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Homo sapiens (cDNA) (huge0)
Gene : KIAA0580
DDBJ      :             KIAA0580
Swiss-Prot:ARAP2_HUMAN  RecName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2;AltName: Full=Centaurin-delta-1;         Short=Cnt-d1;AltName: Full=PARX protein;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  196/199 : Viruses  0/175   --->[See Alignment]
a.116.1b.55.1d.15.1g.45.1
:1631 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   415->511 2codA PDBj 1e-41 100.0 %
:BLT:PDB   614->726 2iqjB PDBj 4e-15 38.9 %
:BLT:PDB   848->926 1u5dB PDBj 8e-05 31.6 %
:BLT:PDB   1042->1208 2ee5A PDBj 9e-15 26.5 %
:RPS:PDB   407->511 2codA PDBj 6e-13 83.8 %
:RPS:PDB   515->613 2dkpA PDBj 2e-09 18.2 %
:RPS:PDB   598->726 2crrA PDBj 3e-25 32.8 %
:RPS:PDB   848->925 3cxbB PDBj 2e-09 18.7 %
:RPS:PDB   1042->1229 2ee4A PDBj 3e-31 26.2 %
:RPS:PDB   1256->1331 1ef5A PDBj 2e-09 13.3 %
:RPS:PDB   1363->1466 1eazA PDBj 2e-10 15.2 %
:RPS:SCOP  410->511 2codA1  b.55.1.1 * 1e-16 85.3 %
:RPS:SCOP  517->607 2codA1  b.55.1.1 * 2e-10 26.0 %
:RPS:SCOP  613->726 1dcqA2  g.45.1.1 * 4e-32 33.9 %
:RPS:SCOP  812->928 1upqA  b.55.1.1 * 2e-08 21.0 %
:RPS:SCOP  949->1037 1v61A  b.55.1.1 * 2e-04 11.0 %
:RPS:SCOP  1045->1219 1pbwA  a.116.1.1 * 9e-29 20.3 %
:RPS:SCOP  1253->1331 2c5lC1  d.15.1.5 * 2e-05 14.1 %
:RPS:SCOP  1310->1459 1u5eA1  b.55.1.1 * 1e-10 18.1 %
:HMM:SCOP  342->504 1u5eA1 b.55.1.1 * 2.1e-22 27.3 %
:HMM:SCOP  505->613 1x1fA1 b.55.1.1 * 1.2e-14 28.4 %
:HMM:SCOP  610->731 1dcqA2 g.45.1.1 * 2.7e-37 42.5 %
:HMM:SCOP  804->968 1btkA_ b.55.1.1 * 8.7e-25 26.4 %
:HMM:SCOP  941->1038 1qqgA1 b.55.1.2 * 1.1e-08 23.7 %
:HMM:SCOP  1049->1229 1f7cA_ a.116.1.1 * 6.2e-43 32.6 %
:HMM:SCOP  1246->1352 1wgrA_ d.15.1.5 * 0.00061 19.0 %
:HMM:SCOP  1352->1504 1x1fA1 b.55.1.1 * 1.5e-20 21.3 %
:RPS:PFM   515->604 PF00169 * PH 6e-04 30.3 %
:RPS:PFM   624->726 PF01412 * ArfGap 6e-22 48.5 %
:RPS:PFM   1056->1201 PF00620 * RhoGAP 3e-21 33.8 %
:HMM:PFM   1056->1205 PF00620 * RhoGAP 5.9e-43 36.0 150/153  
:HMM:PFM   411->500 PF00169 * PH 4.6e-13 30.3 89/104  
:HMM:PFM   517->605 PF00169 * PH 6.5e-10 29.2 89/104  
:HMM:PFM   838->927 PF00169 * PH 4.4e-10 23.0 87/104  
:HMM:PFM   948->1037 PF00169 * PH 2.2e-05 14.4 90/104  
:HMM:PFM   1363->1460 PF00169 * PH 7.5e-11 22.6 93/104  
:HMM:PFM   614->728 PF01412 * ArfGap 9.6e-37 42.5 113/117  
:HMM:PFM   1256->1339 PF00788 * RA 2.2e-08 23.5 81/93  
