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Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : alaS
DDBJ      :alaS         alanyl-tRNA synthetase
Swiss-Prot:SYA_BACSU    RecName: Full=Alanyl-tRNA synthetase;         EC=6.1.1.7;AltName: Full=Alanine--tRNA ligase;         Short=AlaRS;

Homologs  Archaea  68/68 : Bacteria  907/915 : Eukaryota  195/199 : Viruses  0/175   --->[See Alignment]
a.203.1b.43.3d.104.1d.206.1d.67.1
:878 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   4->426 1yfrA PDBj e-109 47.7 %
:BLT:PDB   558->684 1wxoB PDBj 3e-10 35.6 %
:RPS:PDB   7->426 2cvsA PDBj 7e-64 11.5 %
:RPS:PDB   456->699 2e1bA PDBj 9e-49 29.2 %
:RPS:PDB   675->877 3c9iF PDBj 5e-21 13.4 %
:RPS:SCOP  4->245 1riqA2  d.104.1.1 * e-109 54.8 %
:RPS:SCOP  246->464 1riqA1  a.203.1.1 * 2e-57 34.6 %
:RPS:SCOP  453->554 2e1bA1  b.43.3.6 * 8e-17 27.6 %
:RPS:SCOP  558->700 1v4pA  d.67.1.2 * 3e-38 28.0 %
:RPS:SCOP  767->829 1jrmA  d.206.1.1 * 2e-07 17.5 %
:HMM:SCOP  3->245 1riqA2 d.104.1.1 * 4.5e-90 58.1 %
:HMM:SCOP  246->465 1riqA1 a.203.1.1 * 1.3e-72 46.8 %
:HMM:SCOP  554->722 1nyrA3 d.67.1.1 * 2.1e-52 46.1 %
:RPS:PFM   8->556 PF01411 * tRNA-synt_2c e-167 53.2 %
:RPS:PFM   655->697 PF07973 * tRNA_SAD 9e-10 53.5 %
:RPS:PFM   697->770 PF12128 * DUF3584 4e-04 34.3 %
:RPS:PFM   827->872 PF02272 * DHHA1 3e-05 39.1 %
:HMM:PFM   8->557 PF01411 * tRNA-synt_2c 6.2e-223 53.8 543/551  
:HMM:PFM   655->698 PF07973 * tRNA_SAD 8.6e-22 65.9 44/44  
:HMM:PFM   802->871 PF02272 * DHHA1 5.2e-21 42.4 66/68  
:HMM:PFM   696->744 PF06160 * EzrA 0.00013 26.5 49/559  
:BLT:SWISS 1->878 SYA_BACSU 0.0 100.0 %
:COIL
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB14682.1 GT:GENE alaS GT:PRODUCT alanyl-tRNA synthetase GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION complement(2798174..2800810) GB:FROM 2798174 GB:TO 2800810 GB:DIRECTION - GB:GENE alaS GB:PRODUCT alanyl-tRNA synthetase GB:FUNCTION 16.2: Construct biomass (Anabolism) GB:NOTE Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; PubMedId: 12554667, 12682299, 17329819; Product type e : enzyme GB:PROTEIN_ID CAB14682.1 GB:DB_XREF GOA:O34526 InterPro:IPR012947 SubtiList:BG12563 UniProtKB/Swiss-Prot:O34526 GB:GENE:GENE alaS LENGTH 878 SQ:AASEQ MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSGVATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKEEAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWDIGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYTPLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFKVIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAEIMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADVFKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGALRDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIGDKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNHTATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWASIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLFKIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAELKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAKLGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAGGKQPEKLEEALASVEDWVKSVL