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Agrobacterium tumefaciens str. C58 (atum0)
Chromosome : circular
Gene : folD
DDBJ      :folD         methylenetetrahydrofolate dehydrogenase
Swiss-Prot:FOLD_AGRT5   RecName: Full=Bifunctional protein folD;Includes:  RecName: Full=Methylenetetrahydrofolate dehydrogenase;           EC=1.5.1.5;Includes:  RecName: Full=Methenyltetrahydrofolate cyclohydrolase;           EC=3.5.4.9;

Homologs  Archaea  27/68 : Bacteria  886/915 : Eukaryota  186/199 : Viruses  0/175   --->[See Alignment]
c.2.1c.58.1
:299 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   2->292 1a4iB PDBj 4e-64 45.3 %
:RPS:PDB   2->292 1b0aA PDBj 8e-39 44.8 %
:RPS:SCOP  2->149 1edzA2  c.58.1.2 * 1e-33 23.1 %
:RPS:SCOP  122->290 1a4iA1  c.2.1.7 * 3e-16 52.2 %
:HMM:SCOP  1->121 1b0aA2 c.58.1.2 * 5.9e-40 49.6 %
:HMM:SCOP  122->293 1a4iA1 c.2.1.7 * 2.6e-46 44.7 %
:RPS:PFM   3->120 PF00763 * THF_DHG_CYH 2e-30 49.2 %
:RPS:PFM   126->291 PF02882 * THF_DHG_CYH_C 8e-40 58.3 %
:HMM:PFM   125->290 PF02882 * THF_DHG_CYH_C 6.1e-66 57.3 157/161  
:HMM:PFM   4->120 PF00763 * THF_DHG_CYH 1e-43 50.0 116/117  
:BLT:SWISS 1->299 FOLD_AGRT5 e-158 100.0 %
:PROS 269->277|PS00767|THF_DHG_CYH_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAK86400.2 GT:GENE folD GT:PRODUCT methylenetetrahydrofolate dehydrogenase GT:DATABASE GIB00072CH01 GT:ORG atum0 GB:ACCESSION GIB00072CH01 GB:CHROMOSOME circular GB:LOCATION 572284..573183 GB:FROM 572284 GB:TO 573183 GB:DIRECTION + GB:GENE folD GB:PRODUCT methylenetetrahydrofolate dehydrogenase GB:PROTEIN_ID AAK86400.2 GB:DB_XREF GI:159139690 GB:GENE:GENE folD LENGTH 299 SQ:AASEQ MAVVIDGKAKAASVTEAVRKSAEALEAEKGVKPGLAVVIVGNDPASHAYVNSKSKMAKQCGFNSIQHTLPEETTQAALLKLVGELNTDASIHGILVQLPLPKHFNSDEIIQSILPEKDVDGLSVLNAGKLATGDLATGLISCTPAGAMLLVRGIHGDDLSGLNAVVIGRSNLFGKPMGQLLLNANATVTMAHSRTKDLVTVCKTADILVAAVGRAAMVKGDWVKPGATVIDVGINRIAAPEKGEGKSKLVGDVAFDEASAVAAAITPVPGGVGPMTIAMLMANTVIAAHRALGKTAPKF GT:EXON 1|1-299:0| SW:ID FOLD_AGRT5 SW:DE RecName: Full=Bifunctional protein folD;Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; EC=1.5.1.5;Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase; EC=3.5.4.9; SW:GN Name=folD; OrderedLocusNames=Atu0589; ORFNames=AGR_C_1042; SW:KW Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis;Hydrolase; Methionine biosynthesis; Multifunctional enzyme; NADP;One-carbon metabolism; Oxidoreductase; Purine biosynthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->299|FOLD_AGRT5|e-158|100.0|299/299| GO:SWS:NREP 9 GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0000105|"GO:histidine biosynthetic process"|Histidine biosynthesis| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0009086|"GO:methionine biosynthetic process"|Methionine biosynthesis| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0006730|"GO:one-carbon metabolic process"|One-carbon metabolism| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| GO:SWS GO:0006164|"GO:purine nucleotide biosynthetic process"|Purine biosynthesis| PROS 