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Homo sapiens (cDNA) (huge0)
Gene : KIAA0053
DDBJ      :             KIAA0053
Swiss-Prot:RHG25_HUMAN  RecName: Full=Rho GTPase-activating protein 25;AltName: Full=Rho-type GTPase-activating protein 25;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  171/199 : Viruses  0/175   --->[See Alignment]
a.116.1b.55.1d.162.1
:666 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   68->173 1v89A PDBj 2e-60 99.1 %
:BLT:PDB   197->375 1grnB PDBj 7e-22 34.1 %
:RPS:PDB   70->171 3cxbB PDBj 1e-17 25.3 %
:RPS:PDB   164->374 3byiD PDBj 1e-40 25.0 %
:RPS:SCOP  63->170 1v89A  b.55.1.1 * 7e-17 95.4 %
:RPS:SCOP  177->374 1xa6A1  a.116.1.1 * 6e-40 27.6 %
:RPS:SCOP  483->587 1a5zA2  d.162.1.1 * 3e-04 16.7 %
:HMM:SCOP  58->220 1x1fA1 b.55.1.1 * 5e-32 38.2 %
:HMM:SCOP  176->374 1xa6A1 a.116.1.1 * 2.3e-53 37.8 %
:RPS:PFM   68->169 PF00169 * PH 2e-14 40.0 %
:RPS:PFM   198->343 PF00620 * RhoGAP 2e-31 46.5 %
:RPS:PFM   550->658 PF12128 * DUF3584 3e-04 24.0 %
:HMM:PFM   198->346 PF00620 * RhoGAP 6.3e-44 40.8 147/153  
:HMM:PFM   69->170 PF00169 * PH 1.4e-20 33.7 95/104  
:HMM:PFM   562->660 PF11559 * ADIP 1.8e-05 20.4 98/151  
:BLT:SWISS 41->666 RHG25_HUMAN 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0053 GT:ORG huge0 GT:GENE KIAA0053 GT:PRODUCT KIAA0053 GT:DATABASE huge2038 LENGTH 666 SQ:AASEQ TGPGCRPPASQPPLGFLSPLRPLFAHCPMSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA SW:ID RHG25_HUMAN SW:DE RecName: Full=Rho GTPase-activating protein 25;AltName: Full=Rho-type GTPase-activating protein 25; SW:GN Name=ARHGAP25; Synonyms=KIAA0053; SW:KW 3D-structure; Alternative splicing; Coiled coil; Complete proteome;GTPase activation; Phosphoprotein; Polymorphism. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 41->666|RHG25_HUMAN|0.0|100.0|626/645| GO:SWS:NREP 1 GO:SWS GO:0005096|"GO:GTPase activator activity"|GTPase activation| SEG 412->430|srtdsfssmtsdsdttspt| SEG 615->623|eelekekkk| BL:PDB:NREP 2 BL:PDB:REP 68->173|1v89A|2e-60|99.1|106/118| BL:PDB:REP 197->375|1grnB|7e-22|34.1|170/197| RP:PDB:NREP 2 RP:PDB:REP 70->171|3cxbB|1e-17|25.3|95/103| RP:PDB:REP 164->374|3byiD|1e-40|25.0|204/209| RP:PFM:NREP 3 RP:PFM:REP 68->169|PF00169|2e-14|40.0|95/102|PH| RP:PFM:REP 198->343|PF00620|2e-31|46.5|144/152|RhoGAP| RP:PFM:REP 550->658|PF12128|3e-04|24.0|100/1179|DUF3584| HM:PFM:NREP 3 HM:PFM:REP 198->346|PF00620|6.3e-44|40.8|147/153|RhoGAP| HM:PFM:REP 69->170|PF00169|1.4e-20|33.7|95/104|PH| HM:PFM:REP 562->660|PF11559|1.8e-05|20.4|98/151|ADIP| GO:PFM:NREP 2 GO:PFM GO:0005622|"GO:intracellular"|PF00620|IPR000198| GO:PFM GO:0007165|"GO:signal transduction"|PF00620|IPR000198| RP:SCP:NREP 3 RP:SCP:REP 63->170|1v89A|7e-17|95.4|108/118|b.55.1.1| RP:SCP:REP 177->374|1xa6A1|6e-40|27.6|192/196|a.116.1.1| RP:SCP:REP 483->587|1a5zA2|3e-04|16.7|90/172|d.162.1.1| HM:SCP:REP 58->220|1x1fA1|5e-32|38.2|136/0|b.55.1.1|1/1|PH domain-like| HM:SCP:REP 176->374|1xa6A1|2.3e-53|37.8|193/0|a.116.1.1|1/1|GTPase activation domain, GAP| OP:NHOMO 3631 OP:NHOMOORG 171 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----YUF-----7684344444444444434444444555355324454444554444532344522327534564637745554564-79839765466699PMK-R-EU*****xSKPLQjV**M*I***H*n*LRMRtLdpYHdSQLvFI*NwfpdJaZSKIJ7QCIYHRFD----------1364342--1---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 364 STR:RPRED 54.7 SQ:SECSTR ###############################################HHHGGcccccccccccccccccEEEEEEEccccccccEEEEEEEETTEEEEEcccccccccEEEETTcEcEEEEEEccccccTTEEEEEETTcEEEccccccEEEEcccHccccccHHHHHHTTccccccTTccHHHHHHHHTcHHTccccHHHHHHHHHHHHHTTTcTTTTTccccHHHHHHHHHHHHTTccccTTcGccHHHHHHHHHHHHHHcccccccHHHHHHHHHHHTcccHcHHHHHHHHHHHHTTccHHHHHHHHHHHHHHHHHHHTHHHHcccHHHHHHHHHHHHTccTTccccHHHHcHHHHHHHHHHHHHTHHHHHTccccccccHHHHHTTcccHHHHHHccccccccEEEc############################################################################################################################################################################################################################################################### DISOP:02AL 1-6,8-12,39-68,100-129,144-165,349-352,379-574,663-667| PSIPRED cccccccccccHHccccccccccccccccccccccEEEEEcccccccccHHHccccccccccccccccEEEEEEEEccccccccEEEEEEEEccEEEEEEcccccccccEEEcccccccccccccccccEEEEEEcccccccccccccccccccccHHHHHHHHHHcccccccccccccccHHHHHHHHHccccccHHHHHHHHHHHHHHHccccccEEEccccHHHHHHHHHHHHccccccccccccHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHcccccHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHcEEEEEcccHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHcccc //