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Homo sapiens (cDNA) (huge0)
Gene : KIAA0521
DDBJ      :             KIAA0521
Swiss-Prot:ARHGI_HUMAN  RecName: Full=Rho guanine nucleotide exchange factor 18;AltName: Full=114 kDa Rho-specific guanine nucleotide exchange factor;AltName: Full=p114-Rho-GEF;         Short=p114RhoGEF;AltName: Full=Septin-associated RhoGEF;         Short=SA-RhoGEF;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  84/199 : Viruses  0/175   --->[See Alignment]
a.87.1b.55.1
:1050 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   135->476 1x86A PDBj 2e-37 29.9 %
:RPS:PDB   136->476 1dbhA PDBj 4e-38 14.4 %
:RPS:SCOP  117->354 1txdA1  a.87.1.1 * 3e-40 28.6 %
:RPS:SCOP  352->476 1xcgA2  b.55.1.1 * 4e-22 27.0 %
:HMM:SCOP  116->351 1xcgA1 a.87.1.1 * 2.9e-61 32.5 %
:HMM:SCOP  350->477 1xcgA2 b.55.1.1 * 1.4e-36 46.1 %
:RPS:PFM   143->331 PF00621 * RhoGEF 1e-18 30.3 %
:HMM:PFM   140->331 PF00621 * RhoGEF 1e-38 30.9 178/180  
:HMM:PFM   375->474 PF00169 * PH 1.2e-09 22.3 94/104  
:BLT:SWISS 14->1050 ARHGI_HUMAN 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0521 GT:ORG huge0 GT:GENE KIAA0521 GT:PRODUCT KIAA0521 GT:DATABASE huge2038 LENGTH 1050 SQ:AASEQ WRRAACGRSGRASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRRLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAERPEVARRDSAPTESRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGGKDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFF SW:ID ARHGI_HUMAN SW:DE RecName: Full=Rho guanine nucleotide exchange factor 18;AltName: Full=114 kDa Rho-specific guanine nucleotide exchange factor;AltName: Full=p114-Rho-GEF; Short=p114RhoGEF;AltName: Full=Septin-associated RhoGEF; Short=SA-RhoGEF; SW:GN Name=ARHGEF18; Synonyms=KIAA0521; SW:KW Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;Guanine-nucleotide releasing factor; Phosphoprotein; Polymorphism. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 14->1050|ARHGI_HUMAN|0.0|100.0|1037/1173| GO:SWS:NREP 2 GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0005085|"GO:guanyl-nucleotide exchange factor activity"|Guanine-nucleotide releasing factor| SEG 2->13|rraacgrsgras| SEG 254->270|klllqqnkkfqnlikki| SEG 393->404|lailltdvllll| SEG 480->491|eeegpfslpeee| SEG 751->804|qlrheqqrwererqwqhqeleragarlqeregearqlrerleqeraelerqrqa| SEG 809->832|lerlreaqraverererlellrrl| SEG 913->923|qfqrqaavqqq| SEG 933->941|kggkdkggk| SEG 988->1009|spapppdpgfpapspppadsps| SEG 1014->1039|lkaggtallpgppapsplpatplsak| BL:PDB:NREP 1 BL:PDB:REP 135->476|1x86A|2e-37|29.9|335/362| RP:PDB:NREP 1 RP:PDB:REP 136->476|1dbhA|4e-38|14.4|326/332| RP:PFM:NREP 1 RP:PFM:REP 143->331|PF00621|1e-18|30.3|175/179|RhoGEF| HM:PFM:NREP 2 HM:PFM:REP 140->331|PF00621|1e-38|30.9|178/180|RhoGEF| HM:PFM:REP 375->474|PF00169|1.2e-09|22.3|94/104|PH| GO:PFM:NREP 3 GO:PFM GO:0005089|"GO:Rho guanyl-nucleotide exchange factor activity"|PF00621|IPR000219| GO:PFM GO:0005622|"GO:intracellular"|PF00621|IPR000219| GO:PFM GO:0035023|"GO:regulation of Rho protein signal transduction"|PF00621|IPR000219| RP:SCP:NREP 2 RP:SCP:REP 117->354|1txdA1|3e-40|28.6|231/234|a.87.1.1| RP:SCP:REP 352->476|1xcgA2|4e-22|27.0|122/127|b.55.1.1| HM:SCP:REP 116->351|1xcgA1|2.9e-61|32.5|228/0|a.87.1.1|1/1|DBL homology domain (DH-domain)| HM:SCP:REP 350->477|1xcgA2|1.4e-36|46.1|128/0|b.55.1.1|1/1|PH domain-like| OP:NHOMO 690 OP:NHOMOORG 84 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----211-------3---------------------------------1-111111-----------------------------------1-11--11--1-1---4--579FLGB8898899KO8H5d*F5QEQ7976C49BB58765H67H987982113223152271133------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 418 STR:RPRED 39.8 SQ:SECSTR ###########################################################################cccTTcccccTTcEEEEEcccc######cEEEEEccccEEEEEGGGEEEcccccccccccccHHHHHHHHHHHHHHHHHHHHHHHTTTHHHHHcTTccHHHHHHHHTTHHHHHHHHHHHHHHHHHHHHcccGGGccTTccccccHHHHHHHHHHHHHTTTTHHHHHHHHHHTcTTHHHHHHHHHHcTTHHHHHHHHTHHHHHHHTHHHHTTHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHTHHHHHHHHHHHcHHHHHHHHHTccccTHHHHHHTTEEccccccGGGTcccEEEEEEEETTccccEEEEEEccEEEEEEcTTccccTTcccccEEEEEEEEcccEEEEcccccccccEEEEccTTcccccEEEEcccHHHHHHHHHHHHHHTTTHHHHHHHTccccHHHHHHHHTcc####################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################### DISOP:02AL 1-1,3-135,171-171,408-416,473-521,523-524,528-553,576-659,710-732,767-790,842-869,873-873,878-903,919-996,1019-1041| PSIPRED ccccccccccccccHHccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHcccHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHHHHccccccccHHHHHHHHHHHcccHHHHHHHHHHHHHHHcHHHHHHHHHHHHHccHHHHHHHHHHHcccccccccHHHHHHHHHHHHccHHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccEEccccccccEEEEcccEEEEccccccEEEEEEEEccEEEEEEEcccccccccccccccEEEEEEEEEEEcccccccEEEEEEcccccEEEEEEEccHHHHHHHHHHHHHHHHHHHHHHcccccccccHHHHHHHHHHHHHHHHHHHHccHHHHHHcHHHHHHHHHHHHHccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHHHccccccccccHHccccccccccccccccccccccccccccccccccccccccHHHccccccccccccccccccccccccccEEEccccccccccHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHcHHHHcccccccccccccccHHHcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcHHHccccccccHHcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHccccccccccccccccccccccHHHHHHccccHHHccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccc 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