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Homo sapiens (cDNA) (huge0)
Gene : KIAA1465
DDBJ      :             KIAA1465
Swiss-Prot:ISLR2_HUMAN  RecName: Full=Immunoglobulin superfamily containing leucine-rich repeat protein 2;Flags: Precursor;

Homologs  Archaea  0/68 : Bacteria  1/915 : Eukaryota  67/199 : Viruses  0/175   --->[See Alignment]
b.1.1b.1.6c.10.2
:785 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   59->262 2v70A PDBj 2e-23 29.9 %
:BLT:PDB   371->417 2dm3A PDBj 5e-05 44.7 %
:RPS:PDB   113->266 3ciyA PDBj 5e-24 20.8 %
:RPS:PDB   271->412 3dhmA PDBj 3e-05 13.7 %
:RPS:PDB   377->423 2cr3A PDBj 1e-06 21.3 %
:RPS:PDB   582->637 2cuhA PDBj 4e-04 19.6 %
:RPS:SCOP  59->270 1gwbA  c.10.2.7 * 3e-22 24.0 %
:RPS:SCOP  271->412 1u2cA1  b.1.6.2 * 4e-05 11.2 %
:RPS:SCOP  378->420 1g0yR2  b.1.1.4 * 2e-06 20.9 %
:HMM:SCOP  61->282 1m0zA_ c.10.2.7 * 4.4e-47 32.3 %
:HMM:SCOP  279->422 1he7A_ b.1.1.4 * 1.4e-11 27.1 %
:RPS:PFM   225->272 PF02957 * TT_ORF2 4e-04 47.7 %
:HMM:PFM   140->162 PF00560 * LRR_1 6e-05 54.5 22/22  
:HMM:PFM   379->412 PF07679 * I-set 3.6e-05 26.5 34/90  
:HMM:PFM   250->270 PF01463 * LRRCT 6.1e-05 45.0 20/25  
:HMM:PFM   573->609 PF00041 * fn3 0.00018 27.0 37/85  
:BLT:SWISS 41->785 ISLR2_HUMAN 0.0 100.0 %
:TM
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA1465 GT:ORG huge0 GT:GENE KIAA1465 GT:PRODUCT KIAA1465 GT:DATABASE huge2038 LENGTH 785 SQ:AASEQ GHNTCVYLAWAIFPALPRRVWRRGFSPRTFTESRRILGAAMFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFLLVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPAGGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYSDRLPLGAEAVNIAQEINGNYRQTAG SW:ID ISLR2_HUMAN SW:DE RecName: Full=Immunoglobulin superfamily containing leucine-rich repeat protein 2;Flags: Precursor; SW:GN Name=ISLR2; Synonyms=KIAA1465; ORFNames=UNQ1885/PRO4329; SW:KW Complete proteome; Disulfide bond; Glycoprotein;Immunoglobulin domain; Leucine-rich repeat; Membrane; Polymorphism;Repeat; Signal; Transmembrane. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 41->785|ISLR2_HUMAN|0.0|100.0|745/745| GO:SWS:NREP 2 GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| TM:NTM 3 TM:REGION 1->17| TM:REGION 36->58| TM:REGION 633->655| SEG 46->58|alwlvwallgvag| SEG 189->202|lrslrinnnrlrtl| SEG 330->347|geddgvgaeegegegdgd| SEG 350->370|tqtqaqtptpapawpappatp| SEG 470->486|etetepeedtsegeeae| SEG 544->575|plaarwgpgpggaggaprpgrrplrllylcpa| SEG 699->710|paggeaggeepe| BL:PDB:NREP 2 BL:PDB:REP 59->262|2v70A|2e-23|29.9|197/210| BL:PDB:REP 371->417|2dm3A|5e-05|44.7|47/110| RP:PDB:NREP 4 RP:PDB:REP 113->266|3ciyA|5e-24|20.8|154/661| RP:PDB:REP 271->412|3dhmA|3e-05|13.7|95/100| RP:PDB:REP 377->423|2cr3A|1e-06|21.3|47/99| RP:PDB:REP 