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Homo sapiens (cDNA) (huge0)
Gene : KIAA2029
DDBJ      :             KIAA2029
Swiss-Prot:ATS16_HUMAN  RecName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 16;         Short=ADAMTS-16;         Short=ADAM-TS 16;         Short=ADAM-TS16;         EC=3.4.24.-;Flags: Precursor;

Homologs  Archaea  0/68 : Bacteria  1/915 : Eukaryota  73/199 : Viruses  0/175   --->[See Alignment]
a.29.7b.11.1d.92.1g.5.1g.60.1
:1021 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   96->372 2jihA PDBj 4e-44 36.6 %
:BLT:PDB   381->437 1lslA PDBj 4e-16 54.4 %
:BLT:PDB   676->783 1lslA PDBj 2e-08 32.0 %
:BLT:PDB   787->875 1lslA PDBj 2e-07 36.7 %
:BLT:PDB   855->950 1lslA PDBj 6e-08 33.3 %
:BLT:PDB   925->979 1lslA PDBj 1e-04 35.7 %
:RPS:PDB   96->518 3dslA PDBj 3e-41 26.6 %
:RPS:PDB   724->785 2bbxA PDBj 2e-05 22.6 %
:RPS:PDB   988->1020 2cq7A PDBj 1e-06 21.2 %
:RPS:SCOP  96->291 1r54A  d.92.1.9 * 6e-42 30.8 %
:RPS:SCOP  347->453 1hdfA  b.11.1.1 * 2e-14 8.6 %
:RPS:SCOP  724->753 1mknA  g.5.1.1 * 2e-04 15.2 %
:RPS:SCOP  738->875 1pi1A  a.29.7.1 * 6e-07 13.6 %
:RPS:SCOP  925->974 1lslA1  g.60.1.1 * 9e-07 32.0 %
:HMM:SCOP  83->291 1bkcA_ d.92.1.10 * 2.9e-55 38.5 %
:HMM:SCOP  379->437 1lslA2 g.60.1.1 * 2.3e-19 50.8 %
:HMM:SCOP  728->783 1lslA2 g.60.1.1 * 6.8e-11 43.1 %
:HMM:SCOP  784->844 1lslA2 g.60.1.1 * 2.5e-10 33.3 %
:HMM:SCOP  851->911 1lslA2 g.60.1.1 * 3.6e-07 32.7 %
:HMM:SCOP  917->977 1lslA2 g.60.1.1 * 5.1e-13 37.3 %
:RPS:PFM   96->288 PF01421 * Reprolysin 7e-36 49.7 %
:RPS:PFM   388->437 PF00090 * TSP_1 2e-10 57.1 %
:RPS:PFM   558->655 PF05986 * ADAM_spacer1 4e-25 48.0 %
:RPS:PFM   925->966 PF00090 * TSP_1 1e-04 47.8 %
:HMM:PFM   545->655 PF05986 * ADAM_spacer1 7.3e-40 39.6 111/114  
:HMM:PFM   89->292 PF01421 * Reprolysin 7.1e-34 32.6 190/199  
:HMM:PFM   387->437 PF00090 * TSP_1 2.1e-15 46.9 49/49  
:HMM:PFM   731->783 PF00090 * TSP_1 1.3e-06 34.8 46/49  
:HMM:PFM   790->828 PF00090 * TSP_1 1.2e-07 35.9 39/49  
:HMM:PFM   855->878 PF00090 * TSP_1 2.3e-08 45.8 24/49  
:HMM:PFM   930->972 PF00090 * TSP_1 1.2e-07 29.3 41/49  
:HMM:PFM   987->1018 PF08686 * PLAC 3.9e-14 43.8 32/34  
:BLT:SWISS 1->1021 ATS16_HUMAN 0.0 98.5 %
:PROS 421->428|PS00097|CARBAMOYLTRANSFERASE
:REPEAT 6|388->432|663->719|723->778|782->839|843->906|920->972
:SEG

SeqInfo AminoSeq See neighboring genes
Links HUGE Abbreviations Back to title page
