Homo sapiens (cDNA) (huge0)
Gene : KIAA0921
DDBJ : KIAA0921
Swiss-Prot:NRX2A_HUMAN RecName: Full=Neurexin-2-alpha;AltName: Full=Neurexin II-alpha;Flags: Precursor;
Homologs Archaea 0/68 : Bacteria 0/915 : Eukaryota 67/199 : Viruses 0/175 --->[See Alignment]
b.29.1
d.84.1
g.3.11
g.77.1
:1658 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB 123->200 2jd4B PDBj 5e-04 26.6 %
:BLT:PDB 218->261 1pxxA PDBj 8e-05 43.9 %
:BLT:PDB 277->465 2h0bD PDBj 5e-85 88.7 %
:BLT:PDB 491->649 1pz9B PDBj 7e-09 27.6 %
:BLT:PDB 678->712 1w0yL PDBj 6e-06 52.9 %
:BLT:PDB 715->887 2r16A PDBj 1e-77 79.8 %
:BLT:PDB 893->1060 1pz8D PDBj 8e-14 32.7 %
:BLT:PDB 1072->1111 1u67A PDBj 3e-05 42.5 %
:BLT:PDB 1113->1286 3bopC PDBj 3e-94 100.0 %
:RPS:PDB 116->204 3b69A PDBj 2e-08 15.4 %
:RPS:PDB 222->261 1bf9A PDBj 2e-04 32.5 %
:RPS:PDB 245->672 2c5dA PDBj 3e-22 13.1 %
:RPS:PDB 678->714 1bf9A PDBj 2e-07 50.0 %
:RPS:PDB 698->1072 2c5dA PDBj 2e-38 15.6 %
:RPS:PDB 1068->1115 3b4vC PDBj 5e-05 22.9 %
:RPS:PDB 1112->1286 3bopA PDBj 1e-29 98.8 %
:RPS:PDB 1471->1580 2b5lD PDBj 6e-04 12.3 %
:RPS:SCOP 114->204 1dykA1 b.29.1.4 * 6e-11 22.0 %
:RPS:SCOP 222->261 1cqeA2 g.3.11.1 * 4e-09 32.5 %
:RPS:SCOP 278->472 1dykA2 b.29.1.4 * 8e-18 16.2 %
:RPS:SCOP 478->672 1dykA1 b.29.1.4 * 2e-18 21.3 %
:RPS:SCOP 678->714 1cqeA2 g.3.11.1 * 9e-10 37.8 %
:RPS:SCOP 697->880 1dykA1 b.29.1.4 * 3e-21 17.9 %
:RPS:SCOP 894->1054 1dykA1 b.29.1.4 * 3e-24 26.1 %
:RPS:SCOP 1063->1108 1rfxA g.77.1.1 * 1e-05 4.3 %
:RPS:SCOP 1081->1110 1h30A1 b.29.1.4 * 1e-06 20.0 %
:RPS:SCOP 1111->1281 1c4rA b.29.1.4 * 2e-22 78.9 %
:RPS:SCOP 1474->1571 2sicI d.84.1.1 * 1e-04 7.1 %
:HMM:SCOP 39->222 1d2sA_ b.29.1.4 * 2.3e-36 32.9 %
:HMM:SCOP 220->261 1cqeA2 g.3.11.1 * 5.1e-05 38.1 %
:HMM:SCOP 276->455 1d2sA_ b.29.1.4 * 3.5e-41 34.2 %
:HMM:SCOP 473->671 1d2sA_ b.29.1.4 * 1.6e-44 39.1 %
:HMM:SCOP 683->864 1h30A1 b.29.1.4 * 7e-42 34.3 %
:HMM:SCOP 892->1069 1d2sA_ b.29.1.4 * 6.2e-49 36.1 %
:HMM:SCOP 1080->1262 1h30A1 b.29.1.4 * 2.2e-36 27.7 %
:RPS:PFM 114->204 PF00054 * Laminin_G_1 2e-06 30.1 %
:RPS:PFM 310->439 PF02210 * Laminin_G_2 3e-13 35.6 %
:RPS:PFM 506->654 PF00054 * Laminin_G_1 1e-17 41.7 %
:RPS:PFM 745->866 PF02210 * Laminin_G_2 3e-11 32.5 %
:RPS:PFM 922->1050 PF02210 * Laminin_G_2 6e-20 45.5 %
:RPS:PFM 1145->1263 PF02210 * Laminin_G_2 1e-09 32.3 %
:RPS:PFM 1471->1571 PF03154 * Atrophin-1 6e-06 36.2 %
:HMM:PFM 73->202 PF02210 * Laminin_G_2 9.2e-24 30.4 125/128
:HMM:PFM 310->443 PF02210 * Laminin_G_2 2.2e-25 30.6 124/128
:HMM:PFM 506->651 PF02210 * Laminin_G_2 4.5e-32 45.2 126/128
:HMM:PFM 745->866 PF02210 * Laminin_G_2 5.2e-23 35.5 121/128
:HMM:PFM 922->1050 PF02210 * Laminin_G_2 2.3e-31 36.3 124/128
:HMM:PFM 1145->1263 PF02210 * Laminin_G_2 2.9e-26 27.1 118/128
:HMM:PFM 679->701 PF00008 * EGF 3e-05 39.1 23/32
