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Homo sapiens (cDNA) (huge0)
Gene : KIAA0091
DDBJ      :             KIAA0091
Swiss-Prot:MBTP1_HUMAN  RecName: Full=Membrane-bound transcription factor site-1 protease;         EC=3.4.21.112;AltName: Full=S1P endopeptidase;AltName: Full=Site-1 protease;AltName: Full=Subtilisin/kexin-isozyme 1;         Short=SKI-1;Flags: Precursor;

Homologs  Archaea  11/68 : Bacteria  117/915 : Eukaryota  111/199 : Viruses  0/175   --->[See Alignment]
c.41.1
:1058 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   203->479 1bh6A PDBj 9e-26 34.6 %
:RPS:PDB   203->479 3cnqS PDBj 9e-39 32.0 %
:RPS:SCOP  193->479 1a2qA  c.41.1.1 * 4e-48 32.1 %
:HMM:SCOP  180->485 1p8jA2 c.41.1.1 * 2e-66 34.5 %
:RPS:PFM   212->451 PF00082 * Peptidase_S8 2e-22 39.9 %
:HMM:PFM   201->470 PF00082 * Peptidase_S8 1.2e-37 33.2 253/307  
:BLT:SWISS 7->1058 MBTP1_HUMAN 0.0 100.0 %
:PROS 255->265|PS00137|SUBTILASE_HIS
:PROS 418->428|PS00138|SUBTILASE_SER
:TM
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0091 GT:ORG huge0 GT:GENE KIAA0091 GT:PRODUCT KIAA0091 GT:DATABASE huge2038 LENGTH 1058 SQ:AASEQ SYSLVTMKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAFNGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDHPNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNERTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKKIDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVVAGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKPQASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQNGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAEQTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTNFRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSLVIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTLANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGRIVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQINKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV SW:ID MBTP1_HUMAN SW:DE RecName: Full=Membrane-bound transcription factor site-1 protease; EC=3.4.21.112;AltName: Full=S1P endopeptidase;AltName: Full=Site-1 protease;AltName: Full=Subtilisin/kexin-isozyme 1; Short=SKI-1;Flags: Precursor; SW:GN Name=MBTPS1; Synonyms=KIAA0091, S1P, SKI1; SW:KW Autocatalytic cleavage; Calcium; Cholesterol metabolism;Complete proteome; Direct protein sequencing; Endoplasmic reticulum;Glycoprotein; Golgi apparatus; Hydrolase; Lipid metabolism; Membrane;Phosphoprotein; Polymorphism; Protease; Serine protease; Signal;Steroid metabolism; Transmembrane; Zymogen. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 7->1058|MBTP1_HUMAN|0.0|100.0|1052/1052| GO:SWS:NREP 10 GO:SWS GO:0008203|"GO:cholesterol metabolic process"|Cholesterol metabolism| GO:SWS GO:0005783|"GO:endoplasmic reticulum"|Endoplasmic reticulum| GO:SWS GO:0005794|"GO:Golgi apparatus"|Golgi apparatus| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0006629|"GO:lipid metabolic process"|Lipid metabolism| GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0008233|"GO:peptidase activity"|Protease| GO:SWS GO:0008236|"GO:serine-type peptidase activity"|Serine protease| GO:SWS GO:0008202|"GO:steroid metabolic process"|Steroid metabolism| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| PROS 255->265|PS00137|SUBTILASE_HIS|PDOC00125| PROS 418->428|PS00138|SUBTILASE_SER|PDOC00125| TM:NTM 3 TM:REGION 2->23| TM:REGION 52->73| TM:REGION 1006->1028| SEG 14->21|llllvvll| SEG 164->177|ssrplrraslslgs| SEG 401->412|gagvrgsgvkgg| SEG 1029->1044|kaksrpkrrkprvkrp| BL:PDB:NREP 1 BL:PDB:REP 203->479|1bh6A|9e-26|34.6|257/274| RP:PDB:NREP 