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Homo sapiens (cDNA) (huge0)
Gene : KIAA0032
DDBJ      :             KIAA0032
Swiss-Prot:HERC3_HUMAN  RecName: Full=Probable E3 ubiquitin-protein ligase HERC3;         EC=6.3.2.-;AltName: Full=HECT domain and RCC1-like domain-containing protein 3;

Homologs  Archaea  0/68 : Bacteria  67/915 : Eukaryota  197/199 : Viruses  0/175   --->[See Alignment]
b.69.5d.148.1
:1054 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   40->386 1i2mD PDBj 1e-29 29.4 %
:BLT:PDB   703->1033 1c4zA PDBj 2e-60 37.3 %
:RPS:PDB   5->387 1a12A PDBj 3e-29 26.3 %
:RPS:PDB   703->1047 1c4zA PDBj 2e-72 37.5 %
:RPS:SCOP  28->387 1a12A  b.69.5.1 * 2e-84 28.6 %
:RPS:SCOP  688->1049 1nd7A  d.148.1.1 * 4e-83 26.6 %
:HMM:SCOP  3->384 1a12A_ b.69.5.1 * 9.1e-103 41.6 %
:HMM:SCOP  683->1049 1nd7A_ d.148.1.1 * 2.5e-109 43.7 %
:RPS:PFM   57->103 PF00415 * RCC1 5e-05 38.8 %
:RPS:PFM   107->156 PF00415 * RCC1 4e-08 46.9 %
:RPS:PFM   160->209 PF00415 * RCC1 4e-08 42.0 %
:RPS:PFM   213->261 PF00415 * RCC1 6e-08 44.9 %
:RPS:PFM   265->312 PF00415 * RCC1 1e-06 43.8 %
:RPS:PFM   764->1054 PF00632 * HECT 1e-46 36.8 %
:HMM:PFM   7->53 PF00415 * RCC1 1.7e-05 32.6 46/51  
:HMM:PFM   56->103 PF00415 * RCC1 8e-16 45.8 48/51  
:HMM:PFM   107->156 PF00415 * RCC1 7.4e-17 40.0 50/51  
:HMM:PFM   159->209 PF00415 * RCC1 3.4e-16 45.1 51/51  
:HMM:PFM   212->261 PF00415 * RCC1 1.6e-17 42.0 50/51  
:HMM:PFM   264->312 PF00415 * RCC1 3.1e-16 44.9 49/51  
:HMM:PFM   317->380 PF00415 * RCC1 1.2e-08 32.7 49/51  
:HMM:PFM   757->1053 PF00632 * HECT 5.4e-83 40.5 291/308  
:BLT:SWISS 5->1054 HERC3_HUMAN 0.0 100.0 %
:PROS 43->53|PS00626|RCC1_2
:PROS 93->103|PS00626|RCC1_2
:PROS 251->261|PS00626|RCC1_2
:REPEAT 6|29->72|79->122|132->175|185->228|237->280|289->333
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0032 GT:ORG huge0 GT:GENE KIAA0032 GT:PRODUCT KIAA0032 GT:DATABASE huge2038 LENGTH 1054 SQ:AASEQ KIRTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA SW:ID HERC3_HUMAN SW:DE RecName: Full=Probable E3 ubiquitin-protein ligase HERC3; EC=6.3.2.-;AltName: Full=HECT domain and RCC1-like domain-containing protein 3; SW:GN Name=HERC3; Synonyms=KIAA0032; SW:KW Complete proteome; Cytoplasm; Cytoplasmic vesicle; Ligase;Polymorphism; Repeat; Ubl conjugation; Ubl conjugation pathway. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 5->1054|HERC3_HUMAN|0.0|100.0|1050/1050| GO:SWS:NREP 3 GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0031410|"GO:cytoplasmic vesicle"|Cytoplasmic vesicle| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| PROS 43->53|PS00626|RCC1_2|PDOC00544| PROS 93->103|PS00626|RCC1_2|PDOC00544| PROS 251->261|PS00626|RCC1_2|PDOC00544| NREPEAT 1 REPEAT 6|29->72|79->122|132->175|185->228|237->280|289->333| SEG 752->763|keffllllkell| SEG 973->988|fhefplekkkkfllfl| BL:PDB:NREP 2 BL:PDB:REP 40->386|1i2mD|1e-29|29.4|330/390| BL:PDB:REP 703->1033|1c4zA|2e-60|37.3|330/350| RP:PDB:NREP 2 RP:PDB:REP 5->387|1a12A|3e-29|26.3|365/401| RP:PDB:REP 703->1047|1c4zA|2e-72|37.5|344/350| RP:PFM:NREP 6 RP:PFM:REP 57->103|PF00415|5e-05|38.8|47/49|RCC1| RP:PFM:REP 107->156|PF00415|4e-08|46.9|49/49|RCC1| RP:PFM:REP 160->209|PF00415|4e-08|42.0|49/49|RCC1| RP:PFM:REP 213->261|PF00415|6e-08|44.9|49/49|RCC1| RP:PFM:REP 265->312|PF00415|1e-06|43.8|48/49|RCC1| RP:PFM:REP 764->1054|PF00632|1e-46|36.8|285/297|HECT| HM:PFM:NREP 8 HM:PFM:REP 7->53|PF00415|1.7e-05|32.6|46/51|RCC1| HM:PFM:REP 56->103|PF00415|8e-16|45.8|48/51|RCC1| HM:PFM:REP 107->156|PF00415|7.4e-17|40.0|50/51|RCC1| HM:PFM:REP 159->209|PF00415|3.4e-16|45.1|51/51|RCC1| HM:PFM:REP 212->261|PF00415|1.6e-17|42.0|50/51|RCC1| HM:PFM:REP 264->312|PF00415|3.1e-16|44.9|49/51|RCC1| HM:PFM:REP 317->380|PF00415|1.2e-08|32.7|49/51|RCC1| HM:PFM:REP 757->1053|PF00632|5.4e-83|40.5|291/308|HECT| GO:PFM:NREP 3 GO:PFM GO:0005622|"GO:intracellular"|PF00632|IPR000569| GO:PFM GO:0006464|"GO:protein