GT:ID KIAA2029 GT:ORG huge0 GT:GENE KIAA2029 GT:PRODUCT KIAA2029 GT:DATABASE huge2038 LENGTH 1021 SQ:AASEQ LYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRYHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSKSNL SW:ID ATS16_HUMAN SW:DE RecName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 16; Short=ADAMTS-16; Short=ADAM-TS 16; Short=ADAM-TS16; EC=3.4.24.-;Flags: Precursor; SW:GN Name=ADAMTS16; Synonyms=KIAA2029; SW:KW Alternative splicing; Cleavage on pair of basic residues;Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein;Hydrolase; Metal-binding; Metalloprotease; Phosphoprotein;Polymorphism; Protease; Repeat; Secreted; Signal; Zinc; Zymogen. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->1021|ATS16_HUMAN|0.0|98.5|1021/1224| GO:SWS:NREP 6 GO:SWS GO:0005578|"GO:proteinaceous extracellular matrix"|Extracellular matrix| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0008237|"GO:metallopeptidase activity"|Metalloprotease| GO:SWS GO:0008233|"GO:peptidase activity"|Protease| GO:SWS GO:0005576|"GO:extracellular region"|Secreted| PROS 421->428|PS00097|CARBAMOYLTRANSFERASE|PDOC00091| NREPEAT 1 REPEAT 6|388->432|663->719|723->778|782->839|843->906|920->972| SEG 84->95|neelnvetlvvv| SEG 292->305|pkpvkeykypeklp| BL:PDB:NREP 6 BL:PDB:REP 96->372|2jihA|4e-44|36.6|265/284| BL:PDB:REP 381->437|1lslA|4e-16|54.4|57/113| BL:PDB:REP 676->783|1lslA|2e-08|32.0|88/113| BL:PDB:REP 787->875|1lslA|2e-07|36.7|78/113| BL:PDB:REP 855->950|1lslA|6e-08|33.3|78/113| BL:PDB:REP 925->979|1lslA|1e-04|35.7|55/113| RP:PDB:NREP 3 RP:PDB:REP 96->518|3dslA|3e-41|26.6|372/416| RP:PDB:REP 724->785|2bbxA|2e-05|22.6|48/49| RP:PDB:REP 988->1020|2cq7A|1e-06|21.2|33/49| RP:PFM:NREP 4 RP:PFM:REP 96->288|PF01421|7e-36|49.7|179/198|Reprolysin| RP:PFM:REP 388->437|PF00090|2e-10|57.1|49/50|TSP_1| RP:PFM:REP 558->655|PF05986|4e-25|48.0|98/113|ADAM_spacer1| RP:PFM:REP 925->966|PF00090|1e-04|47.8|40/50|TSP_1| HM:PFM:NREP 8 HM:PFM:REP 545->655|PF05986|7.3e-40|39.6|111/114|ADAM_spacer1| HM:PFM:REP 89->292|PF01421|7.1e-34|32.6|190/199|Reprolysin| HM:PFM:REP 387->437|PF00090|2.1e-15|46.9|49/49|TSP_1| HM:PFM:REP 731->783|PF00090|1.3e-06|34.8|46/49|TSP_1| HM:PFM:REP 790->828|PF00090|1.2e-07|35.9|39/49|TSP_1| HM:PFM:REP 855->878|PF00090|2.3e-08|45.8|24/49|TSP_1| HM:PFM:REP 930->972|PF00090|1.2e-07|29.3|41/49|TSP_1| HM:PFM:REP 987->1018|PF08686|3.9e-14|43.8|32/34|PLAC| GO:PFM:NREP 4 GO:PFM GO:0004222|"GO:metalloendopeptidase activity"|PF01421|IPR001590| GO:PFM GO:0006508|"GO:proteolysis"|PF01421|IPR001590| GO:PFM GO:0004222|"GO:metalloendopeptidase activity"|PF05986|IPR010294| GO:PFM GO:0031012|"GO:extracellular matrix"|PF05986|IPR010294| RP:SCP:NREP 5 RP:SCP:REP 96->291|1r54A|6e-42|30.8|182/206|d.92.1.9| RP:SCP:REP 347->453|1hdfA|2e-14|8.6|93/100|b.11.1.1| RP:SCP:REP 724->753|1mknA|2e-04|15.2|30/59|g.5.1.1| RP:SCP:REP 738->875|1pi1A|6e-07|13.6|125/185|a.29.7.1| RP:SCP:REP 925->974|1lslA1|9e-07|32.0|48/54|g.60.1.1| HM:SCP:REP 83->291|1bkcA_|2.9e-55|38.5|200/255|d.92.1.10|1/1|Metalloproteases ("zincins"), catalytic domain| HM:SCP:REP 379->437|1lslA2|2.3e-19|50.8|59/59|g.60.1.1|1/6|TSP-1 type 1 repeat| HM:SCP:REP 728->783|1lslA2|6.8e-11|43.1|51/59|g.60.1.1|3/6|TSP-1 type 1 