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Homo sapiens (cDNA) (huge0)
Gene : KIAA0538
DDBJ      :             KIAA0538
Swiss-Prot:RASL2_HUMAN  RecName: Full=Ras GTPase-activating protein 4;AltName: Full=Ras p21 protein activator 4;AltName: Full=RasGAP-activating-like protein 2;AltName: Full=Calcium-promoted Ras inactivator;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  180/199 : Viruses  0/175   --->[See Alignment]
a.116.1b.55.1b.7.1
:816 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   20->226 1dqvA PDBj 1e-19 33.7 %
:BLT:PDB   249->575 3bxjB PDBj 3e-26 29.8 %
:BLT:PDB   586->718 1bwnB PDBj 3e-05 28.1 %
:RPS:PDB   16->254 1dqvA PDBj 8e-29 22.3 %
:RPS:PDB   239->577 3bxjA PDBj 6e-43 24.9 %
:RPS:PDB   578->722 1bwnA PDBj 8e-16 22.2 %
:RPS:SCOP  16->143 1wfjA  b.7.1.2 * 4e-23 20.8 %
:RPS:SCOP  128->257 1a25A  b.7.1.2 * 2e-25 36.8 %
:RPS:SCOP  277->575 1werA  a.116.1.2 * 2e-58 29.3 %
:RPS:SCOP  581->718 1b55A  b.55.1.1 * 6e-34 28.8 %
:HMM:SCOP  9->147 1wfjA_ b.7.1.2 * 6.6e-27 26.7 %
:HMM:SCOP  123->255 1ugkA_ b.7.1.2 * 4e-35 38.2 %
:HMM:SCOP  277->625 1werA_ a.116.1.2 * 1.6e-78 37.9 %
:HMM:SCOP  578->723 1btkA_ b.55.1.1 * 2e-31 35.7 %
:RPS:PFM   22->100 PF00168 * C2 1e-11 37.8 %
:RPS:PFM   148->228 PF00168 * C2 3e-18 45.7 %
:RPS:PFM   336->523 PF00616 * RasGAP 8e-29 34.2 %
:RPS:PFM   695->718 PF00779 * BTK 4e-06 58.3 %
:HMM:PFM   336->525 PF00616 * RasGAP 1.5e-48 40.1 187/197  
:HMM:PFM   20->101 PF00168 * C2 2.3e-22 35.4 82/85  
:HMM:PFM   148->228 PF00168 * C2 1.4e-24 39.5 81/85  
:HMM:PFM   694->723 PF00779 * BTK 1.3e-15 46.7 30/32  
:HMM:PFM   591->684 PF00169 * PH 1.3e-07 18.8 85/104  
:BLT:SWISS 14->816 RASL2_HUMAN 0.0 99.8 %
:PROS 481->495|PS00509|RAS_GTPASE_ACTIV_1
:REPEAT 2|15->127|143->251
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0538 GT:ORG huge0 GT:GENE KIAA0538 GT:PRODUCT KIAA0538 GT:DATABASE huge2038 LENGTH 816 SQ:AASEQ DPGVWLPPSRDPAMAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKMPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGTEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT SW:ID RASL2_HUMAN SW:DE RecName: Full=Ras GTPase-activating protein 4;AltName: Full=Ras p21 protein activator 4;AltName: Full=RasGAP-activating-like protein 2;AltName: Full=Calcium-promoted Ras inactivator; SW:GN Name=RASA4; Synonyms=CAPRI, GAPL, KIAA0538; SW:KW Cell membrane; Complete proteome; Cytoplasm; GTPase activation;Membrane; Metal-binding; Polymorphism; Repeat; Zinc; Zinc-finger. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 14->816|RASL2_HUMAN|0.0|99.8|803/803| GO:SWS:NREP 5 GO:SWS GO:0005886|"GO:plasma membrane"|Cell membrane| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0005096|"GO:GTPase activator activity"|GTPase activation| GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| PROS 481->495|PS00509|RAS_GTPASE_ACTIV_1|PDOC00438| NREPEAT 1 REPEAT 2|15->127|143->251| SEG 797->808|ssspagsppsep| BL:PDB:NREP 3 BL:PDB:REP 20->226|1dqvA|1e-19|33.7|205/275| BL:PDB:REP 249->575|3bxjB|3e-26|29.8|299/358| BL:PDB:REP 586->718|1bwnB|3e-05|28.1|128/161| RP:PDB:NREP 3 RP:PDB:REP 16->254|1dqvA|8e-29|22.3|238/275| RP:PDB:REP 239->577|3bxjA|6e-43|24.9|305/348| RP:PDB:REP 578->722|1bwnA|8e-16|22.2|144/166| RP:PFM:NREP 4 RP:PFM:REP 22->100|PF00168|1e-11|37.8|79/85|C2| RP:PFM:REP 148->228|PF00168|3e-18|45.7|81/85|C2| RP:PFM:REP 336->523|PF00616|8e-29|34.2|187/195|RasGAP| RP:PFM:REP 