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Homo sapiens (cDNA) (huge0)
Gene : KIAA0034
DDBJ      :             KIAA0034
Swiss-Prot:CLH1_HUMAN   RecName: Full=Clathrin heavy chain 1;AltName: Full=CLH-17;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  193/199 : Viruses  0/175   --->[See Alignment]
a.118.1a.65.1b.69.6d.157.1
:1685 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   11->503 1bpoB PDBj 0.0 100.0 %
:BLT:PDB   1192->1526 1b89A PDBj e-161 95.5 %
:RPS:PDB   11->503 1bpoB PDBj 3e-80 97.2 %
:RPS:PDB   657->981 1dk5A PDBj 9e-42 14.5 %
:RPS:PDB   1210->1526 1b89A PDBj 3e-91 95.8 %
:RPS:SCOP  11->340 1bpoA2  b.69.6.1 * 1e-42 100.0 %
:RPS:SCOP  341->497 1bpoA1  a.118.1.4 * 1e-49 91.1 %
:RPS:SCOP  706->944 1a8aA  a.65.1.1 * 3e-25 16.1 %
:RPS:SCOP  1100->1176 2cfuA2  d.157.1.13 * 4e-04 13.0 %
:RPS:SCOP  1218->1526 1b89A  a.118.1.3 * 9e-37 95.5 %
:HMM:SCOP  13->340 1c9lA2 b.69.6.1 * 1.9e-147 60.4 %
:HMM:SCOP  341->497 1bpoA1 a.118.1.4 * 6e-66 62.4 %
:HMM:SCOP  454->789 1b89A_ a.118.1.3 * 7.4e-105 41.8 %
:HMM:SCOP  822->939 1bpoA1 a.118.1.4 * 3.8e-23 28.8 %
:HMM:SCOP  896->1045 1b89A_ a.118.1.3 * 6.9e-36 35.9 %
:HMM:SCOP  1046->1190 1b89A_ a.118.1.3 * 5.4e-34 32.2 %
:HMM:SCOP  1192->1527 1b89A_ a.118.1.3 * 4.8e-121 42.3 %
:RPS:PFM   158->197 PF01394 * Clathrin_propel 4e-09 64.1 %
:RPS:PFM   341->364 PF09268 * Clathrin-link 3e-08 91.7 %
:RPS:PFM   703->831 PF00637 * Clathrin 4e-06 28.4 %
:RPS:PFM   854->985 PF00637 * Clathrin 1e-07 29.7 %
:RPS:PFM   995->1128 PF00637 * Clathrin 7e-17 33.3 %
:RPS:PFM   1099->1173 PF04053 * Coatomer_WDAD 2e-04 30.6 %
:HMM:PFM   553->688 PF00637 * Clathrin 7.3e-25 23.3 133/144  
:HMM:PFM   699->836 PF00637 * Clathrin 1.9e-28 24.3 136/144  
:HMM:PFM   849->978 PF00637 * Clathrin 2.3e-31 32.0 128/144  
:HMM:PFM   989->1129 PF00637 * Clathrin 8.4e-37 30.9 139/144  
:HMM:PFM   1139->1277 PF00637 * Clathrin 2.3e-32 30.4 138/144  
:HMM:PFM   1285->1427 PF00637 * Clathrin 1.1e-35 27.9 140/144  
:HMM:PFM   1433->1575 PF00637 * Clathrin 8.7e-34 32.4 139/144  
:HMM:PFM   29->66 PF01394 * Clathrin_propel 2.5e-07 38.9 36/37  
:HMM:PFM   70->104 PF01394 * Clathrin_propel 0.00013 20.0 35/37  
:HMM:PFM   113->143 PF01394 * Clathrin_propel 7.8e-07 19.4 31/37  
:HMM:PFM   159->197 PF01394 * Clathrin_propel 4.3e-09 38.9 36/37  
:HMM:PFM   209->244 PF01394 * Clathrin_propel 4.8e-09 27.8 36/37  
:HMM:PFM   266->298 PF01394 * Clathrin_propel 5.4e-06 24.2 33/37  
:HMM:PFM   306->340 PF01394 * Clathrin_propel 2e-06 40.0 35/37  
:HMM:PFM   341->364 PF09268 * Clathrin-link 1.4e-16 70.8 24/24  
:HMM:PFM   1099->1174 PF04053 * Coatomer_WDAD 3.3e-08 34.2 73/444  
