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Homo sapiens (cDNA) (huge0)
Gene : KIAA0050
DDBJ      :             KIAA0050
Swiss-Prot:ACAP1_HUMAN  RecName: Full=Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1;AltName: Full=Centaurin-beta-1;         Short=Cnt-b1;

Homologs  Archaea  2/68 : Bacteria  10/915 : Eukaryota  197/199 : Viruses  0/175   --->[See Alignment]
a.238.1b.55.1d.211.1g.45.1
:796 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   60->413 2q13A PDBj 2e-12 21.7 %
:BLT:PDB   463->736 2b0oG PDBj 3e-28 36.3 %
:RPS:PDB   137->284 2d1lB PDBj 1e-09 10.3 %
:RPS:PDB   318->436 2codA PDBj 4e-20 20.5 %
:RPS:PDB   463->748 2b0oH PDBj 1e-33 30.7 %
:RPS:SCOP  60->314 2elbA1  a.238.1.1 * 1e-37 19.0 %
:RPS:SCOP  308->434 1wg7A  b.55.1.1 * 3e-20 30.7 %
:RPS:SCOP  463->578 1dcqA2  g.45.1.1 * 4e-42 41.4 %
:RPS:SCOP  648->748 1n11A  d.211.1.1 * 1e-19 34.3 %
:HMM:SCOP  70->280 1x04A1 a.238.1.1 * 2.1e-20 22.0 %
:HMM:SCOP  259->416 1u5eA1 b.55.1.1 * 7.7e-25 25.0 %
:HMM:SCOP  459->580 1dcqA2 g.45.1.1 * 1e-43 51.6 %
:HMM:SCOP  648->749 1ot8A_ d.211.1.1 * 7e-23 42.0 %
:RPS:PFM   232->317 PF01496 * V_ATPase_I 7e-04 39.2 %
:RPS:PFM   323->414 PF00169 * PH 1e-11 33.7 %
:RPS:PFM   463->576 PF01412 * ArfGap 5e-33 54.9 %
:RPS:PFM   695->726 PF00023 * Ank 2e-04 43.8 %
:HMM:PFM   463->577 PF01412 * ArfGap 2e-41 48.7 113/117  
:HMM:PFM   323->415 PF00169 * PH 7.9e-15 33.3 93/104  
:HMM:PFM   663->693 PF00023 * Ank 2.3e-06 35.5 31/33  
:HMM:PFM   696->726 PF00023 * Ank 1.1e-06 45.2 31/33  
:BLT:SWISS 57->796 ACAP1_HUMAN 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0050 GT:ORG huge0 GT:GENE KIAA0050 GT:PRODUCT KIAA0050 GT:DATABASE huge2038 LENGTH 796 SQ:AASEQ DTPFPLGKELCPQALPRGGPSPPSPSSPLPGTESASTCIPRGPASRARWPHSRQAEMTVKLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGTGLLESGRHYLAASRAFVVGICDLARLGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGFREARRDFWRGAESLEAALTHNAEVPRRRAQEAEEAGAALRTARAGYRGRALDYALQINVIEDKRKFDIMEFVLRLVEAQATHFQQGHEELSRLSQYRKELGAQLHQLVLNSAREKRDMEQRHVLLKQKELGGEEPEPSLREGPGGLVMEGHLFKRASNAFKTWSRRWFTIQSNQLVYQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGSGHLAIGSAATLGSGGMARGREPGGVGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLGSLHPGALLFRASGHPPSLPTMADALAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLLRLAKMREAEAAQGQAGDETYLDIFRDFSLMASDDPEKLSRRSHDLHTL SW:ID ACAP1_HUMAN SW:DE RecName: Full=Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1;AltName: Full=Centaurin-beta-1; Short=Cnt-b1; SW:GN Name=ACAP1; Synonyms=CENTB1, KIAA0050; SW:KW Acetylation; ANK repeat; Complete proteome; GTPase activation;Metal-binding; Nitration; Phosphoprotein; Polymorphism;Protein transport; Repeat; Transport; Zinc; Zinc-finger. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 57->796|ACAP1_HUMAN|0.0|100.0|740/740| GO:SWS:NREP 4 GO:SWS GO:0005096|"GO:GTPase activator activity"|GTPase activation| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0015031|"GO:protein transport"|Protein transport| GO:SWS GO:0006810|"GO:transport"|Transport| SEG 15->31|lprggpsppspssplpg| SEG 86->103|eletrlekllklgtglle| SEG 157->168|tqhtlqqqiqtl| SEG 198->216|aevprrraqeaeeagaalr| SEG 583->608|rgrrggrgrprgqppvppkpsirprp| SEG 755->764|eaeaaqgqag| BL:PDB:NREP 2 BL:PDB:REP 60->413|2q13A|2e-12|21.7|345/364| BL:PDB:REP 463->736|2b0oG|3e-28|36.3|226/253| RP:PDB:NREP 3 RP:PDB:REP 137->284|2d1lB|1e-09|10.3|145/222| RP:PDB:REP 318->436|2codA|4e-20|20.5|112/115| RP:PDB:REP 463->748|2b0oH|1e-33|30.7|238/262| RP:PFM:NREP 4 RP:PFM:REP 232->317|PF01496|7e-04|39.2|79/631|V_ATPase_I| RP:PFM:REP 323->414|PF00169|1e-11|33.7|92/102|PH| RP:PFM:REP 463->576|PF01412|5e-33|54.9|113/118|ArfGap| RP:PFM:REP 