Homo sapiens (cDNA) (huge0)
Gene : KIAA0053
DDBJ : KIAA0053
Swiss-Prot:RHG25_HUMAN RecName: Full=Rho GTPase-activating protein 25;AltName: Full=Rho-type GTPase-activating protein 25;
Homologs Archaea 0/68 : Bacteria 0/915 : Eukaryota 171/199 : Viruses 0/175 --->[See Alignment]
a.116.1
b.55.1
d.162.1
:666 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB 68->173 1v89A PDBj 2e-60 99.1 %
:BLT:PDB 197->375 1grnB PDBj 7e-22 34.1 %
:RPS:PDB 70->171 3cxbB PDBj 1e-17 25.3 %
:RPS:PDB 164->374 3byiD PDBj 1e-40 25.0 %
:RPS:SCOP 63->170 1v89A b.55.1.1 * 7e-17 95.4 %
:RPS:SCOP 177->374 1xa6A1 a.116.1.1 * 6e-40 27.6 %
:RPS:SCOP 483->587 1a5zA2 d.162.1.1 * 3e-04 16.7 %
:HMM:SCOP 58->220 1x1fA1 b.55.1.1 * 5e-32 38.2 %
:HMM:SCOP 176->374 1xa6A1 a.116.1.1 * 2.3e-53 37.8 %
:RPS:PFM 68->169 PF00169 * PH 2e-14 40.0 %
:RPS:PFM 198->343 PF00620 * RhoGAP 2e-31 46.5 %
:RPS:PFM 550->658 PF12128 * DUF3584 3e-04 24.0 %
:HMM:PFM 198->346 PF00620 * RhoGAP 6.3e-44 40.8 147/153
:HMM:PFM 69->170 PF00169 * PH 1.4e-20 33.7 95/104
:HMM:PFM 562->660 PF11559 * ADIP 1.8e-05 20.4 98/151
:BLT:SWISS 41->666 RHG25_HUMAN 0.0 100.0 %
:SEG
SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0053
GT:ORG huge0
GT:GENE KIAA0053
GT:PRODUCT KIAA0053
GT:DATABASE huge2038
LENGTH 666
SQ:AASEQ TGPGCRPPASQPPLGFLSPLRPLFAHCPMSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTMSQDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSGEEEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAALEISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEA
SW:ID RHG25_HUMAN
SW:DE RecName: Full=Rho GTPase-activating protein 25;AltName: Full=Rho-type GTPase-activating protein 25;
SW:GN Name=ARHGAP25; Synonyms=KIAA0053;
SW:KW 3D-structure; Alternative splicing; Coiled coil; Complete proteome;GTPase activation; Phosphoprotein; Polymorphism.
SW:EXACT F
SW:FUNC +
BL:SWS:NREP 1
BL:SWS:REP 41->666|RHG25_HUMAN|0.0|100.0|626/645|
GO:SWS:NREP 1
GO:SWS GO:0005096|"GO:GTPase activator activity"|GTPase activation|
SEG 412->430|srtdsfssmtsdsdttspt|
SEG 615->623|eelekekkk|
BL:PDB:NREP 2
BL:PDB:REP 68->173|1v89A|2e-60|99.1|106/118|
BL:PDB:REP 197->375|1grnB|7e-22|34.1|170/197|
RP:PDB:NREP 2
RP:PDB:REP 70->171|3cxbB|1e-17|25.3|95/103|
RP:PDB:REP 164->374|3byiD|1e-40|25.0|204/209|
RP:PFM:NREP 3
RP:PFM:REP 68->169|PF00169|2e-14|40.0|95/102|PH|
RP:PFM:REP 198->343|PF00620|2e-31|46.5|144/152|RhoGAP|
RP:PFM:REP 550->658|PF12128|3e-04|24.0|100/1179|DUF3584|
HM:PFM:NREP 3
HM:PFM:REP 198->346|PF00620|6.3e-44|40.8|147/153|RhoGAP|
HM:PFM:REP 69->170|PF00169|1.4e-20|33.7|95/104|PH|
HM:PFM:REP 562->660|PF11559|1.8e-05|20.4|98/151|ADIP|
GO:PFM:NREP 2
GO:PFM GO:0005622|"GO:intracellular"|PF00620|IPR000198|
GO:PFM GO:0007165|"GO:signal transduction"|PF00620|IPR000198|
RP:SCP:NREP 3
RP:SCP:REP 63->170|1v89A|7e-17|95.4|108/118|b.55.1.1|
RP:SCP:REP 177->374|1xa6A1|6e-40|27.6|192/196|a.116.1.1|
RP:SCP:REP 483->587|1a5zA2|3e-04|16.7|90/172|d.162.1.1|
HM:SCP:REP 58->220|1x1fA1|5e-32|38.2|136/0|b.55.1.1|1/1|PH domain-like|
HM:SCP:REP 176->374|1xa6A1|2.3e-53|37.8|193/0|a.116.1.1|1/1|GTPase activation domain, GAP|
OP:NHOMO 3631
OP:NHOMOORG 171
OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----YUF-----7684344444444444434444444555355324454444554444532344522327534564637745554564-79839765466699PMK-R-EU*****xSKPLQjV**M*I***H*n*LRMRtLdpYHdSQLvFI*NwfpdJaZSKIJ7QCIYHRFD----------1364342--1---- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
STR:NPRED 364
STR:RPRED 54.7
SQ:SECSTR ###############################################HHHGGcccccccccccccccccEEEEEEEccccccccEEEEEEEETTEEEEEcccccccccEEEETTcEcEEEEEEccccccTTEEEEEETTcEEEccccccEEEEcccHccccccHHHHHHTTccccccTTccHHHHHHHHTcHHTccccHHHHHHHHHHHHHTTTcTTTTTccccHHHHHHHHHHHHTTccccTTcGccHHHHHHHHHHHHHHcccccccHHHHHHHHHHHTcccHcHHHHHHHHHHHHTTccHHHHHHHHHHHHHHHHHHHTHHHHcccHHHHHHHHHHHHTccTTccccHHHHcHHHHHHHHHHHHHTHHHHHTccccccccHHHHHTTcccHHHHHHccccccccEEEc###############################################################################################################################################################################################################################################################
DISOP:02AL 1-6,8-12,39-68,100-129,144-165,349-352,379-574,663-667|
PSIPRED cccccccccccHHccccccccccccccccccccccEEEEEcccccccccHHHccccccccccccccccEEEEEEEEccccccccEEEEEEEEccEEEEEEcccccccccEEEcccccccccccccccccEEEEEEcccccccccccccccccccccHHHHHHHHHHcccccccccccccccHHHHHHHHHccccccHHHHHHHHHHHHHHHccccccEEEccccHHHHHHHHHHHHccccccccccccHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHcccccHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHcEEEEEcccHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHcccc
//
[GTOP]