:HMM:PFM 1076->1105 PF00008 * EGF 0.00013 37.9 29/32
:BLT:SWISS 22->1658 NRX2A_HUMAN 0.0 99.9 %
:TM
:REPEAT 4|281->458|717->876|898->1072|1116->1274
:REPEAT 3|225->257|675->711|1073->1108
:REPEAT 2|123->224|568->674
:SEG
SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA0921
GT:ORG huge0
GT:GENE KIAA0921
GT:PRODUCT KIAA0921
GT:DATABASE huge2038
LENGTH 1658
SQ:AASEQ SLSGGRGPGGAGAAVGMASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
SW:ID NRX2A_HUMAN
SW:DE RecName: Full=Neurexin-2-alpha;AltName: Full=Neurexin II-alpha;Flags: Precursor;
SW:GN Name=NRXN2; Synonyms=KIAA0921;
SW:KW Alternative promoter usage; Alternative splicing; Calcium;Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain;Glycoprotein; Membrane; Metal-binding; Polymorphism; Repeat; Signal;Transmembrane.
SW:EXACT F
SW:FUNC +
BL:SWS:NREP 1
BL:SWS:REP 22->1658|NRX2A_HUMAN|0.0|99.9|1637/1712|
GO:SWS:NREP 4
GO:SWS GO:0007155|"GO:cell adhesion"|Cell adhesion|
GO:SWS GO:0016020|"GO:membrane"|Membrane|
GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding|
GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane|
TM:NTM 2
TM:REGION 29->47|
TM:REGION 1580->1602|
NREPEAT 3
REPEAT 4|281->458|717->876|898->1072|1116->1274|
REPEAT 3|225->257|675->711|1073->1108|
REPEAT 2|123->224|568->674|
SEG 1->21|slsggrgpggagaavgmasgs|
SEG 27->40|ppplllllllalaa|
SEG 81->106|lllylddggdcdflelllvdgrlrlr|
SEG 518->536|sqgrragggagshssaqra|
SEG 543->552|lldghlylll|
SEG 1293->1323|llsaettattlladmattimettttmatttt|
SEG 1379->1400|pppvatrspfvpppptfypflt|
SEG 1410->1422|pppaarrppsggp|
SEG 1585->1600|vvgivaaaalcilill|
SEG 1635->1654|kekapaapktpskakknkdk|
BL:PDB:NREP 9
BL:PDB:REP 123->200|2jd4B|5e-04|26.6|73/375|
BL:PDB:REP 218->261|1pxxA|8e-05|43.9|41/552|
BL:PDB:REP 277->465|2h0bD|5e-85|88.7|177/178|
BL:PDB:REP 491->649|1pz9B|7e-09|27.6|138/187|
BL:PDB:REP 678->712|1w0yL|6e-06|52.9|34/133|
BL:PDB:REP 715->887|2r16A|1e-77|79.8|173/175|
BL:PDB:REP 893->1060|1pz8D|8e-14|32.7|162/177|
BL:PDB:REP 1072->1111|1u67A|3e-05|42.5|40/553|
BL:PDB:REP 1113->1286|3bopC|3e-94|100.0|168/169|
RP:PDB:NREP 8
RP:PDB:REP 116->204|3b69A|2e-08|15.4|78/626|
RP:PDB:REP 222->261|1bf9A|2e-04|32.5|36/41|
RP:PDB:REP 245->672|2c5dA|3e-22|13.1|359/380|
RP:PDB:REP 678->714|1bf9A|2e-07|50.0|36/41|
RP:PDB:REP 698->1072|2c5dA|2e-38|15.6|359/380|
RP:PDB:REP 1068->1115|3b4vC|5e-05|22.9|48/206|
RP:PDB:REP 1112->1286|3bopA|1e-29|98.8|168/168|
RP:PDB:REP 1471->1580|2b5lD|6e-04|12.3|106/175|
RP:PFM:NREP 7
RP:PFM:REP 114->204|PF00054|2e-06|30.1|87/132|Laminin_G_1|
RP:PFM:REP 310->439|PF02210|3e-13|35.6|119/126|Laminin_G_2|
RP:PFM:REP 506->654|PF00054|1e-17|41.7|127/132|Laminin_G_1|
RP:PFM:REP 745->866|PF02210|3e-11|32.5|122/126|Laminin_G_2|
RP:PFM:REP 922->1050|PF02210|6e-20|45.5|123/126|Laminin_G_2|
