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Homo sapiens (cDNA) (huge0)
Gene : KIAA0567
DDBJ      :             KIAA0567
Swiss-Prot:OPA1_HUMAN   RecName: Full=Dynamin-like 120 kDa protein, mitochondrial;AltName: Full=Optic atrophy protein 1;Contains:  RecName: Full=Dynamin-like 120 kDa protein, form S1;Flags: Precursor;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  196/199 : Viruses  0/175   --->[See Alignment]
c.37.1d.95.2
:978 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   159->221 1tvqA PDBj 5e-05 36.5 %
:BLT:PDB   280->520 2akaB PDBj 3e-25 32.8 %
:RPS:PDB   299->355 2atxA PDBj 7e-04 22.8 %
:RPS:PDB   369->512 3cdkA PDBj 1e-06 12.3 %
:RPS:PDB   752->976 1annA PDBj 1e-04 16.6 %
:RPS:SCOP  306->562 1jwyB  c.37.1.8 * 2e-40 30.1 %
:RPS:SCOP  540->655 1r7mA2  d.95.2.1 * 2e-07 15.7 %
:HMM:SCOP  275->589 2akaB1 c.37.1.8 * 1.4e-55 26.1 %
:RPS:PFM   309->486 PF00350 * Dynamin_N 5e-20 41.2 %
:HMM:PFM   309->487 PF00350 * Dynamin_N 3.8e-39 34.1 167/168  
:HMM:PFM   273->322 PF07632 * DUF1593 2.8e-05 28.6 49/260  
:BLT:SWISS 19->978 OPA1_HUMAN 0.0 99.9 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0567 GT:ORG huge0 GT:GENE KIAA0567 GT:PRODUCT KIAA0567 GT:DATABASE huge2038 LENGTH 978 SQ:AASEQ TGAPAWPSRRLRDLPAGGMWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQQFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFDQWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPNSEDLVKLAPDFDKIVESLSLLKDFFTSGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK SW:ID OPA1_HUMAN SW:DE RecName: Full=Dynamin-like 120 kDa protein, mitochondrial;AltName: Full=Optic atrophy protein 1;Contains: RecName: Full=Dynamin-like 120 kDa protein, form S1;Flags: Precursor; SW:GN Name=OPA1; Synonyms=KIAA0567; SW:KW Acetylation; Alternative splicing; Apoptosis; Coiled coil;Complete proteome; Deafness; Disease mutation; GTP-binding; Membrane;Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding;Phosphoprotein; Polymorphism; Sensory transduction; Transit peptide;Transmembrane; Vision. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 19->978|OPA1_HUMAN|0.0|99.9|960/960| GO:SWS:NREP 9 GO:SWS GO:0006915|"GO:apoptosis"|Apoptosis| GO:SWS GO:0005525|"GO:GTP binding"|GTP-binding| GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0005739|"GO:mitochondrion"|Mitochondrion| GO:SWS GO:0005743|"GO:mitochondrial inner membrane"|Mitochondrion inner membrane| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0050896|"GO:response to stimulus"|Sensory transduction| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| GO:SWS GO:0007601|"GO:visual perception"|Vision| SEG 249->264|rilerlekenkelrkl| SEG 526->539|ssesieaireyeee| BL:PDB:NREP 2 BL:PDB:REP 159->221|1tvqA|5e-05|36.5|63/125| BL:PDB:REP 280->520|2akaB|3e-25|32.8|229/299| RP:PDB:NREP 3 RP:PDB:REP 299->355|2atxA|7e-04|22.8|57/186| RP:PDB:REP 369->512|3cdkA|1e-06|12.3|138/229| RP:PDB:REP 752->976|1annA|1e-04|16.6|223/315| RP:PFM:NREP 1 RP:PFM:REP 309->486|PF00350|5e-20|41.2|160/165|Dynamin_N| HM:PFM:NREP 2 HM:PFM:REP 309->487|PF00350|3.8e-39|34.1|167/168|Dynamin_N| HM:PFM:REP 273->322|PF07632|2.8e-05|28.6|49/260|DUF1593| GO:PFM:NREP 2 GO:PFM GO:0003924|"GO:GTPase activity"|PF00350|IPR001401| GO:PFM GO:0005525|"GO:GTP binding"|PF00350|IPR001401| RP:SCP:NREP 2 RP:SCP:REP 306->562|1jwyB|2e-40|30.1|226/281|c.37.1.8| RP:SCP:REP 540->655|1r7mA2|2e-07|15.7|83/105|d.95.2.1| HM:SCP:REP 275->589|2akaB1|1.4e-55|26.1|299/0|c.37.1.8|1/1|P-loop containing nucleoside triphosphate hydrolases| OP:NHOMO 1282 OP:NHOMOORG 196 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 23-1224-41213444583674678866634447768556567444438B77795687866743333323333333332333333332-364545333334525652353AGLAMJE6633467OY4O5g*K2NAK4544A48A838342C53I6776426655334C34785331332N12233H77M8F72222118 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 522 STR:RPRED 53.4 SQ:SECSTR ##############################################################################################################################################################EEEEEEEcHHHHHHHTTccHHHHHHHTTcccEEEEEEETTEEEEEEccccEEEEEEETTccEE##########################################################TTHHHHHHHHHHHHTTc##ccccccEEEEEEEEEcTTccHHHHHHHHHHccccccccccccccEEEEEEccccEEEEEEETTcTTc###cHHHHHTTccTTcEEEEcccTTcTTccccHHHHHHHHHHTcccEEEEEccccccccTTHHHHHTHTcEEEEEEccccccHHHHHHHTTTccEEEEccHHHHHHHHHHHHHTccEEEEcTTTTcGTcGGTTccEEEETTEEEEEETTcEEEcc#######################################################################################################################################################################################################################################cccccccccHHHHHHHHHHccccccHHHHHHHHTTccHHHHHHHHHcccHHHHHHHHccHHHHHHHHHHHccHHHHHHccccccHHHHHHccHH#HHHHHHHHHHHHHcccHHHHHHHHccHHHHTccccccccccHHHHHHHHHHHHHHHTTTcccHHHHHHHHHHccHHHHHHHHHHHHHHHcccHHHHHHHHccHHHHHHH#HHHHHHHHHHHHHHHHHHHH## DISOP:02AL 1-3,87-92,204-231,253-276,385-393,521-537,602-602,803-803,977-979| PSIPRED cccccccccHHHcccccccHHHHHHHHHHHHHHHHccccccccEEccHHHccHHHHHcccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHcccEEccccccccccHHHHHHHHHHHHccccccccHHccccccEEHHHHHHHHHHHHHcccHHHHHHHHHHHHHcccHHHHHHHHcccccccccccccccccccccHHHHcccccHHHHHHHHHHHHHHcccccccccccHHHHHHHHccccccHHHHHHHHccHHHHHHHHHHHHHHHHHcccccccccccEEEEEccccccHHHHHHHHHccccccccccccEEEccEEEEEEEccccHHHHHcccccccccccccHHHHHHHHHHHHHHcccccccccccEEEEEEEccccccEEEEEcccEEEcccccccHHHHHHHHHHHHHHHccccEEEEEEEcccccHHHHHHHHHHHcccccccEEEEEEccccccccccccHHHHHHHHcccccccccccEEEEEcccccccccHHHHHHHHHHHHHHcHHHHHccccHHHccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHccccHHHHcccccccccHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHHcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHccccccHHHHHHHHHHHHHHHHccccccHHHcccHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccHHHHccccHHHHHHHHHHHHHHHHHHHHHHHHHHHcc //