Homo sapiens (cDNA) (huge0)
Gene : KIAA1437
DDBJ : KIAA1437
Swiss-Prot:LRC8A_HUMAN RecName: Full=Leucine-rich repeat-containing protein 8A;
Homologs Archaea 2/68 : Bacteria 136/915 : Eukaryota 187/199 : Viruses 0/175 --->[See Alignment]
c.10.2
:811 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB 585->674 1u0nD PDBj 5e-04 32.2 %
:BLT:PDB 645->771 2o6qA PDBj 1e-13 38.6 %
:RPS:PDB 569->782 1dceA PDBj 3e-20 20.1 %
:RPS:SCOP 402->527 1fo1A1 c.10.2.3 * 6e-04 11.0 %
:RPS:SCOP 569->765 1o6sA2 c.10.2.1 * 1e-23 33.0 %
:HMM:SCOP 412->782 1o6vA2 c.10.2.1 * 8.9e-56 33.9 %
:RPS:PFM 2->58 PF12534 * DUF3733 5e-26 78.9 %
:HMM:PFM 2->64 PF12534 * DUF3733 5.3e-32 52.4 63/65
:HMM:PFM 99->157 PF12534 * DUF3733 2.9e-22 37.9 58/65
:HMM:PFM 664->683 PF00560 * LRR_1 0.00056 36.8 19/22
:HMM:PFM 687->705 PF00560 * LRR_1 7.5e-06 57.9 19/22
:BLT:SWISS 2->811 LRC8A_HUMAN 0.0 100.0 %
:TM
:REPEAT 4|587->622|649->693|695->739|741->785
:SEG
SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA1437
GT:ORG huge0
GT:GENE KIAA1437
GT:PRODUCT KIAA1437
GT:DATABASE huge2038
LENGTH 811
SQ:AASEQ TMIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWVTKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKERLWRADKEQA
SW:ID LRC8A_HUMAN
SW:DE RecName: Full=Leucine-rich repeat-containing protein 8A;
SW:GN Name=LRRC8A; Synonyms=KIAA1437, LRRC8; ORFNames=UNQ221/PRO247;
SW:KW Chromosomal rearrangement; Complete proteome; Glycoprotein;Leucine-rich repeat; Membrane; Phosphoprotein; Repeat; Transmembrane.
SW:EXACT F
SW:FUNC +
BL:SWS:NREP 1
BL:SWS:REP 2->811|LRC8A_HUMAN|0.0|100.0|810/810|
GO:SWS:NREP 2
GO:SWS GO:0016020|"GO:membrane"|Membrane|
GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane|
TM:NTM 3
TM:REGION 26->48|
TM:REGION 266->288|
TM:REGION 319->341|
NREPEAT 1
REPEAT 4|587->622|649->693|695->739|741->785|
SEG 270->280|iikvikfilii|
SEG 446->456|lvelevlklel|
SEG 541->559|lrelkrlkvlrlksnlskl|
BL:PDB:NREP 2
BL:PDB:REP 585->674|1u0nD|5e-04|32.2|87/265|
BL:PDB:REP 645->771|2o6qA|1e-13|38.6|127/270|
RP:PDB:NREP 1
RP:PDB:REP 569->782|1dceA|3e-20|20.1|209/566|
RP:PFM:NREP 1
RP:PFM:REP 2->58|PF12534|5e-26|78.9|57/65|DUF3733|
HM:PFM:NREP 4
HM:PFM:REP 2->64|PF12534|5.3e-32|52.4|63/65|DUF3733|
HM:PFM:REP 99->157|PF12534|2.9e-22|37.9|58/65|DUF3733|
HM:PFM:REP 664->683|PF00560|0.00056|36.8|19/22|LRR_1|
HM:PFM:REP 687->705|PF00560|7.5e-06|57.9|19/22|LRR_1|
RP:SCP:NREP 2
RP:SCP:REP 402->527|1fo1A1|6e-04|11.0|126/160|c.10.2.3|
RP:SCP:REP 569->765|1o6sA2|1e-23|33.0|185/381|c.10.2.1|
HM:SCP:REP 412->782|1o6vA2|8.9e-56|33.9|345/0|c.10.2.1|1/1|L domain-like|
OP:NHOMO 4762
OP:NHOMOORG 325
OP:PATTERN --------------------------------------------------13---------------- ----1-------------------------------------------------------------------------------------------3---12---221----------------1-------------------1-412211-11------------1131-----------------------11111-----------------1----1------1-----------------------------------------------------1-----------------1111111111111-----------------------------2---11--------------------------------------------------------------11111-1----------------------------------------------------------------------------------------111111-----111-------111--------11-1------1------1---------------1-1------------------------------------------1--------------111---1-111-11111111111-1111-1--1--------------------------------------------------------------------------------------------------1--1------4-1-----------------------3---11111112--1-11111----------1111-----111----11111111------12--34HG------------------------------------------------- 1---JKB-----35A23124333433422232333334344342233422223221412555323311-12112222-2322222311-33231311111112CA85LB8*jutr*YRNOMZiQ**N*K**w9*r*RXRSsPdzcObSVOnSMlJrflqLSKMiZLDeTS*FIUI-B79*34245x*r*1**2EBEABE -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
STR:NPRED 343
STR:RPRED 42.3
SQ:SECSTR #############################################################################################################################################################################################################################################################################################################################################################################################################################################################################cTHHHHHcTTccEEEcTTcccccccTTcTTccccccEEEcTTccccccccTTTTcTTccEEEcccccccccccccccccTTccEEEcccccccEEccGGGGGGTTcHTEEEEEEEETTccEEEEEcccTTTTcccccccHHHHHHHHHHHHHHHHHHHHcTTcHHHHHHcTTTHHHHHHHHcTGGGHHHHHHHHHHHHHcGGGHHHHHHHHHHHHHHHHHHHHHHTTccEEccccccccccGGGGGcTTccEEEcccccccccGGcGTTcccccEEEcccccccccTGGGGGcTTccEEEcTTcGGGGccccTHHHHHcTTHHHTTccTTTTTcEEEEEcTTT#######
DISOP:02AL 73-73,75-88,178-230,809-812|
PSIPRED ccccHHHHHHHHHHccccccccHHHHHHHHHHHHHHHHHHHHccccEEcccEEEEEEcccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHcccHHcccccHHHHHHHHHHHHHHHccccHHHHHHHHHHcccccccHHHccccccccccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHEEEEcccEEEEEEEHHHHHHHHHHHHHHHEcccEEEEEEEEEEEcccHHHHccccEEEEcccHHHHHHHHHHHHHHHcccccccccHHHHHHHHccccccccccEEcccccccccHHHHHHHHHHHHHHcccccccccccccHHHcccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHHccccccEEEcccccHHHccHHHHccccccEEEcccccccccccccccHHHcccccccEEEcccccccccHHHHcccccccEEEcccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEcccccccccccccHHcccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEccccccccccHHHHccccccEEEEEccccccccccHHHHHHHHHHHHHcc
//
[GTOP]