:BLT:SWISS 1->1631 ARAP2_HUMAN 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0580 GT:ORG huge0 GT:GENE KIAA0580 GT:PRODUCT KIAA0580 GT:DATABASE huge2038 LENGTH 1631 SQ:AASEQ IPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQLETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIESLITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGSPPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVSGSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGEALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEECFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGASAKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDTQVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGILKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKPPTSWGLTAYSEKHHWHLCCDSSQTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKDDKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVIEELNVVLQRSRTLPKELQDEQILK SW:ID ARAP2_HUMAN SW:DE RecName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2;AltName: Full=Centaurin-delta-1; Short=Cnt-d1;AltName: Full=PARX protein; SW:GN Name=ARAP2; Synonyms=CENTD1, KIAA0580; SW:KW 3D-structure; Complete proteome; Cytoplasm; GTPase activation;Metal-binding; Phosphoprotein; Polymorphism; Repeat; Zinc;Zinc-finger. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->1631|ARAP2_HUMAN|0.0|100.0|1631/1704| GO:SWS:NREP 3 GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0005096|"GO:GTPase activator activity"|GTPase activation| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| SEG 150->162|stsgtnsgngtng| SEG 470->484|fevvttqrtfvfrve| SEG 834->845|sklssekkllee| BL:PDB:NREP 4 BL:PDB:REP 415->511|2codA|1e-41|100.0|97/115| BL:PDB:REP 614->726|2iqjB|4e-15|38.9|108/123| BL:PDB:REP 848->926|1u5dB|8e-05|31.6|76/107| BL:PDB:REP 1042->1208|2ee5A|9e-15|26.5|166/219| RP:PDB:NREP 7 RP:PDB:REP 407->511|2codA|6e-13|83.8|105/115| RP:PDB:REP 515->613|2dkpA|2e-09|18.2|99/128| RP:PDB:REP 598->726|2crrA|3e-25|32.8|125/141| RP:PDB:REP 848->925|3cxbB|2e-09|18.7|75/103| RP:PDB:REP 1042->1229|2ee4A|3e-31|26.2|187/209| RP:PDB:REP 1256->1331|1ef5A|2e-09|13.3|75/88| RP:PDB:REP 1363->1466|1eazA|2e-10|15.2|99/103| RP:PFM:NREP 3 RP:PFM:REP 515->604|PF00169|6e-04|30.3|89/102|PH| RP:PFM:REP 624->726|PF01412|6e-22|48.5|101/118|ArfGap| RP:PFM:REP 1056->1201|PF00620|3e-21|33.8|145/152|RhoGAP| HM:PFM:NREP 8 HM:PFM:REP 1056->1205|PF00620|5.9e-43|36.0|150/153|RhoGAP| HM:PFM:REP 411->500|PF00169|4.6e-13|30.3|89/104|PH| HM:PFM:REP 517->605|PF00169|6.5e-10|29.2|89/104|PH| HM:PFM:REP 838->927|PF00169|4.4e-10|23.0|87/104|PH| HM:PFM:REP 948->1037|PF00169|2.2e-05|14.4|90/104|PH| HM:PFM:REP 1363->1460|PF00169|7.5e-11|22.6|93/104|PH| HM:PFM:REP 614->728|PF01412|9.6e-37|42.5|113/117|ArfGap| HM:PFM:REP 1256->1339|PF00788|2.2e-08|23.5|81/93|RA| GO:PFM:NREP 5 GO:PFM GO:0008060|"GO:ARF GTPase activator activity"|PF01412|IPR001164| GO:PFM GO:0008270|"GO:zinc