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Homo sapiens (cDNA) (huge0)
Gene : KIAA1406
DDBJ      :             KIAA1406
Swiss-Prot:ANC2_HUMAN   RecName: Full=Anaphase-promoting complex subunit 2;         Short=APC2;AltName: Full=Cyclosome subunit 2;

Homologs  Archaea  0/68 : Bacteria  0/915 : Eukaryota  181/199 : Viruses  0/175   --->[See Alignment]
a.4.5e.40.1
:571 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   261->445 2hyeC PDBj 7e-12 26.2 %
:BLT:PDB   506->566 1lddA PDBj 4e-05 36.1 %
:RPS:PDB   259->557 3dqvC PDBj 3e-39 21.5 %
:RPS:SCOP  255->460 2hyeC3  e.40.1.1 * 3e-52 25.5 %
:RPS:SCOP  495->566 1lddA  a.4.5.34 * 2e-26 31.9 %
:HMM:SCOP  260->445 1ldjA3 e.40.1.1 * 2.2e-29 28.4 %
:HMM:SCOP  495->567 1lddA_ a.4.5.34 * 3.7e-23 49.3 %
:RPS:PFM   261->460 PF00888 * Cullin 8e-17 30.8 %
:RPS:PFM   506->566 PF08672 * APC2 3e-09 47.5 %
:HMM:PFM   71->100 PF00888 * Cullin 0.00086 26.7 30/589  
:HMM:PFM   115->483 PF00888 * Cullin 2.4e-84 31.5 324/589  
:HMM:PFM   506->566 PF08672 * APC2 1.8e-24 41.7 60/60  
:BLT:SWISS 1->571 ANC2_HUMAN 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA1406 GT:ORG huge0 GT:GENE KIAA1406 GT:PRODUCT KIAA1406 GT:DATABASE huge2038 LENGTH 571 SQ:AASEQ LLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWLGKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIEDLKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMFVVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNCS SW:ID ANC2_HUMAN SW:DE RecName: Full=Anaphase-promoting complex subunit 2; Short=APC2;AltName: Full=Cyclosome subunit 2; SW:GN Name=ANAPC2; Synonyms=APC2, KIAA1406; SW:KW Alternative splicing; Cell cycle; Cell division; Complete proteome;Mitosis; Phosphoprotein; Ubl conjugation pathway. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->571|ANC2_HUMAN|0.0|100.0|571/822| GO:SWS:NREP 3 GO:SWS GO:0007049|"GO:cell cycle"|Cell cycle| GO:SWS GO:0051301|"GO:cell division"|Cell division| GO:SWS GO:0007067|"GO:mitosis"|Mitosis| SEG 190->201|gltgdsdgtgdl| SEG 240->254|kssskrrssdiisll| BL:PDB:NREP 2 BL:PDB:REP 261->445|2hyeC|7e-12|26.2|183/719| BL:PDB:REP 506->566|1lddA|4e-05|36.1|61/74| RP:PDB:NREP 1 RP:PDB:REP 259->557|3dqvC|3e-39|21.5|274/363| RP:PFM:NREP 2 RP:PFM:REP 261->460|PF00888|8e-17|30.8|198/578|Cullin| RP:PFM:REP 506->566|PF08672|3e-09|47.5|59/60|APC2| HM:PFM:NREP 3 HM:PFM:REP 71->100|PF00888|0.00086|26.7|30/589|Cullin| HM:PFM:REP 115->483|PF00888|2.4e-84|31.5|324/589|Cullin| HM:PFM:REP 506->566|PF08672|1.8e-24|41.7|60/60|APC2| GO:PFM:NREP 3 GO:PFM GO:0006511|"GO:ubiquitin-dependent protein catabolic process"|PF00888|IPR001373| GO:PFM GO:0031461|"GO:cullin-RING ubiquitin ligase complex"|PF00888|IPR001373| GO:PFM GO:0031625|"GO:ubiquitin protein ligase binding"|PF00888|IPR001373| RP:SCP:NREP 2 RP:SCP:REP 255->460|2hyeC3|3e-52|25.5|204/273|e.40.1.1| RP:SCP:REP 495->566|1lddA|2e-26|31.9|72/74|a.4.5.34| HM:SCP:REP 260->445|1ldjA3|2.2e-29|28.4|183/0|e.40.1.1|1/1|Cullin homology domain| HM:SCP:REP 495->567|1lddA_|3.7e-23|49.3|73/0|a.4.5.34|1/1|"Winged helix" DNA-binding domain| OP:NHOMO 455 OP:NHOMOORG 181 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----222-211-11211112331222222221222222222222222222222222121222121--1-1-1112222112-111123-24112332212211122-2442223324111-13255131Ac52426111-21211-222231-21222212111221121483212-32Y3232264671333424232 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 305 STR:RPRED 53.4 SQ:SECSTR ##################################################################################################################################################################################################################################################################ccTHHHHHHHHHHHHHHHHTTccccHHHHHHHHHHHHHTTcHHHHHHHHHHHHHHHHHHHHHHHHHHcccccGGGcccTcccccccccTTTccccccccccccHHHHHHHHHHHHHHHTTcTTccccccTGTcEEEEEccccccEEEEEEEHHHHHHHHTcTTcTTEEHHHHHHHHcccHHHHHHHHHHHcccccEEEccccccccccccccccEEEEEccccccTHHHHHHHHHHHHHHHHHH###HHHHHHHHHHccEEcHHHHHHHHHHHGGGccTTccHHHTTTccccHHHHHHHEccTTEEEE##### DISOP:02AL 2-2,198-198,202-223,237-245,326-336,479-498,571-572| PSIPRED cHHHHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHccccccccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHccccHHHHHHHHHHHccccccccHHHHHHcccHHHHccccccccccccHHHHcccccccccccccHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHccccccccccEEEEEEccccccccccccEEccHHHHHHHHHHHHHHHHcccccEEEEEEccEEEEEEEEEccEEEEEEEcHHHHHHHHHHcccccEEHHHHHHHHcccHHHHHHHHHHHHcccEEEEccccEEEEEccccccccEEEEcccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHcccccccccccHHHHHHHHHHHHHcccEEEEccEEEEccccc //