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Homo sapiens (cDNA) (huge0)
Gene : KIAA0037
DDBJ      :             KIAA0037
Swiss-Prot:ADCY7_HUMAN  RecName: Full=Adenylate cyclase type 7;         EC=4.6.1.1;AltName: Full=Adenylate cyclase type VII;AltName: Full=ATP pyrophosphate-lyase 7;AltName: Full=Adenylyl cyclase 7;

Homologs  Archaea  0/68 : Bacteria  122/915 : Eukaryota  90/199 : Viruses  0/175   --->[See Alignment]
d.58.29
:1088 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   272->461 1azsA PDBj 3e-71 63.2 %
:BLT:PDB   879->1077 1culB PDBj 6e-90 83.7 %
:RPS:PDB   278->443 1ab8A PDBj 3e-42 26.7 %
:RPS:PDB   879->1077 1cs4B PDBj 9e-51 82.1 %
:RPS:SCOP  278->443 1ab8A  d.58.29.1 * 4e-43 26.7 %
:RPS:SCOP  879->1060 1ab8A  d.58.29.1 * 1e-44 80.6 %
:HMM:SCOP  272->461 1azsA_ d.58.29.1 * 2.3e-57 34.7 %
:HMM:SCOP  880->1076 1azsB_ d.58.29.1 * 3.9e-57 40.6 %
:RPS:PFM   284->441 PF00211 * Guanylate_cyc 3e-35 43.0 %
:RPS:PFM   494->593 PF06327 * DUF1053 1e-09 40.0 %
:RPS:PFM   886->1073 PF00211 * Guanylate_cyc 2e-34 43.1 %
:HMM:PFM   279->460 PF00211 * Guanylate_cyc 2.1e-59 37.4 182/187  
:HMM:PFM   879->1075 PF00211 * Guanylate_cyc 3.8e-66 49.7 181/187  
:HMM:PFM   493->599 PF06327 * DUF1053 6.9e-23 33.3 96/101  
:BLT:SWISS 9->1088 ADCY7_HUMAN 0.0 100.0 %
:PROS 1008->1031|PS00452|GUANYLATE_CYCLASE_1
:TM
:REPEAT 2|265->428|871->1045
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0037 GT:ORG huge0 GT:GENE KIAA0037 GT:PRODUCT KIAA0037 GT:DATABASE huge2038 LENGTH 1088 SQ:AASEQ RHACQGWRMPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN SW:ID ADCY7_HUMAN SW:DE RecName: Full=Adenylate cyclase type 7; EC=4.6.1.1;AltName: Full=Adenylate cyclase type VII;AltName: Full=ATP pyrophosphate-lyase 7;AltName: Full=Adenylyl cyclase 7; SW:GN Name=ADCY7; Synonyms=KIAA0037; SW:KW ATP-binding; cAMP biosynthesis; Complete proteome; Glycoprotein;Lyase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Repeat;Transmembrane. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 9->1088|ADCY7_HUMAN|0.0|100.0|1080/1080| GO:SWS:NREP 7 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0006171|"GO:cAMP biosynthetic process"|cAMP biosynthesis| GO:SWS GO:0016829|"GO:lyase activity"|Lyase| GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| PROS 1008->1031|PS00452|GUANYLATE_CYCLASE_1|PDOC00425| TM:NTM 10 TM:REGION 40->62| TM:REGION 73->95| TM:REGION 101->123| TM:REGION 143->165| TM:REGION 182->204| TM:REGION 603->625| TM:REGION 630->652| TM:REGION 673->695| TM:REGION 740->762| TM:REGION 804->826| NREPEAT 1 REPEAT 2|265->428|871->1045| SEG 42->61|llltlllvaatacvaliiia| SEG 77->90|aflvlavfaalsvl| SEG 95->112|cllrrwlralalltwacl| SEG 154->161|gavavgav| SEG 463->478|prsqqppppsqhlprp| SEG 633->649|fglvacvlglvlglcfa| SEG 753->766|vvlltvalvaylvl| SEG 836->847|kkkfkkeheefe| SEG 850->861|envnrlllenvl| BL:PDB:NREP 2 BL:PDB:REP 272->461|1azsA|3e-71|63.2|190/190| BL:PDB:REP 879->1077|1culB|6e-90|83.7|190/190| RP:PDB:NREP 2 RP:PDB:REP 278->443|1ab8A|3e-42|26.7|166/177| RP:PDB:REP 879->1077|1cs4B|9e-51|82.1|190/190| RP:PFM:NREP 3 RP:PFM:REP 284->441|PF00211|3e-35|43.0|158/178|Guanylate_cyc| RP:PFM:REP 494->593|PF06327|1e-09|40.0|90/100|DUF1053| RP:PFM:REP 886->1073|PF00211|2e-34|43.1|170/178|Guanylate_cyc| HM:PFM:NREP 3 HM:PFM:REP 279->460|PF00211|2.1e-59|37.4|182/187|Guanylate_cyc| HM:PFM:REP 879->1075|PF00211|3.8e-66|49.7|181/187|Guanylate_cyc| HM:PFM:REP 493->599|PF06327|6.9e-23|33.3|96/101|DUF1053| GO:PFM:NREP 9 GO:PFM GO:0009190|"GO:cyclic nucleotide biosynthetic process"|PF00211|IPR001054| GO:PFM GO:0016849|"GO:phosphorus-oxygen lyase activity"|PF00211|IPR001054| GO:PFM GO:0023034|"GO:intracellular signaling pathway"|PF00211|IPR001054| GO:PFM GO:0004016|"GO:adenylate cyclase activity"|PF06327|IPR009398| GO:PFM GO:0009190|"GO:cyclic nucleotide biosynthetic process"|PF06327|IPR009398| GO:PFM GO:0016021|"GO:integral to membrane"|PF06327|IPR009398| GO:PFM