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Homo sapiens (cDNA) (huge0)
Gene : KIAA0093
DDBJ      :             KIAA0093
Swiss-Prot:NEDD4_HUMAN  RecName: Full=E3 ubiquitin-protein ligase NEDD4;         EC=6.3.2.-;AltName: Full=Neural precursor cell expressed developmentally down-regulated protein 4;         Short=NEDD-4;AltName: Full=Cell proliferation-inducing gene 53 protein;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  196/199 : Viruses  0/175   --->[See Alignment]
b.7.1b.72.1d.148.1
:927 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   29->179 3b7yB PDBj 3e-81 100.0 %
:BLT:PDB   223->250 1wr3A PDBj 2e-08 71.4 %
:BLT:PDB   374->406 1wr4A PDBj 1e-11 69.7 %
:BLT:PDB   377->417 1zcnA PDBj 4e-05 41.5 %
:BLT:PDB   447->482 1wr7A PDBj 4e-16 88.9 %
:BLT:PDB   496->540 1i5hW PDBj 1e-22 88.9 %
:BLT:PDB   546->918 2oniA PDBj e-166 83.3 %
:RPS:PDB   29->179 3b7yB PDBj 1e-28 95.2 %
:RPS:PDB   223->254 2dmvA PDBj 5e-08 50.0 %
:RPS:PDB   374->411 2dmvA PDBj 6e-11 55.3 %
:RPS:PDB   440->589 3d08A PDBj 2e-26 16.4 %
:RPS:PDB   575->919 1c4zA PDBj 6e-90 34.2 %
:RPS:SCOP  37->185 1wfjA  b.7.1.2 * 1e-23 23.7 %
:RPS:SCOP  223->250 1i5hW  b.72.1.1 * 1e-07 46.4 %
:RPS:SCOP  368->414 1i5hW  b.72.1.1 * 9e-11 38.3 %
:RPS:SCOP  440->481 1i5hW  b.72.1.1 * 2e-11 50.0 %
:RPS:SCOP  496->540 1i5hW  b.72.1.1 * 2e-15 88.9 %
:RPS:SCOP  548->921 1nd7A  d.148.1.1 * e-115 51.9 %
:HMM:SCOP  26->179 1dqvA2 b.7.1.2 * 1.9e-30 34.5 %
:HMM:SCOP  208->252 1tk7A1 b.72.1.1 * 1.8e-12 50.0 %
:HMM:SCOP  365->409 1tk7A1 b.72.1.1 * 2.6e-12 47.6 %
:HMM:SCOP  439->481 1tk7A2 b.72.1.1 * 1.7e-11 58.1 %
:HMM:SCOP  491->540 1i5hW_ b.72.1.1 * 1.9e-12 50.0 %
:HMM:SCOP  547->921 1nd7A_ d.148.1.1 * 8.1e-126 43.3 %
:RPS:PFM   48->133 PF00168 * C2 2e-14 48.2 %
:RPS:PFM   223->249 PF00397 * WW 3e-06 66.7 %
:RPS:PFM   378->406 PF00397 * WW 2e-05 51.7 %
:RPS:PFM   451->479 PF00397 * WW 7e-05 51.7 %
:RPS:PFM   503->531 PF00397 * WW 3e-06 62.1 %
:RPS:PFM   622->923 PF00632 * HECT 7e-74 49.5 %
:HMM:PFM   622->924 PF00632 * HECT 2.6e-97 42.8 292/308  
:HMM:PFM   220->249 PF00397 * WW 5e-16 63.3 30/30  
:HMM:PFM   377->406 PF00397 * WW 1.3e-14 60.0 30/30  
:HMM:PFM   450->479 PF00397 * WW 8.2e-16 56.7 30/30  
:HMM:PFM   502->531 PF00397 * WW 1.6e-16 73.3 30/30  
:HMM:PFM   49->133 PF00168 * C2 1e-23 42.7 82/85  
:HMM:PFM   278->359 PF11679 * DUF3275 0.00038 27.2 81/214  
:BLT:SWISS 38->143 KPC2_DROME 1e-12 39.0 %
:BLT:SWISS 125->927 NEDD4_HUMAN 0.0 100.0 %
:PROS 224->249|PS01159|WW_DOMAIN_1
:PROS 381->406|PS01159|WW_DOMAIN_1
:PROS 454->479|PS01159|WW_DOMAIN_1
:PROS 506->531|PS01159|WW_DOMAIN_1
:REPEAT 4|223->252|380->409|453->482|505->534
