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Homo sapiens (cDNA) (huge0)
Gene : KIAA0055
DDBJ      :             KIAA0055
Swiss-Prot:UBP8_HUMAN   RecName: Full=Ubiquitin carboxyl-terminal hydrolase 8;         EC=3.1.2.15;AltName: Full=Ubiquitin thioesterase 8;AltName: Full=Ubiquitin-specific-processing protease 8;AltName: Full=Deubiquitinating enzyme 8;         Short=hUBPy;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  197/199 : Viruses  1/175   --->[See Alignment]
a.118.23b.72.1c.46.1d.3.1
:1120 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   8->141 2a9uA PDBj 1e-70 100.0 %
:BLT:PDB   176->322 1whbA PDBj 2e-83 98.6 %
:BLT:PDB   764->1111 2gfoA PDBj e-179 96.1 %
:RPS:PDB   8->134 2a9uB PDBj 9e-26 100.0 %
:RPS:PDB   185->329 1cwsA PDBj 1e-09 17.2 %
:RPS:PDB   780->1108 2aynA PDBj 2e-45 27.3 %
:RPS:SCOP  8->141 2a9uA1  a.118.23.1 * 6e-40 99.3 %
:RPS:SCOP  183->317 2gwfA1  c.46.1.4 * 5e-16 100.0 %
:RPS:SCOP  651->679 1f8aB1  b.72.1.1 * 6e-04 31.0 %
:RPS:SCOP  764->1111 2gfoA1  d.3.1.9 * 2e-84 93.8 %
:HMM:SCOP  8->141 2a9uA1 a.118.23.1 * 4.9e-50 57.5 %
:HMM:SCOP  177->325 1whbA_ c.46.1.4 * 4.4e-31 25.5 %
:HMM:SCOP  774->1108 2gfoA1 d.3.1.9 * 2.2e-109 43.7 %
:RPS:PFM   10->115 PF08969 * DUF1873 6e-27 67.9 %
:RPS:PFM   112->173 PF07946 * DUF1682 5e-04 38.3 %
:RPS:PFM   780->1108 PF00443 * UCH 5e-79 46.8 %
:HMM:PFM   778->1108 PF00443 * UCH 1.4e-87 45.2 259/271  
:HMM:PFM   8->115 PF08969 * DUF1873 5.5e-47 60.2 108/111  
:HMM:PFM   186->307 PF00581 * Rhodanese 2.3e-11 22.2 108/113  
:HMM:PFM   474->744 PF09731 * Mitofilin 5.9e-06 16.8 161/583  
:BLT:SWISS 3->1120 UBP8_HUMAN 0.0 100.0 %
:PROS 825->834|PS00304|SASP_1
:PROS 780->795|PS00972|UCH_2_1
:PROS 1053->1070|PS00973|UCH_2_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0055 GT:ORG huge0 GT:GENE KIAA0055 GT:PRODUCT KIAA0055 GT:DATABASE huge2038 LENGTH 1120 SQ:AASEQ FIMPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDENIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT SW:ID UBP8_HUMAN SW:DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase 8; EC=3.1.2.15;AltName: Full=Ubiquitin thioesterase 8;AltName: Full=Ubiquitin-specific-processing protease 8;AltName: Full=Deubiquitinating enzyme 8; Short=hUBPy; SW:GN Name=USP8; Synonyms=KIAA0055, UBPY; SW:KW 3D-structure; Complete proteome; Hydrolase; Phosphoprotein;Polymorphism; Protease; SH3-binding; Thiol protease;Ubl conjugation pathway. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 3->1120|UBP8_HUMAN|0.0|100.0|1118/1118| GO:SWS:NREP 4 GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0008233|"GO:peptidase activity"|Protease| GO:SWS GO:0017124|"GO:SH3 domain binding"|SH3-binding| GO:SWS GO:0008234|"GO:cysteine-type peptidase activity"|Thiol protease| PROS 825->834|PS00304|SASP_1|PDOC00276| PROS 780->795|PS00972|UCH_2_1|PDOC00750| PROS 1053->1070|PS00973|UCH_2_2|PDOC00750| SEG 476->515|eknkqekelrerqqeeqkeklrkeeqeqkakkkqeaeene| SEG 518->541|ekqqkakeemekkeseqakkedke| SEG 682->702|ppemapssappstppthkakp| SEG 1090->1101|vsdisvssvkss| BL:PDB:NREP 3 BL:PDB:REP 8->141|2a9uA|1e-70|100.0|133/133| BL:PDB:REP 176->322|1whbA|2e-83|98.6|147/157| BL:PDB:REP 764->1111|2gfoA|e-179|96.1|335/335| RP:PDB:NREP 3 RP:PDB:REP 8->134|2a9uB|9e-26|100.0|126/126| RP:PDB:REP 185->329|1cwsA|1e-09|17.2|134/178| RP:PDB:REP 780->1108|2aynA|2e-45|27.3|286/337| RP:PFM:NREP 3 RP:PFM:REP 10->115|PF08969|6e-27|67.9|106/110|DUF1873| RP:PFM:REP 