GO:0009190|"GO:cyclic nucleotide biosynthetic process"|PF00211|IPR001054| GO:PFM GO:0016849|"GO:phosphorus-oxygen lyase activity"|PF00211|IPR001054| GO:PFM GO:0023034|"GO:intracellular signaling pathway"|PF00211|IPR001054| RP:SCP:NREP 2 RP:SCP:REP 278->443|1ab8A|4e-43|26.7|166/177|d.58.29.1| RP:SCP:REP 879->1060|1ab8A|1e-44|80.6|175/177|d.58.29.1| HM:SCP:REP 272->461|1azsA_|2.3e-57|34.7|190/0|d.58.29.1|1/2|Nucleotide cyclase| HM:SCP:REP 880->1076|1azsB_|3.9e-57|40.6|197/0|d.58.29.1|2/2|Nucleotide cyclase| OP:NHOMO 2315 OP:NHOMOORG 212 OP:PATTERN -------------------------------------------------------------------- -1----1--------2322-21115122222-2222---------2--------------11-----------------------1-----------------1------------------------------1-11111---2-3113-------------111-1466-----------------11-------------------------------------------------------------------------------------------------------------------------------------1-----------------------------------1---------1----31-----------41------2----------------2------2------112222221-----1------2-------------------------------------------------1-------1----1---------------2--156-------------1-1---22111--------------1133------------1211--1------3334------------------------------11---1-------------------1-------2--------------------------------------------------------------------------------------------------2212-21-----------------111-1-1-1------------------------------------------------------------2-DD2233--------2------------------------------11------1- 221133G-2---445--------------------------------------------------------------------------------------------35**bbaqUVHFIEGJGTTEVFn*J5PIpFHFENDILKAIEFBQEAbFGMLOKUgh*jSMdKNuekPR-tp15-------1----DC2222- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 511 STR:RPRED 47.0 SQ:SECSTR #################################################################################################################################################################################################################################################ccccHHHHHHHHHHHHHHHHHHHHHcTTTTEEEEEEETccccHHHHHHHHHHHHHHHHHccccccEEEEEEEccTTHHHTHHHHHHHHHHHHcccTTcEEEEEEccccTTcccccTTcEEEEEEEcccccccGGGTTcccTTcTTcccccHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEEccccTTcccHHHHHHHHHHHHHHTccccccTTTTcccccccccHHHHHHHHHHHccEEEEEEEEEEETTTcccTHHH###################################################################################################################################################################################################################################################################################################################################cccTTccccHHHHHHHHHHHHHHHHHHHHcccTTTTTEEEEEEE##cccccccccEEEEEEEEEEEEcTTHHHHccccTTTTTTHHHHHHHHHHHHHHHGGGGcGGGTTEEEEEEETTEEEEEEccccccccHcccccccTHHHHHHHHHHHHHHHHHHHHHHHHTcccccEEEEEEEEEEEEcccccccccEEEcHHHHHHHHHHHTccTTcEEEEHHHHHHHHHTTccEEEEEEEEETTTEEEEEEEEcc########### DISOP:02AL 1-4,260-273,465-552,872-880,1080-1089| PSIPRED cccccccccccccHHcccccccccHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHHHHccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHccccccccccccccEEEcccEEEEEEEEEcccHHHHHHHccHHHHHHHHHHHHHHHHHHHHHcccEEEEEEEEEEEEEEccccccHHHHHHHHHHHHHHHHHHHHHHHcccccEEEEEEEEEEEEEEEEEccccccccccccHHHHHHHHHHcccccEEEEcHHHHHHHccccEEEEcccccccEEEcccEEEEEEEEcccccccccccccccccccccHHHHHHHHHHcccccccccccccccccccccccccccccccccccccccccccccHHHHHHHcccccHHHHHHHHHHHHccccccccccccHHccEEEEEEEEccccccccccccccccHHHHHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccHHcccHHHcccccHHHHHHHHHHHHHHHHHHHHHHccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHccccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHccccccccccccccEEEEEEEEcccHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHccccEEEEEEcccEEEEEEcccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccEEEEEEEccccEEEEEEccccccccEEcHHHHHHHHHHHcccccEEEEcHHHHHHHHHccEEEEEccEEEEcccccEEEEEEEcccccccccccc //