:BLT:SWISS 11->1671 CLH1_HUMAN 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0034 GT:ORG huge0 GT:GENE KIAA0034 GT:PRODUCT KIAA0034 GT:DATABASE huge2038 LENGTH 1685 SQ:AASEQ QEETITPDSAMAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM SW:ID CLH1_HUMAN SW:DE RecName: Full=Clathrin heavy chain 1;AltName: Full=CLH-17; SW:GN Name=CLTC; Synonyms=CLH17, CLTCL2, KIAA0034; SW:KW Acetylation; Alternative splicing; Coated pit; Complete proteome;Cytoplasmic vesicle; Direct protein sequencing; Membrane;Phosphoprotein. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 11->1671|CLH1_HUMAN|0.0|100.0|1661/1675| GO:SWS:NREP 3 GO:SWS GO:0005905|"GO:coated pit"|Coated pit| GO:SWS GO:0031410|"GO:cytoplasmic vesicle"|Cytoplasmic vesicle| GO:SWS GO:0016020|"GO:membrane"|Membrane| SEG 455->468|kqllekwlkedkle| SEG 1672->1683|ppygqpqpgfgy| BL:PDB:NREP 2 BL:PDB:REP 11->503|1bpoB|0.0|100.0|493/493| BL:PDB:REP 1192->1526|1b89A|e-161|95.5|311/311| RP:PDB:NREP 3 RP:PDB:REP 11->503|1bpoB|3e-80|97.2|493/493| RP:PDB:REP 657->981|1dk5A|9e-42|14.5|297/316| RP:PDB:REP 1210->1526|1b89A|3e-91|95.8|309/311| RP:PFM:NREP 6 RP:PFM:REP 158->197|PF01394|4e-09|64.1|39/39|Clathrin_propel| RP:PFM:REP 341->364|PF09268|3e-08|91.7|24/24|Clathrin-link| RP:PFM:REP 703->831|PF00637|4e-06|28.4|125/139|Clathrin| RP:PFM:REP 854->985|PF00637|1e-07|29.7|123/139|Clathrin| RP:PFM:REP 995->1128|PF00637|7e-17|33.3|132/139|Clathrin| RP:PFM:REP 1099->1173|PF04053|2e-04|30.6|72/417|Coatomer_WDAD| HM:PFM:NREP 16 HM:PFM:REP 553->688|PF00637|7.3e-25|23.3|133/144|Clathrin| HM:PFM:REP 699->836|PF00637|1.9e-28|24.3|136/144|Clathrin| HM:PFM:REP 849->978|PF00637|2.3e-31|32.0|128/144|Clathrin| HM:PFM:REP 989->1129|PF00637|8.4e-37|30.9|139/144|Clathrin| HM:PFM:REP 1139->1277|PF00637|2.3e-32|30.4|138/144|Clathrin| HM:PFM:REP 1285->1427|PF00637|1.1e-35|27.9|140/144|Clathrin| HM:PFM:REP 1433->1575|PF00637|8.7e-34|32.4|139/144|Clathrin| HM:PFM:REP 29->66|PF01394|2.5e-07|38.9|36/37|Clathrin_propel| HM:PFM:REP 70->104|PF01394|0.00013|20.0|35/37|Clathrin_propel| HM:PFM:REP 113->143|PF01394|7.8e-07|19.4|31/37|Clathrin_propel| HM:PFM:REP 159->197|PF01394|4.3e-09|38.9|36/37|Clathrin_propel| HM:PFM:REP 209->244|PF01394|4.8e-09|27.8|36/37|Clathrin_propel| HM:PFM:REP 266->298|PF01394|5.4e-06|24.2|33/37|Clathrin_propel| HM:PFM:REP 306->340|PF01394|2e-06|40.0|35/37|Clathrin_propel| HM:PFM:REP 341->364|PF09268|1.4e-16|70.8|24/24|Clathrin-link| HM:PFM:REP 1099->1174|PF04053|3.3e-08|34.2|73/444|Coatomer_WDAD| GO:PFM:NREP 26 GO:PFM GO:0005198|"GO:structural molecule activity"|PF01394|IPR001473| GO:PFM GO:0005515|"GO:protein binding"|PF01394|IPR001473| GO:PFM GO:0006886|"GO:intracellular protein transport"|PF01394|IPR001473| GO:PFM GO:0016192|"GO:vesicle-mediated transport"|PF01394|IPR001473| GO:PFM GO:0030130|"GO:clathrin coat of trans-Golgi network vesicle"|PF01394|IPR001473| GO:PFM GO:0030132|"GO:clathrin coat of coated pit"|PF01394|IPR001473| GO:PFM GO:0005198|"GO:structural molecule activity"|PF09268|IPR015348| GO:PFM GO:0005515|"GO:protein binding"|PF09268|IPR015348| GO:PFM GO:0006886|"GO:intracellular protein transport"|PF09268|IPR015348| GO:PFM