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Homo sapiens (cDNA) (huge0)
Gene : KIAA1437
DDBJ      :             KIAA1437
Swiss-Prot:LRC8A_HUMAN  RecName: Full=Leucine-rich repeat-containing protein 8A;

Homologs  Archaea  2/68 : Bacteria  136/915 : Eukaryota  187/199 : Viruses  0/175   --->[See Alignment]
c.10.2
:811 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   585->674 1u0nD PDBj 5e-04 32.2 %
:BLT:PDB   645->771 2o6qA PDBj 1e-13 38.6 %
:RPS:PDB   569->782 1dceA PDBj 3e-20 20.1 %
:RPS:SCOP  402->527 1fo1A1  c.10.2.3 * 6e-04 11.0 %
:RPS:SCOP  569->765 1o6sA2  c.10.2.1 * 1e-23 33.0 %
:HMM:SCOP  412->782 1o6vA2 c.10.2.1 * 8.9e-56 33.9 %
:RPS:PFM   2->58 PF12534 * DUF3733 5e-26 78.9 %
:HMM:PFM   2->64 PF12534 * DUF3733 5.3e-32 52.4 63/65  
:HMM:PFM   99->157 PF12534 * DUF3733 2.9e-22 37.9 58/65  
:HMM:PFM   664->683 PF00560 * LRR_1 0.00056 36.8 19/22  
:HMM:PFM   687->705 PF00560 * LRR_1 7.5e-06 57.9 19/22  
:BLT:SWISS 2->811 LRC8A_HUMAN 0.0 100.0 %
:TM
:REPEAT 4|587->622|649->693|695->739|741->785
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA1437 GT:ORG huge0 GT:GENE KIAA1437 GT:PRODUCT KIAA1437 GT:DATABASE huge2038 LENGTH 811 SQ:AASEQ TMIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWVTKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKERLWRADKEQA SW:ID LRC8A_HUMAN SW:DE RecName: Full=Leucine-rich repeat-containing protein 8A; SW:GN Name=LRRC8A; Synonyms=KIAA1437, LRRC8; ORFNames=UNQ221/PRO247; SW:KW Chromosomal rearrangement; Complete proteome; Glycoprotein;Leucine-rich repeat; Membrane; Phosphoprotein; Repeat; Transmembrane. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 2->811|LRC8A_HUMAN|0.0|100.0|810/810| GO:SWS:NREP 2 GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| TM:NTM 3 TM:REGION 26->48| TM:REGION 266->288| TM:REGION 319->341| NREPEAT 1 REPEAT 4|587->622|649->693|695->739|741->785| SEG 270->280|iikvikfilii| SEG 446->456|lvelevlklel| SEG 541->559|lrelkrlkvlrlksnlskl| BL:PDB:NREP 2 BL:PDB:REP 585->674|1u0nD|5e-04|32.2|87/265| BL:PDB:REP 645->771|2o6qA|1e-13|38.6|127/270| RP:PDB:NREP 1 RP:PDB:REP 569->782|1dceA|3e-20|20.1|209/566| RP:PFM:NREP 1 RP:PFM:REP 2->58|PF12534|5e-26|78.9|57/65|DUF3733| HM:PFM:NREP 4 HM:PFM:REP 2->64|PF12534|5.3e-32|52.4|63/65|DUF3733| HM:PFM:REP 99->157|PF12534|2.9e-22|37.9|58/65|DUF3733| HM:PFM:REP 664->683|PF00560|0.00056|36.8|19/22|LRR_1| HM:PFM:REP 687->705|PF00560|7.5e-06|57.9|19/22|LRR_1| RP:SCP:NREP 2 RP:SCP:REP 402->527|1fo1A1|6e-04|11.0|126/160|c.10.2.3| RP:SCP:REP 569->765|1o6sA2|1e-23|33.0|185/381|c.10.2.1| HM:SCP:REP 412->782|1o6vA2|8.9e-56|33.9|345/0|c.10.2.1|1/1|L domain-like| OP:NHOMO 4762 OP:NHOMOORG 325 OP:PATTERN --------------------------------------------------13---------------- ----1-------------------------------------------------------------------------------------------3---12---221----------------1-------------------1-412211-11------------1131-----------------------11111-----------------1----1------1-----------------------------------------------------1-----------------1111111111111-----------------------------2---11--------------------------------------------------------------11111-1----------------------------------------------------------------------------------------111111-----111-------111--------11-1------1------1---------------1-1------------------------------------------1--------------111---1-111-11111111111-1111-1--1--------------------------------------------------------------------------------------------------1--1------4-1-----------------------3---11111112--1-11111----------1111-----111----11111111------12--34HG------------------------------------------------- 1---JKB-----35A23124333433422232333334344342233422223221412555323311-12112222-2322222311-33231311111112CA85LB8*jutr*YRNOMZiQ**N*K**w9*r*RXRSsPdzcObSVOnSMlJrflqLSKMiZLDeTS*FIUI-B79*34245x*r*1**2EBEABE ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 343 STR:RPRED 42.3 SQ:SECSTR #############################################################################################################################################################################################################################################################################################################################################################################################################################################################################cTHHHHHcTTccEEEcTTcccccccTTcTTccccccEEEcTTccccccccTTTTcTTccEEEcccccccccccccccccTTccEEEcccccccEEccGGGGGGTTcHTEEEEEEEETTccEEEEEcccTTTTcccccccHHHHHHHHHHHHHHHHHHHHcTTcHHHHHHcTTTHHHHHHHHcTGGGHHHHHHHHHHHHHcGGGHHHHHHHHHHHHHHHHHHHHHHTTccEEccccccccccGGGGGcTTccEEEcccccccccGGcGTTcccccEEEcccccccccTGGGGGcTTccEEEcTTcGGGGccccTHHHHHcTTHHHTTccTTTTTcEEEEEcTTT####### DISOP:02AL 73-73,75-88,178-230,809-812| PSIPRED ccccHHHHHHHHHHccccccccHHHHHHHHHHHHHHHHHHHHccccEEcccEEEEEEcccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHcccHHcccccHHHHHHHHHHHHHHHccccHHHHHHHHHHcccccccHHHccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHEEEEcccEEEEEEEHHHHHHHHHHHHHHHEcccEEEEEEEEEEEcccHHHHccccEEEEcccHHHHHHHHHHHHHHHcccccccccHHHHHHHHccccccccccEEcccccccccHHHHHHHHHHHHHHcccccccccccccHHHcccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHHccccccEEEcccccHHHccHHHHccccccEEEcccccccccccccccHHHcccccccEEEcccccccccHHHHcccccccEEEcccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEcccccccccccccHHcccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEEEccccccccccHHHHHHHHHHHHHcc //