Homo sapiens (cDNA) (huge0)
Gene : KIAA0123
DDBJ : KIAA0123
Swiss-Prot:MPPA_HUMAN RecName: Full=Mitochondrial-processing peptidase subunit alpha; EC=3.4.24.64;AltName: Full=Alpha-MPP;AltName: Full=P-55;Flags: Precursor;
Homologs Archaea 0/68 : Bacteria 263/915 : Eukaryota 195/199 : Viruses 1/175 --->[See Alignment]
d.185.1
:528 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB 71->490 1hr9G PDBj 3e-61 38.4 %
:RPS:PDB 59->515 1bccA PDBj 5e-83 26.3 %
:RPS:SCOP 71->279 1ezvA1 d.185.1.1 * 3e-54 24.0 %
:RPS:SCOP 294->514 1bccA2 d.185.1.1 * 3e-54 20.7 %
:HMM:SCOP 65->289 1bccB1 d.185.1.1 * 1.8e-42 33.2 %
:HMM:SCOP 302->509 1bccB2 d.185.1.1 * 3.9e-38 28.6 %
:RPS:PFM 92->223 PF00675 * Peptidase_M16 1e-15 33.3 %
:RPS:PFM 236->431 PF05193 * Peptidase_M16_C 6e-12 31.1 %
:HMM:PFM 80->229 PF00675 * Peptidase_M16 4.7e-47 37.4 147/149
:HMM:PFM 235->434 PF05193 * Peptidase_M16_C 2.2e-43 30.9 178/183
:BLT:SWISS 17->528 MPPA_HUMAN 0.0 99.8 %
:PROS 100->123|PS00143|INSULINASE
:SEG
SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0123
GT:ORG huge0
GT:GENE KIAA0123
GT:PRODUCT KIAA0123
GT:DATABASE huge2038
LENGTH 528
SQ:AASEQ RRKMAAVVLAATRLLRGSGSWGCSRLRFGPPAYRRFSSGGAYPNIPLSSPLPGVPKPVFATVDGQEKFETKVTTLDNGLRVASQNKFGQFCTVGILINSGSRYEAKYLSGIAHFLEKLAFSSTARFDSKDEILLTLEKHGGICDCQTSRDTTMYAVSADSKGLDTVVALLADVVLQPRLTDEEVEMTRMAVQFELEDLNLRPDPEPLLTEMIHEAAYRENTVGLHRFCPTENVAKINREVLHSYLRNYYTPDRMVLAGVGVEHEHLVDCARKYLLGVQPAWGSAEAVDIDRSVAQYTGGIAKLERDMSNVSLGPTPIPELTHIMVGLESCSFLEEDFIPFAVLNMMMGGGGSFSAGGPGKGMFSRLYLNVLNRHHWMYNATSYHHSYEDTGLLCIHASADPRQVREMVEIITKEFILMGGTVDTVELERAKTQLTSMLMMNLESRPVIFEDVGRQVLATRSRKLPHELCTLIRNVKPEDVKRVASKMLRGKPAVAALGDLTDLPTYEDIQTALSSKDGRLPRTYRLFR
SW:ID MPPA_HUMAN
SW:DE RecName: Full=Mitochondrial-processing peptidase subunit alpha; EC=3.4.24.64;AltName: Full=Alpha-MPP;AltName: Full=P-55;Flags: Precursor;
SW:GN Name=PMPCA; Synonyms=INPP5E, KIAA0123, MPPA;
SW:KW Acetylation; Complete proteome; Hydrolase; Metalloprotease;Mitochondrion; Protease; Transit peptide.
