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Homo sapiens (cDNA) (huge0)
Gene : KIAA1142
DDBJ      :             KIAA1142
Swiss-Prot:PAK4_HUMAN   RecName: Full=Serine/threonine-protein kinase PAK 4;         EC=2.7.11.1;AltName: Full=p21-activated kinase 4;         Short=PAK-4;

Homologs  Archaea  16/68 : Bacteria  493/915 : Eukaryota  198/199 : Viruses  5/175   --->[See Alignment]
d.144.1
:467 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   39->73 2ov2J PDBj 3e-17 100.0 %
:BLT:PDB   175->467 2q0nA PDBj e-167 100.0 %
:RPS:PDB   34->76 1eesB PDBj 3e-14 51.2 %
:RPS:PDB   177->463 2bvaB PDBj 1e-38 95.3 %
:RPS:SCOP  192->450 1nw1A  d.144.1.8 * 5e-49 8.2 %
:RPS:SCOP  431->460 1xqzA  d.144.1.7 * 1e-04 23.3 %
:HMM:SCOP  186->462 1howA_ d.144.1.7 * 4.6e-81 36.4 %
:RPS:PFM   39->75 PF00786 * PBD 2e-06 45.9 %
:RPS:PFM   202->444 PF00069 * Pkinase 2e-43 39.3 %
:HMM:PFM   202->448 PF00069 * Pkinase 3.2e-71 36.4 247/260  
:HMM:PFM   39->92 PF00786 * PBD 1.3e-17 37.0 54/59  
:BLT:SWISS 97->467 PAK4_HUMAN 0.0 99.7 %
:PROS 203->227|PS00107|PROTEIN_KINASE_ATP
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA1142 GT:ORG huge0 GT:GENE KIAA1142 GT:PRODUCT KIAA1142 GT:DATABASE huge2038 LENGTH 467 SQ:AASEQ PEAPRGVVTCLRALLSHQHQTRPHRVPGTMFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR SW:ID PAK4_HUMAN SW:DE RecName: Full=Serine/threonine-protein kinase PAK 4; EC=2.7.11.1;AltName: Full=p21-activated kinase 4; Short=PAK-4; SW:GN Name=PAK4; Synonyms=KIAA1142; SW:KW 3D-structure; Alternative splicing; ATP-binding; Complete proteome;Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism;Serine/threonine-protein kinase; Transferase. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 97->467|PAK4_HUMAN|0.0|99.7|371/591| GO:SWS:NREP 5 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0016301|"GO:kinase activity"|Kinase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0004674|"GO:protein serine/threonine kinase activity"|Serine/threonine-protein kinase| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 203->227|PS00107|PROTEIN_KINASE_ATP|PDOC00100| SEG 118->136|ssssssrpptrargapspg| SEG 145->174|pqlappactpaapavpgppgprspqrepqr| BL:PDB:NREP 2 BL:PDB:REP 39->73|2ov2J|3e-17|100.0|35/35| BL:PDB:REP 175->467|2q0nA|e-167|100.0|292/293| RP:PDB:NREP 2 RP:PDB:REP 34->76|1eesB|3e-14|51.2|43/46| RP:PDB:REP 177->463|2bvaB|1e-38|95.3|274/274| RP:PFM:NREP 2 RP:PFM:REP 39->75|PF00786|2e-06|45.9|37/52|PBD| RP:PFM:REP 202->444|PF00069|2e-43|39.3|242/256|Pkinase| HM:PFM:NREP 2 HM:PFM:REP 202->448|PF00069|3.2e-71|36.4|247/260|Pkinase| HM:PFM:REP 39->92|PF00786|1.3e-17|37.0|54/59|PBD| GO:PFM:NREP 3 GO:PFM GO:0004672|"GO:protein kinase activity"|PF00069|IPR017442| GO:PFM GO:0005524|"GO:ATP binding"|PF00069|IPR017442| GO:PFM GO:0006468|"GO:protein amino acid phosphorylation"|PF00069|IPR017442| RP:SCP:NREP 2 RP:SCP:REP 192->450|1nw1A|5e-49|8.2|257/365|d.144.1.8| RP:SCP:REP 431->460|1xqzA|1e-04|23.3|30/277|d.144.1.7| HM:SCP:REP 186->462|1howA_|4.6e-81|36.4|269/362|d.144.1.7|1/1|Protein kinase-like (PK-like)| OP:NHOMO 44037 OP:NHOMOORG 712 OP:PATTERN -------1-----1-1--111-1----4---------------31-14-------1-6---1--1--- 4P*4X34333334457899-9933IB9999998CADD6SH3jPo33435545657434227763MDHOMNI555555522248-1-----2--1--2-----------1-222222222222222--------2--888HI---O2VCE87774533------334ARRRD------------4464411212111111111111111111221111111211-122223212111111-1111111111111111111111111111111-11111111111111111111111111111111111111111111111111121122111111121111111111113111141111112111211111---S-f1---------3311---1----------------11-1-1-1-2-----1-1--1---11-2---11-11--1111111111----3--------------------------------11-------1211111-1111--121111-22-22211-1--25642232333222623221-----------4A51A553-----1111----2----1FFFD**-3-----------------------1-----1-172-2-1-1---12----2--11-12------2---------------1-----2--1--------11-------1-------------------1-1---------------------------4---------11A-2-----------------------1114323321224111111------------1--2-----11111----2---------113---1111---------------1-111-111---11-111--------------44 aWck***6*******y**qv********zt*U***z**z*w***vyy*******t*************Yz*******q**********-********ry***v***L*************************p******************************************f*************v********* --------------------------------------------------------------------------------------------------------------------------------------------1-------------1---------------73-1- STR:NPRED 346 STR:RPRED 74.1 SQ:SECSTR ################################cccccccccccccccccccccccccTTccccccccccGGGGcccTcccccccc#########################################################################################cccHHHHHHHTTcccccccGGGcccEEEEEccTTccEEEEEEGGGTEEEEEEEccHHHHHHcccHHHHHHHHTTcccTTcccEEEEEccccccEEEEEccTTccHHHHHHHTTccHHHHHHHHHHHHHHHHHHHHTTEEcccccGGGEEEcGGGcEEEccTTcEEccTTccEccTTccccGGGccHHHHHHcEEcHHHHHHHHHHHHHHHHTTcccccTTccGGGHHHHHHTTccccccHTTccHHHHHHHHHHTcccGGGcccHHHHHHHHTTTccccccccccccTHHHHT DISOP:02AL 1-3,17-40,57-190,234-235,465-468| PSIPRED cccccEEEEEEHHHHccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHccccccHHHHHHHHEEEEEcccEEEEEEEEcccccEEEEEEEEccccHHHHHHHHHHHHHHHccccccccEEEEEEEccEEEEEEEccccccHHHHHHHccccHHHHHHHHHHHHHHHHHHHHcccccccccHHHEEEcccccEEEEcccEEHHHccccccccccccccccccHHHHHccccccHHHHHHHHHHHHHHHccccccccccHHHHHHHHHcccccccccHHHHcHHHHHHHHHHccccHHHcccHHHHHccHHHHHcccHHHHHHHHHHHHcc //