695->726|PF00023|2e-04|43.8|32/33|Ank| HM:PFM:NREP 4 HM:PFM:REP 463->577|PF01412|2e-41|48.7|113/117|ArfGap| HM:PFM:REP 323->415|PF00169|7.9e-15|33.3|93/104|PH| HM:PFM:REP 663->693|PF00023|2.3e-06|35.5|31/33|Ank| HM:PFM:REP 696->726|PF00023|1.1e-06|45.2|31/33|Ank| GO:PFM:NREP 6 GO:PFM GO:0015078|"GO:hydrogen ion transmembrane transporter activity"|PF01496|IPR002490| GO:PFM GO:0015986|"GO:ATP synthesis coupled proton transport"|PF01496|IPR002490| GO:PFM GO:0033177|"GO:proton-transporting two-sector ATPase complex, proton-transporting domain"|PF01496|IPR002490| GO:PFM GO:0008060|"GO:ARF GTPase activator activity"|PF01412|IPR001164| GO:PFM GO:0008270|"GO:zinc ion binding"|PF01412|IPR001164| GO:PFM GO:0032312|"GO:regulation of ARF GTPase activity"|PF01412|IPR001164| RP:SCP:NREP 4 RP:SCP:REP 60->314|2elbA1|1e-37|19.0|248/258|a.238.1.1| RP:SCP:REP 308->434|1wg7A|3e-20|30.7|127/150|b.55.1.1| RP:SCP:REP 463->578|1dcqA2|4e-42|41.4|116/122|g.45.1.1| RP:SCP:REP 648->748|1n11A|1e-19|34.3|99/404|d.211.1.1| HM:SCP:REP 70->280|1x04A1|2.1e-20|22.0|200/0|a.238.1.1|1/1|BAR/IMD domain-like| HM:SCP:REP 259->416|1u5eA1|7.7e-25|25.0|156/0|b.55.1.1|1/1|PH domain-like| HM:SCP:REP 459->580|1dcqA2|1e-43|51.6|122/122|g.45.1.1|1/1|ArfGap/RecO-like zinc finger| HM:SCP:REP 648->749|1ot8A_|7e-23|42.0|100/0|d.211.1.1|1/1|Ankyrin repeat| OP:NHOMO 2505 OP:NHOMOORG 209 OP:PATTERN -------------1--1--------------------------------------------------- --1----------------------------------------------------------------------------------1----------1------------1-------------------------------------------------------------------------------------------1---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------3---------------------------------------------------------------------------------------------------------------------------------------------------------11------1-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1------------------------------------------------------- 2333AAB-A4526664555674374634443555553656356444456555554646555544343424445444424444444556-33453445555424B7B1BG6FlWXnaQGBDDINJqqGlI**gCnT*DEFDZBIWJ8LHGDSEAmEROMQBGOE89D7ED9H68EB3656v65552DDEH5JA6677776 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 694 STR:RPRED 87.2 SQ:SECSTR ###########################################################HHTHHHHHHHHHHHHHHHHHHHHHHHTcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccTTccHHHHHHHHHHTcHHHHHHHHHHHHHHTccccHHHHHHHHHHHHHHHHHHHHHHHHTccTTcTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccHHHHccccccEEEEEEEcccccccccEEEEEEEcccEEEEEEcccccccccEEETTTEEEEEEEEEETTTEEEEEEccccEEEEcccHHHHHHHHHHHHHHHHHHHHHHcTTccccccccccccTTccccccccccccTTTTTTcHHTHHHHHHHHcTTTTccTTTccccccEEETTTTEEEcHHHHHHHHHHcTTTccEEETTTccccTTTTHHHHHccHHHHHHHHTTTccccccccccTTccHHHHHHHHHHHHTccTTcccGGcHHHHHHHHHTcHHHHHHHHHHHHHHHTTccHTTccTTcccccccHHHHHHHHHTTcHHHHHHHHHTTccTTccccccHHccHHHHHHHTccGGGHHHHHHHHHHcccTTcccTTcccHHHHHHHTTcHHHHHHHHHTTccTTcccTTcccHHHHHHHTTcHHHHHHHHHHHc########################################### DISOP:02AL 1-1,12-53,199-208,287-324,358-362,415-469,554-556,785-797| PSIPRED ccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccHHHHcHHHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccccccccEEEcccccccccccccccEEEEEEEEcccEEEEccccccccccEEccccccEEEccccccccEEEEEEcccEEEEEEccHHHHHHHHHHHHHHHHHHHHHccccccccccccccccccccccccccccccccccccccHHHHHHHHcccccccEEEEccccccccccccHHHHHHHHHHHHHccccccEEEEEEEEcccccHHHHHHHHHHccHHHHHHHHHcccccccccccccccHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccccccHHHHHccccHHHHHccccccccccccccccHHHHHHHcccHHHHHHHHHccccccccccccccccHHHHHHHcccHHHHHHHHHccccccccccccccHHHHHHHcccHHHHHHHHHccccccccccccccHHHHHHHHccHHHHHHHHHHHcccccccccccccccHHHHHHHHHHHccccHHHHHHHHHHHccc //