695->718|PF00779|4e-06|58.3|24/32|BTK| HM:PFM:NREP 5 HM:PFM:REP 336->525|PF00616|1.5e-48|40.1|187/197|RasGAP| HM:PFM:REP 20->101|PF00168|2.3e-22|35.4|82/85|C2| HM:PFM:REP 148->228|PF00168|1.4e-24|39.5|81/85|C2| HM:PFM:REP 694->723|PF00779|1.3e-15|46.7|30/32|BTK| HM:PFM:REP 591->684|PF00169|1.3e-07|18.8|85/104|PH| GO:PFM:NREP 4 GO:PFM GO:0005096|"GO:GTPase activator activity"|PF00616|IPR001936| GO:PFM GO:0005622|"GO:intracellular"|PF00616|IPR001936| GO:PFM GO:0051056|"GO:regulation of small GTPase mediated signal transduction"|PF00616|IPR001936| GO:PFM GO:0023034|"GO:intracellular signaling pathway"|PF00779|IPR001562| RP:SCP:NREP 4 RP:SCP:REP 16->143|1wfjA|4e-23|20.8|125/136|b.7.1.2| RP:SCP:REP 128->257|1a25A|2e-25|36.8|125/132|b.7.1.2| RP:SCP:REP 277->575|1werA|2e-58|29.3|273/324|a.116.1.2| RP:SCP:REP 581->718|1b55A|6e-34|28.8|132/163|b.55.1.1| HM:SCP:REP 9->147|1wfjA_|6.6e-27|26.7|135/0|b.7.1.2|1/2|C2 domain (Calcium/lipid-binding domain, CaLB)| HM:SCP:REP 123->255|1ugkA_|4e-35|38.2|131/138|b.7.1.2|2/2|C2 domain (Calcium/lipid-binding domain, CaLB)| HM:SCP:REP 277->625|1werA_|1.6e-78|37.9|322/324|a.116.1.2|1/1|GTPase activation domain, GAP| HM:SCP:REP 578->723|1btkA_|2e-31|35.7|140/169|b.55.1.1|1/1|PH domain-like| OP:NHOMO 2209 OP:NHOMOORG 180 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----CEB---1-42644214433344433444444344241333443544435432444343321232113122231-2321111211-24242321123232A9D-K-BTicWpnVMBBDLTIz*7mH**g8eTwBGECbHPSPANCACaCEbEUSSR9DMDHH77WCAL7KK8---131--118237385--22313 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 722 STR:RPRED 88.5 SQ:SECSTR ##cTTcccEE###cTcccEHHHHHHHHHHHHHccHHHHHccccccccccHHHHTTccccccEEEEEEETTEEccEEcTTccGGGTcHHHHTTccccEEEETTcccccccccGGGcHHHHHHHHTTccEEEEEEccccGGGGccccccccEEEEEEEEEEccccccccEEEEEEEEEccccEcccEEcccEEEEEEEEEEEcTTccTTcEEEEEEEcccEEEEEEEEcccTTcccccEEccEEEEEEcccccccEEcEEccccEEcccEEEEEEcccccGGGGHHHHHHHHTTHHHHHTccccHHHHHHHHccHHHHHHHHHHHHHHHHHTTcccHHHHHHHHHHHHHcccccTTcccccHHHHHHHHHHHHHcHHHHHHHHHHHHHHHHHccccccccTTTccTTT##cc########HHHHHHHHHHHHHHHHHHHHHHHGGGGGccHHHHHHHHHHHHHHHHTTc##TcHHHHHHHHHHHHTTTTHHHHHHcGGGGTcccccccHHHHHHHHHHHHHHHHHHTTcccccccTTTTcGGGHHHHHHHHHHHHHHHHHTccccccccccccccHHHHccccEEEEEEEEEcccccTTccccEEEEEEEEcccEEEEEEEETTTTEEEEEGGGEEEEEEccccccccGGGcccccccHHEcccEEEEEEccHHHHHHHHHHHHHHHTTccccccEEccccEETTEETTTccccTTccccEEccc##cccccccccccccccc########################################################################### DISOP:02AL 1-2,7-19,250-259,409-424,506-507,563-573,587-600,765-779,793-809| PSIPRED ccccccccccccccccccEEEEEEEEcccccccccccccccEEEEEEccEEEEEEEEEEEccccccccEEEEEEcccccEEEEEEEEcccccccccEEEEEEEHHHccccccccHHHHHHHcccccccccccEEEEEEccccccccEEEEEEEEcccccccccccccccEEEEEEccEEEEEEEEEcccccccccEEEEEcccccccEEEEEEEEcccccccccEEEEEEEHHHccccccccccEEcccccccccccccccccccccEEEEccccccHHHHHHHHHHHHHHHcccccccccccHHHHcccccHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHcccHHHEEcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccHHHcccccccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHccccccccEEEEEEHHHHHHHHccccccccHHcccccccccHHHHHHHHHHHHHHHHHHcccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccccccccHHHcccEEEEEcccccccccccccEEEEEEccccEEccccccccEEEEEEHHHEEEEEEEEcccccccccEEEEEEccccccccEEEEcccHHHHHHHHHHHHHHccccccccccccccEEcccccHHHHHHHHcccccccEEccccHHHccccccccHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccccccHHHHHHHHHHHHHHHHHHHHccccccccccEEEEEEcc //