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Homo sapiens (cDNA) (huge0)
Gene : KIAA1596
DDBJ      :             KIAA1596
Swiss-Prot:FANCM_HUMAN  RecName: Full=Fanconi anemia group M protein;         Short=Protein FACM;         EC=3.6.1.-;AltName: Full=ATP-dependent RNA helicase FANCM;AltName: Full=Fanconi anemia-associated polypeptide of 250 kDa;         Short=FAAP250;AltName: Full=Protein Hef ortholog;

Homologs  Archaea  24/68 : Bacteria  0/915 : Eukaryota  50/199 : Viruses  0/175   --->[See Alignment]
a.60.2c.52.1
:1151 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   945->1129 2bhnA PDBj 5e-12 29.4 %
:RPS:PDB   933->1133 2bhnC PDBj 3e-17 25.5 %
:RPS:SCOP  923->1058 1j22A  c.52.1.20 * 3e-35 27.1 %
:RPS:SCOP  1069->1130 1bvsA2  a.60.2.1 * 2e-06 12.9 %
:HMM:SCOP  921->1058 1j23A_ c.52.1.20 * 8.6e-26 33.6 %
:HMM:SCOP  1061->1131 1z00B1 a.60.2.5 * 2.6e-08 24.3 %
:BLT:SWISS 1->1151 FANCM_HUMAN 0.0 99.8 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA1596 GT:ORG huge0 GT:GENE KIAA1596 GT:PRODUCT KIAA1596 GT:DATABASE huge2038 LENGTH 1151 SQ:AASEQ KRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRRFPVNRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI SW:ID FANCM_HUMAN SW:DE RecName: Full=Fanconi anemia group M protein; Short=Protein FACM; EC=3.6.1.-;AltName: Full=ATP-dependent RNA helicase FANCM;AltName: Full=Fanconi anemia-associated polypeptide of 250 kDa; Short=FAAP250;AltName: Full=Protein Hef ortholog; SW:GN Name=FANCM; Synonyms=KIAA1596; SW:KW Alternative splicing; ATP-binding; Complete proteome; DNA damage;DNA repair; DNA-binding; Fanconi anemia; Helicase; Hydrolase;Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->1151|FANCM_HUMAN|0.0|99.8|1151/2048| GO:SWS:NREP 8 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0006974|"GO:response to DNA damage stimulus"|DNA damage| GO:SWS GO:0006281|"GO:DNA repair"|DNA repair| GO:SWS GO:0003677|"GO:DNA binding"|DNA-binding| GO:SWS GO:0004386|"GO:helicase activity"|Helicase| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0005634|"GO:nucleus"|Nucleus| SEG 97->110|lsysppplsglsdl| SEG 615->627|lddeaelseedae| SEG 630->647|ssdendeseneqdsslld| BL:PDB:NREP 1 BL:PDB:REP 945->1129|2bhnA|5e-12|29.4|180/211| RP:PDB:NREP 1 RP:PDB:REP 933->1133|2bhnC|3e-17|25.5|184/194| RP:SCP:NREP 2 RP:SCP:REP 923->1058|1j22A|3e-35|27.1|129/131|c.52.1.20| RP:SCP:REP 1069->1130|1bvsA2|2e-06|12.9|62/71|a.60.2.1| HM:SCP:REP 921->1058|1j23A_|8.6e-26|33.6|131/131|c.52.1.20|1/1|Restriction endonuclease-like| HM:SCP:REP 1061->1131|1z00B1|2.6e-08|24.3|70/0|a.60.2.5|1/1|RuvA domain 2-like| OP:NHOMO 108 OP:NHOMOORG 74 OP:PATTERN 11-1-11111111111-------1--------1-1--------------1111-1---11-------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------1-----------------------------------------------------------------------------------------------21111111111131121313H2121211111-14111111111312-11-----11--------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 234 STR:RPRED 20.3 SQ:SECSTR #################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################################ccccccccEEEEEGGGT#GccccHHHHTT#ccccEEEEccccccEEEETTEEEEEEEHHHHHHHHTTcHHHHHHHHHHTTccEEEEEEEcccccGGGGGGcccHHHHHHHHHHHHHHHccEEEEEccHHHHHHHHHHHHHTccHHHHHHHccccTTcHHHHHHHHHTTcTTccHHHHHHHHHHHccHHHHHTccHHHHHTcTTccHHHHHHHHHHHHccccccccHHHHTTHHHHH## DISOP:02AL 1-3,142-156,173-183,253-270,345-376,402-403,405-453,460-483,486-505,508-517,533-548,563-612,622-643,713-726,755-770,774-906,1060-1077,1148-1152| PSIPRED cccccccccccccccccccccccHHHHHHHHHHHHHHHHHHHcccccccccccccccccccEEEEEcccEEEEEHHHHHHHHHHHHHHHHHHHHHHHccccccccHHHHHHHHHHHcccccccccccccccccccccccHHHcccccHHHcccHHHcccccccccccccccccccccccccccEEccccccccccccccccEEEEEEcccccccccccccccccccccccccccccccHHHccccccccccHHHcccccccccccccccccccccccccccccccccccccccHHHHHccccccccccccccHHHHHHccccHHHHHHHHEEEEEcccccccccHHHHccccccccccccccccccHHHHccccccccccccccccccccccccccEEcccHHHcccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHccccccccccccccccccccEEEcccccccccccccccccccccEEEEccccccccccccccccccccccccccHHccccccccccHHccccccccccccccccHHcccccccccccccccccccHHHHHHHHHHHHHHHHcccHHHHHHcccccccccccccccHHHHccccHHHHHHcccccHHHHHHHHHccHHHccEEEEEEEccccccEEcccccHHHHHHHHccccccccccccccccEEEEEEccccccccccccHHHHHHHHHHHHHHHHHHHcccccccccEEEEcccccHHccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccHHHHHHHcccccccccccccccccccccccHHcccccccccccccccccccccccccccccccccccccccccccccEEEEEEEccEEcccccHHHHHHHccccEEEEEEcccccEEEcccEEEEEccHHHHHHcccccHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHHHHHHHHHHccccEEEEEEccHHHHHHHHHHHHHHcccccHHHHHHHHHHHHHHHHHHHccccccccHHHHHHHHHHcccHHHHHHccHHHHHHcccccHHHHHHHHHHHHcccccccccHHHHHHHHHccc //