[GTOP] [HELP] [ORGANISMS] [SEARCH] [SUMMARY]
Homo sapiens (cDNA) (huge0)
Gene : KIAA0230
DDBJ      :             KIAA0230
Swiss-Prot:PXDN_HUMAN   RecName: Full=Peroxidasin homolog;         EC=1.11.1.7;AltName: Full=Vascular peroxidase 1;AltName: Full=Melanoma-associated antigen MG50;AltName: Full=p53-responsive gene 2 protein;Flags: Precursor;

Homologs  Archaea  0/68 : Bacteria  24/915 : Eukaryota  77/199 : Viruses  0/175   --->[See Alignment]
a.93.1b.1.1c.10.2d.58.4g.27.1
:1496 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   53->261 2v70A PDBj 3e-21 30.2 %
:BLT:PDB   261->628 1cs6A PDBj 3e-40 34.0 %
:BLT:PDB   739->1329 2nqxA PDBj e-123 41.5 %
:BLT:PDB   1437->1487 1u5mA PDBj 2e-05 35.3 %
:RPS:PDB   56->224 3cigA PDBj 2e-19 20.1 %
:RPS:PDB   263->629 1bihA PDBj 2e-64 17.4 %
:RPS:PDB   735->1332 2efbA PDBj 0.0 40.0 %
:RPS:SCOP  53->249 1gwbA  c.10.2.7 * 3e-19 25.4 %
:RPS:SCOP  261->352 1cs6A1  b.1.1.4 * 1e-16 32.6 %
:RPS:SCOP  336->628 2cb2A1  d.58.4.17 * 3e-31 10.1 %
:RPS:SCOP  755->1331 1cxp.1  a.93.1.2 * 0.0 44.6 %
:RPS:SCOP  1432->1493 1u5mA  g.27.1.2 * 6e-13 34.4 %
:HMM:SCOP  52->270 1m0zA_ c.10.2.7 * 1.6e-49 34.1 %
:HMM:SCOP  263->358 2cqvA1 b.1.1.4 * 2.2e-23 35.5 %
:HMM:SCOP  355->450 2avgA1 b.1.1.4 * 4.3e-28 39.6 %
:HMM:SCOP  446->537 1g1cA_ b.1.1.4 * 2.1e-27 44.6 %
:HMM:SCOP  538->631 1g1cA_ b.1.1.4 * 6e-27 45.7 %
:HMM:SCOP  752->1332 1dnu.1 a.93.1.2 * 2.6e-207 46.3 %
:HMM:SCOP  1432->1489 1u5mA_ g.27.1.2 * 1.2e-09 45.6 %
:RPS:PFM   265->342 PF07679 * I-set 3e-11 36.7 %
:RPS:PFM   365->446 PF07679 * I-set 1e-15 44.7 %
:RPS:PFM   453->536 PF07679 * I-set 3e-15 42.5 %
:RPS:PFM   548->628 PF07679 * I-set 1e-15 45.7 %
:RPS:PFM   759->1294 PF03098 * An_peroxidase e-118 52.5 %
:RPS:PFM   1436->1487 PF00093 * VWC 2e-12 50.0 %
:HMM:PFM   758->1306 PF03098 * An_peroxidase 8.1e-181 49.8 508/525  
:HMM:PFM   263->345 PF07679 * I-set 1.3e-21 34.6 81/90  
:HMM:PFM   359->445 PF07679 * I-set 1.6e-21 38.4 86/90  
:HMM:PFM   450->536 PF07679 * I-set 3.7e-25 39.1 87/90  
:HMM:PFM   542->628 PF07679 * I-set 2.8e-22 37.9 87/90  
:HMM:PFM   1435->1487 PF00093 * VWC 8.5e-12 39.6 53/57  
:BLT:SWISS 18->1496 PXDN_HUMAN 0.0 100.0 %
:PROS 1451->1487|PS01208|VWFC_1
:REPEAT 4|263->355|357->447|448->537|540->630