ion binding"|PF01412|IPR001164| GO:PFM GO:0032312|"GO:regulation of ARF GTPase activity"|PF01412|IPR001164| GO:PFM GO:0005622|"GO:intracellular"|PF00620|IPR000198| GO:PFM GO:0007165|"GO:signal transduction"|PF00620|IPR000198| RP:SCP:NREP 8 RP:SCP:REP 410->511|2codA1|1e-16|85.3|102/102|b.55.1.1| RP:SCP:REP 517->607|2codA1|2e-10|26.0|86/102|b.55.1.1| RP:SCP:REP 613->726|1dcqA2|4e-32|33.9|112/122|g.45.1.1| RP:SCP:REP 812->928|1upqA|2e-08|21.0|105/107|b.55.1.1| RP:SCP:REP 949->1037|1v61A|2e-04|11.0|89/132|b.55.1.1| RP:SCP:REP 1045->1219|1pbwA|9e-29|20.3|172/184|a.116.1.1| RP:SCP:REP 1253->1331|2c5lC1|2e-05|14.1|78/97|d.15.1.5| RP:SCP:REP 1310->1459|1u5eA1|1e-10|18.1|149/168|b.55.1.1| HM:SCP:REP 342->504|1u5eA1|2.1e-22|27.3|161/0|b.55.1.1|1/5|PH domain-like| HM:SCP:REP 505->613|1x1fA1|1.2e-14|28.4|109/0|b.55.1.1|2/5|PH domain-like| HM:SCP:REP 610->731|1dcqA2|2.7e-37|42.5|120/122|g.45.1.1|1/1|ArfGap/RecO-like zinc finger| HM:SCP:REP 804->968|1btkA_|8.7e-25|26.4|144/169|b.55.1.1|3/4|PH domain-like| HM:SCP:REP 941->1038|1qqgA1|1.1e-08|23.7|93/0|b.55.1.2|4/5|PH domain-like| HM:SCP:REP 1049->1229|1f7cA_|6.2e-43|32.6|181/191|a.116.1.1|1/1|GTPase activation domain, GAP| HM:SCP:REP 1246->1352|1wgrA_|0.00061|19.0|100/0|d.15.1.5|1/1|Ubiquitin-like| HM:SCP:REP 1352->1504|1x1fA1|1.5e-20|21.3|136/0|b.55.1.1|5/5|PH domain-like| OP:NHOMO 3404 OP:NHOMOORG 196 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 2211CA7-522-5595454544445554444445664545255324555655452444756554443424444545513457753655-56646748776497HJI1J55G*sw*zfRFLKQdQ**I*K***M*o*JKLIzITnWAVPMLmEB*MdWZZESaHEDF6FDDOGJGD1436D53332ACFC5J72134451 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 1026 STR:RPRED 62.9 SQ:SECSTR ######################################################################################################################################################################################################################################################################################################################################################################################################################cccccEEEEEEEcccccccccEEEEEEEcccEEEEEEcccccccccEEETTTEEEEEEETTTEEEEEEccccEEEEcccHHHHHHHHHHHHHHHHHHcTTccccccccccEEEEEEEEccccEEEEEEETTEEEEEccTTcccEEEEEcGGGcEEEEccGGGccccEEEEEccccccEEEEcccHHHHHHHccccccTTTTTTcHHHHHHHHHHcGGGcccccccccccccEETTTTEEccHHHHHHHHHHcTTTccccccccccccccHHHHHHHHHTHHHHHHHHGGGccTccTTccccccHHHHHHHHHHHHTccTTccccHHHHccccHHHHHHHTccGGGHHHHHHHHHHcccTTcccTT##cccHHHHHHHTTcHHHHHHHHHT################cccccccccEEEEEEEccccccccccccccccccEEEEEEEETTEEEEEcccccccccEEEETTcEcEEEEEEccEccccccTTEEEEEETTcccEEEEcccHHHHHHHHHHHHHH#####################################