modification process"|PF00632|IPR000569| GO:PFM GO:0016881|"GO:acid-amino acid ligase activity"|PF00632|IPR000569| RP:SCP:NREP 2 RP:SCP:REP 28->387|1a12A|2e-84|28.6|343/401|b.69.5.1| RP:SCP:REP 688->1049|1nd7A|4e-83|26.6|357/374|d.148.1.1| HM:SCP:REP 3->384|1a12A_|9.1e-103|41.6|361/0|b.69.5.1|1/1|RCC1/BLIP-II| HM:SCP:REP 683->1049|1nd7A_|2.5e-109|43.7|364/0|d.148.1.1|1/1|Hect, E3 ligase catalytic domain| OP:NHOMO 4753 OP:NHOMOORG 264 OP:PATTERN -------------------------------------------------------------------- ---------------------1------------------13-----1---12211----E7---------------------------------------11---5---------------------------1-31112----------------------------------------------------------1------11---------1-------------11------------------------------------------------------------------------------------------3--1------------1--------1------1-21--1-------3---1----------------------------------------1----------------------------------------------------------------------------------------------------------------1---------------1--1--1--------------------156-------------3-1--22--1-1126---------------------------------------------------------------2-----------------------------------------------------------------------------------------------1-1-2111-----------------------------1--1-------------------------------------------------------------1111-----------------------------------------------2- 7667PQM-QAA2ACD77779AA9BAA888AA8A9998767577868BB9A9AAB69A9ABBA886875187577655565776787BA-7E879A96765866EDE3M***lrgqmoUTSSVaV*uNzM**oH*f*XMSRlNZmZQZSTRlPQ*OmbZWTihPVWJIaNPtCHcZ7GMJ*JGFKIYQVZ9ZSGNfwdcX ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 717 STR:RPRED 68.0 SQ:SECSTR ####EEEEEEcTTcTTcccTT###ccEEEEEEEEcccccEEEEEEcccEEEEEETTccEEEEEccTTcTTccccTTGGGccEEccccccEEEEEEcccEEEEEETTccEEEEEcEEETTEEEEccccTccEEEEEEEcccccEEEEEEcccEEEEEETTccEEEEEcccGGGGHHHHHccEEcccccccccccccEEEEEEETTEEEEEETTccEEEEEccTTcTTcccccccEEEEEEcGGGcTccEEEEEEcccEEEEEETTccEEEEEccGGGTTcccTTcccEEEEEEcccccccEEEEEEcccEEEEEEETTccEEEEEccTTcTTcccccccEEEEEEcccTT###########GGTTTEEEEEEEEcccEEEEEEEEccc##########################################################################################################################################################################################################################################################################################################################ccccccEEEccccHHHHHHHHHHHHcGGGGGccccEEETTcccccccHHHHHHHHHHHHHHTcGGGccEEEETTTTEEEEcTTccccHHHHHHHHHHHHHHHHTTccccccccHHHHHHHTTccccHHHHHHHcHHHHHHHHHHHHcccccHHHHTccccEEEccTTTccEEEEccTTTTTccccTTTHHHHHHHHHHHHHTcTTHHHHHHHHHHHHHHHcccccccccTHHHHHHHHcccccccTTTcTTcEEEcccccccHHHHHHHHHHHTccHHHHHHHHHHHcccccccTTcGGGGccEEEEEEEccccccEEEGGGTEEEEEEcccHHHHHHHHHHHHHHcc##### DISOP:02AL 678-703| PSIPRED cccEEEEEEccccccccccccccccccccEEccccccccEEEEEEcccEEEEEEcccEEEEEEccccccccccccccccEEcccccccEEEEEEEcccEEEEEEccccEEEEEcccccccccccccccEEccEEEccccccEEEEEEEcccEEEEEEccccEEEEEcccccEEccccccccccccEEcccccccEEEEEEEcccEEEEEEccccEEEEEccccccccccccccccccEEEcccccccEEEEEEcccEEEEEEccccEEEEEccccccccccccccEEccEEcccccccEEEEEEEccccEEEEEccccEEEEEcccccccccccccccccccEEEccccccccccccccccccccEEEEEEEEccccEEEEEEcccEEccccccEEccccccccEEcccccccccccccccccccccccccccccccccccccEEEcccccccccccccccccHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHccccccccHHHHHHHHHHHHHHHcccccHHHHHHHHHccccHHHHHHHHHHHHHHHHHHcccccccccccccccHHHHHHHHHHHHHHHHHccccccHHHcccHHHHHHHHHHHHHHHHHHHHcccccccccccccEEEEcccEEEcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccEEEEEEcHHHHHHHHHHHHHcccHHHHccEEEEEEEccccccccccHHHHHHHHHHHHHccccccEEEcccccEEcccccccccHHHHHHHHHHHHHHHHccccccccccHHHHHHHccccccHHHHHHHHHHHHHHHHHHHccccccHHHccccccEEEccccccEEEEEEcccccccEEccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHcccHHHHHHHccccccccHHHHHHHcEEEcccccccHHHHHHHHHHHcccHHHHHHHHHHHHccccccccccccccEEEEEcccccccccccEEEEEEEEccccccHHHHHHHHHHHHHcccccccc //