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0093 GT:ORG huge0 GT:GENE KIAA0093 GT:PRODUCT KIAA0093 GT:DATABASE huge2038 LENGTH 927 SQ:AASEQ SRFSSSSSTVACPGRGRARPVCWKRSEMATCAVEVFGLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNQESSENWEIIREDEATMYSSQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD SW:ID NEDD4_HUMAN SW:DE RecName: Full=E3 ubiquitin-protein ligase NEDD4; EC=6.3.2.-;AltName: Full=Neural precursor cell expressed developmentally down-regulated protein 4; Short=NEDD-4;AltName: Full=Cell proliferation-inducing gene 53 protein; SW:GN Name=NEDD4; Synonyms=KIAA0093, NEDD4-1; ORFNames=PIG53; SW:KW 3D-structure; Alternative splicing; Complete proteome; Cytoplasm;Host-virus interaction; Ligase; Phosphoprotein; Polymorphism; Repeat;Ubl conjugation pathway. SW:EXACT F SW:FUNC + BL:SWS:NREP 2 BL:SWS:REP 38->143|KPC2_DROME|1e-12|39.0|105/700| BL:SWS:REP 125->927|NEDD4_HUMAN|0.0|100.0|803/1319| GO:SWS:NREP 3 GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0044419|"GO:interspecies interaction between organisms"|Host-virus interaction| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| PROS 224->249|PS01159|WW_DOMAIN_1|PDOC50020| PROS 381->406|PS01159|WW_DOMAIN_1|PDOC50020| PROS 454->479|PS01159|WW_DOMAIN_1|PDOC50020| PROS 506->531|PS01159|WW_DOMAIN_1|PDOC50020| NREPEAT 1 REPEAT 4|223->252|380->409|453->482|505->534| SEG 211->222|lqqqqepsplpp| SEG 310->316|pspppss| SEG 336->355|gnsavsqpasssnhssrrgs| SEG 418->433|tssqssagpqsqasts| BL:PDB:NREP 7 BL:PDB:REP 29->179|3b7yB|3e-81|100.0|146/146| BL:PDB:REP 223->250|1wr3A|2e-08|71.4|28/36| BL:PDB:REP 374->406|1wr4A|1e-11|69.7|33/36| BL:PDB:REP 377->417|1zcnA|4e-05|41.5|40/143| BL:PDB:REP 447->482|1wr7A|4e-16|88.9|36/41| BL:PDB:REP 496->540|1i5hW|1e-22|88.9|45/50| BL:PDB:REP 546->918|2oniA|e-166|83.3|359/364| RP:PDB:NREP 5 RP:PDB:REP 29->179|3b7yB|1e-28|95.2|146/146| RP:PDB:REP 223->254|2dmvA|5e-08|50.0|32/43| RP:PDB:REP 374->411|2dmvA|6e-11|55.3|38/43| RP:PDB:REP 440->589|3d08A|2e-26|16.4|122/182| RP:PDB:REP 575->919|1c4zA|6e-90|34.2|333/350| RP:PFM:NREP 6 RP:PFM:REP 48->133|PF00168|2e-14|48.2|83/85|C2| RP:PFM:REP 223->249|PF00397|3e-06|66.7|27/30|WW| RP:PFM:REP 378->406|PF00397|2e-05|51.7|29/30|WW| RP:PFM:REP 451->479|PF00397|7e-05|51.7|29/30|WW| RP:PFM:REP 503->531|PF00397|3e-06|62.1|29/30|WW| RP:PFM:REP 622->923|PF00632|7e-74|49.5|289/297|HECT| HM:PFM:NREP 7 HM:PFM:REP 622->924|PF00632|2.6e-97|42.8|292/308|HECT| HM:PFM:REP 220->249|PF00397|5e-16|63.3|30/30|WW| HM:PFM:REP 377->406|PF00397|1.3e-14|60.0|30/30|WW| HM:PFM:REP 450->479|PF00397|8.2e-16|56.7|30/30|WW| HM:PFM:REP 502->531|PF00397|1.6e-16|73.3|30/30|WW| HM:PFM:REP 49->133|PF00168|1e-23|42.7|82/85|C2| HM:PFM:REP 278->359|PF11679|0.00038|27.2|81/214|DUF3275| GO:PFM:NREP 7 GO:PFM GO:0005515|"GO:protein binding"|PF00397|IPR001202| GO:PFM GO:0005515|"GO:protein binding"|PF00397|IPR001202| GO:PFM GO:0005515|"GO:protein binding"|PF00397|IPR001202| GO:PFM GO:0005515|"GO:protein binding"|PF00397|IPR001202| GO:PFM GO:0005622|"GO:intracellular"|PF00632|IPR000569| GO:PFM GO:0006464|"GO:protein modification process"|PF00632|IPR000569| GO:PFM GO:0016881|"GO:acid-amino acid ligase activity"|PF00632|IPR000569| RP:SCP:NREP 6 RP:SCP:REP 37->185|1wfjA|1e-23|23.7|135/136|b.7.1.2| RP:SCP:REP 223->250|1i5hW|1e-07|46.4|28/50|b.72.1.1| RP:SCP:REP 