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Homo sapiens (cDNA) (huge0)
Gene : KIAA0088
DDBJ      :             KIAA0088
Swiss-Prot:GANAB_HUMAN  RecName: Full=Neutral alpha-glucosidase AB;         EC=3.2.1.84;AltName: Full=Glucosidase II subunit alpha;AltName: Full=Alpha-glucosidase 2;Flags: Precursor;

Homologs  Archaea  19/68 : Bacteria  265/915 : Eukaryota  191/199 : Viruses  0/175   --->[See Alignment]
b.30.5b.71.1c.1.8
:943 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   348->927 2qmjA PDBj 5e-73 32.9 %
:RPS:PDB   174->942 3cttA PDBj e-102 27.0 %
:RPS:SCOP  205->370 1we5A2  b.30.5.11 * 1e-07 19.7 %
:RPS:SCOP  373->721 1we5A4  c.1.8.13 * e-102 28.9 %
:RPS:SCOP  723->804 1we5A3  b.71.1.4 * 9e-21 30.4 %
:HMM:SCOP  40->371 2f2hA2 b.30.5.11 * 9.7e-15 27.2 %
:HMM:SCOP  372->722 2f2hA4 c.1.8.13 * 9.6e-91 39.5 %
:HMM:SCOP  723->805 2f2hA3 b.71.1.4 * 2.2e-25 48.8 %
:RPS:PFM   364->809 PF01055 * Glyco_hydro_31 e-127 51.6 %
:HMM:PFM   365->809 PF01055 * Glyco_hydro_31 8.3e-164 45.8 439/450  
:BLT:SWISS 21->943 GANAB_HUMAN 0.0 99.9 %
:PROS 537->544|PS00129|GLYCOSYL_HYDROL_F31_1
:PROS 644->674|PS00707|GLYCOSYL_HYDROL_F31_2
:TM
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0088 GT:ORG huge0 GT:GENE KIAA0088 GT:PRODUCT KIAA0088 GT:DATABASE huge2038 LENGTH 943 SQ:AASEQ AAVAAVAARRRRSWASLVLAFLGVCLGITLAVDRSNFKTCEESSFCKRQRSIRPGLSPYRALLDSLQLGPDSLTVHLIHEVTKVLLVLELQGLQKNMTRFRIDELEPRRPRYRVPDVLVADPPIARLSVSGRDENSVELTMAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLEFEHQRAPRVSQGSKDPAEGDGAQPEETPRDGDKPEETQGKAEKDEPGAWEETFKTHSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNPMALYGSVPVLLAHNPHRDLGIFWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQTDVRWMSETGIIDVFLLLGPSISDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRTMLERLASKRRKLVAIVDPHIKVDSGYRVHEELRNLGLYVKTRDGSDYEGWCWPGSAGYPDFTNPTMRAWWANMFSYDNYEGSAPNLFVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLRQRSGGMERPFVLARAFFAGSQRFGAVWTGDNTAEWDHLKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYSLLPFWYTLLYQAHREGIPVMRPLWVQYPQDVTTFNIDDQYLLGDALLVHPVSDSGAHGVQVYLPGQGEVWYDIQSYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSECMKDDPITLFVALSPQGTAQGELFLDDGYTFNYQTRQEFLLRRFSFSGNTLVSSSADPEGHFETPIWIERVVIIGAGKPAAVVLQTKGSPESRLSFQHDPETSVLVLRKPGINVASDWSIHLR SW:ID GANAB_HUMAN SW:DE RecName: Full=Neutral alpha-glucosidase AB; EC=3.2.1.84;AltName: Full=Glucosidase II subunit alpha;AltName: Full=Alpha-glucosidase 2;Flags: Precursor; SW:GN Name=GANAB; Synonyms=G2AN, KIAA0088; SW:KW Alternative splicing; Complete proteome; Direct protein sequencing;Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Hydrolase;Polymorphism; Signal. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 21->943|GANAB_HUMAN|0.0|99.9|923/944| GO:SWS:NREP 3 GO:SWS GO:0005783|"GO:endoplasmic reticulum"|Endoplasmic reticulum| GO:SWS GO:0005794|"GO:Golgi apparatus"|Golgi apparatus| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| PROS 537->544|PS00129|GLYCOSYL_HYDROL_F31_1|PDOC00120| PROS 644->674|PS00707|GLYCOSYL_HYDROL_F31_2|PDOC00120| TM:NTM 2 TM:REGION 15->35| TM:REGION 625->647| SEG 1->20|aavaavaarrrrswaslvla| SEG 156->168|rldlledrsllls| BL:PDB:NREP 1 BL:PDB:REP 348->927|2qmjA|5e-73|32.9|572/863| RP:PDB:NREP 1 RP:PDB:REP 174->942|3cttA|e-102|27.0|740/862| RP:PFM:NREP 1 RP:PFM:REP 364->809|PF01055|e-127|51.6|434/434|Glyco_hydro_31| HM:PFM:NREP 1 HM:PFM:REP 365->809|PF01055|8.3e-164|45.8|439/450|Glyco_hydro_31| GO:PFM:NREP 2 GO:PFM GO:0004553|"GO:hydrolase activity, hydrolyzing O-glycosyl compounds"|PF01055|IPR000322| GO:PFM GO:0005975|"GO:carbohydrate metabolic process"|PF01055|IPR000322| RP:SCP:NREP 3 RP:SCP:REP 