269->277|PS00767|THF_DHG_CYH_2|PDOC00616| SEG 252->264|dvafdeasavaaa| BL:PDB:NREP 1 BL:PDB:REP 2->292|1a4iB|4e-64|45.3|289/295| RP:PDB:NREP 1 RP:PDB:REP 2->292|1b0aA|8e-39|44.8|281/287| RP:PFM:NREP 2 RP:PFM:REP 3->120|PF00763|2e-30|49.2|118/118|THF_DHG_CYH| RP:PFM:REP 126->291|PF02882|8e-40|58.3|156/160|THF_DHG_CYH_C| HM:PFM:NREP 2 HM:PFM:REP 125->290|PF02882|6.1e-66|57.3|157/161|THF_DHG_CYH_C| HM:PFM:REP 4->120|PF00763|1e-43|50.0|116/117|THF_DHG_CYH| GO:PFM:NREP 4 GO:PFM GO:0003824|"GO:catalytic activity"|PF00763|IPR000672| GO:PFM GO:0009396|"GO:folic acid and derivative biosynthetic process"|PF00763|IPR000672| GO:PFM GO:0003824|"GO:catalytic activity"|PF02882|IPR000672| GO:PFM GO:0009396|"GO:folic acid and derivative biosynthetic process"|PF02882|IPR000672| RP:SCP:NREP 2 RP:SCP:REP 2->149|1edzA2|1e-33|23.1|143/146|c.58.1.2| RP:SCP:REP 122->290|1a4iA1|3e-16|52.2|157/160|c.2.1.7| HM:SCP:REP 1->121|1b0aA2|5.9e-40|49.6|121/121|c.58.1.2|1/1|Aminoacid dehydrogenase-like, N-terminal domain| HM:SCP:REP 122->293|1a4iA1|2.6e-46|44.7|170/170|c.2.1.7|1/1|NAD(P)-binding Rossmann-fold domains| OP:NHOMO 1583 OP:NHOMOORG 1099 OP:PATTERN ------------------11111-21111111-----------11-1111111--------111--11 1111211111111111111-11111111111111111222122111111111221111112221222211111111111112311111111111111--1111111111111111111111111111111111111111111121111111111111111111111111111111111111112211111121111111111111111111111111111111111111111211111111111111111111111111111221111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111222111211111111111111111111111111111111111111111111111-1-------1211311122211322111111121111313111111111111-11111111111111111111111111111111112311112211111111111111121111111111111111112111111111111111111111-1111111111111111111111111212122111111121111111111111111111111111111111111112111111111111111111111111-1111111111111111111111111111-111111111111111111111111111111111111111111111111111111111111111111111111111111-11111111121111111111111112111111111111332211122211111111121111111111111111111111111111111111111111111111111----1-111-1-1---111111---1111111111111 ----331-311-12111-1-111111111111111211111111111222332311211222333333233232333-3333333223-111111111112-1423-16245757753443343764E1Kc5-8453442524554432353364553333223242633D21121333Y2222163641431147433 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 298 STR:RPRED 99.7 SQ:SECSTR ccEEccHHHHHHHHHHHHHHHHHHHHHTTccccEEEEEEEcccHHHHHHHHHHHHHHHHHTcEEccEEEcTTccHHHHHHHHHHHHTcTTccEEEEcccccTTccHHHHHTTccTTTcTTcccHHHHHHHHTTcTTcccccHHHHHHHHHHHHTTccccTTcEEEEEcccTTTHHHHHHHHHTTTcEEEEEccccccHHHHHHHccEEEEccccTTcccTTTccTTcEEEEccEEEEEcEcEEcTTccEEccccHHHHHHHccEEcccccccHHHHHHHHHHHHHHHHHHTTTTcccT# DISOP:02AL 295-300| PSIPRED ccEEEEHHHHHHHHHHHHHHHHHHHHHccccccEEEEEEEcccHHHHHHHHHHHHHHHHHccEEEEEEccccccHHHHHHHHHHHcccccccEEEEEccccccccHHHHHHHcccccccccccHHHHHHHHccccccccccccHHHHHHHHHHHccccccccEEEEEcccccHHHHHHHHHHHcccEEEEEccccccHHHHHHHccEEEEEccccccccHHHcccccEEEEEEEEEcccccccccccEEEEEEcHHHHHHHccEEccccccccHHHHHHHHHHHHHHHHHHHccccccc //