SW:EXACT F
SW:FUNC +
BL:SWS:NREP 1
BL:SWS:REP 17->528|MPPA_HUMAN|0.0|99.8|512/525|
GO:SWS:NREP 4
GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase|
GO:SWS GO:0008237|"GO:metallopeptidase activity"|Metalloprotease|
GO:SWS GO:0005739|"GO:mitochondrion"|Mitochondrion|
GO:SWS GO:0008233|"GO:peptidase activity"|Protease|
PROS 100->123|PS00143|INSULINASE|PDOC00130|
SEG 5->16|aavvlaatrllr|
SEG 163->175|ldtvvalladvvl|
SEG 345->362|mmmggggsfsaggpgkgm|
BL:PDB:NREP 1
BL:PDB:REP 71->490|1hr9G|3e-61|38.4|398/451|
RP:PDB:NREP 1
RP:PDB:REP 59->515|1bccA|5e-83|26.3|438/442|
RP:PFM:NREP 2
RP:PFM:REP 92->223|PF00675|1e-15|33.3|129/145|Peptidase_M16|
RP:PFM:REP 236->431|PF05193|6e-12|31.1|167/180|Peptidase_M16_C|
HM:PFM:NREP 2
HM:PFM:REP 80->229|PF00675|4.7e-47|37.4|147/149|Peptidase_M16|
HM:PFM:REP 235->434|PF05193|2.2e-43|30.9|178/183|Peptidase_M16_C|
GO:PFM:NREP 5
GO:PFM GO:0004222|"GO:metalloendopeptidase activity"|PF00675|IPR011765|
GO:PFM GO:0006508|"GO:proteolysis"|PF00675|IPR011765|
GO:PFM GO:0004222|"GO:metalloendopeptidase activity"|PF05193|IPR007863|
GO:PFM GO:0006508|"GO:proteolysis"|PF05193|IPR007863|
GO:PFM GO:0008270|"GO:zinc ion binding"|PF05193|IPR007863|
RP:SCP:NREP 2
RP:SCP:REP 71->279|1ezvA1|3e-54|24.0|200/213|d.185.1.1|
RP:SCP:REP 294->514|1bccA2|3e-54|20.7|208/213|d.185.1.1|
HM:SCP:REP 65->289|1bccB1|1.8e-42|33.2|217/0|d.185.1.1|1/2|LuxS/MPP-like metallohydrolase|
HM:SCP:REP 302->509|1bccB2|3.9e-38|28.6|203/204|d.185.1.1|2/2|LuxS/MPP-like metallohydrolase|
OP:NHOMO 941
OP:NHOMOORG 459
OP:PATTERN -------------------------------------------------------------------- 111-1-----------------11-1----------1111111111--111-111111--111-111111----------------11-----111-----------1-1---------------111111----1---1111111----111-1--------1---11-2------------------1-11111111111111111111111111111111--------11------------------------------------------------------------------------------------------11111-----1-11111--1111-21--1---111111--1-1111--1--11111-11111111111111111111111111111---1--1-11111111111111111111--11121221121111111111111111111111111---11111111111111111---1-1-----------------------------------------------------------------------1--------1-11--313121112-------2------------------------1--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------11111111---------------------------------------1--------- 2222333-733-2222232222222222232222222222222222222222222222222222222222222222211222222222-23222222222222455-33368C5657434234155373Dm4156A3324434823453243253444434443335353443332332Y2222256A52432233332 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------1----
STR:NPRED 472
STR:RPRED 89.4
SQ:SECSTR ###########################################cTTEEEEcccccccTcHHHHTHTccccEEEEcccccEEEEEEcccccEEEEEEEccccTTccTTTTTHHHHHHHHHccccccccHHHHHHHHHHTTTcEEEEEEccccEEEEEEEccccHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHTTcHHHHHHHHHHHHHTTTcGGGccccccHHHHHHccHHHHHHHHHHHccGGGEEEEEEEccHHHHHHHHHHHcccccccccHHHHcccccccccccccEEEEEcTTcccEEcccTTcccEEEEEEEEEccTTcGGGTHHHHHHHHHcEEEcccccTTccccTccHHHHHHHHTTcccEEEEEEEEccccEEEEEEEEEcTTTHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHTTccHHHHHHHHHHHHHHHcccccHHHHHHHHHcccHHHHHHHHHHHcTccccEEEEEccTTcccHHHHHTTccc#############
DISOP:02AL 1-6,40-48,513-518|
PSIPRED cccccccHHHHHHHHHHcccHHHHHccccHHHHcccccccccccccccccccccccccccccccccccccEEEEEccccEEEEEcccccEEEEEEEEccccccccccccccHHHHHHHHHccccccccHHHHHHHHHHHccEEEEEEcccEEEEEEEEcHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHcccccccccccccHHHHHHccHHHHHHHHHHHcccccEEEEEEcccHHHHHHHHHHHHcccccccccccccccccccccccccEEEEEcccccEEEEcccccccEEEEEEEEccccccHHHHHHHHHHHHHcccccccccccccccHHHHHHHHHHHccccEEEEEEEcccccccEEEEEEEEcHHHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHccccccHHHHHHHHHcccHHHHHHHHHHHcccccEEEEEEcccccccHHHHHHHcccccccccccccccc
//
[GTOP]