582->637|2cuhA|4e-04|19.6|56/115| RP:PFM:NREP 1 RP:PFM:REP 225->272|PF02957|4e-04|47.7|44/121|TT_ORF2| HM:PFM:NREP 4 HM:PFM:REP 140->162|PF00560|6e-05|54.5|22/22|LRR_1| HM:PFM:REP 379->412|PF07679|3.6e-05|26.5|34/90|I-set| HM:PFM:REP 250->270|PF01463|6.1e-05|45.0|20/25|LRRCT| HM:PFM:REP 573->609|PF00041|0.00018|27.0|37/85|fn3| RP:SCP:NREP 3 RP:SCP:REP 59->270|1gwbA|3e-22|24.0|183/265|c.10.2.7| RP:SCP:REP 271->412|1u2cA1|4e-05|11.2|89/103|b.1.6.2| RP:SCP:REP 378->420|1g0yR2|2e-06|20.9|43/103|b.1.1.4| HM:SCP:REP 61->282|1m0zA_|4.4e-47|32.3|220/0|c.10.2.7|1/1|L domain-like| HM:SCP:REP 279->422|1he7A_|1.4e-11|27.1|107/107|b.1.1.4|1/1|Immunoglobulin| OP:NHOMO 2497 OP:NHOMOORG 68 OP:PATTERN -------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------1----------------------------------------------------------------------------------------------------i--******eLFGNQkLyqEtJ**pAum*GPJEsPZncDVJLDgLFsNnelg46C2N494OA7C7222------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 403 STR:RPRED 51.3 SQ:SECSTR ##########################################################EHHHHHHHcHHHHTTccccccccccccccccccccccccccTTccccccccccccEEEcccccccTTccccccccccTTcTTccEEEcccccccEEcTTTTTTcccccEEEcccccccEEcTTcccccccccEEEcTTcccccccHHHHHHHccccEEEcTTccEEccTTTHHHHHHHHHcccccTTTTTTcEEEcGGGTTccTTcccGTTccccEEEEEccccEEEEEccTTcTTccEEEcEEEEEcccEEEccEEEEccccTTcccccccccTTccTTEE########################ccEEEEEEEEEcccEEEETTccTTTcEEEEEEEEETTEEEEEEEEEccccccccccccccccccc########################################################################################################################################################EEEEEETTccEEEEcccccccEEEEEEETTEEcccEEEEEEcccccTTTccccccc#################################################################################################################################################### DISOP:02AL 1-1,357-371,417-481,492-493,495-499,696-715,739-757,780-786| PSIPRED cccEEEEcccccHHHHHHHHHHcccccccEEHHHHHHHHHHHHHHHHHHHHHHcccccccccccEEEcccccEEEEEccccccccccccccccEEEEcccccccEEcHHHHcccccccEEEcccccccEEcHHHHcccccccEEEccccccEEEcHHHccccccccEEEcccccEEEEcHHHHcccccccEEEccccccccccHHHHcccccccEEEcccccccccccHHHHHHHHHHccccccccccEEEcccHHHcccEEEEccccccccccccccccccccccccccccccEEEEEEEcccccccEEEEEEEccccEEEEccccccccccccccccccccccccEEEcccccccccccEEEccccccEEEEcccccEEEEEEEEHHcEEEEEEEEEccccEEEEEEEEEEEccccccccccccccccccccEEEEccccccccccccccccccccccccccEEEcccccccccccccccEEEccccccccccccccccccccEEEEcccccccHHHccEEEEEEEEEEcccccHHEEEEcccEEEcccccccccccccccccccEEEEEccccccccEEEEHHcccccEEEEccccccccEEEEEEccccccEEEEEEEEccccccccEEEEHHHHHHHccccccHHHHHHHHHHHcccccEEEEEccccccHHHHHHHcccccHHHHcccccccccccccccccHHHccccccccHHHcccccccccHHHHHHccccccccccccHHHHHcccccccccccccHHccHHHHcccccccccc //