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Homo sapiens (cDNA) (huge0)
Gene : KIAA0439
DDBJ      :             KIAA0439
Swiss-Prot:NED4L_PONAB  RecName: Full=E3 ubiquitin-protein ligase NEDD4-like;         EC=6.3.2.-;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  196/199 : Viruses  0/175   --->[See Alignment]
b.7.1b.72.1d.148.1d.266.1
:995 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   82->194 2nsqA PDBj 4e-59 100.0 %
:BLT:PDB   238->266 1wr3A PDBj 6e-14 96.6 %
:BLT:PDB   238->301 1tk7A PDBj 5e-07 38.4 %
:BLT:PDB   404->438 1wr4A PDBj 2e-17 97.1 %
:BLT:PDB   516->551 1wr7A PDBj 1e-18 100.0 %
:BLT:PDB   574->608 1i5hW PDBj 4e-12 74.3 %
:BLT:PDB   614->986 2oniA PDBj 0.0 100.0 %
:RPS:PDB   81->194 3b7yA PDBj 1e-22 73.5 %
:RPS:PDB   238->268 2dwvA PDBj 5e-08 38.7 %
:RPS:PDB   247->306 1adtA PDBj 3e-04 5.0 %
:RPS:PDB   406->436 2dmvA PDBj 2e-09 61.3 %
:RPS:PDB   519->561 2dk1A PDBj 3e-09 16.3 %
:RPS:PDB   574->605 2dwvA PDBj 2e-08 28.1 %
:RPS:PDB   644->988 1c4zA PDBj 2e-91 35.7 %
:RPS:SCOP  79->194 2ep6A1  b.7.1.1 * 3e-19 34.7 %
:RPS:SCOP  221->266 2e45A1  b.72.1.1 * 2e-07 28.3 %
:RPS:SCOP  238->266 1o6wA2  b.72.1.1 * 6e-08 34.5 %
:RPS:SCOP  238->295 1pu1A  d.266.1.1 * 1e-06 5.2 %
:RPS:SCOP  403->439 1i5hW  b.72.1.1 * 3e-10 45.9 %
:RPS:SCOP  410->488 1pu1A  d.266.1.1 * 7e-08 7.5 %
:RPS:SCOP  519->550 1i5hW  b.72.1.1 * 2e-11 65.6 %
:RPS:SCOP  574->608 1i5hW  b.72.1.1 * 2e-10 74.3 %
:RPS:SCOP  616->989 1nd7A  d.148.1.1 * e-116 52.2 %
:HMM:SCOP  79->194 1dqvA2 b.7.1.2 * 9.1e-24 40.4 %
:HMM:SCOP  223->267 1tk7A1 b.72.1.1 * 4.9e-12 50.0 %
:HMM:SCOP  395->439 1tk7A1 b.72.1.1 * 8.7e-13 42.9 %
:HMM:SCOP  511->556 1jmqA_ b.72.1.1 * 1.3e-11 48.8 %
:HMM:SCOP  559->608 1i5hW_ b.72.1.1 * 3.6e-12 48.0 %
:HMM:SCOP  615->989 1nd7A_ d.148.1.1 * 1.9e-126 43.8 %
:RPS:PFM   79->148 PF00168 * C2 9e-14 54.5 %
:RPS:PFM   238->264 PF00397 * WW 2e-04 59.3 %
:RPS:PFM   408->436 PF00397 * WW 1e-05 62.1 %
:RPS:PFM   520->548 PF00397 * WW 5e-05 55.2 %
:RPS:PFM   690->991 PF00632 * HECT 6e-80 50.5 %
:HMM:PFM   690->992 PF00632 * HECT 2.6e-97 43.5 292/308  
:HMM:PFM   235->264 PF00397 * WW 1.3e-16 63.3 30/30  
:HMM:PFM   407->436 PF00397 * WW 8.6e-18 60.0 30/30  
:HMM:PFM   519->548 PF00397 * WW 2.7e-17 60.0 30/30  
:HMM:PFM   570->599 PF00397 * WW 8.6e-15 66.7 30/30  
:HMM:PFM   79->148 PF00168 * C2 7.4e-21 48.5 66/85  
:BLT:SWISS 79->995 NED4L_PONAB 0.0 99.5 %
:PROS 239->264|PS01159|WW_DOMAIN_1
:PROS 411->436|PS01159|WW_DOMAIN_1
:PROS 523->548|PS01159|WW_DOMAIN_1
:PROS 574->599|PS01159|WW_DOMAIN_1
:REPEAT 3|411->439|523->551|574->602