GT:EXON 1|1-878:0| SW:ID SYA_BACSU SW:DE RecName: Full=Alanyl-tRNA synthetase; EC=6.1.1.7;AltName: Full=Alanine--tRNA ligase; Short=AlaRS; SW:GN Name=alaS; OrderedLocusNames=BSU27410; SW:KW Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm;Ligase; Nucleotide-binding; Protein biosynthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->878|SYA_BACSU|0.0|100.0|878/878| GO:SWS:NREP 6 GO:SWS GO:0004812|"GO:aminoacyl-tRNA ligase activity"|Aminoacyl-tRNA synthetase| GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006412|"GO:translation"|Protein biosynthesis| COIL:NAA 32 COIL:NSEG 1 COIL:REGION 732->763| SEG 299->315|grgyvlrrllrravrya| SEG 427->438|nqqrerarnarq| SEG 843->848|gggggg| BL:PDB:NREP 2 BL:PDB:REP 4->426|1yfrA|e-109|47.7|409/448| BL:PDB:REP 558->684|1wxoB|3e-10|35.6|118/154| RP:PDB:NREP 3 RP:PDB:REP 7->426|2cvsA|7e-64|11.5|410/657| RP:PDB:REP 456->699|2e1bA|9e-49|29.2|209/216| RP:PDB:REP 675->877|3c9iF|5e-21|13.4|201/221| RP:PFM:NREP 4 RP:PFM:REP 8->556|PF01411|e-167|53.2|541/546|tRNA-synt_2c| RP:PFM:REP 655->697|PF07973|9e-10|53.5|43/44|tRNA_SAD| RP:PFM:REP 697->770|PF12128|4e-04|34.3|67/1179|DUF3584| RP:PFM:REP 827->872|PF02272|3e-05|39.1|46/67|DHHA1| HM:PFM:NREP 4 HM:PFM:REP 8->557|PF01411|6.2e-223|53.8|543/551|tRNA-synt_2c| HM:PFM:REP 655->698|PF07973|8.6e-22|65.9|44/44|tRNA_SAD| HM:PFM:REP 802->871|PF02272|5.2e-21|42.4|66/68|DHHA1| HM:PFM:REP 696->744|PF06160|0.00013|26.5|49/559|EzrA| GO:PFM:NREP 12 GO:PFM GO:0000166|"GO:nucleotide binding"|PF01411|IPR018164| GO:PFM GO:0004813|"GO:alanine-tRNA ligase activity"|PF01411|IPR018164| GO:PFM GO:0005524|"GO:ATP binding"|PF01411|IPR018164| GO:PFM GO:0005737|"GO:cytoplasm"|PF01411|IPR018164| GO:PFM GO:0006412|"GO:translation"|PF01411|IPR018164| GO:PFM GO:0006419|"GO:alanyl-tRNA aminoacylation"|PF01411|IPR018164| GO:PFM GO:0005524|"GO:ATP binding"|PF07973|IPR012947| GO:PFM GO:0005737|"GO:cytoplasm"|PF07973|IPR012947| GO:PFM GO:0006412|"GO:translation"|PF07973|IPR012947| GO:PFM GO:0016876|"GO:ligase activity, forming aminoacyl-tRNA and related compounds"|PF07973|IPR012947| GO:PFM GO:0043039|"GO:tRNA aminoacylation"|PF07973|IPR012947| GO:PFM GO:0003676|"GO:nucleic acid binding"|PF02272|IPR003156| RP:SCP:NREP 5 RP:SCP:REP 4->245|1riqA2|e-109|54.8|228/236|d.104.1.1| RP:SCP:REP 246->464|1riqA1|2e-57|34.6|211/212|a.203.1.1| RP:SCP:REP 453->554|2e1bA1|8e-17|27.6|87/87|b.43.3.6| RP:SCP:REP 558->700|1v4pA|3e-38|28.0|143/151|d.67.1.2| RP:SCP:REP 767->829|1jrmA|2e-07|17.5|63/104|d.206.1.1| HM:SCP:REP 3->245|1riqA2|4.5e-90|58.1|229/0|d.104.1.1|1/1|Class II aaRS and biotin synthetases| HM:SCP:REP 246->465|1riqA1|1.3e-72|46.8|220/0|a.203.1.1|1/1|Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)| HM:SCP:REP 554->722|1nyrA3|2.1e-52|46.1|167/179|d.67.1.1|1/1|ThrRS/AlaRS common domain| OP:NHOMO 1514 OP:NHOMOORG 1170 OP:PATTERN 22211121222222221122222121112221111111111111111122222123233332223111 