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Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : aprE
DDBJ      :aprE         serine alkaline protease (subtilisin E)
Swiss-Prot:SUBT_BACSU   RecName: Full=Subtilisin E;         EC=3.4.21.62;Flags: Precursor;

Homologs  Archaea  23/68 : Bacteria  310/915 : Eukaryota  183/199 : Viruses  0/175   --->[See Alignment]
c.41.1d.58.3
:381 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   36->106 1scjB PDBj 2e-35 97.2 %
:BLT:PDB   107->381 1scjA PDBj e-139 99.3 %
:RPS:PDB   36->104 3bgoP PDBj 5e-11 77.6 %
:RPS:PDB   107->381 1cseE PDBj 7e-60 64.2 %
:RPS:SCOP  36->106 1scjB  d.58.3.2 * 6e-21 97.2 %
:RPS:SCOP  107->381 1a2qA  c.41.1.1 * 2e-84 78.2 %
:HMM:SCOP  36->106 1scjB_ d.58.3.2 * 3.4e-24 56.3 %
:HMM:SCOP  107->382 1v6cA_ c.41.1.1 * 2.7e-95 50.9 %
:RPS:PFM   125->353 PF00082 * Peptidase_S8 4e-27 45.9 %
:HMM:PFM   114->365 PF00082 * Peptidase_S8 3e-70 49.0 247/307  
:HMM:PFM   37->103 PF05922 * Inhibitor_I9 5.1e-13 34.3 67/87  
:BLT:SWISS 1->381 SUBT_BACSU 0.0 100.0 %
:PROS 134->145|PS00136|SUBTILASE_ASP
:PROS 170->180|PS00137|SUBTILASE_HIS
:PROS 325->335|PS00138|SUBTILASE_SER
:TM
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB12870.2 GT:GENE aprE GT:PRODUCT serine alkaline protease (subtilisin E) GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION complement(1104423..1105568) GB:FROM 1104423 GB:TO 1105568 GB:DIRECTION - GB:GENE aprE GB:PRODUCT serine alkaline protease (subtilisin E) GB:FUNCTION 16.11: Scavenge (Catabolism) GB:NOTE Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 12950930, 14688235, 15205417, 17666034, 3108260, 9811547; Product type e : enzyme GB:PROTEIN_ID CAB12870.2 GB:DB_XREF GOA:P04189 InterPro:IPR010259 PDB:1SCJ SubtiList:BG10190 UniProtKB/Swiss-Prot:P04189 GB:GENE:GENE aprE LENGTH 381 SQ:AASEQ MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFKQTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHIAHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSETNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIEWAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAKYPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVAGAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ GT:EXON 1|1-381:0| SW:ID SUBT_BACSU SW:DE RecName: Full=Subtilisin E; EC=3.4.21.62;Flags: Precursor; SW:GN Name=aprE; Synonyms=apr, aprA, sprE; OrderedLocusNames=BSU10300; SW:KW 3D-structure; Calcium; Complete proteome; Hydrolase; Metal-binding;Protease; Secreted; Serine protease; Signal; Sporulation; Zymogen. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->381|SUBT_BACSU|0.0|100.0|381/381| GO:SWS:NREP 6 GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0008233|"GO:peptidase activity"|Protease| GO:SWS GO:0005576|"GO:extracellular region"|Secreted| GO:SWS GO:0008236|"GO:serine-type peptidase activity"|Serine protease| GO:SWS GO:0030435|"GO:sporulation resulting in formation of a cellular spore"|Sporulation| PROS 134->145|PS00136|SUBTILASE_ASP|PDOC00125| PROS 170->180|PS00137|SUBTILASE_HIS|PDOC00125| PROS 