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0230 GT:ORG huge0 GT:GENE KIAA0230 GT:PRODUCT KIAA0230 GT:DATABASE huge2038 LENGTH 1496 SQ:AASEQ SRPWWLRASERPSAPSAMAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCEDCRTRGQFNAFSYHFRGRRSLEFSYQEDKPTKKTRPRKIPSVGRQGEHLSNSTSAFSTRSDASGTNDFREFVLEMQKTITDLRTQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECKDGQVTCFVEACPPATCAVPVNIPGACCPVCLQKRAEEKP SW:ID PXDN_HUMAN SW:DE RecName: Full=Peroxidasin homolog; EC=1.11.1.7;AltName: Full=Vascular peroxidase 1;AltName: Full=Melanoma-associated antigen MG50;AltName: Full=p53-responsive gene 2 protein;Flags: Precursor; SW:GN Name=PXDN; Synonyms=KIAA0230, MG50, PRG2, VPO, VPO1; SW:KW Alternative splicing; Calcium; Complete proteome; Disulfide bond;Glycoprotein; Heme; Hydrogen peroxide; Immunoglobulin domain; Iron;Leucine-rich repeat; Metal-binding; Oxidoreductase; Peroxidase;Phosphoprotein; Polymorphism; Repeat; Secreted; Signal. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 18->1496|PXDN_HUMAN|0.0|100.0|1479/1479| GO:SWS:NREP 6 GO:SWS GO:0042744|"GO:hydrogen peroxide catabolic process"|Hydrogen peroxide| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| GO:SWS GO:0004601|"GO:peroxidase activity"|Peroxidase| GO:SWS GO:0005576|"GO:extracellular region"|Secreted| PROS 1451->1487|PS01208|VWFC_1|PDOC00928| NREPEAT 1 REPEAT 4|263->355|357->447|448->537|540->630| SEG 100->113|rrlrnlntlllnnn| SEG 126->138|lenlkylylykne| SEG 1363->1372|kptkktrprk| BL:PDB:NREP 4 BL:PDB:REP 53->261|2v70A|3e-21|30.2|205/210| BL:PDB:REP 261->628|1cs6A|3e-40|34.0|350/382| BL:PDB:REP 739->1329|2nqxA|e-123|41.5|579/595| BL:PDB:REP 1437->1487|1u5mA|2e-05|35.3|51/73| RP:PDB:NREP 3 RP:PDB:REP 56->224|3cigA|2e-19|20.1|169/663| RP:PDB:REP 263->629|1bihA|2e-64|17.4|363/391| RP:PDB:REP 735->1332|2efbA|0.0|40.0|588/595| RP:PFM:NREP 6 RP:PFM:REP 265->342|PF07679|3e-11|36.7|78/89|I-set| RP:PFM:REP 365->446|PF07679|1e-15|44.7|81/89|I-set| RP:PFM:REP 453->536|PF07679|3e-15|42.5|84/89|I-set| RP:PFM:REP 548->628|PF07679|1e-15|45.7|81/89|I-set| RP:PFM:REP 759->1294|PF03098|e-118|52.5|459/473|An_peroxidase| RP:PFM:REP 1436->1487|PF00093|2e-12|50.0|52/55|VWC| HM:PFM:NREP 6 HM:PFM:REP 758->1306|PF03098|8.1e-181|49.8|508/525|An_peroxidase| HM:PFM:REP 263->345|PF07679|1.3e-21|34.6|81/90|I-set| HM:PFM:REP 359->445|PF07679|1.6e-21|38.4|86/90|I-set| HM:PFM:REP 450->536|PF07679|3.7e-25|39.1|87/90|I-set| HM:PFM:REP 542->628|PF07679|2.8e-22|37.9|87/90|I-set| HM:PFM:REP 1435->1487|PF00093|8.5e-12|39.6|53/57|VWC| GO:PFM:NREP 4 GO:PFM GO:0004601|"GO:peroxidase activity"|PF03098|IPR002007| GO:PFM GO:0006979|"GO:response to oxidative stress"|PF03098|IPR002007| GO:PFM GO:0020037|"GO:heme binding"|PF03098|IPR002007| GO:PFM