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Homo sapiens (cDNA) (huge0)
Gene : KIAA0070
DDBJ      :             KIAA0070
Swiss-Prot:SYK_HUMAN    RecName: Full=Lysyl-tRNA synthetase;         EC=6.1.1.6;AltName: Full=Lysine--tRNA ligase;         Short=LysRS;

Homologs  Archaea  63/68 : Bacteria  899/915 : Eukaryota  197/199 : Viruses  0/175   --->[See Alignment]
b.40.4d.104.1
:601 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   74->580 3bjuA PDBj 0.0 100.0 %
:RPS:PDB   75->579 3bjuD PDBj 8e-94 99.0 %
:RPS:SCOP  75->218 1bbuA1  b.40.4.1 * 9e-27 30.5 %
:RPS:SCOP  226->579 1bbuA2  d.104.1.1 * e-113 49.4 %
:HMM:SCOP  74->218 1e1oA1 b.40.4.1 * 6.1e-44 38.1 %
:HMM:SCOP  226->579 1bbuA2 d.104.1.1 * 5.4e-114 40.9 %
:RPS:PFM   132->209 PF01336 * tRNA_anti 7e-09 46.5 %
:RPS:PFM   226->575 PF00152 * tRNA-synt_2 4e-53 38.6 %
:HMM:PFM   227->578 PF00152 * tRNA-synt_2 3.3e-94 33.3 315/323  
:HMM:PFM   131->210 PF01336 * tRNA_anti 5.6e-16 33.8 74/76  
:BLT:SWISS 5->601 SYK_HUMAN 0.0 99.8 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0070 GT:ORG huge0 GT:GENE KIAA0070 GT:PRODUCT KIAA0070 GT:DATABASE huge2038 LENGTH 601 SQ:AASEQ PSGKMAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGSSV SW:ID SYK_HUMAN SW:DE RecName: Full=Lysyl-tRNA synthetase; EC=6.1.1.6;AltName: Full=Lysine--tRNA ligase; Short=LysRS; SW:GN Name=KARS; Synonyms=KIAA0070; SW:KW 3D-structure; Acetylation; Aminoacyl-tRNA synthetase; ATP-binding;Complete proteome; Cytoplasm; Direct protein sequencing; Ligase;Nucleotide-binding; Phosphoprotein; Polymorphism;Protein biosynthesis. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 5->601|SYK_HUMAN|0.0|99.8|597/597| GO:SWS:NREP 6 GO:SWS GO:0004812|"GO:aminoacyl-tRNA ligase activity"|Aminoacyl-tRNA synthetase| GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006412|"GO:translation"|Protein biosynthesis| SEG 24->47|knelkrrlkaekkvaekeakqkel| SEG 55->64|ataaatnhtt| BL:PDB:NREP 1 BL:PDB:REP 74->580|3bjuA|0.0|100.0|503/503| RP:PDB:NREP 1 RP:PDB:REP 75->579|3bjuD|8e-94|99.0|499/499| RP:PFM:NREP 2 RP:PFM:REP 132->209|PF01336|7e-09|46.5|71/74|tRNA_anti| RP:PFM:REP 226->575|PF00152|4e-53|38.6|329/337|tRNA-synt_2| HM:PFM:NREP 2 HM:PFM:REP 227->578|PF00152|3.3e-94|33.3|315/323|tRNA-synt_2| HM:PFM:REP 131->210|PF01336|5.6e-16|33.8|74/76|tRNA_anti| GO:PFM:NREP 7 GO:PFM GO:0003676|"GO:nucleic acid binding"|PF01336|IPR004365| GO:PFM GO:0000166|"GO:nucleotide binding"|PF00152|IPR004364| GO:PFM GO:0004812|"GO:aminoacyl-tRNA ligase activity"|PF00152|IPR004364| GO:PFM GO:0005524|"GO:ATP binding"|PF00152|IPR004364| GO:PFM GO:0005737|"GO:cytoplasm"|PF00152|IPR004364| GO:PFM GO:0006412|"GO:translation"|PF00152|IPR004364| GO:PFM GO:0006418|"GO:tRNA aminoacylation for protein translation"|PF00152|IPR004364| RP:SCP:NREP 2 RP:SCP:REP 75->218|1bbuA1|9e-27|30.5|141/144|b.40.4.1| RP:SCP:REP 