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Agrobacterium tumefaciens str. C58 (atum0)
Chromosome : circular
Gene : leuA
DDBJ      :leuA         2-isopropylmalate synthase
Swiss-Prot:LEU1_AGRT5   RecName: Full=2-isopropylmalate synthase;         EC=2.3.3.13;AltName: Full=Alpha-isopropylmalate synthase;AltName: Full=Alpha-IPM synthetase;

Homologs  Archaea  53/68 : Bacteria  695/915 : Eukaryota  119/199 : Viruses  0/175   --->[See Alignment]
a.5.7c.1.10d.270.1
:569 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   18->562 3figA PDBj e-156 52.6 %
:RPS:PDB   21->561 3bg9A PDBj 1e-79 12.4 %
:RPS:SCOP  30->338 1sr9A2  c.1.10.5 * 8e-82 60.8 %
:RPS:SCOP  397->446 1sr9A1  a.5.7.1 * 9e-13 45.5 %
:RPS:SCOP  454->562 1sr9A3  d.270.1.1 * 4e-18 38.9 %
:HMM:SCOP  30->338 1sr9A2 c.1.10.5 * 7.8e-98 36.2 %
:HMM:SCOP  397->448 1sr9A1 a.5.7.1 * 6.4e-14 50.0 %
:HMM:SCOP  450->564 1sr9A3 d.270.1.1 * 9.2e-34 40.4 %
:RPS:PFM   49->289 PF00682 * HMGL-like 2e-26 36.3 %
:RPS:PFM   448->564 PF08502 * LeuA_dimer 3e-18 38.3 %
:HMM:PFM   49->303 PF00682 * HMGL-like 1.7e-65 33.3 237/237  
:HMM:PFM   437->564 PF08502 * LeuA_dimer 1.5e-30 34.9 126/133  
:BLT:SWISS 12->569 LEU1_AGRT5 0.0 100.0 %
:PROS 48->64|PS00815|AIPM_HOMOCIT_SYNTH_1
:PROS 250->263|PS00816|AIPM_HOMOCIT_SYNTH_2

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID AAK88005.2 GT:GENE leuA GT:PRODUCT 2-isopropylmalate synthase GT:DATABASE GIB00072CH01 GT:ORG atum0 GB:ACCESSION GIB00072CH01 GB:CHROMOSOME circular GB:LOCATION complement(2236659..2238368) GB:FROM 2236659 GB:TO 2238368 GB:DIRECTION - GB:GENE leuA GB:PRODUCT 2-isopropylmalate synthase GB:PROTEIN_ID AAK88005.2 GB:DB_XREF GI:159140400 GB:GENE:GENE leuA LENGTH 569 SQ:AASEQ MDGKITTISKGMTDASVKYRPYPTINIPDRTWPGKTIDKAPIWCSVDLRDGNQSLVNPMGHDRKARMFKLLLEMGFKEIEIGFPSASQTDFDFARWCVEEGNVPDDVSLQVLVQCRPELITRTFEALEGANKPIIHFYNSTSELQRRVVFGKDVHGIKQIAVDAAKMITDMAAKAGGGFRFEYSPESFTGTELEVALEICNAVVEVVKPTADNKLILNLPSTVEMATPNIYADQIEWMCRNIDNRENVIISLHPHNDRGTGIAATELALMAGADRVEGTLFGNGERTGNVDVVTLALNMYTQGVDPELDCRDIERIKAVYEYSNEMTIPERHPYVGELVYTAFSGSHQDAINKGMKAIKVANHPVWEVPYLPIDPKDVGRSYEAIIRINSQSGKGGIAYILQQDYGINLPRNLQVEFREDIQRITDEEGVELPAKRIYERFIERYVTQPNARIKFVDHHTYPAGDFKGVRIVAAEITDNGEVKRIEGKGTGPIDGFINALSVYLGVDLSVNDYSEHSLQHGSNASAIAYVEMEHPGGKLFGAGVNTNIVAASLEAIVSAANRVLEERAK GT:EXON 1|1-569:0| SW:ID LEU1_AGRT5 SW:DE RecName: Full=2-isopropylmalate synthase; EC=2.3.3.13;AltName: Full=Alpha-isopropylmalate synthase;AltName: Full=Alpha-IPM synthetase; SW:GN Name=leuA; OrderedLocusNames=Atu2264; ORFNames=AGR_C_4114; SW:KW Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;Complete proteome; Leucine biosynthesis; Transferase. SW:EXACT F SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 12->569|LEU1_AGRT5|0.0|100.0|558/558| GO:SWS:NREP 4 GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0009082|"GO:branched chain family amino acid biosynthetic process"|Branched-chain amino acid biosynthesis| GO:SWS GO:0009098|"GO:leucine biosynthetic process"|Leucine biosynthesis| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 48->64|PS00815|AIPM_HOMOCIT_SYNTH_1|PDOC00643| PROS 250->263|PS00816|AIPM_HOMOCIT_SYNTH_2|PDOC00643| BL:PDB:NREP 1 BL:PDB:REP 18->562|3figA|e-156|52.6|530/574| RP:PDB:NREP 1 RP:PDB:REP 21->561|3bg9A|1e-79|12.4|516/601| RP:PFM:NREP 2 RP:PFM:REP 49->289|PF00682|2e-26|36.3|223/237|HMGL-like| RP:PFM:REP 