1 RP:PDB:REP 203->479|3cnqS|9e-39|32.0|253/264| RP:PFM:NREP 1 RP:PFM:REP 212->451|PF00082|2e-22|39.9|228/285|Peptidase_S8| HM:PFM:NREP 1 HM:PFM:REP 201->470|PF00082|1.2e-37|33.2|253/307|Peptidase_S8| GO:PFM:NREP 2 GO:PFM GO:0004252|"GO:serine-type endopeptidase activity"|PF00082|IPR000209| GO:PFM GO:0006508|"GO:proteolysis"|PF00082|IPR000209| RP:SCP:NREP 1 RP:SCP:REP 193->479|1a2qA|4e-48|32.1|268/275|c.41.1.1| HM:SCP:REP 180->485|1p8jA2|2e-66|34.5|293/334|c.41.1.1|1/1|Subtilisin-like| OP:NHOMO 419 OP:NHOMOORG 239 OP:PATTERN ----------------1--1---1------11----------------1--1---1-131-------- ----1-----------------------------------1----1--------1-----13--51-443------------1-----1-1-----------11-1------------------------------2--33------22---1------1-------1212----1-------511-------51111122113213323655552322122332------32------------------------------------------------------------------------------------------311-1----1------111---------3111---11-11411212------------------1--1------------------------2---1--------1---11-----------------------------------------------------------------------------------------------1-----------------------------------11----2--------------1-1-12-------21--------------------------------1--1-1--1-------111------1----------------------------------------------------------------------------------------------------1-----------------------------------------------------------------------1-------------------------------------------------------------------------1--1------ -1-1361---1-------1-------111-------------------452232233------1-----1---1-------11122-------1-------------11232131221111111211213C112231111111211111-111111111--6121221231--11-111F111111121-11--12221 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 475 STR:RPRED 44.9 SQ:SECSTR #################################################################TTccccHHHHHHHcccHHHHHHHHHHHHHTcEEEEEcTTccEEEEEEEHHHHHHHcTTcccEEEEETTTTEEEEEccccccccGGGTEETTEEEETTccccccccccccccccccccccccccccccccccHHHHHHTTHHHHHHTTcccTTcEEEEEEccccTTccccccEEEEccTTcccTTcccccHHHHHHHHHHcccccHHHcTTcEEEEEEcccTTccccHHHHHHHHHHHHHTTccEEEEcccccccccHHHHHHHHHHHHTTcEEEEEccccccTccccccTTTcTTcEEEEEEcTTccccTTccccTTccEEEcccEETTccEEEEcccEEEEETTTEEEEEccHHHHHHHHHHHHHHHHHHHHHcTTccHHHHHHHHHHTccccccccHHHHTTccccHHHHTcTTTTEEEEccccccTTHHHTccccEEEEccccEEEEcccccEEcTTccccccTTccccccE###################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################### DISOP:02AL 1-2,26-41,81-94,599-603,887-907,1028-1059| PSIPRED cccEEEEHHHHHHHHHHHHHHHccHHHccHHHccccccccccccccccccccccccccccEEEEEEcccccHHHHHHHHHHHHHHcccccEEEEEccccHHcccccccEEEEEcccHHHHHHHHccccHHHccHHHHHccHHHHccccccccccccccHHHHHHHccHHHHHccccccccccccccccccccccccccHHHHccHHHHHHccccccccEEEEEcccccccccccEEEccccccccccccccccccHHHHHHHHHcccccccccccccEEEEEEEcccccccHHHHHHHHHHHHHccccEEEEcccccccccHHHHHHHHHHHHcccEEEEEccccccccccccccccccEEEEEEEEcccccccccccccccEEEccccccccccEEEEcccccccccccccEEEEEcHHHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHHcccccccccccccccccccHHHHHHHHHHccccEEEcccEEcccccccEEcEEccccccccccEEEEEEEcccccccccEEccccccccccccccEEEEEEEcccccccccccEEEEEEEEccccccccEEEcccEEEEEccccccccccccccEEEEEEEEEccccccccccEEEHHHHcccccccccccccccccccccccccccEEEccHHHHHHHHHHHHHHHHHHccccEEccHHHccEEEEEEccccccHHHHHHHHHHHHHccEEEEEEEccccEEEEEEEEEEccccEEEcccccccccHHHHHHHHHHccHHcccEEccEEEEcccEEEEEcccEEEEcccccEEEEEEcccHHHHHHcHHHHEEccccEEEccccccccccEEEEEccccccccccccccHHHHHHHHHHHHHcccccHHHHccccccccccccccccccccccccHHHHHHHHHHHHccccccccccccccccccccccccccHHHHHccccEEEEcccEEEccccccccccccccccccccccccccccccccccHHHcccccHHHHHHHHHHHHEEEEEEcccccccHHcccHHccHHHHHHHcccccccc //