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Homo sapiens (cDNA) (huge0)
Gene : KIAA0067
DDBJ      :             KIAA0067
Swiss-Prot:SETB1_HUMAN  RecName: Full=Histone-lysine N-methyltransferase SETDB1;         EC=2.1.1.43;AltName: Full=SET domain bifurcated 1;AltName: Full=ERG-associated protein with SET domain;         Short=ESET;AltName: Full=Histone H3-K9 methyltransferase 4;AltName: Full=H3-K9-HMTase 4;AltName: Full=Lysine N-methyltransferase 1E;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  158/199 : Viruses  0/175   --->[See Alignment]
b.34.9b.85.7d.10.1e.11.1
:1300 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   205->406 3dlmA PDBj e-121 100.0 %
:BLT:PDB   690->873 2o8jA PDBj 2e-27 37.4 %
:BLT:PDB   1174->1299 2r3aA PDBj 3e-18 41.1 %
:RPS:PDB   17->106 3dyjA PDBj 7e-04 11.1 %
:RPS:PDB   200->406 3dlmA PDBj 4e-31 98.1 %
:RPS:PDB   606->667 3c2iA PDBj 1e-12 21.3 %
:RPS:PDB   785->868 3dalB PDBj 1e-11 20.7 %
:RPS:PDB   1207->1298 3dalB PDBj 8e-14 15.3 %
:RPS:SCOP  259->322 2hqxA1  b.34.9.1 * 4e-06 18.6 %
:RPS:SCOP  298->428 1bgwA  e.11.1.1 * 4e-05 17.2 %
:RPS:SCOP  595->667 1ub1A  d.10.1.3 * 3e-14 21.9 %
:RPS:SCOP  698->880 1ml9A  b.85.7.1 * 1e-33 30.7 %
:RPS:SCOP  1213->1290 1ml9A  b.85.7.1 * 1e-19 30.8 %
:HMM:SCOP  266->324 2gfaA1 b.34.9.1 * 0.0003 24.5 %
:HMM:SCOP  603->680 1d9nA_ d.10.1.3 * 1.5e-14 33.8 %
:HMM:SCOP  697->1297 1ml9A_ b.85.7.1 * 3.5e-88 42.5 %
:RPS:PFM   691->804 PF05033 * Pre-SET 1e-20 54.5 %
:RPS:PFM   1210->1274 PF00856 * SET 1e-08 50.8 %
:HMM:PFM   823->1275 PF00856 * SET 1.7e-65 53.8 158/158  
:HMM:PFM   690->804 PF05033 * Pre-SET 8.7e-22 41.6 101/103  
:HMM:PFM   604->673 PF01429 * MBD 2.9e-14 21.4 70/77  
:BLT:SWISS 10->1300 SETB1_HUMAN 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0067 GT:ORG huge0 GT:GENE KIAA0067 GT:PRODUCT KIAA0067 GT:DATABASE huge2038 LENGTH 1300 SQ:AASEQ SWKTGEDKSMSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDLHKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRPNMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRMEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKTSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGSEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGAIECRGRLL SW:ID SETB1_HUMAN SW:DE RecName: Full=Histone-lysine N-methyltransferase SETDB1; EC=2.1.1.43;AltName: Full=SET domain bifurcated 1;AltName: Full=ERG-associated protein with SET domain; Short=ESET;AltName: Full=Histone H3-K9 methyltransferase 4;AltName: Full=H3-K9-HMTase 4;AltName: Full=Lysine N-methyltransferase 1E; SW:GN Name=SETDB1; Synonyms=KIAA0067, KMT1E; SW:KW 3D-structure; Alternative splicing; Chromatin regulator;Chromosomal protein; Coiled coil; Complete proteome; Isopeptide bond;Methyltransferase; Nucleus; Phosphoprotein; Polymorphism; Repeat;Repressor; S-adenosyl-L-methionine; Transcription;Transcription regulation; Transferase; Ubl conjugation. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 10->1300|SETB1_HUMAN|0.0|100.0|1291/1291| GO:SWS:NREP 7 GO:SWS GO:0016568|"GO:chromatin modification"|Chromatin regulator| GO:SWS GO:0005694|"GO:chromosome"|Chromosomal protein| GO:SWS GO:0008168|"GO:methyltransferase activity"|Methyltransferase| GO:SWS GO:0005634|"GO:nucleus"|Nucleus| GO:SWS GO:0006350|"GO:transcription"|Transcription| GO:SWS GO:0045449|"GO:regulation of transcription"|Transcription regulation| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| SEG 117->127|rdsssedessr| SEG 130->140|eiieipdeddd| SEG 456->478|pveppqptappappfppapplsp| SEG 537->558|splgstasapapsalpappapp| SEG 905->924|edpeesnddssddnfckded| SEG 962->976|gpphipvppsipvgg| SEG 1109->1124|ltlssstesegesgts| BL:PDB:NREP 3 BL:PDB:REP 205->406|3dlmA|e-121|100.0|202/208| BL:PDB:REP 690->873|2o8jA|2e-27|37.4|171/254| BL:PDB:REP 1174->1299|2r3aA|3e-18|41.1|124/270| RP:PDB:NREP 5 RP:PDB:REP 17->106|3dyjA|7e-04|11.1|90/311| RP:PDB:REP 200->406|3dlmA|4e-31|98.1|207/208| RP:PDB:REP 606->667|3c2iA|1e-12|21.3|61/70| RP:PDB:REP 785->868|3dalB|1e-11|20.7|83/166| RP:PDB:REP 