205->370|1we5A2|1e-07|19.7|122/247|b.30.5.11| RP:SCP:REP 373->721|1we5A4|e-102|28.9|332/338|c.1.8.13| RP:SCP:REP 723->804|1we5A3|9e-21|30.4|79/80|b.71.1.4| HM:SCP:REP 40->371|2f2hA2|9.7e-15|27.2|232/0|b.30.5.11|1/1|Galactose mutarotase-like| HM:SCP:REP 372->722|2f2hA4|9.6e-91|39.5|334/0|c.1.8.13|1/1|(Trans)glycosidases| HM:SCP:REP 723->805|2f2hA3|2.2e-25|48.8|80/0|b.71.1.4|1/1|Glycosyl hydrolase domain| OP:NHOMO 1629 OP:NHOMOORG 475 OP:PATTERN ------1122222221-31111------1--------------------------------111---- 342-4---------------------------------------121-12--1----1----212-122111----33----3-----3364-2-------3-11211-2--------------------------222-----3---2----11-----------2-211---------------1134-21----------------2322-----1----11444441-2--------------------2321211-313111112--1-1--11--------1111111111111-----------------------1--35----------21--13313------3-1------3---1121------211---------1----------------------------------11----------------------1------------1-----------------------------------1-1-111111111111-------1------1--------1111------------1----------------------1-------------------------2-------------------------------11-11-2-11-------------------------------1311-2-2222211121-212231222121233233122211---3332333333233323111-2221--111111111111-----------------11111-1--------------------3----------------------1-------1----------1111111111--------11--11---------------1---1--------1-------121111-131-22 --1222A-422-22396B8A685969B33333322211121221116645889988666555123111-1112133111223331234-67763443332123433-486Z8B7BEF64678769B7G4Gn9297G6654B466667656B55D5A8D46GO8DH95835-754B2224b44378J6AC8531146461 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 768 STR:RPRED 81.4 SQ:SECSTR #############################################################################################################################################################################EEEEEEEETTEEEEEEEETTcccccccccccccccccccccccEEEEETTTccEEEEGGGcccEEETTEE#EEEEEcccccEEEEEcccccccccccTccEEEEEccccccccTTcccccccEEEEEEEccTTccEEEEEEcccccEEEEEEcTTcccccGGGccEEcccccccTTTEEEEEEccccEEEEEEEEccHHHHHHHHHHHHcccccccGGGGcEEEcccccccHHHHHHHHHHHHHTTccccEEEEcGGGccTTcTTcccTTTTTTHHHHHHHHHHTTcEEEEEEcccEEccccTTcccHHHHTcccccTTccccccEEETTEEEEcccTTcHHHHHHHHHHHHHcccccccTTcccccTTTcccccccTTTTcccTTcEETTEEHHHHGGGHHHHHHHHHHHHHHHHccTTccccEEEccccTTGGGTcEEEcccccccHHHHHHHHHHHHHHHHTTcccEEcEETcccccccHHHHHHHHHHHTTcccEEEcccTTcccccGGGGcTTcHHHHHHHHHHHHHTHHHHHHHHHHHHHTccccEEcTHHHHTTcGGGTTccccEEETTTEEEEccccTTccEEEEEEccccccEEETTTcccccccEEEEEEccTTccEEEEETTEEEEEEEcccccHHHHTTccEEEEEEccTTcEEEEEEEEcccccTTTTTTTccEEEEEEEEccEEEEEEEEEccccTTccEEEEEEEEcccccEEEEEEcTTccccccEEEEETTTTEEEEEcccEETTccEEEEE# DISOP:02AL 1-7,905-914| PSIPRED ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEccccccccHHHHHHHHHHHccccccEEEEcccEEEEcccEEEEEEEccccEEEEEEEEEEcccEEEEEEccccccccccccHHHHcccccEEEEEEEcccccEEEEEEccccEEEEEEEcccEEEEEEccEEEEEEcccccEEEEEEcccccccccccccccccccccccccccccccccccEEEEEccccEEEEEccccccccccccEEEEEEEccccccEEEEccccccccccccccccEEEEEEEcccccccccccccEEEEEEEEEEccccEEEEEEcccccEEEEEcccccccEEEEccccccccccccccccEEEEEEccEEEEEEEEcccHHHHHHHHHHHcccccccHHHHHHHEHHccccccHHHHHHHHHHHHHccccEEEEEEcccEEccEEEEEEcHHHcccHHHHHHHHHHcccEEEEEEccEEccccccHHHHHHHHcccEEEcccccEEEEEEEccccEEcccccHHHHHHHHHHHHHHHHcccccccEEEEccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHcccccccEEEEEEcccccccccEEEcccccccHHHHHHHHHHHHHHHHccccccccccccccccccHHHHHHHHHHHHHcHHHEccccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccEEEHHHHHccccHHHccccccEEEcccEEEEEEEccccEEEEEEEcccccEEEEcccccEEEccEEEEEEEcHHHccEEEEccEEEEEcccccccccccccccEEEEEEEccccEEEEEEEEEccccccEEEccEEEEEEEEEEccEEEEEEEccccccccccEEEEEEEEccccccEEEEEEccccccEEEEEEccccEEEEEEcccccccccEEEEEc //