RP:PFM:REP 1145->1263|PF02210|1e-09|32.3|117/126|Laminin_G_2|
RP:PFM:REP 1471->1571|PF03154|6e-06|36.2|94/648|Atrophin-1|
HM:PFM:NREP 8
HM:PFM:REP 73->202|PF02210|9.2e-24|30.4|125/128|Laminin_G_2|
HM:PFM:REP 310->443|PF02210|2.2e-25|30.6|124/128|Laminin_G_2|
HM:PFM:REP 506->651|PF02210|4.5e-32|45.2|126/128|Laminin_G_2|
HM:PFM:REP 745->866|PF02210|5.2e-23|35.5|121/128|Laminin_G_2|
HM:PFM:REP 922->1050|PF02210|2.3e-31|36.3|124/128|Laminin_G_2|
HM:PFM:REP 1145->1263|PF02210|2.9e-26|27.1|118/128|Laminin_G_2|
HM:PFM:REP 679->701|PF00008|3e-05|39.1|23/32|EGF|
HM:PFM:REP 1076->1105|PF00008|0.00013|37.9|29/32|EGF|
RP:SCP:NREP 11
RP:SCP:REP 114->204|1dykA1|6e-11|22.0|87/189|b.29.1.4|
RP:SCP:REP 222->261|1cqeA2|4e-09|32.5|38/42|g.3.11.1|
RP:SCP:REP 278->472|1dykA2|8e-18|16.2|181/185|b.29.1.4|
RP:SCP:REP 478->672|1dykA1|2e-18|21.3|171/189|b.29.1.4|
RP:SCP:REP 678->714|1cqeA2|9e-10|37.8|37/42|g.3.11.1|
RP:SCP:REP 697->880|1dykA1|3e-21|17.9|180/189|b.29.1.4|
RP:SCP:REP 894->1054|1dykA1|3e-24|26.1|157/189|b.29.1.4|
RP:SCP:REP 1063->1108|1rfxA|1e-05|4.3|46/89|g.77.1.1|
RP:SCP:REP 1081->1110|1h30A1|1e-06|20.0|30/186|b.29.1.4|
RP:SCP:REP 1111->1281|1c4rA|2e-22|78.9|171/180|b.29.1.4|
RP:SCP:REP 1474->1571|2sicI|1e-04|7.1|98/107|d.84.1.1|
HM:SCP:REP 39->222|1d2sA_|2.3e-36|32.9|170/0|b.29.1.4|1/6|Concanavalin A-like lectins/glucanases|
HM:SCP:REP 220->261|1cqeA2|5.1e-05|38.1|42/42|g.3.11.1|1/3|EGF/Laminin|
HM:SCP:REP 276->455|1d2sA_|3.5e-41|34.2|161/0|b.29.1.4|2/6|Concanavalin A-like lectins/glucanases|
HM:SCP:REP 473->671|1d2sA_|1.6e-44|39.1|169/0|b.29.1.4|3/6|Concanavalin A-like lectins/glucanases|
HM:SCP:REP 683->864|1h30A1|7e-42|34.3|181/191|b.29.1.4|4/6|Concanavalin A-like lectins/glucanases|
HM:SCP:REP 892->1069|1d2sA_|6.2e-49|36.1|166/0|b.29.1.4|5/6|Concanavalin A-like lectins/glucanases|
HM:SCP:REP 1080->1262|1h30A1|2.2e-36|27.7|177/191|b.29.1.4|6/6|Concanavalin A-like lectins/glucanases|
OP:NHOMO 1834
OP:NHOMOORG 67
OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------2----------------------------------------------------------------------------------------------------2--UdinlnRGIFEGUKp*HoG**b9sP*DKKGkHKfICKDDCcBCpEeLVS8C8CFDE8UHBZ5DE6------------------------ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
STR:NPRED 1352
STR:RPRED 81.5
SQ:SECSTR ##########################################cEEEEEEEEEEEEccTTccccccEEEEEEEEEEcccEEEEEEEEEcTTcccEEEEEEETTEEEEEEEcccccEEEETccccTTcccEEEEEEEETTEEEEEETTEEEEcEEEEEccccccEEEEEEEccccTGGGcccccccccTcccccEEEEEEEETTccHHHHHHTTcTTEEccccccGGGccEEEEcccEEEEEETTccccEccccccccTTEEEEccTTcEEEEEcGcccEETTccTTccccEEEEEEEccccccEcEEEEEEEEccccEEEEEEETTcEEEEEEEETTEEEEEEEEccccEEEcEEEEccccccccccEEEEEccTTEEEEEETTEEEEEETTEEEEEEEccccccEEccEEEEEEccccccGGGccccccccccEEEEEEEETTcccccccHHHHHHHcGTEEEEccEEcGGccccccccccEEEccccEEEEcccccccEEEEEEEEEccccEEEEEEEEcTTccc###EEEcTTTTcccEEEEEEcccEEEEEETTEEEEEEEEcccTTccEEEEEEETTEEEEEETTEEcTTTTEEcccccccccEEEEEEEccccccGccccTccTcccccccccccEEEEEEEEEcccccHHHHHHHHHTcccEEcEETTEEEGGGcccccTTcccEEccccEcccccccccccccTTcEETTccTTccccEEEEEEEGccccccEEEEEEEEccccEEEEEEEccTTcEEEEEEEETTEEEEEEEEcccccEEEEccccccccccEEEEEccTTEEEEEETEEEEEEEccccccEEccccEEEEEEcGGGccccccccccEEEEEEHHHHTTEEcccccccHHHHHHHcGGGccccccccccEEEccccEEEEcccccccEEEEEEEEEccccEEEEEEEcTTTTcccEEEEEEcccEEEEEETTEEEEEEEEEcccTTcccEEEEEEEETTTEEEEEEccccccccccccTHTTcccEEEEcccccccGGGcccccccccccEEEEEEEEEccccccTTTccEEcTTccTTccccccccGGGccEEEEcccEEEEETTccccEEEEcccTTccccccEEEEcTTccEEEEEccTTccccccccEEEEEEEcccccEEEEEEEEcTTccEEEEEEEETTEEEEEEEETTEEEEEEEcccccTTcccEEEEEEEETTEEEEEETTEEEEEcccccccccccccEEEEEEEcccccccccEEEEEEEETTccHHHHHHTTcTTEEEEccEEEcccccc###################################################################################################################################################################################HHHHHHHccccTT####cccccTTEEEccccccccccccccccccccEEEcccTTccccccccEEEEEcccccccccccHHHHHHHHHHHTTTcccEEEccccccccccc##############################################################################
DISOP:02AL 1-8,16-22,150-160,1001-1006,1311-1577,1613-1613,1619-1620,1625-1625,1629-1655|
PSIPRED cccccccccccccccccccccccccccccccEEEEcccccEEEEEEEcccccEEEEEccccccccEEEEEEEEEEcccccEEEEEcccccccEEEEEEEccEEEEEEEcccccEEEEEcccccccccEEEEEEEEEccEEEEEEccccEEEEEccccccEEccccEEEEEEcccccccccccccccccccccEEEEEEEEccEEEcccccccccccEEEccccccccccccccEEEEcccccEEEEcccccccccccHHcccccccccccccccccccEEEEEEccccEEEEccccccccccEEEEEEEEEEccccEEEEEEcccccEEEEEEcccEEEEEEEcccccEEEEEEccccccccccEEEEEEEEccccccEEEccEEEEEEcccEEEEEEcccccccccccccEEEEcccccccccccccccccEEEEEEEEEcccccccccccccccccccEEEccccccccccccccccEEEEccccEEEEccccccccEEEEEEEEEccccEEEEEEcccccccccEEccccccccEEEEEEEccEEEEEEEcccccEEEEccccEEccccEEEEEEEEEccEEEEEEcccccEEEEcccccEEEEcccEEEcccccccccccccccccccccccccccccEEEEEEccEEEccHHHHHHcccccEEEcccccccccccccccccccEEEcccccEEEEEccccccccccccccccEEccccEEEEEEccccccccccEEEEEEEEccccEEEEEEcccccccEEEEEEEccEEEEEEEcccccEEEEcccccccccEEEEEEEEEccEEEEEEccEEEEEEEcccccEEEEEEEEEccEEccccccccccccccccccEEEccccccccccccccEEEEccccccccccEEEEEEEcccccEEEEcccccccEEEEEEEEEEccccEEEEEEccccccEEEEEEcccEEEEEEEcccccEEEEEEccccccccEEEEEEEEEEccEEEEEEEccEEEEEcccccccEEEcccEEEEEEcccccccccccccccccccEEEEEEEEccEEcccHHHHHHcccccccccccccccccccccccccEEEcccccEEEEccccccccccccccEEEEEEccccEEEEEEcccccccccccEEEEEEEEEccccEEEEEEEcccccccEEEEEEEccEEEEEEEcccccEEEEEcccEEccccEEEEEEEEEccEEEEEEccEEcccccccccccEEEEccccEEEEEEccccccEEEEEEEEEcccccccccccccccEEEEcccEEEccccccccccccccccccHHHHccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccEEcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHHHcccccccccEEccccccccccccccEEEEEcccccccccccccccccccccc
//
[GTOP]