cTTcccTTccccEEEcHHHHHHHHcccccTTcccHHHHTccHHHHTTccTTcccHHHHHHHHTHHcccccccTTcccccHHHHccccccccHHHHHHHHHHHHTccccTTTTTccccHHHHHHHHHHHHHcTTccTHHHHTccHHHHHHHHHHHHHHcccccccTTTHHHHHHHHccccHHHHHHHHHHHTTTccTTHHHHHHHHHHHHHHHHHTHHHHcccHHHHHHHHHHHHccccccccccccHHHHHHHTHHHHTTccccHHTccccccHHHHHTTccccGGGcTTcEEEEEccccccccccEEEcccccTHHHHHHHTTTTTccccHHHHHHHHHHHHHHHGGEEccccccTTTTTccccccTTTcEEEEEEEcHHHHHHHHHHHHHHHHcccEEEEEEEEcTTTcTTccccEEEEEEEEcccEEEEEccTTcccccEEEEGGGccEEEEcTTHHHHTcccEEEEEccccEEEEEcccHHHHHHHHHHHHHHHHHTcccccEEccccEETTEccccc################################################################################################################################################ DISOP:02AL 10-27,40-40,46-46,60-78,221-246,248-249,270-280,340-413,459-459,461-469,496-531,543-573,587-617,697-714,733-738,740-743,802-814,829-847,863-876,951-958,973-1008,1020-1038,1239-1276,1471-1485,1521-1535,1571-1596,1625-1632| PSIPRED cccEEEEEEcccccccHHHcccccccccEEEEEEccEEEEcccccHHHHHHHHHHcccccccccccccccccccccccccccccccccccccccccEEccccEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccccccccccccccccccccccccEEEEEEEEEEEccccccccccccccccccEEccccccEEEcccccccccccccccccccHHHHccccccccccccccccccccccccccHHHHHHHccccccHHHHHHHHHHHHHHHHcccccccccccEEEEEcccccHHHHHHcHHHEEEcccccccccEEEEccccEEEEEEccccccccccccccHHcccccccccHHHHHHccccccccccccccccccccccccccccccccccEEEEEEcccccccccEEEEEEEEEccEEEEEcccccccccccccccEEEEEcccccccEEEEccccEEEEEcccHHHHHHccEEEEccccccccccccccccccccccccccccccccccEEEccccccccccccccccccccEEcccccccccccccccccccEEEEccEEEEEccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccEEEEccccccEEEEEEEcEEEEcccccccccccccEEEEEEEEcccccccHHHHHHHHHHHHHHHHHHHHHHccccccccccccHHHHHHHHHHHHHccHHHHcccccccHHHccHHHHHHHHcccHHHHHHHHHccccccccccccccccHHHHHHHccccHHHHHHHHHcccccccccccccccccccccccHHHHHHcccccccccccccccccHHHcccEEEEEcccEEEEEEcccccccccccccccEEEEEccccccccccccEEEEEEEEccccEEEEEcccHHHHHHHHHHHHHHcccccccccccccccccEEEEEcccccccccccEEEEEcccEEEEEccccccccccccHHHHccccccccccccccEEEEEEEccccEEEEEEcccccccccccccccccccccccHHHHccccccccHHHHHHHHHHHHHccccccEEEccccHHHHHHHHHHHHccccccccccccccHHHHHHHHHHHHHHcccccccHHHHHHHHHHHccccHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHcccccccccccHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHccccHHcccccccccEEHHHHcccccccEEEEEcccccHHHHHHHHHHHHccccccccccEEEEEEccccccccccHHHHHHHHHHHHcccccccccEEEEccccHHHHHHccccHHHccccccEEEEEcccccccccccccEEEEEEEcccEEEEEEccccccccccccHHHHHHEccccccccccccccEEEEEccccEEEEEccHHHHHHHHHHHHHEEEccccccccccHHHHHHcccccccccEEEEEEcccccHHHHHHHHHHHHHcccccHHHHcccccccccHHHHHHHHHHHHHHHHHHHHHcHHHccccccHHccccccccccccccccccccHHHccccccEEccccccccHHHHHHHHHHHHHccccccccccHHHcc 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