GO:0055114|"GO:oxidation reduction"|PF03098|IPR002007| RP:SCP:NREP 5 RP:SCP:REP 53->249|1gwbA|3e-19|25.4|197/265|c.10.2.7| RP:SCP:REP 261->352|1cs6A1|1e-16|32.6|92/97|b.1.1.4| RP:SCP:REP 336->628|2cb2A1|3e-31|10.1|287/307|d.58.4.17| RP:SCP:REP 755->1331|1cxp.1|0.0|44.6|561/570|a.93.1.2| RP:SCP:REP 1432->1493|1u5mA|6e-13|34.4|61/73|g.27.1.2| HM:SCP:REP 52->270|1m0zA_|1.6e-49|34.1|217/0|c.10.2.7|1/1|L domain-like| HM:SCP:REP 263->358|2cqvA1|2.2e-23|35.5|93/0|b.1.1.4|1/4|Immunoglobulin| HM:SCP:REP 355->450|2avgA1|4.3e-28|39.6|96/0|b.1.1.4|2/4|Immunoglobulin| HM:SCP:REP 446->537|1g1cA_|2.1e-27|44.6|92/98|b.1.1.4|3/4|Immunoglobulin| HM:SCP:REP 538->631|1g1cA_|6e-27|45.7|94/98|b.1.1.4|4/4|Immunoglobulin| HM:SCP:REP 752->1332|1dnu.1|2.6e-207|46.3|564/0|a.93.1.2|1/1|Heme-dependent peroxidases| HM:SCP:REP 1432->1489|1u5mA_|1.2e-09|45.6|57/0|g.27.1.2|1/1|FnI-like domain| OP:NHOMO 10891 OP:NHOMOORG 101 OP:PATTERN -------------------------------------------------------------------- -------------------------1---------------------------11-----1-----11--------------------------------------1---------------------------------------11---------------------1----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1-1------------------2-------------------1-1------------31-1----------------------------------------------------------------------------------------------------------------------------1------------------------------------------------------------1------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------111----------------------------------------------------------------------------------------------------4- ----12--------3----------------------------111-----111-----------------------------------------------------P-2**********************U************q******w******k***********o**S------------------1----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 1340 STR:RPRED 89.6 SQ:SECSTR ############################################ccGGGcccccccccccTTcccccccccccccccccccccEEcTTcccccccTTTTcTTTTccEEEccccccccccTHHHHHcTTccEEEcTTcccccccTTcTTccccccEEEcTTcccccccccTTTTcTTccEEEcccccccccccccccccTTccEEEcccccccEEccGGGGGGTTHcccccTTTTTTTcEEEcccEEEEccccTTccHHcccccEEcccccEEEEETTccEEEcccEEccccccEEEEEEcccccTTTTTEEEcTTcccEEEccccGGGcEEEEEEEEETTEEEEcccEEEEEEcEEEEccccEEEEEcccTTEEEEEcccccEEEcccEEEEEEEETTccGGGccccccTTEcEEEEEEEEcTTccccEEEEEEEEccccccccccccccEEEEEcccEEEETTccEEEEEEEEcccccccEEEETTEEccccTTccccTTcEEEEccccGGGcEEEEEEEcccccccEEEEEEEEEEEEEEEEEccccEEEEcTTccEEEEcEEEEEcccccEEEETTEEcccccccEEEETTEEEEcccccTTcEEEEEEEEETTEEEEEEEEEEEcTccccHHHHEHHHHHHHHHTTccccTTcccHHHHTHHHHHHTccTTTTTHHHHHHHTccHHHHHHHHHHHHHHHHHHEEEEEEEcccTccEEE############cccTTccccccccccccc#ccccccccccTTcccccTTTTcTTEEcccccccccTTcccccTTccTTcccTTcccccHHHHHHHTTcccTTcEEEEEEHHHHHHHHHHHHHHcccccccccccccHHHHHHTTcccccccccEEccTTcTHHHHTccEEccccccccccccccccHHHHHcccccEEccccccccHHHHcccHHHHHHTcccccccccccccccccTTccccccccccccHHHHTTTTTcccccccccTTTTccHHHHHHHHHHHHHHHHHHHHHHHHcTTccHHHHHHHHHHHHHHHHHHHHHHTTHHHHHGGGHHHHccccccccTTccccccTTHHHHHGGGGGGccccEEEcccTTcccccTTEEEGGGcTTccHHHHTTTcHHHHHHHHHHcEEEcccTTccccHHHHTccccTTccccccHHHHHHHHHHHTTcccHHHHHHHTTccccccHHHHHHHHTcHHHHHHHHHHHccGGGccHHHHHHHccccTTccccHHHHHHHHHHHHHHHHTcTTcTTccTTccHHHHHHHTTccHHHHHHHHcccccEEEccccccccTTTTEEEGGGccccccGGGccc##############################################################################################ccccccccTTccEEccccEEcccccEEEEEETTEEEEEEccccccccccccccccccccccEETT##### DISOP:02AL 7-26,489-495,852-861,1360-1380,1491-1497| PSIPRED ccccccccccccccccccccccccccccHHHHHHHHHHHHHHHHHcccccccccccEEEEccEEEEccccccccccccccEEEEEEcccEEEEEcccHHcccccccEEEccccccccccccHHcccccccEEEccccEEEEEcHHHHcccccccEEEEcccEEEEEcHHHHccccccEEEEcccccEEEEccccccccccccEEEEccccEEccccEEEccHHccccccccccEEEEEEEccccccccEEEEEEHHHccccccEEEEcccEEEEEccccEEEEEEEEcccccEEEEEEccEEEcccccEEEEEEcccEEEEccccHHHcEEEEEEEEEcccEEEEEEEEEEEEEcccccccEEcccEEEEEccccEEEEEEEccccccEEEEEEccEEEccccccEEEEccccEEEEEccHHHcEEEEEEEEcccccEEEEEEEEEccccEEEEcccEEEEEccccEEEEEEEEEccccEEEEEEccEEccccccEEEccccEEEEEEccHHHcEEEEEEEEEccEEEEEEEEEEEEccccccEEcccEEEEEEccccEEEEEEEEEccccEEEEEEccEEccccccEEEccccEEEEccccHHHcEEEEEEEEEccccEEEEEEEEEEEccccccccccccccccccEEEEEEccccccccccccccccccccEEEEEEccccEEEEEEccccccHHHHHHccccccccEEEEEcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHcccHHcccccccccccccccccccccccHHHHHHHHccccccccccHHHHHHHHHHHHHHHHHccccccccccccccccccccccccccccccEEccccccccccccccEEEEEccccccccccccccccccHHHHHHHHHHHEEccccccccHHHHHHHHcccccccEEEEccccccccccccccccccccccccccccccEEEEcccccccccHHHHHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHHHHccccEEEcHHHHHcccccccccccccccHHHHHHHHHHHHHHHHccccEEEEcccccccccccEEHHHHccccHHEEccccHHHHHHHHccccHHHccccccccHHHHHHHcccccccEEHHHHHHHHHHHHcccccHHHHHHHccccccccHHHHHHHcccHHHHHHHHHHcccHHHEEEEEHHHHccccccccccHHHHHHHHHHHHHHccccEEEEEccccccHHHHHHHHHccHHHHHHHHcccHHHcccccEEccccccccccHHHcccccccccccccccccccccccccEEccccccccEEEccccccccccccccccccccccccccccEEEcccccccccccHHHHHHHHHHHHHHHHHHcccHHHcccccccEEEccccccccccEEcccccccEEccccEEEEEEEEccccccccccccccccccccccccccccc //