325->335|PS00138|SUBTILASE_SER|PDOC00125| TM:NTM 1 TM:REGION 6->28| SEG 248->272|avssgivvaaaagnegssgststvg| BL:PDB:NREP 2 BL:PDB:REP 36->106|1scjB|2e-35|97.2|71/71| BL:PDB:REP 107->381|1scjA|e-139|99.3|275/275| RP:PDB:NREP 2 RP:PDB:REP 36->104|3bgoP|5e-11|77.6|67/71| RP:PDB:REP 107->381|1cseE|7e-60|64.2|274/274| RP:PFM:NREP 1 RP:PFM:REP 125->353|PF00082|4e-27|45.9|229/285|Peptidase_S8| HM:PFM:NREP 2 HM:PFM:REP 114->365|PF00082|3e-70|49.0|247/307|Peptidase_S8| HM:PFM:REP 37->103|PF05922|5.1e-13|34.3|67/87|Inhibitor_I9| GO:PFM:NREP 2 GO:PFM GO:0004252|"GO:serine-type endopeptidase activity"|PF00082|IPR000209| GO:PFM GO:0006508|"GO:proteolysis"|PF00082|IPR000209| RP:SCP:NREP 2 RP:SCP:REP 36->106|1scjB|6e-21|97.2|71/71|d.58.3.2| RP:SCP:REP 107->381|1a2qA|2e-84|78.2|275/275|c.41.1.1| HM:SCP:REP 36->106|1scjB_|3.4e-24|56.3|71/0|d.58.3.2|1/1|Protease propeptides/inhibitors| HM:SCP:REP 107->382|1v6cA_|2.7e-95|50.9|269/0|c.41.1.1|1/1|Subtilisin-like| OP:NHOMO 1557 OP:NHOMOORG 516 OP:PATTERN 111-------------1-11-1-2-112--21--------------1A1-11---2-134-------1 --1-21--111----1111-1-----11111-------1111-1-312-11141441---BB21C56A8D1---------1-2--1-------1-----11221-2--33---------------1--1---113133334---71153-11211----11-211-14334----1--2----G3824--1-263333354436435465988774633233743------731---1------------------1--1---------------------------------------------------------------311-2----1-----111111111----41111--11-2431121213--1-11----------21-1-----2-------------11---3---1--------11--21--1--2------------------------------------------------------------1-1--1111112111111-12222-211-2-11--1113-----11---1--1------------1132--A-4------1-----122-423------83-2---------------------------21-22-4121-5234383244325332239--311---------------------------------------------------------------------1------------------------A---------2-2-----------------11111------11111113-1-----212-----------1-211111231111254543112--------------------------------------------------3-121-1----2- 11-2551-1---137556423322223222222978BB7C9BC22222ACEDGGA9F36322733222131334111-1214444422-1-3581221221819BD12F1D322233121113145233AUA196B212151322-111-211431122--31511-1112--11-241B221765535658B331122 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 355 STR:RPRED 93.2 SQ:SECSTR ##########################HHHHTcEEEcEEEEEEEcTTEEEHHHTccHHHHHHTTcEEEEEcccccEEEEEEcTTTHHHHHTcTTEEEEEEccEEEEccccccTHHHHHTHHHHHHHTcccTTcEEEEEEccccTTcTTccEEEEEEccTTccTTccccccHHHHHHHHHHccccccccccccTTcEEEEEEcccTTccccHHHHHHHHHHHHHTTccEEEEccccccccHHHHHHHHHHHHHTcEEEEEcccccccTTccccccTTTcTTcEEEEEEcTTccccTTccccTTccEEEEcccEEEEETTTEEEEEccHHHHHHHHHHHHHHHHHHcTTccHHHHHHHHHHTccccccHHHHTTccccHHHHTc DISOP:02AL 381-382| PSIPRED cccHHHHHHHHHHHHHHHHHHHcccccccccccccccEEEEEEcccccHHHHHHHHHHHHHcccEEEEEEccEEEEEEEccHHHHHHHHHccccEEEEcccEEEcccccccccHHHccHHHHHHccccccccEEEEEcccccccccccccccccccccccccccccccccHHHHHHHHHcccccccccccccccEEEEEEEEcccccccHHHHHHHHHHHHHccccEEEcccccccccHHHHHHHHHHHHcccEEEEEcccccccccccEEccccccccEEEEEcccccccccccccccccccccccccccEEEcccccEEEEccccHHHHHHHHHHHHHHHHcccccHHHHHHHHHHHcccccccccccccEEcHHHHcc //