368->414|1i5hW|9e-11|38.3|47/50|b.72.1.1| RP:SCP:REP 440->481|1i5hW|2e-11|50.0|42/50|b.72.1.1| RP:SCP:REP 496->540|1i5hW|2e-15|88.9|45/50|b.72.1.1| RP:SCP:REP 548->921|1nd7A|e-115|51.9|370/374|d.148.1.1| HM:SCP:REP 26->179|1dqvA2|1.9e-30|34.5|142/145|b.7.1.2|1/1|C2 domain (Calcium/lipid-binding domain, CaLB)| HM:SCP:REP 208->252|1tk7A1|1.8e-12|50.0|42/45|b.72.1.1|1/4|WW domain| HM:SCP:REP 365->409|1tk7A1|2.6e-12|47.6|42/45|b.72.1.1|2/4|WW domain| HM:SCP:REP 439->481|1tk7A2|1.7e-11|58.1|43/0|b.72.1.1|3/4|WW domain| HM:SCP:REP 491->540|1i5hW_|1.9e-12|50.0|50/50|b.72.1.1|4/4|WW domain| HM:SCP:REP 547->921|1nd7A_|8.1e-126|43.3|372/0|d.148.1.1|1/1|Hect, E3 ligase catalytic domain| OP:NHOMO 3886 OP:NHOMOORG 196 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 443497K-F65266746546676666566676666666563665657666678656656555655555-5555555534555455587-46565664444664A9B2RLAjrvkrprWPQSTfY**Q*L**oH*b*UOPRsLVmcQZSQMtPT*RuabWLj*POOKIgILdDOWL4A99*86577MCML5HD87TXQTK ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 810 STR:RPRED 87.4 SQ:SECSTR ###########HHHHHTccTTccEEEEEccccccEEEcccccTTcEEEEEEEEEEEccccccTTccccEEEEEEEEETTTEEEEEEEcccccccccccccEEEEEEEcTTTcEEEEEEEEGGGTTcccEEEEEEEEccccccccccccEEEEcEEEEcccccTTcccccEEEEEEEEccccccccHHHHHHHHHHHHHHHHHTTccTHHHTTccccHHHHHHHHHTHHHHTTcGGGHHHHTTcccTTcHTccHHHHHHHHHHHHTTcTTcccccc###################################################################################HHHHHTTTcccTTcEccccccHHHHHHHHHHHHTTccHHHHHTccccTTccHHHHHTTE#################ccccccEEEEEccccccTTccccccGGGcccccccccccccccccccHHHHHHHHHHHcGGGcccTTHHHHHHHccHHHTHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHTGGGcccHHHHHHHHcTTHHHHHHHHHHHHccccHHHHHHHHHHHHccGGGGGccccEEETTcccccccHHHHHHHHHHHHHHTcGGGccEEEETTTTEEEEcTEEEEETccccHHHHHHHHHHHHHHHHTTccccccccHHHHHHHTTccccHHHHHHHcHHHHHHHHHHHHccccHTccccEEEEcTTTccEEEEccTTTTTccccTTTHHHHHHHHHHHHHTcTTHHHHHHHHHHHHHHHcccccccccTHHHHHHHHcccccccTTTcTTcEEEcccccccHHHHHHHHHHHTccHHHHHHHHHHHcccccccTTcGGGHHHHHGGGccEEEEEEEcccccEEEGGGTEEEEEEcccHHHHHHHHHHHHHHcc###### DISOP:02AL 1-6,8-12,14-37,163-168,178-198,208-218,244-452,484-507,509-509,530-539,925-925,927-928| PSIPRED ccccccccccccccccccHHHHHHHHHcccccEEEEccEEccccccEEEEEEEEcccccccccccccccEEEEEEcccccccccEEEEEEEEEccccccccEEEEEEcccccEEEEEEEEccccccccEEEEEEEEHHHcccccccccccEEEccccccccccccccccEEEEEEEEccccccccccccccccccccccEEcccccccccccccccccccccccEEEEcccccEEEccccccEEEcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccEEEcccccEEEcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHccccccEEEEEccccccccccccccccccccccccccccHHccccccccccEEcccccccccccccccccccccccccHHHHcccccccccHHHHHHHHHHHHHccccccccEEEEEcHHHHHHHHHHHHHcccHHHHccccEEEEEEccEEccccccHHHHHHHHHHHHHccccccEEEcccccEEEEEccccccccHHHHHHHHHHHHHHHHHHHcccEEcccccHHHHHHHHcccccHHHHHHHcHHHHHHHHHHHHcccHHccEEEEEEEEEcccccEEEccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHcccHHHHHHHccccccccHHHHHHHcEEccccccccHHHHHHHHHHHcccHHHHHHHHHHHccccccccccHHHHcccccccEEEEEccccccccccccEEEEEEEccccccHHHHHHHHHHHHHHcccccccc //