199 : Viruses  0/175   --->[See Alignment]
a.27.1b.51.1c.26.1
:904 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   60->893 2bteA PDBj e-133 36.9 %
:RPS:PDB   58->902 2bteA PDBj e-132 36.9 %
:RPS:SCOP  58->287 1h3nA3  c.26.1.1 * 6e-46 45.0 %
:RPS:SCOP  282->434 1h3nA2  b.51.1.1 * 3e-18 21.2 %
:RPS:SCOP  445->682 1h3nA3  c.26.1.1 * 8e-49 51.3 %
:RPS:SCOP  700->888 1rqgA1  a.27.1.1 * 2e-13 13.3 %
:HMM:SCOP  51->683 1h3nA3 c.26.1.1 * 1e-131 32.3 %
:HMM:SCOP  692->836 1h3nA1 a.27.1.1 * 1.7e-17 35.2 %
:RPS:PFM   64->677 PF00133 * tRNA-synt_1 1e-50 37.7 %
:HMM:PFM   62->319 PF00133 * tRNA-synt_1 8e-28 30.5 203/601  
:HMM:PFM   445->602 PF00133 * tRNA-synt_1 6.1e-11 23.8 143/601  
:HMM:PFM   639->679 PF00133 * tRNA-synt_1 5e-10 39.0 41/601  
:HMM:PFM   727->850 PF08264 * Anticodon_1 1.4e-15 27.0 115/152  
:BLT:SWISS 2->904 SYLM_HUMAN 0.0 100.0 %
:PROS 92->103|PS00178|AA_TRNA_LIGASE_I

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0028 GT:ORG huge0 GT:GENE KIAA0028 GT:PRODUCT KIAA0028 GT:DATABASE huge2038 LENGTH 904 SQ:AASEQ RMASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQMAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFLVQD SW:ID SYLM_HUMAN SW:DE RecName: Full=Probable leucyl-tRNA synthetase, mitochondrial; EC=6.1.1.4;AltName: Full=Leucine--tRNA ligase; Short=LeuRS;Flags: Precursor; SW:GN Name=LARS2; Synonyms=KIAA0028; SW:KW Acetylation; Aminoacyl-tRNA synthetase; ATP-binding;Complete proteome; Ligase; Mitochondrion; Nucleotide-binding;Polymorphism; Protein biosynthesis; Transit peptide. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 2->904|SYLM_HUMAN|0.0|100.0|903/903| GO:SWS:NREP 6 GO:SWS GO:0004812|"GO:aminoacyl-tRNA ligase activity"|Aminoacyl-tRNA synthetase| GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0005739|"GO:mitochondrion"|Mitochondrion| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006412|"GO:translation"|Protein biosynthesis| PROS 92->103|PS00178|AA_TRNA_LIGASE_I|PDOC00161| BL:PDB:NREP 1 BL:PDB:REP 60->893|2bteA|e-133|36.9|805/876| RP:PDB:NREP 1 RP:PDB:REP 58->902|2bteA|e-132|36.9|818/876| RP:PFM:NREP 1 RP:PFM:REP 64->677|PF00133|1e-50|37.7|501/593|tRNA-synt_1| HM:PFM:NREP 4 HM:PFM:REP 62->319|PF00133|8e-28|30.5|203/601|tRNA-synt_1| HM:PFM:REP 445->602|PF00133|6.1e-11|23.8|143/601|tRNA-synt_1| HM:PFM:REP 639->679|PF00133|5e-10|39.0|41/601|tRNA-synt_1| HM:PFM:REP 727->850|PF08264|1.4e-15|27.0|115/152|Anticodon_1| GO:PFM:NREP 6 GO:PFM GO:0000166|"GO:nucleotide binding"|PF00133|IPR002300| GO:PFM GO:0004812|"GO:aminoacyl-tRNA ligase activity"|PF00133|IPR002300| GO:PFM GO:0005524|"GO:ATP binding"|PF00133|IPR002300| GO:PFM