GO:0016192|"GO:vesicle-mediated transport"|PF09268|IPR015348| GO:PFM GO:0030130|"GO:clathrin coat of trans-Golgi network vesicle"|PF09268|IPR015348| GO:PFM GO:0030132|"GO:clathrin coat of coated pit"|PF09268|IPR015348| GO:PFM GO:0005515|"GO:protein binding"|PF00637|IPR000547| GO:PFM GO:0006886|"GO:intracellular protein transport"|PF00637|IPR000547| GO:PFM GO:0016192|"GO:vesicle-mediated transport"|PF00637|IPR000547| GO:PFM GO:0005515|"GO:protein binding"|PF00637|IPR000547| GO:PFM GO:0006886|"GO:intracellular protein transport"|PF00637|IPR000547| GO:PFM GO:0016192|"GO:vesicle-mediated transport"|PF00637|IPR000547| GO:PFM GO:0005515|"GO:protein binding"|PF00637|IPR000547| GO:PFM GO:0006886|"GO:intracellular protein transport"|PF00637|IPR000547| GO:PFM GO:0016192|"GO:vesicle-mediated transport"|PF00637|IPR000547| GO:PFM GO:0005198|"GO:structural molecule activity"|PF04053|IPR006692| GO:PFM GO:0005515|"GO:protein binding"|PF04053|IPR006692| GO:PFM GO:0006886|"GO:intracellular protein transport"|PF04053|IPR006692| GO:PFM GO:0016192|"GO:vesicle-mediated transport"|PF04053|IPR006692| GO:PFM GO:0030117|"GO:membrane coat"|PF04053|IPR006692| RP:SCP:NREP 5 RP:SCP:REP 11->340|1bpoA2|1e-42|100.0|330/330|b.69.6.1| RP:SCP:REP 341->497|1bpoA1|1e-49|91.1|157/157|a.118.1.4| RP:SCP:REP 706->944|1a8aA|3e-25|16.1|230/318|a.65.1.1| RP:SCP:REP 1100->1176|2cfuA2|4e-04|13.0|77/502|d.157.1.13| RP:SCP:REP 1218->1526|1b89A|9e-37|95.5|308/319|a.118.1.3| HM:SCP:REP 13->340|1c9lA2|1.9e-147|60.4|328/0|b.69.6.1|1/1|Clathrin heavy-chain terminal domain| HM:SCP:REP 341->497|1bpoA1|6e-66|62.4|157/0|a.118.1.4|1/4|ARM repeat| HM:SCP:REP 454->789|1b89A_|7.4e-105|41.8|325/0|a.118.1.3|1/5|ARM repeat| HM:SCP:REP 822->939|1bpoA1|3.8e-23|28.8|118/0|a.118.1.4|3/4|ARM repeat| HM:SCP:REP 896->1045|1b89A_|6.9e-36|35.9|145/0|a.118.1.3|3/5|ARM repeat| HM:SCP:REP 1046->1190|1b89A_|5.4e-34|32.2|143/0|a.118.1.3|4/5|ARM repeat| HM:SCP:REP 1192->1527|1b89A_|4.8e-121|42.3|336/0|a.118.1.3|5/5|ARM repeat| OP:NHOMO 371 OP:NHOMOORG 193 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1111111-311111111221111111111111111111111111111111111111111111131111-11111111-1111111111-12111111111111121-2213333A342222231332526Q213222222211212212212151765425A11222613311141111I1111141-41231121421 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 1481 STR:RPRED 87.9 SQ:SECSTR ##########ccccccEEEEEEEEGGGGTccTTcccTTTEEEEETTEEEEEEccTTccEEEEEETTcTTccEEEEccccEEEEccccccEEEEETTEEEEEETTTTEEEEEEEccccccEEEEEETTEEEEEcccEEEEEEccccccccccEEccGGGTTcEEEEEEEcTTccEEEEEEEEEETTEEEEEEEEEEcTTccEEEEEccEEEEEEEccTTccccEEEEEEEEEETTEEEEEEEEcccccTTccccccEEEEccccTTcTTccEEEEEEETTTTEEEEEETTcEEEEEETTTccEEEEEEcccccEEEEEEETTTTEEEEEETTcEEEEEEEcTTTHHHHHHHTcccHHHHHHHHHHHTccccHHHHHHHHHHHHHTTcHHHHHHHHHHcGGGTTccHHHHHHHHTcccccccccHHHHHHHHHHHHcccccHHHHHHHHHHHHTTcHHHHHHHHHTTcccccHHHHHHHHTTcHHHHHHHHTTTTccHHHHHTTcHHccHHHHHHHTTccGGGGH#HHHHHHHHHHTccTHHH########HHHHHHHHHHcTTTccHHHHHHHHHHHHHcHHH########HHHHcTTHHHHHHHHHHHHHHTTcccTT###TTTTccccHHHHHHHHHHHHHHHH##HcccHHHHHcccccccccccccHHHHHHHHHHHTcTcccccHHHHHHHHTTccHHHcHHHHHHHHHHHHHHHcHHHHHHHHHHHcccHccHHHHHHHHcccHHHHHHHHHHccHHHHHHHHHHHHHccccccHHHHHHHHHHccHHHHHHHHHHHHHHHcccHHHHHHTTccTHHHHHHHHHHHccccccccccHHHHHHHHHHHHHHHHHTTTcccccHHHHHHHHHHccHHHHHHHHHHHHHHHccHHHHHTTcccHHHHHHHHHHHHHHHcHHHHHHHHHHHHHcccHHHHHHHHTcccHHHHHHHHHHTTTTTHHHHHHHHHHHccccHHHHH##################HHHHHHHccHHHHHHHHHHHccc##ccHHHHHHHHHHHHHHHHccccccccccccTTccHHHHHHHHHTTccccHHHHHHHHHHHHHHHcccHHHHHTcHHHHHHccHHHHHHHHHHHccHHHHHHHHHHHHTcccccHHcHHHHHHHHTTccHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHTTcccccHHHHHHHHccHHHHHHHHTTTTTcccTTTHHHHHHHTTcHHHHHHHHHTTTcHHHHHHHHHHHTcHHHHHHHHHHHHHTTcHHHHHHTTTTTTTcHHHHHHHHHHHHHTTcHHHHHHHHHHHTTcTTccHTTHHHHHHHHHTTcHHHHcHHHHHHcTTccHHHHHHHHHTTTcHHHHHHHHHHTTcHHHHHHEEHHcTTTTccHHHHHHHHHHcccTHHHHHHHHHHHHHcGGGHHHHHHHHGGGccHHHHHHHHHHTTcTTTTHHHHHHHHTTccHHHHHHHHHHHHHTTcHHHHHHHHHHcccccHHHHHHHHTTcccHHHHHHHHHHHcccEEEEc######################################################################################################################################################## DISOP:02AL 1-5,1624-1643,1658-1658,1685-1686| PSIPRED ccccccccHHHcccccEEEEEEEcHHHcccccccccccEEEEEcccEEEEEEccccccEEEEEEccccccHHcccccccEEEEcccccEEEEEcccEEEEEEHHHHHHHccccccccEEEEEEEcccEEEEEEcccEEEEEEccccccEEHHHccccccccEEEEEEEcccccEEEEEEEEccccccccEEEEEEEcccccccHHHEEEEEEEEEccccccccEEEEEEEcccccEEEEEEEccccccccccccEEEEEEEcccccccccEEEEEEcccccEEEEEEcccEEEEEEccccEEEEEEEcccccEEEEEccccccEEEEEEccccEEEEEEcccHHHHHHHHccccHHHHHHHHHccccccHHHHHHHHHHHHHHcccHHHHHHHHHHccccccccHHHHHHHHccccccccccHHHHHHHHHHccccccHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHccccHHHHHHHHHHccHHHHHHHHHHccccccHHHHHHHHHHHcccHHHHHHHHHHccccccccHHHHHHHHHHcccccHHHHHHHHHHHccccccccccEEEEEEEccccHHHHHHHHHcccEEEEcHHHHHHHHHHccHHHHHHHHcccHHHHHHHHHccccccHHHHHHHHHcccHHHHHHHHHHHHHccccccEEEEEEHHHHHHHHccHHHHHHHHHHcccHHHHHHHHHHHccccccHHHHHHHHHHHHHHcccHHHHHHHcccccccHHHHHHHHHcccccccccEEEEEHHHcHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHcccccHHHHHHHHHHHcccccHHHHHHHHHHHcHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHccccHHHHHHHcccccHHHHHHHHHcccccEEEEEEEccccHHHHHHHHcccHHHHHHHHHHHHHccHHHHHHHccccccHHHHHHHHHHHHcccccccHHHHHHHHHHHHHccccHHHHHHHHHHHcccccccccccccHHHHHHHHHccccHHHHHHHHHccccHHHHHHHHHHccHHHHHHHHHHHHcccHHHHHHHHHHcccHHHHHHHHHHcccHHHHHHHHHHHHHHccccccccccccccccccHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHcccccccHHHHHHHHHHcccHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHcccccHHHHcccccEEEEHHHHHHHHHHHHHcccHHHHHHHHHHHccccccHHHHHHHHHHHHHcccHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHccHHHccHHHHHHHHHHHcHHHHHHHHHHHHHHHcHHHHHHHHHHHHHcccHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHcHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccHHHHccccccccccccccccccccccccccccccccc //