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Homo sapiens (cDNA) (huge0)
Gene : KIAA0231
DDBJ      :             KIAA0231
Swiss-Prot:LRC8B_HUMAN  RecName: Full=Leucine-rich repeat-containing protein 8B;AltName: Full=T-cell activation leucine repeat-rich protein;

Homologs  Archaea  2/68 : Bacteria  58/915 : Eukaryota  179/199 : Viruses  0/175   --->[See Alignment]
c.10.2
:823 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   585->739 2o6qA PDBj 3e-13 34.9 %
:RPS:PDB   519->709 3ciyB PDBj 3e-14 22.8 %
:RPS:PDB   682->739 3bz5A PDBj 3e-04 10.5 %
:RPS:SCOP  449->794 1g9uA  c.10.2.6 * 8e-23 18.1 %
:HMM:SCOP  442->795 1o6vA2 c.10.2.1 * 3.8e-53 35.4 %
:RPS:PFM   21->78 PF12534 * DUF3733 4e-09 38.6 %
:HMM:PFM   21->86 PF12534 * DUF3733 7.2e-29 52.3 65/65  
:HMM:PFM   114->172 PF12534 * DUF3733 2e-22 43.1 58/65  
:HMM:PFM   629->653 PF00560 * LRR_1 0.00096 50.0 20/22  
:HMM:PFM   700->720 PF00560 * LRR_1 2.3e-05 42.9 21/22  
:HMM:PFM   769->790 PF00560 * LRR_1 0.00096 45.5 22/22  
:BLT:SWISS 21->823 LRC8B_HUMAN 0.0 100.0 %
:TM
:REPEAT 3|607->646|655->692|701->738
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0231 GT:ORG huge0 GT:GENE KIAA0231 GT:PRODUCT KIAA0231 GT:DATABASE huge2038 LENGTH 823 SQ:AASEQ SILDLFNFFHCISVLLQGKVMITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKVEFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTCLDKC SW:ID LRC8B_HUMAN SW:DE RecName: Full=Leucine-rich repeat-containing protein 8B;AltName: Full=T-cell activation leucine repeat-rich protein; SW:GN Name=LRRC8B; Synonyms=KIAA0231; ORFNames=UNQ6413/PRO21207; SW:KW Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane;Polymorphism; Repeat; Transmembrane. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 21->823|LRC8B_HUMAN|0.0|100.0|803/803| GO:SWS:NREP 2 GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| TM:NTM 3 TM:REGION 5->27| TM:REGION 283->305| TM:REGION 325->347| NREPEAT 1 REPEAT 3|607->646|655->692|701->738| SEG 53->67|limllvavlagalql| SEG 201->213|lklskskillsss| SEG 279->293|lkqiivkvilfvlii| SEG 740->753|glfqckklqclllg| BL:PDB:NREP 1 BL:PDB:REP 585->739|2o6qA|3e-13|34.9|152/270| RP:PDB:NREP 2 RP:PDB:REP 519->709|3ciyB|3e-14|22.8|189/668| RP:PDB:REP 682->739|3bz5A|3e-04|10.5|57/450| RP:PFM:NREP 1 RP:PFM:REP 21->78|PF12534|4e-09|38.6|57/65|DUF3733| HM:PFM:NREP 5 HM:PFM:REP 21->86|PF12534|7.2e-29|52.3|65/65|DUF3733| HM:PFM:REP 114->172|PF12534|2e-22|43.1|58/65|DUF3733| HM:PFM:REP 629->653|PF00560|0.00096|50.0|20/22|LRR_1| HM:PFM:REP 700->720|PF00560|2.3e-05|42.9|21/22|LRR_1| HM:PFM:REP 769->790|PF00560|0.00096|45.5|22/22|LRR_1| RP:SCP:NREP 1 RP:SCP:REP 449->794|1g9uA|8e-23|18.1|326/353|c.10.2.6| HM:SCP:REP 442->795|1o6vA2|3.8e-53|35.4|328/0|c.10.2.1|1/1|L domain-like| OP:NHOMO 3366 OP:NHOMOORG 239 OP:PATTERN --------------------------------------------------13---------------- ----1------------------------------------------------------------------------------------------13----1---121------------------------------------1-412211---------------1131------------------------------1-------------------1------1---------------------------------------------------------------------------------------------------11-1111-1-----2---11---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1----------------1------------------------------------------------------------1--------------------1---1---1---1-1----11-----1--------------------------------------------------------------------------------------------------1--1------4-1-----------------------3--------1------1-----------------1------11------------------11--34GF------------------------------------------------- ----EI4-----24712--222111112212121111111111211111111111-312111111111-12-1121112211112-11-111211111111119862L36*bbZdePMHIFLZIvuJzE**jA*l*NOLKhIUmMHNILFjFEXJjVccFJJKZTAAMNO*DIQD-143*-1-34LaL*-pN167C878 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 384 STR:RPRED 46.7 SQ:SECSTR #######################################################################################################################################################################################################################################################################################################################################################################################################################################################HHHHHHHHHccccccccccccccEEcTTccccccccEEEEETTTTEEEEEEEETTccEEEEEcccTTTTcccccccHHHccccccTTTTcccccEEEccccccHccccTTTTTTcTTccEcccccccTcccccccccccccTTccEEEcccccccEEcTTTTTTcccccEEEcccccccEETTcccccccccEEEcTTcccccccHHHHHHHHccccEEEcTTccEEccTTTTHHHcccccTTTTTTTcEEEcTGGGTTccTTcccGGGcGGGGccccTHHHHHcTTEEcTTccccccccHHHHHHHccccEEETccEEccTcccccEEcTTTTTTcccccEEEccccccccccccTTccTTcTTccEEEcccGGGccccHHHH DISOP:02AL 96-106,192-245,247-248| PSIPRED cHHHHHHHHHHHHHHHccccEEEHHHHHHHHHHccccccccHHHHHHHHHHHHHHHHHHHHccccEEcccEEEEEccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHccccccccccHHHHHHHHHHHHHHHccccHHHHHHHHHHccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHEEEEcccEEEEEEEHHHHHHHHHHHHHHHEcccEEEEEEEEEEEcccHHHcccccEEEEEccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccEEEEEcccccccccccHHHHHHHHHHHHHcccccccccccccHHHHHcccccEEEccccccccccHHHHHHccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEcccccccccccHHHcccccccEEEccccccccccHHHHccccccEEEccccccccccccccHHHHcccccccEEEcccccccccHHHHHHcccccEEEcccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccccHHHcccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHcccccccEEEccccccccccHHHcccccccEEEccccccccccHHHHccccccEEEEEccccccccccHHHHHHHHHHHHcc //