GO:0005737|"GO:cytoplasm"|PF00133|IPR002300| GO:PFM GO:0006412|"GO:translation"|PF00133|IPR002300| GO:PFM GO:0006418|"GO:tRNA aminoacylation for protein translation"|PF00133|IPR002300| RP:SCP:NREP 4 RP:SCP:REP 58->287|1h3nA3|6e-46|45.0|230/494|c.26.1.1| RP:SCP:REP 282->434|1h3nA2|3e-18|21.2|151/192|b.51.1.1| RP:SCP:REP 445->682|1h3nA3|8e-49|51.3|238/494|c.26.1.1| RP:SCP:REP 700->888|1rqgA1|2e-13|13.3|173/210|a.27.1.1| HM:SCP:REP 51->683|1h3nA3|1e-131|32.3|465/495|c.26.1.1|1/1|Nucleotidylyl transferase| HM:SCP:REP 692->836|1h3nA1|1.7e-17|35.2|125/128|a.27.1.1|1/1|Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases|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dl627553332842522532261263454349H24442724244354134b4442353562353434323 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 896 STR:RPRED 99.1 SQ:SECSTR #####THGGccEEEEGGGGccTTccHHHHHHHHHHHcccTTTEEEEEEEccEEEEEEHHHHHHHHHHHHHHcccccccccTTcEEEEEEccccccccccHHHHHHHHHHHHHHHHHHHTTcEEEcccccccccHHHHHHHHHTTccHHHHHHHHHHHHHHHHHHTTccccGGGcccTTcHHHHHHHHHHHHHHHHTTcEEEEEEEEEEETTTTEEEcGGGcTTccccccTTcccEEEEEEEEEEcGGGGHHHHHHTTTTccccHHHHHHHHHHHccEEEEEEEEEcccHccccccEEEEEEccGGGGGGccEEEEcTTcTHHHHcccHHHHHHHHHHHHHHEEEEEEEEcTTTccEEEEEEcTTccTTcTTcEEEEcGGGcHHHHHHHHHTTccccccEcccccccccEcccGGGTTccHHHHHHHHHHHHHHHTcEEEEEEccccccccEEcccccccccEEEETTTEEEEcccTTcccccccHHHHccccccGGGGcHHHHEEEccccccEEEccccEEcHHHHTTTHHHHTTcTTcccccccHHHHHHHccccEEEEcGGGTTTHHHHHHHHHHHHHHTTcccccccccccEEcccEEEcEEEEEcccEEEHHHHHHTTcEEEEcTTccEEEEEcccccTTTTccccHHHHHHHccHHHHHHHHHccccTTccEEEcHHHHHHHHHHHHHHHHHHHHHHTHHHEcHHHTcccccccTTccTHHHHHHHHHHHHHHHHHHHHHHTTcHHHHHHHHHHHHHHHHHHHHHccHccHHHHHHHHHHHHHHTTTcHHHHHHHHHTTHHHHHHHHHHHHccccGGGTccccccHHHcHccccEEEEEEETTEEEEEEEEcccccccHHHHHHHHTTccccHHHHHcccccEEEEETT#TEEEEEc## DISOP:02AL 1-3,12-31,36-51,634-645| PSIPRED cHHHHHHHHcccHHHHHHHHHHccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHcccccccccccccEEEEEcccccccccccHHHHHHHHHHHHHHHHHHHcccEEEcccccccccHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHcccEEEccccEEcccHHHHHHHHHHHHHHHHcccEEcccEEEEccccccccccHHHHHHccccccccccEEcccccEEEEEcccHHHHHHHHHHccccccccHHHccccccccEEEEccccccccccccccEEEEEEccccccccccEEEEccccHHHHHHHcccHHHHHHHHcccccccccccccccccccccEEEEcccccccccccEEEccccccccccHHHHHcccEEEEEEEcccccEEEEccHHHccccHHHHHHHHHHHHHHccccccEEEEEccccEEEccccccEEccEEEEccccEEEEEHHHccHHHHHHHHHcccccccHHHccccccccccccccccccccccccEEEcccHHHHHHcccccccccccHHHHHccccccEEEccHHHHHHHHHHHHHHHHHHHHcccccccccHHHHEHHcEEEcHHccccccccccHHHHHccccccHHHHHHHHHcccccHHHHHccccccHHHHHHHcccHHHHHHHHHHccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccEEEcccccccHHHHcHHHHHHHHEEEccccEEEEEccccccccHHHHHHHHHccHHHHHHHccccEEEEEEEccccEEEEEEcc //