448->564|PF08502|3e-18|38.3|115/132|LeuA_dimer| HM:PFM:NREP 2 HM:PFM:REP 49->303|PF00682|1.7e-65|33.3|237/237|HMGL-like| HM:PFM:REP 437->564|PF08502|1.5e-30|34.9|126/133|LeuA_dimer| GO:PFM:NREP 3 GO:PFM GO:0003824|"GO:catalytic activity"|PF00682|IPR000891| GO:PFM GO:0003852|"GO:2-isopropylmalate synthase activity"|PF08502|IPR013709| GO:PFM GO:0009098|"GO:leucine biosynthetic process"|PF08502|IPR013709| RP:SCP:NREP 3 RP:SCP:REP 30->338|1sr9A2|8e-82|60.8|309/310|c.1.10.5| RP:SCP:REP 397->446|1sr9A1|9e-13|45.5|44/46|a.5.7.1| RP:SCP:REP 454->562|1sr9A3|4e-18|38.9|108/115|d.270.1.1| HM:SCP:REP 30->338|1sr9A2|7.8e-98|36.2|309/0|c.1.10.5|1/1|Aldolase| HM:SCP:REP 397->448|1sr9A1|6.4e-14|50.0|52/0|a.5.7.1|1/1|post-HMGL domain-like| HM:SCP:REP 450->564|1sr9A3|9.2e-34|40.4|114/152|d.270.1.1|1/1|2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain| OP:NHOMO 1304 OP:NHOMOORG 867 OP:PATTERN ---3--2212222222-33233322--21121322333333332232113222322-----2-12-12 1131211111111111111-111111111111111122221211111-2111111111--112111211121111111-121122222111112---11--2-1111221---------------22133333323111212222222322222111111111122121221111111111111222233-21111111111111111111112111111131--11111123-1111111111111111111--------------------111-1--------111-----1------------------111111111-22-23-------1-13122----2-2--111222232123-212212--1-221111-----221121122311111111111111-11111111212-3111221222212211121121111121111111111111323-----------------------------21111122221233342312222232222222322222211222312223121212231212111111111111122-3222333122112-222133231221214222111111111--1-------11111332211221-2121111111111111111111-1-1111-11--111211211111111111-11-1111111111111111232121111111111111111111211111111-11111111111111-1---------22222111111-111-111111111111113111211211211113111---------211111111111111111111111111111121222222--------------------------------------2--21222221 ------1-------12221211123221122222222111111211111222111122211114423124433142424433344422-13221111111211323--21---------------------------------------------------------------1-112181111121211431121112 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 562 STR:RPRED 98.8 SQ:SECSTR EEEEEcccccHHHHHHHHHTcccHHHHHHHHHHHHHHHTccccEEEETTHHHHHHcTTccHHHHHHTHHHHHHHcccEEEEEEccHHHHHHHTccccHHHHHHcccccEEEEEcccHHHHHHHHHHHHHHTccEEEEEcccccHHHHHHHHHHHHHHHTcEEEEEEEEHHHHHHcGEEccccTTcccccTTcHHHHHHHHHHHHHcTEEEEEcccEEEEEcTTccccHHHHHHHHHHHHHHcTTccHccEEEEccTTcccTHHHHHHHHHTTccEEEEccGGGccTTccccHHHHHHHHTTcTTcccccHHHHHHHHHHHHHHHHHGGGGcGGGTTcccccTTHHHHcccHHHHHHHHHHHHTTTHHHHHHHHHHHHHHTTcccccHHHHHHHHHHHHHHHHTTccHHHHHHGGGcccccHHHHHHHTTcccccTTcccHHHHHHHHcccccccccTTTTcccccHHHHHHHHHTcccccHHHHHHHHHcHHHHHHHHHHHHHHcccccTTcccHHHHHHcccTTcEEEcccTTTcccEEEccccccTTTTccEEEEEccTH####### DISOP:02AL 1-6,8-18,567-570| PSIPRED ccccHHHHHcccccccccccccccccccccccccccccccEEEEEcccccccccccccccHHHHHHHHHHHHHccccEEEEEEccccHHHHHHHHHHHHHcccccccEEEEEEcccHHHHHHHHHHHHHccccEEEEEccccHHHHHHHHcccHHHHHHHHHHHHHHHHHcccccccEEEEEEcccccccccHHHHHHHHHHHHHHHHccccccEEEEEccccccccHHHHHHHHHHHHHHcccccccEEEEEEEccccHHHHHHHHHHHccccEEEEEEcccccccccccHHHHHHHHHHccccccccHHHHHHHHHHHHHHHccccccccccccccHHHHcccHHHHHHHccHHHHHHccccccccccccccHHHHccccEEEEEEEcHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHccccccEEEEEEEEEEccccccEEEEEEEEEEccEEEEEEEEccccHHHHHHHHHHHcccccEEEEEEEEEccccccEEEEEEEEEEEccEEEEEEEccccHHHHHHHHHHHHHHHHHHHHcc //