1207->1298|3dalB|8e-14|15.3|85/166| RP:PFM:NREP 2 RP:PFM:REP 691->804|PF05033|1e-20|54.5|101/103|Pre-SET| RP:PFM:REP 1210->1274|PF00856|1e-08|50.8|59/146|SET| HM:PFM:NREP 3 HM:PFM:REP 823->1275|PF00856|1.7e-65|53.8|158/158|SET| HM:PFM:REP 690->804|PF05033|8.7e-22|41.6|101/103|Pre-SET| HM:PFM:REP 604->673|PF01429|2.9e-14|21.4|70/77|MBD| GO:PFM:NREP 4 GO:PFM GO:0005634|"GO:nucleus"|PF05033|IPR007728| GO:PFM GO:0008270|"GO:zinc ion binding"|PF05033|IPR007728| GO:PFM GO:0016568|"GO:chromatin modification"|PF05033|IPR007728| GO:PFM GO:0018024|"GO:histone-lysine N-methyltransferase activity"|PF05033|IPR007728| RP:SCP:NREP 5 RP:SCP:REP 259->322|2hqxA1|4e-06|18.6|59/90|b.34.9.1| RP:SCP:REP 298->428|1bgwA|4e-05|17.2|122/679|e.11.1.1| RP:SCP:REP 595->667|1ub1A|3e-14|21.9|73/125|d.10.1.3| RP:SCP:REP 698->880|1ml9A|1e-33|30.7|179/260|b.85.7.1| RP:SCP:REP 1213->1290|1ml9A|1e-19|30.8|74/260|b.85.7.1| HM:SCP:REP 266->324|2gfaA1|0.0003|24.5|53/0|b.34.9.1|2/2|Tudor/PWWP/MBT| HM:SCP:REP 603->680|1d9nA_|1.5e-14|33.8|74/75|d.10.1.3|1/1|DNA-binding domain| HM:SCP:REP 697->1297|1ml9A_|3.5e-88|42.5|266/0|b.85.7.1|1/1|SET domain| OP:NHOMO 991 OP:NHOMOORG 158 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 11--221-1--122211-111111111111111-11111111111111121111-11111111-----------------------2--12211231-11-2-124-2436CDEACB78578C8SO5N5**C4NEQ6868D99B849868B84D9EB9869A5677356393376-111-32243EGFM1J73-11-13 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 730 STR:RPRED 56.2 SQ:SECSTR ################HHHHHHHHHHHHTTTccTTcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHH##################################################################################ccTTcEEEcTcEEcEETTEETTcEEEEEcTTccEEEEEEEEEEEETTEEEEEEEEccccEEEEcGGGEEEcccccGGGccTTcEEEEEEEccccEEEEEEEEEEcccTTTTccEEEEETTccEEEEcGGGEEEcccccccGGGGcccHHHHHHHHHHHHHTTccccccccTTcEEEEEETTEEEEEEEEEEETTEEEEEETTTTEEEEEETTcTTcccTcTTcccEEEEccTTEEEEEcE#################################################################################################################################################################################cccccTTccTTcEEEEEEccccTTTTEEEEEEcTTccEEccHHHHHHHHcHHTcccccTTTc#####################ccTTTTcccccccEEcccccccccccEEcccccccccccccccGGGccccccccccTccTTcHHHHHTccccccTTccccTTTcccTcccccccHHTTccHHHHHHHcccEEEcccccHHHHTccTTEEcccccEEEEEEcccccTTEEEcccccEEEcGGGccccTTEEEEEETTEEEEcEEEEcccc#EEEEcccEEcGG################################################################################################################################################################################################################################################################################TccTTEEEEEcccEEEEEcccccTTcEEcccccEEEcEEEcccEEEETTEEEEEEEcccTTcccGGGGcEEcccTTTccEEEEEETTEEEEcEEEEEEcccccTTcccEEEEcHHHHHHTTcccccTTcccHHHHTc# DISOP:02AL 1-11,115-131,150-205,410-578,626-627,852-854,888-917,926-1130| PSIPRED ccccccccccccccccEEcccccEEEcHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccEEEEcccccccccccccEEcccccccEEEEccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHcccccHHHccccccccccccccccccEEEEEEEcccccccccccEEEEEEEEcccccEEEEEEccccccEEEEEEEEEEcccccccEEEEEEEEEEEccccEEEEEccEEcccccccccEEEEEEEEccccccccccHHHHHHHHHHHHHHHccccHHHHHHHHHHHHcccccEEEEEcccEEEEEEccEEEEEEEEEccccEEEEHHcccccEEEEEcccccccHHHcccccccccccccccccccccccccccccccEEccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccEEccccccccccccccccccccccccccHHHcccccccccHHHcccEEEEEEEcccccccccEEEEcccccccccHHHHHHHHHHcccccEEEEEEcccccEEccccccccccEEEEcccccccccccEEEEEccccccccccEEEEEEEccccccccccHHHccccccccccccccccccHHHHHHHccccccccccccccccccccccccccEEEEccccccccccccccEEEEccccccEEEEEEccccEEEEEccccccccEEEEEEEHHccHHHHHHHHHHHcccEEEEcccccEEEHHccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccEEEEEcccccHHccccccccccccHHHcccccccccHHHHHHHHHcccccccccccHHHccccccccHHHcccccccccccccccccccccccccccccccccccccccccccccccHHHccccccccccccccccccccccccHHHHHHHcccHHHcccccccccHHHHccccccEEEEEEEEccccEEEEEccccccccEEEEEEEEEEEHHHHcccHHHHcccccEEEEEccccccHHHHHHccccccEEEEEEEEccccccEEEEEEEEccccccccEEEEEccccccccccEEEEccccccccccccc //