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Homo sapiens (cDNA) (huge0)
Gene : KIAA0106
DDBJ      :             KIAA0106
Swiss-Prot:PRDX6_HUMAN  RecName: Full=Peroxiredoxin-6;         EC=1.11.1.15;AltName: Full=Antioxidant protein 2;AltName: Full=1-Cys peroxiredoxin;         Short=1-Cys PRX;AltName: Full=Acidic calcium-independent phospholipase A2;         Short=aiPLA2;         EC=3.1.1.-;AltName: Full=Non-selenium glutathione peroxidase;         Short=NSGPx;         EC=1.11.1.7;AltName: Full=24 kDa protein;AltName: Full=Liver 2D page spot 40;AltName: Full=Red blood cells page spot 12;

Homologs  Archaea  54/68 : Bacteria  619/915 : Eukaryota  196/199 : Viruses  0/175   --->[See Alignment]
c.47.1
:238 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   19->238 1prxA PDBj e-124 99.5 %
:RPS:PDB   19->238 2cv4D PDBj 3e-35 30.5 %
:RPS:SCOP  19->238 1prxA  c.47.1.10 * 1e-48 99.1 %
:HMM:SCOP  18->237 1xccA_ c.47.1.10 * 2.1e-65 41.0 %
:RPS:PFM   21->159 PF00578 * AhpC-TSA 1e-17 43.8 %
:HMM:PFM   21->158 PF00578 * AhpC-TSA 1.1e-32 37.2 121/124  
:HMM:PFM   180->219 PF10417 * 1-cysPrx_C 1.2e-14 50.0 40/40  
:BLT:SWISS 15->238 PRDX6_HUMAN e-130 100.0 %

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0106 GT:ORG huge0 GT:GENE KIAA0106 GT:PRODUCT KIAA0106 GT:DATABASE huge2038 LENGTH 238 SQ:AASEQ GCLLSQRRPLITVAMPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP SW:ID PRDX6_HUMAN SW:DE RecName: Full=Peroxiredoxin-6; EC=1.11.1.15;AltName: Full=Antioxidant protein 2;AltName: Full=1-Cys peroxiredoxin; Short=1-Cys PRX;AltName: Full=Acidic calcium-independent phospholipase A2; Short=aiPLA2; EC=3.1.1.-;AltName: Full=Non-selenium glutathione peroxidase; Short=NSGPx; EC=1.11.1.7;AltName: Full=24 kDa protein;AltName: Full=Liver 2D page spot 40;AltName: Full=Red blood cells page spot 12; SW:GN Name=PRDX6; Synonyms=AOP2, KIAA0106; SW:KW 3D-structure; Acetylation; Antioxidant; Complete proteome; Cytoplasm;Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond;Hydrolase; Lipid degradation; Lysosome; Multifunctional enzyme;Oxidoreductase; Peroxidase; Phosphoprotein; Redox-active center. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 15->238|PRDX6_HUMAN|e-130|100.0|224/224| GO:SWS:NREP 10 GO:SWS GO:0016209|"GO:antioxidant activity"|Antioxidant| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0031410|"GO:cytoplasmic vesicle"|Cytoplasmic vesicle| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0016042|"GO:lipid catabolic process"|Lipid degradation| GO:SWS GO:0005764|"GO:lysosome"|Lysosome| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| GO:SWS GO:0004601|"GO:peroxidase activity"|Peroxidase| BL:PDB:NREP 1 BL:PDB:REP 19->238|1prxA|e-124|99.5|219/219| RP:PDB:NREP 1 RP:PDB:REP 19->238|2cv4D|3e-35|30.5|203/237| RP:PFM:NREP 1 RP:PFM:REP 21->159|PF00578|1e-17|43.8|121/122|AhpC-TSA| HM:PFM:NREP 2 HM:PFM:REP 21->158|PF00578|1.1e-32|37.2|121/124|AhpC-TSA| HM:PFM:REP 180->219|PF10417|1.2e-14|50.0|40/40|1-cysPrx_C| GO:PFM:NREP 2 GO:PFM GO:0016209|"GO:antioxidant activity"|PF00578|IPR000866| GO:PFM GO:0016491|"GO:oxidoreductase activity"|PF00578|IPR000866| RP:SCP:NREP 1 RP:SCP:REP 19->238|1prxA|1e-48|99.1|220/220|c.47.1.10| HM:SCP:REP 18->237|1xccA_|2.1e-65|41.0|217/0|c.47.1.10|1/1|Thioredoxin-like| OP:NHOMO 1675 OP:NHOMOORG 869 OP:PATTERN 111111412222222311111221-----1----111111211-1-1111111-121111234311-- 2121-11----11111111-1-11211111121---1121-2-2---1---------------1-1-111--111111--11-211112211-2111--112222232-211111111111111122222122222-----1111-4322333222211111222322222111111111111-----11-1-----------------111111-----11---11111121--------------------1-1-11-1-----1111---11--1---------------------------------------------121-------------1---11-11--11----112---11--112-1111112--1-----322222211112211111111111-111111--121-111-1111111122-12111----111222222221441311211111111111111--1111111111111-21411222233333332333333443333234353233--222-2111113-11121-3-211-------1121112-3--11112211--2232222-1222212--2211111111111111111111-21112223422222-22222232222221222221--21--11-1112-221211111111111-11211111111111111112222211222222222222222221111111111111111111111111222222212213122---1-1-1--1-111222221411223222233332333312222-1111-1-111121111122122--------------1111331122--------11--------------------------1111111111--1 3311324-A83-2332233233222221111111111111111111221123231111111133322223123321211124232211-34121322222211445132196C66583142353C7271EQ8176C3332945753453362255555555433342A5573443133183213443754342185B63 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 225 STR:RPRED 94.5 SQ:SECSTR #############HHEEEccTTcccccEEEETTEEEETHHHHTTTcEEEEEEccccccHHHHHHHHHHHHTHHHHHHTTEEEEEEEcccHHHHHHHHHHHHHHHcccccccccccEEEccccHHHHHTTcccTTTccTTccccccEEEEEEcTTccEEEEEEcTTTccccHHHHHHHHHHHHHHHHTTccccTTTTccTcEEEcccccHHHHHHHccTTccEEccEEEETTEEEEccc DISOP:02AL 1-7,9-12,238-239| PSIPRED cccEEcccccHHHcccccccccccccccEEEcccccEEEHHHHcccEEEEEEcccccccccHHHHHHHHHHHHHHHHcccEEEEEEcccHHHHHHHHHHHcccccccccccccEEEEEcccHHHHHHHcccccccccccccccEEEEEEEEcccccEEEEEEccccccccHHHHHHHHHHHHHHHHcccEEcccccccccEEccccccHHHHHHHHHcccEEEEcccccccccccccc //