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Homo sapiens (cDNA) (huge0)
Gene : KIAA0910
DDBJ      :             KIAA0910
Swiss-Prot:SYNJ1_HUMAN  RecName: Full=Synaptojanin-1;         EC=3.1.3.36;AltName: Full=Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  196/199 : Viruses  0/175   --->[See Alignment]
a.26.1b.1.18d.151.1d.58.7
:1315 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   562->921 1i9zA PDBj 9e-53 41.7 %
:BLT:PDB   931->1007 2dnrA PDBj 5e-38 100.0 %
:RPS:PDB   315->430 1ahqA PDBj 6e-04 13.8 %
:RPS:PDB   437->508 3bqtB PDBj 7e-11 22.9 %
:RPS:PDB   569->904 2ddsA PDBj 1e-38 13.1 %
:RPS:PDB   926->1008 2dnrA PDBj 4e-04 95.2 %
:RPS:PDB   1200->1278 2bbvA PDBj 1e-06 10.1 %
:RPS:SCOP  86->179 1clcA2  b.1.18.2 * 2e-23 21.3 %
:RPS:SCOP  566->906 1ntfA  d.151.1.2 * 4e-49 22.2 %
:RPS:SCOP  925->1007 1ufwA  d.58.7.1 * 4e-12 39.8 %
:RPS:SCOP  1200->1279 1emrA  a.26.1.1 * 3e-04 15.0 %
:HMM:SCOP  545->930 1i9zA_ d.151.1.2 * 2.3e-74 33.8 %
:HMM:SCOP  915->1008 1ufwA_ d.58.7.1 * 1.4e-14 30.8 %
:RPS:PFM   96->380 PF02383 * Syja_N 4e-47 43.6 %
:RPS:PFM   616->900 PF03372 * Exo_endo_phos 1e-26 49.8 %
:RPS:PFM   903->1045 PF08952 * DUF1866 2e-55 71.1 %
:RPS:PFM   1212->1276 PF06583 * Neogenin_C 6e-04 38.6 %
:HMM:PFM   95->381 PF02383 * Syja_N 5e-87 42.2 277/314  
:HMM:PFM   572->901 PF03372 * Exo_endo_phos 1.5e-58 36.2 246/276  
:HMM:PFM   903->1042 PF08952 * DUF1866 2.5e-58 54.3 138/145  
:BLT:SWISS 37->1279 SYNJ1_HUMAN 0.0 99.8 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0910 GT:ORG huge0 GT:GENE KIAA0910 GT:PRODUCT KIAA0910 GT:DATABASE huge2038 LENGTH 1315 SQ:AASEQ GAAAARPTGSRAGGRLQDQSLPPQRQRERAASEERRMAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPSG SW:ID SYNJ1_HUMAN SW:DE RecName: Full=Synaptojanin-1; EC=3.1.3.36;AltName: Full=Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1; SW:GN Name=SYNJ1; Synonyms=KIAA0910; SW:KW 3D-structure; Alternative splicing; Complete proteome; Cytoplasm;Endocytosis; Hydrolase; Phosphoprotein; Polymorphism; Repeat;RNA-binding. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 37->1279|SYNJ1_HUMAN|0.0|99.8|1243/1573| GO:SWS:NREP 4 GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0006897|"GO:endocytosis"|Endocytosis| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0003723|"GO:RNA binding"|RNA-binding| SEG 24->36|qrqreraaseerr| SEG 1061->1090|llpqhlqpssssglgtspsssprtspcqsp| SEG 1124->1159|aqpatppprpvapptrpappqrppppsgarspaptr| SEG 1181->1194|pspqaglagpgpag| SEG 1280->1314|pqpnletppqppprsrsshslpseassqpqqeqps| BL:PDB:NREP 2 BL:PDB:REP 562->921|1i9zA|9e-53|41.7|302/336| BL:PDB:REP 931->1007|2dnrA|5e-38|100.0|77/91| RP:PDB:NREP 5 RP:PDB:REP 315->430|1ahqA|6e-04|13.8|116/133| RP:PDB:REP 437->508|3bqtB|7e-11|22.9|70/80| RP:PDB:REP 569->904|2ddsA|1e-38|13.1|289/299| RP:PDB:REP 926->1008|2dnrA|4e-04|95.2|83/91| RP:PDB:REP 1200->1278|2bbvA|1e-06|10.1|79/308| RP:PFM:NREP 4 RP:PFM:REP 96->380|PF02383|4e-47|43.6|275/301|Syja_N| RP:PFM:REP 616->900|PF03372|1e-26|49.8|203/261|Exo_endo_phos| RP:PFM:REP 903->1045|PF08952|2e-55|71.1|142/142|DUF1866| RP:PFM:REP 1212->1276|PF06583|6e-04|38.6|57/250|Neogenin_C| HM:PFM:NREP 3 HM:PFM:REP 95->381|PF02383|5e-87|42.2|277/314|Syja_N| HM:PFM:REP 572->901|PF03372|1.5e-58|36.2|246/276|Exo_endo_phos| HM:PFM:REP 903->1042|PF08952|2.5e-58|54.3|138/145|DUF1866| GO:PFM:NREP 4 GO:PFM GO:0003723|"GO:RNA binding"|PF08952|IPR015047| GO:PFM