226->579|1bbuA2|e-113|49.4|342/342|d.104.1.1| HM:SCP:REP 74->218|1e1oA1|6.1e-44|38.1|139/143|b.40.4.1|1/1|Nucleic acid-binding proteins| HM:SCP:REP 226->579|1bbuA2|5.4e-114|40.9|342/342|d.104.1.1|1/1|Class II aaRS and biotin synthetases| OP:NHOMO 2694 OP:NHOMOORG 1159 OP:PATTERN ---1112222222222122222211111111111111111111221211122211111111111--22 2222223222232223322-23222322222233333333212221222111222322--22233232--222222221222122223222222222-12222222222222222222222222222222222222222223332122222222222222222222222222222222222222222211222222222223222222222222222222222222222222222222222222222122222222222222222222222222222222222222333222222222222222222222222322222222222223222222222222222222422222333222222222222222222123222211111222121211111111111111111-111111111213333333333333222111122222---111111111223221211111111---11111111111111111111111122222222222222222222222222222222222222222222222222222222222222222222222333232222222222333333333333333442212222222222222222222222222223333333222222222222222222223-3232223233333333334444445444-44444444444444444444443333333333333333333333343333432333333333333223333333333332333333333333333433333333333322222222222222222223333333332333333333333333233333333333322222233331111111112222222-22222212222212322222222222222212 3321334-93312344433554444453333233333333233333323322222232444443333332233324334433334322-24242322221122345143354422261121131332916O315561211312322221222232323233423313333445523333N3433342582372243332 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 521 STR:RPRED 86.7 SQ:SECSTR #########################################################################cccHHHHHHHHHHHHHHHHHTTcccccccccccccHHHHHHHcTTccTTcccTTccEEEEEEEEEEEEccccEEEEEEEETTEEEEEEEETTTcccHHHHHHHHHHccTTcEEEEEEEEEEcTTccEEEEEEEEEEEEcccccccccHHHHccHHHHHHcHHHHHHHcHHHHHHHHHHHHHHHHHHHHHHHTTcEEcccccEEcccccccccccEEEETTTTEEEEEccccHHHHHHHHHTTccEEEEEEEEEccccccTTcccEEEEEEEEEETccHHHHHHHHHHHHHHHHHHHHcccEEEEcTTccccccEEEEcccccEEEEHHHHHHHHHTcccccGGGTTcHHHHHHHHHHHHHTTccccccccHHHHHHHHHHHHTGGGccccEEEEcccGGGcTTcccccccTTcccEEEEEETTEEEEEEEEccccHHHHHHHHHHHHHHHHTTcTTcccccHHHHHHHHHHcccEEEEEEEHHHHHHHHTTcccGGGTcccccccccccHHHHHEEEEEcc####### DISOP:02AL 1-3,23-79,579-594,598-602| PSIPRED ccHHHHHHHHHHHccccccccccHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccccHHHcccHHHHcccHHHHHHHHHHHHHHHHHcccccccccccccccHHHHHHHHHcccccHHccccEEEEEEEEEEcccccccEEEEEEEcccEEEEEEEEccccccHHHHHHHHHccccccEEEEEEEEcccccccEEEEEEEEEEEEcccccccccccccccHHHHccccEEEEEccHHHHHHHHHHHHHHHHHHHHHHHcccEEEcccccccccccccccEEEEEEccccccEEEcccHHHHHHHHHHcccccEEEEEEEEccccccccccccccEEEEEEccccHHHHHHHHHHHHHHHHHHHHccccEEcccccccccccccccccccccccHHHHHHHHHcccccccccccHHHHHHHHHHHHHHcccccccccHHHHHHHHHHHHHHHccccccEEEEcccccccHHHccccccccEEEEEEEEEccEEccccEEEcccHHHHHHHHHHHHHHHHHcccccccccHHHHHHHHcccccccEEEEcHHHHHHHHHccccHHHccccccccccccccccccHHHHHHccccccc //