112->173|PF07946|5e-04|38.3|60/317|DUF1682| RP:PFM:REP 780->1108|PF00443|5e-79|46.8|325/337|UCH| HM:PFM:NREP 4 HM:PFM:REP 778->1108|PF00443|1.4e-87|45.2|259/271|UCH| HM:PFM:REP 8->115|PF08969|5.5e-47|60.2|108/111|DUF1873| HM:PFM:REP 186->307|PF00581|2.3e-11|22.2|108/113|Rhodanese| HM:PFM:REP 474->744|PF09731|5.9e-06|16.8|161/583|Mitofilin| GO:PFM:NREP 2 GO:PFM GO:0004221|"GO:ubiquitin thiolesterase activity"|PF00443|IPR001394| GO:PFM GO:0006511|"GO:ubiquitin-dependent protein catabolic process"|PF00443|IPR001394| RP:SCP:NREP 4 RP:SCP:REP 8->141|2a9uA1|6e-40|99.3|134/134|a.118.23.1| RP:SCP:REP 183->317|2gwfA1|5e-16|100.0|135/135|c.46.1.4| RP:SCP:REP 651->679|1f8aB1|6e-04|31.0|29/42|b.72.1.1| RP:SCP:REP 764->1111|2gfoA1|2e-84|93.8|339/339|d.3.1.9| HM:SCP:REP 8->141|2a9uA1|4.9e-50|57.5|134/0|a.118.23.1|1/1|USP8 N-terminal domain-like| HM:SCP:REP 177->325|1whbA_|4.4e-31|25.5|149/0|c.46.1.4|1/1|Rhodanese/Cell cycle control phosphatase| HM:SCP:REP 774->1108|2gfoA1|2.2e-109|43.7|334/0|d.3.1.9|1/1|Cysteine proteinases| OP:NHOMO 3667 OP:NHOMOORG 198 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 4334EGC-E551AA95685688777667757777887867677777448877975775675667865737A8777AA5A978896868-7B766876567677CBD3EABfdjeiXmPOOORfN**GyX***D*i*RQNHtMXqTQaNRNjKH*OkjbXIUhNIOPBVFDcFEMG4585j77869GGCV6MIA9BDBDA --------------------------------------------------------------------------------------------------------------------------------------------------------------------------1---- STR:NPRED 791 STR:RPRED 70.6 SQ:SECSTR #######cccccccccccHHHHHHTTcccGGGccHHHHHHHHHHHHHHHHHHHHTTcHHHHHHHHcHHHHHHHHHTTcHHHHTTHHHHHHHHcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHHcHHHHHHHHHHHHHHHGGGHHHHTTccGGGcGGGGGEEEETTEEEcHHHHHHHHTTTTTTEEEEEcccHHHHHTcEETTcEEcccHHHHHHHHcHHHHHHHHHTcccccccTTcEEEEEEEccccccHHHHHHHHHHHHHHHTccTTcccEEcccEEEETTHHHHHTTTcGGGEEccccccTTcGGGHHccEETTcccccccEETTEEEEEccHHHHHHHHHH#########HHcccEEcHHHHHHHHHHcHHHHHHHHcccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccGGGccEEccEEE###################################################################################################################################################################################################################################################################################################################cGGGccEEccccTTccEEccccccHHHHHHHHHHHTcHHHHHHHHTccccccccccccccHHHHHHHHHHHHHHHHHHHcccEEccHHHHHHHHHHccTTcccccccHHHHHHHHHHHHHTTcccccccccccccccTTccHHHHHHHHHHHHHHHcccHHHHHTcEEEEEEEEEcccccccccccEEEEccEEEcccccccHHHHHHHTTEEcccEcTTccEETTTTEEccEEEEEEEEEccccEEEEEEccccccccccccccccccccTccccccccTTTTccccEEEEEEEEEEEccTTccEEEEEEEEETTEcEEEEcTHHHHGGGGccccccEEEEEEEEccEcc###### DISOP:02AL 1-1,6-6,133-179,315-749,1115-1121| PSIPRED cccccccccccEEEccccHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHccccEEEEEEcccHHHHHHccccccccccHHHccccccHHHHHHHccHHHHHHHHHcccccEEEEEcccccccccccccHHHHHHHHHHccccccccccccEEEEcHHHHHHHHccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccEEEEEcccccHHHHHHHHHHHccHHHHHHHHHcccHHHccccccccccHHHHHHHHHHHHHHHccccccccHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHcccccccccccccHHHHHHHHHHHHHccccccccccccccccEEEEEEEEcccccEEEEEHHHHHHcccccccccccHHHHHHHcccHHHcccHHcccccccccccEEEEEEEEcccccEEEEEEEEEEEccccccccccEEEEEHHHcccccHHHHccccccccEEEEEEEccccccccEEEEEEEEccccEEEEEEccEEEEccHHHHHccccEEEEEEEcccccccccc 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