2221111111111111111-1111111111111111111111111111111111111111111111112211-111111111211111212212121-111111111121111111111111111111111111112221111122111111111111111111112111111111111111111211222111333331232222222111111222111212211111121111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111122221111111212121111112111121211111121111111211212111111111111111111111111111111111111111111111111111111111111111111211111111111111111111111111111111111111-1111111111111111111111111211222111112212111111222111111221112111111111121111211111111111111112111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-111111111111111111111-111111-11111111111111111111111111111111111111111111111111111111111111111111111111111111211111111111111111111111111111211111111111111111111111111111111111111111111111111111111111111111111111111111111-11111111111111111112222222222111 1111241-31111111122-112111211111111111111111111111213211111111122111-3212222111221122211-12111111111111222123144743732221323242628L312222222221421222142223332222222442322322222222I2221322442232223222 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 872 STR:RPRED 99.3 SQ:SECSTR #ccEEcHHHHHHHHHHHHTcccEEEEcTTcccTTccccccccccHHHHHHHHHHHHEEEcTTcTTHHHHHTcccccccccccccccEEEccEEEEcHHHHHHHHTTcEEEEccTGGccHHHHHHHHHHHHHTEEEHHHHHHHHHHHHHHHcccHTcTTTTTccccccTTccccccccTTccEEccccccccEEcHHHHHHHHHHHHHHHHHHHHHcccccHHHHcccEEEEEcHHHHHHHTTccTTcHHHHHHHHHHHHHHHHHHHHHHcccTTcTTcGGGGTccTGGGGTccccccccHHHHHHHHHHHcccccccccccccTTHHHHTTcccccccccHTTcHccEEcccEEcHHHHHHHHHTTcccHHHHHHHHHTTTTTcTTccHHHHHHTccTTcccHHHHHHHHHHHHTTccccccccEEHHTTTccccccccTHcccccc##TTTccEcccccTTccTTccEEEEEEETTEEEEEcccccccccccccccccccccTTcccccEEETETTETEEEEEEEccTTcccEEEEEccGGGccccccEEEEEcHHHHHHHHHHHHHHHHHHHHHHHHHTTccEEEEccccccEEEEEEEccccGGHGGHHHHHHHHHHHHHHcccEEEcccHHHccEEEEEEEEEEEEEccccEEEEETTccEEcccccccccGGGTccEEEEEEEEEETTEEEEEEccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH#HHHHHHHHHHHHHHHHHHHHHHH#HHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccccccccccccEEETTEEEccccccccccccccccccccccTTHHHHHHHHHHHHHHHHH# DISOP:02AL 1-3, 428-442| PSIPRED cccccHHHHHHHHHHHHHHcccEEEccccccccccccEEEEEccHHHcccccccccccccccEEccccccccccHHHcccccccHHHHHHHHHHHcccHHHHHHHHHHHHHHcccccccccccEEEEEEEcccHHHHHHHHHHccccHHHEEEcccccccccccccccccEEEEEcccccccccccccccccccccEEEEEEEccHHHHccccccccccccccccEEcccHHHHHHHHcccccccHHHHHHHHHHHHHHHHccccccccccccEEHHHHHHHHHHHHHHHcccccccccccHHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHHccHHHccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHcccccHHHHHHHHHccccEEcHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHcccccccccccccEEccEEEEEEEEccEEEEEEEcccEEEEEEEccccccccccccccEEEEEEccEEEEEEEEEEccccEEEEEEEEcccccccccEEEEEEcHHHHHHHHHHHHHHHHHHHHHHHHccccEEEcccEEccccEEEEEcccccccHHHHHHHHHHHHHHHHccccEEEEEEcHHHHHHHccccccccccccEEEEEEEcccEEccccccccccccccccEEEEEEEEccccEEEEEEEEcHHHHHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccEEEEEEEEccccHHHHHHHHHHHHHHcccEEEEEEEEccccEEEEEEccHHHHHccccHHHHHHHHHHHccccccccccccccccccHHHHHHHHHHHHHHHHHHc //