repeat| HM:SCP:REP 784->844|1lslA2|2.5e-10|33.3|54/59|g.60.1.1|4/6|TSP-1 type 1 repeat| HM:SCP:REP 851->911|1lslA2|3.6e-07|32.7|52/59|g.60.1.1|5/6|TSP-1 type 1 repeat| HM:SCP:REP 917->977|1lslA2|5.1e-13|37.3|59/59|g.60.1.1|6/6|TSP-1 type 1 repeat| OP:NHOMO 3412 OP:NHOMOORG 74 OP:PATTERN -------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ---111-----------------------------------------------------------------------------------------------------5--***s***ecaYcrc**X*Y***D*j*VehW*agvfMhcVRuaP*etnplcolKOsD7J9AgAE*4----1---31------1------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 705 STR:RPRED 69.0 SQ:SECSTR ###############################################################################################cHHHHHHTTTHHHHHHHHHHHHHHHHHHGGGccccTEEEEEEEEEEcccccccccccccHHHHHHHHHHHHHHTTTTTTccccEEEEEEcccccEccccGccccEEEcTTcTTcTTTcEEEEEccHHHHHHHHHHHHHHHTTcccccTTcccccccccTTcccccccccccGccHHHHHHHHHHHHHHccGGGcccTccGGGccccccTTcccccTTcccccccTTHHHHHHHTcccTTccTTTcEEEETTEEcccccccTTccccccTTccccccccTTcEEEccEEEcEccccTTcccEEcccEcTTEccccccccccccTTcEETTTTEHHHEccTTccccHHHHHHHGGGGGGGGccccccccEEccccEETGGGGccccEEcEEEEccccTTcTccTTccccccE##EEETTEEEEccHH##########################################################################################################################################################cccTTcccccccTTcccccHHHHHHHHHHHHHHHHTTc######cEEEEccccccccccccccccccccEEEEEccccccEEETTTTEEEcccTTcccEEEEEccccccccHHHccHHHHHHHHTTccccccccccccccGGGTcccTTccccccc###ccGGGGcccHHHHHHHHHHHHHHHHHHcccccEEEEEEEccc#####cTTcccTTccccccccEEE####EEEEcccccccccc#######ccc##ccccccccccccEEEEEEccc#####################################ccccccHHHHHTTTcTTccccccTTHHHHcccc# DISOP:02AL 1-7,20-39,49-82,709-709,817-820,823-826,882-899,954-966,1018-1022| PSIPRED ccccccHHHccccccccEEcccHHHccccccccccccccccccEEEEEccccccccccccccccccccccccccccccccccccccEEEEEEEEEcHHHHHHccHHHHHHHHHHHHHHHHHHHccccccccEEEEEEEEEEEcccccccEEcccHHHHHHHHHHHHHHHcccccccccEEEEEEEEEEcccccccccEEEEEcccccccccccEEEEEccccHHHHHHHHHHcccccccccccccccccccccEEcHHHcccccccccccccHHHHHHHHHccccEEEEcccccccccccccccccEEEEccccccccccccccccccccccccccHHcccccccccccccEEccccccccccEEccccccccccccccccccccccccccccccccccccccEEcccccccccccccccccccccEEEccccccccccccccHHHHHcccccccccccccEEEEEEEccccccccEEEEEEccccccEEccccccccEEcccccccEEEccEEEEEEccccccccccccccccccccccccccccccccccccccccccEEEccccccccEEEEccccccEEEEEcccccEEEccccccccccEEEEcccEEEEEEcccccEEEEccccccccEEEEEEEccccccccEEEccccccccccccccccEEEccccccccccccccEEEEEEEEEEccccccccccccccccccccccccccccccccEEEcccccccccccccEEEEEEEEEcccccccccccHHHccccccccEEccccccccccccccccccccccccccEEEEEEEEEccccccccEEccHHHcccccccccEEEcccccccccccccccccccccccccccccEEEEEEEEEccccccccccccHHHcccccccccHHcEEEccccccccccccccccccccEEccccccccccccccEEEEEEEEcccccccccccccccccccEEccccccccccccccccccccccccEEEEcccccccccccHHHHHHccccc 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