GO:0004439|"GO:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"|PF08952|IPR015047| GO:PFM GO:0016311|"GO:dephosphorylation"|PF08952|IPR015047| GO:PFM GO:0016021|"GO:integral to membrane"|PF06583|IPR010560| RP:SCP:NREP 4 RP:SCP:REP 86->179|1clcA2|2e-23|21.3|94/100|b.1.18.2| RP:SCP:REP 566->906|1ntfA|4e-49|22.2|279/280|d.151.1.2| RP:SCP:REP 925->1007|1ufwA|4e-12|39.8|83/95|d.58.7.1| RP:SCP:REP 1200->1279|1emrA|3e-04|15.0|80/159|a.26.1.1| HM:SCP:REP 545->930|1i9zA_|2.3e-74|33.8|334/0|d.151.1.2|1/1|DNase I-like| HM:SCP:REP 915->1008|1ufwA_|1.4e-14|30.8|91/0|d.58.7.1|1/1|RNA-binding domain, RBD| OP:NHOMO 1870 OP:NHOMOORG 196 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 3322888-943-7985676666566666656566766666666555666666666666666675555554675455626655555566-7B86887886796788529A9ELJFFLHB889AC9aVCP9y*I5SIR9ABAGBBE95CCB7GA9IAEGCR65488868B77D9BA83643N11133KPMV3SE3456564 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 731 STR:RPRED 55.6 SQ:SECSTR ##########################################################################################################################################################################################################################################################################################################################cHHHHHHHHHHHHHccccEEEEEEcTTccEEEEEEEEcTHHHHTccTTccEEEEEEEEccccccccEEEEEEEccTTccHHHHHHHHHTHHHHHHHcTTEEEEccTTTccHHHcTTccTTcTHHHHHHHTTTcccHHHHHcHHHHHHHHHHTTcTTccHHHHHHHHHHTT##ccGGGccHHHHHHHHHHHHHcc###########################################ccccccccccccTTccccEEEEEEEEEEEccTTTcTTccHHHHHHHHHHccTEEEEEccccEHcTTccccEEEEEEEccHHHHHHHHHHHTTTccEEcTccccTTccEEEEcccTTcccccccEEEEcccEEEEEEEEEEEcccccccccccccEEEEEEEEccccEEEEEEEEccccccccTTccHHHHHHHHHHHHHHHHHccTTccEEEEEEcccccTTTTTcTcTTcTTcHHHHHHHHHTccccEEEEccccccTTTcHHHHHHcTTccccEEEEcTTccccccEEEEEcccccccEEEEEEEcccccccEccHHHHHTcccEEEEETTEEEEEccccccccEEEEEEcEEEEEcHHHHHHHHHHH###ccccEEEEEEEEEcccTTTEccTTccHHHHHHHTTTcEEEEEEEEETTEEEEEEEEEcHHHHHHTccccccccHHHHHcEcccc##########################################################################################################################################################################################ccTccEcccTTTccccccccccEEEEEEEEcTTccEEEEEEEEEEEEEEEcTTcccGGGcEEcccccHHHHHHHHHHHHTccccc#################################### DISOP:02AL 1-37,76-89,980-1316| PSIPRED ccccccccccccccccccccccccccHHHHHHHHHHHHHcccEEEEEEccccccEEEEccccccEEEEEccccEEEEEcccccccccccEEEEEEEEEEEEEEEEEccccEEEEEEEEccEEEEEEccEEEEEEEEEEEEEccccccHHHHHHHHHHHcccccEEEEEcccccccccccccccccccccccccEEEHHHHHHHHHHHccccccEEEEEEEEEEEEEEEEEccEEEEEEEEEEEccccccccccccccccccccccEEEEEEEEEEcccEEEEEEEcccEEEEEEEccccccccccEEcccccccHHHHHHHHHHHHHHcccEEEEEEEcccccHHHHHHHHHHHHHHHcccccccEEEccHHHHHccccHHHHHHHHHHHHHHHHHccEEEEccccEEEEEccEEEEEcHHccccHHHHHHHHHHHHHHHHHHHHcccccccccHHHHHHHHHHHHHHHHHHHHHHHcccccccccHHHHHHHHHHHHHHccccccHHHHHHHEEEEccEEcccccccHHHcccccHHEEEccccccccHHHHHHHHHHHHcccccccEEEEEEEEEccccccccccccccccHHHHHcccccccccccccccccccccEEEEEEEEccccccccEEccccccHHHHHHHHHHHHcccccEEEEEEEEEHHHHHHHHHHHHHHHHccccEEcccccccccccccccEEEEEEEEccEEEEEEEccccccccHHHHHHHHHHHHHHHcccccccccccccEEEEEEEEccEEEccHHHHHHHHHcccHHHHHHHHHHHHHHHccccccccccccccccccEEEEccccccccccccccccccccEEEccccccccccccccccccccccccccccccccccEEEEccccccEEcccccEEEEEEEEEEEEcHHHHHHHHHHHHHHcccccccEEEcccccccccccccccHHHHHHHHHHccccEEcccccccEEEEEEccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccc 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