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0439 GT:ORG huge0 GT:GENE KIAA0439 GT:PRODUCT KIAA0439 GT:DATABASE huge2038 LENGTH 995 SQ:AASEQ PGGWLRRALPGRERLQSPVHAVPPQHGTSHSRLLVTWPGAGRDQDFSSPPLLLLGETDHLHLDLPLSPLPTSDELFLPGICDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD SW:ID NED4L_PONAB SW:DE RecName: Full=E3 ubiquitin-protein ligase NEDD4-like; EC=6.3.2.-; SW:GN Name=NEDD4L; SW:KW Cytoplasm; Ligase; Phosphoprotein; Repeat; Ubl conjugation pathway. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 79->995|NED4L_PONAB|0.0|99.5|917/959| GO:SWS:NREP 2 GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| PROS 239->264|PS01159|WW_DOMAIN_1|PDOC50020| PROS 411->436|PS01159|WW_DOMAIN_1|PDOC50020| PROS 523->548|PS01159|WW_DOMAIN_1|PDOC50020| PROS 574->599|PS01159|WW_DOMAIN_1|PDOC50020| NREPEAT 1 REPEAT 3|411->439|523->551|574->602| SEG 51->73|llllgetdhlhldlplsplptsd| SEG 230->237|lpppplpp| SEG 323->340|agdslglalppppaspgs| SEG 495->511|snpqspqpspynspkpq| SEG 562->573|lnpndlgplppg| BL:PDB:NREP 7 BL:PDB:REP 82->194|2nsqA|4e-59|100.0|108/140| BL:PDB:REP 238->266|1wr3A|6e-14|96.6|29/36| BL:PDB:REP 238->301|1tk7A|5e-07|38.4|64/88| BL:PDB:REP 404->438|1wr4A|2e-17|97.1|35/36| BL:PDB:REP 516->551|1wr7A|1e-18|100.0|36/41| BL:PDB:REP 574->608|1i5hW|4e-12|74.3|35/50| BL:PDB:REP 614->986|2oniA|0.0|100.0|359/364| RP:PDB:NREP 7 RP:PDB:REP 81->194|3b7yA|1e-22|73.5|113/144| RP:PDB:REP 238->268|2dwvA|5e-08|38.7|31/49| RP:PDB:REP 247->306|1adtA|3e-04|5.0|60/301| RP:PDB:REP 406->436|2dmvA|2e-09|61.3|31/43| RP:PDB:REP 519->561|2dk1A|3e-09|16.3|43/50| RP:PDB:REP 574->605|2dwvA|2e-08|28.1|32/49| RP:PDB:REP 644->988|1c4zA|2e-91|35.7|333/350| RP:PFM:NREP 5 RP:PFM:REP 79->148|PF00168|9e-14|54.5|66/85|C2| RP:PFM:REP 238->264|PF00397|2e-04|59.3|27/30|WW| RP:PFM:REP 408->436|PF00397|1e-05|62.1|29/30|WW| RP:PFM:REP 520->548|PF00397|5e-05|55.2|29/30|WW| RP:PFM:REP 690->991|PF00632|6e-80|50.5|289/297|HECT| HM:PFM:NREP 6 HM:PFM:REP 690->992|PF00632|2.6e-97|43.5|292/308|HECT| HM:PFM:REP 235->264|PF00397|1.3e-16|63.3|30/30|WW| HM:PFM:REP 407->436|PF00397|8.6e-18|60.0|30/30|WW| HM:PFM:REP 519->548|PF00397|2.7e-17|60.0|30/30|WW| HM:PFM:REP 570->599|PF00397|8.6e-15|66.7|30/30|WW| HM:PFM:REP 79->148|PF00168|7.4e-21|48.5|66/85|C2| GO:PFM:NREP 6 GO:PFM GO:0005515|"GO:protein binding"|PF00397|IPR001202| GO:PFM GO:0005515|"GO:protein binding"|PF00397|IPR001202| GO:PFM GO:0005515|"GO:protein binding"|PF00397|IPR001202| GO:PFM GO:0005622|"GO:intracellular"|PF00632|IPR000569| GO:PFM GO:0006464|"GO:protein modification process"|PF00632|IPR000569| GO:PFM GO:0016881|"GO:acid-amino acid ligase activity"|PF00632|IPR000569| RP:SCP:NREP 9 RP:SCP:REP 79->194|2ep6A1|3e-19|34.7|101/126|b.7.1.1| RP:SCP:REP 221->266|2e45A1|2e-07|28.3|45/50|b.72.1.1| RP:SCP:REP 238->266|1o6wA2|6e-08|34.5|29/46|b.72.1.1| RP:SCP:REP 238->295|1pu1A|1e-06|5.2|57/91|d.266.1.1| RP:SCP:REP 403->439|1i5hW|3e-10|45.9|37/50|b.72.1.1| RP:SCP:REP 410->488|1pu1A|7e-08|7.5|79/91|d.266.1.1| RP:SCP:REP 519->550|1i5hW|2e-11|65.6|32/50|b.72.1.1| RP:SCP:REP 574->608|1i5hW|2e-10|74.3|35/50|b.72.1.1| RP:SCP:REP 616->989|1nd7A|e-116|52.2|370/374|d.148.1.1| HM:SCP:REP 