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Homo sapiens (cDNA) (huge0)
Gene : KIAA1225
DDBJ      :             KIAA1225
Swiss-Prot:LAP2_HUMAN   RecName: Full=Protein LAP2;AltName: Full=Erbb2-interacting protein;         Short=Erbin;AltName: Full=Densin-180-like protein;

Homologs  Archaea  2/68 : Bacteria  133/915 : Eukaryota  189/199 : Viruses  0/175   --->[See Alignment]
b.36.1c.10.1c.10.2
:1371 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   96->252 2o6rA PDBj 8e-14 34.2 %
:BLT:PDB   279->401 2o6rA PDBj 8e-11 30.7 %
:BLT:PDB   1273->1371 2h3lA PDBj 3e-44 100.0 %
:RPS:PDB   25->409 3cigA PDBj 2e-33 19.6 %
:RPS:PDB   1280->1367 2awwA PDBj 5e-14 29.1 %
:RPS:SCOP  22->401 1o6sA2  c.10.2.1 * 6e-37 25.9 %
:RPS:SCOP  1310->1367 1i16A  b.36.1.2 * 7e-12 22.4 %
:HMM:SCOP  25->425 1o6vA2 c.10.2.1 * 1.2e-82 35.9 %
:HMM:SCOP  247->1049 1a4yA_ c.10.1.1 * 1.2e-19 31.2 %
:HMM:SCOP  1269->1368 1n7tA_ b.36.1.1 * 4.8e-20 34.0 %
:RPS:PFM   1310->1366 PF00595 * PDZ 2e-05 40.4 %
:HMM:PFM   93->114 PF00560 * LRR_1 6.7e-05 40.9 22/22  
:HMM:PFM   369->390 PF00560 * LRR_1 6.3e-05 40.9 22/22  
:HMM:PFM   1287->1365 PF00595 * PDZ 3.1e-16 44.4 72/81  
:BLT:SWISS 1->1371 LAP2_HUMAN 0.0 100.0 %
:REPEAT 5|48->93|94->139|163->208|278->323|347->392
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA1225 GT:ORG huge0 GT:GENE KIAA1225 GT:PRODUCT KIAA1225 GT:DATABASE huge2038 LENGTH 1371 SQ:AASEQ MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKFKAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVKITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS SW:ID LAP2_HUMAN SW:DE RecName: Full=Protein LAP2;AltName: Full=Erbb2-interacting protein; Short=Erbin;AltName: Full=Densin-180-like protein; SW:GN Name=ERBB2IP; Synonyms=ERBIN, KIAA1225, LAP2; SW:KW 3D-structure; Alternative splicing; Cell junction; Complete proteome;Leucine-rich repeat; Phosphoprotein; Polymorphism; Repeat. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->1371|LAP2_HUMAN|0.0|100.0|1371/1412| GO:SWS:NREP 1 GO:SWS GO:0030054|"GO:cell junction"|Cell junction| NREPEAT 1 REPEAT 5|48->93|94->139|163->208|278->323|347->392| SEG 254->268|nlqdlllssnslqql| SEG 533->546|vktsestttvkskv| SEG 596->606|eeseelssdee| SEG 650->662|nsnqnnsncssps| SEG 930->934|sssss| SEG 1292->1303|gfsisggvggrg| BL:PDB:NREP 3 BL:PDB:REP 96->252|2o6rA|8e-14|34.2|149/177| BL:PDB:REP 279->401|2o6rA|8e-11|30.7|121/177| BL:PDB:REP 1273->1371|2h3lA|3e-44|100.0|99/103| RP:PDB:NREP 2 RP:PDB:REP 25->409|3cigA|2e-33|19.6|368/663| RP:PDB:REP 1280->1367|2awwA|5e-14|29.1|86/91| RP:PFM:NREP 1 RP:PFM:REP 1310->1366|PF00595|2e-05|40.4|57/82|PDZ| HM:PFM:NREP 3 HM:PFM:REP 93->114|PF00560|6.7e-05|40.9|22/22|LRR_1| HM:PFM:REP 369->390|PF00560|6.3e-05|40.9|22/22|LRR_1| HM:PFM:REP 1287->1365|PF00595|3.1e-16|44.4|72/81|PDZ| GO:PFM:NREP 1 GO:PFM GO:0005515|"GO:protein binding"|PF00595|IPR001478| RP:SCP:NREP 2 RP:SCP:REP 22->401|1o6sA2|6e-37|25.9|340/381|c.10.2.1| RP:SCP:REP 1310->1367|1i16A|7e-12|22.4|58/130|b.36.1.2| HM:SCP:REP 25->425|1o6vA2|1.2e-82|35.9|384/0|c.10.2.1|1/1|L domain-like| HM:SCP:REP 247->1049|1a4yA_|1.2e-19|31.2|170/0|c.10.1.1|2/2|RNI-like| HM:SCP:REP 1269->1368|1n7tA_|4.8e-20|34.0|100/103|b.36.1.1|1/1|PDZ domain-like| OP:NHOMO 5267 OP:NHOMOORG 324 OP:PATTERN --------------------------------------------------13---------------- ----1------------------------------------------------------------------------------------------13---11--1421----------------1---------1---------4-512211-11------------1131--------------------------------------------------1------------------------------------------------------------11-1--------------1111111111111-----------------------------2----1-------------11-----------------------------------------------11111-1----------------------------------------------------------------------------------------1----1-----1-1--------11--------21-2------1------1---------------1-1------------------------------------------1--------------11----1-111-11111111111-1111-1--1--------------------------------------------------------1---1---1-----1--------------1-----1------1--1------4-1-----------------------3---11-11111----11111----------1111-----111----22122111------12--34IG--------1---------------------------------------- 1---GMA-11--57923214453332433343433234344343333333323331623344212311-22-2332212212223132-23231211111112CAA4b88*irtswhXQPMZlT**S*J***B*m*QWUSwPe*fOXRUOxRLpSsjktOXJOsaLJjUc*IPPG-A89*35246****1**5FAEACJ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 597 STR:RPRED 43.5 SQ:SECSTR #######ccEEcTTTcTTccccccTccccccccccccccccccTcEccccEEcTTccccccTTTTcTTTTccEEEcccccccccTHHHHHcTTccEEEcTTccccccTTcTTccccccEEEcTTcccccccccTTTcTTccEEEccccccccccccccccTTccEEEcccccccEEccGGGGGGTTcEEcEEEcccccccEEcTTTTccEEcEEEcTTccccHHHHHHHHHHHHHHHccccccEEETTccTTcccEcccccccEEcTTTTGGGTTccccEEEcccccccEETTTTTTcTTccEEEcccccccEETTTTTTcTTccEEEcTTccccccccccccEEcTTTTTTcccccEEEccccccccccTTccTTcTTccEEEcTTccccccEEcTTTTGGGTTccccTTTTTGGGGccccEEEcccccccEEcTTTTTTcTTccEEEc###############################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################HHHHHHHHHHHHHHHccccEEEEEETTEEcccHHHHHHHHTTcTTcEEEEEEEETTEEEEEEcEcEEEEccTTcccccEEEEEcTTccccTTcccEEEEEEcTTcHHHHcccTTcEEEEETTEEcccccHHHHHHHHHccccEEEEEEEccccc DISOP:02AL 471-471,513-575,596-606,650-673,719-724,726-727,821-871,892-915,925-944,957-970,1001-1033,1069-1094,1119-1121,1123-1123,1135-1161,1169-1170,1172-1194,1210-1248,1265-1277,1370-1372| PSIPRED cccccccccccccHHHHHcccccccEEEccccccccccHHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEcccccccccccHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHcccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEcccccccccccHHHcccccccEEEccccccccccccHHHHHcccccccccccccHHHHHHHHHHHccccccccccccHHccccccccccccHHHHHccccHHHHHHHcccccccccccccccccHHHEEccccccccccccccccccccccccccccccEEccccccccccccccccccccccccccccEEEcccccccHHHHcccHHHHHHHHccccccccccccccEEEEccccccccHHHHHHHHHHHcccccccccccccHHccccEEEEccccccccccccHHHcccccccHHHHHHHHHHHHHHccccccccHHHHHHHHcccccccccccccHHHHHHHHccccccccccccccccHHHccccHHHcccccccccccccccccEEEEccccccccccccccccccccccccccccccccccccccccccccccccccccEEEEEEEcccHHccHHHccccccEEEEEEcccEEcccEEEEEEcccccccccccccccccccccccEEHHccccccccccccEEccccccHHHHHcccccEEEcccccccccEEEccccccccccccccccccEEEEccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHccccccccccccccccccccccccccccccccEEEEEEEEcccccccccccccccccccHHHHHHccccccccccccccccccEEEEEcccccccccccccHHHHHHHHcccccccccccccccccccccccccccccccccccccccHHHHHcccccHHHHHHccccccccccccccccccHHHcccccccccccccHHHHHHHHHcccccccccccccccccccccEEEEEEEEEEccccccEEEEccccccccccccccccEEEEEEEccccHHHHccccccEEEEEccEEEEcccHHHHHHHHHHcccEEEEEEEEEccc 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