79->194|1dqvA2|9.1e-24|40.4|104/145|b.7.1.2|1/1|C2 domain (Calcium/lipid-binding domain, CaLB)| HM:SCP:REP 223->267|1tk7A1|4.9e-12|50.0|42/45|b.72.1.1|1/4|WW domain| HM:SCP:REP 395->439|1tk7A1|8.7e-13|42.9|42/45|b.72.1.1|2/4|WW domain| HM:SCP:REP 511->556|1jmqA_|1.3e-11|48.8|43/46|b.72.1.1|3/4|WW domain| HM:SCP:REP 559->608|1i5hW_|3.6e-12|48.0|50/50|b.72.1.1|4/4|WW domain| HM:SCP:REP 615->989|1nd7A_|1.9e-126|43.8|372/0|d.148.1.1|1/1|Hect, E3 ligase catalytic domain| OP:NHOMO 3308 OP:NHOMOORG 196 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 443477J-F67266746546666666566676666666563665657666668656656555655555-5555555534555455587-46565664444664A9C2KM8cehXhZoUQMNPURzpMtJ**fGpX*NNMOeLPeZQRQQJdOQzRfUUQIZkLLKGHVFHVBIPJ4999*86577F6DF59A77TXQRI ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 803 STR:RPRED 80.7 SQ:SECSTR ##########################################################################cEcTccccEEEEEEEEETTTEEEEEEEEcccccccccccccEEEEEEEcTTTcEEEEEEEEcccccccEEEEEEEEEccccccccTTcccccccEEEEcccccTTcccccEEEEEEEEcccHHHHHHHHHHHHHHHHHHHHHHTTccTHHHHHccccccEEEEEcccHHHHHHHHHHHHHHHHHHTcGGGccEEEEcHHHHHHHHHHHTcTTTTTccHHHHcccccc############################################################################################ccTHHHTTccccccccHHHHHHHHHHHHTTccHHHHHTccccTTccHHHHHHHHHHHHTTcTTcccccccHHHHHHHHHc##HHHHHHHHHHHTcccTTc##################cccccccccTTccccccGGGcccccccccccccccccccHHHHHHHHHHHHHcccGGGcccTHHHccHHHTHHHHHHHHHHHHHHHHHHHHHHHEEEEcHHTGGGcccHHHHHHHHcTTHHHHHHHHHHHHHcccHHHHHHHHHHHHccGGGGGccccEEETTcccccccHHHHHHHHHHHHHHTcGGGccEEEETTTTEEEEcTEEEEETccccHHHHHHHHHHHHHHHHTTccccccccHHHHHHHTTccccHHHHHHHcHHHHHHHHHHHHccccHTccccEEEEcTTTccEEEEccTTTTTccccTTTHHHHHHHHHHHHHTcTTHHHHHHHHHHHHHHHcccccccccTHHHHHHHHcccccccTTTcTTcEEEcccccccHHHHHHHHHHHTccHHHHHHHHHHHcccccccTTcGGGHHHHHGGGccEEEEEEEcccccEEEGGGTEEEEEEcccHHHHHHHHHHHHHHcc###### DISOP:02AL 1-2,4-4,7-32,173-185,195-244,260-351,367-411,431-517,551-570,627-640,993-993| PSIPRED cccHHHHHcccHHHHcccccccccccccccccccccccccccccccccccEEEcccccEEEEEEEEcccccccccccccccccEEEEEEEcccccccEEEEEEEEEEcccccccccEEEEEEcccccEEEEEEEEccccccccEEEEEEEEHHHccccccccccccccHHHccccccccccccccEEEEEEEcccccccccccccccccccccccccccccccccccccccccccccccHHHccccccEEEEcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccEEEEcccccEEEEcccccccccccccccccccccccccccccccEEcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHccccEEEEEEEcccccccccccccccccccccccccHHHcccccccccEEEcccccEEEEccccccccccHHHccHHHHccHHHHHHHHHHHHHHHHHHHHHHcccccccEEEEEccccHHHHHHHHHHHHccHHHcccEEEEEEEccEEccccccHHHHHHHHHHHHHccccccEEEcccccEEEEEccccccccHHHHHHHHHHHHHHHHHHHccccccccccHHHHHHHHcccccHHHHHHHcHHHHHHHHHHHccccccccEEEEEEccccccEEEEEEcccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHcccHHHHHHHHcccccccHHHHHHHcEEccccccccHHHHHHHHHHHHccHHHHHHHHHHHccccccccccHHHHccccccEEEEEccccccccccccccEEEEEEccccccHHHHHHHHHHHHHHcccccccc //