[GTOP] [HELP] [ORGANISMS] [SEARCH] [SUMMARY]
Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : cwlC
DDBJ      :cwlC         N-acetylmuramoyl-L-alanine amidase
Swiss-Prot:CWLC_BACSU   RecName: Full=Sporulation-specific N-acetylmuramoyl-L-alanine amidase;         EC=3.5.1.28;AltName: Full=Cell wall hydrolase;AltName: Full=Autolysin;

Homologs  Archaea  2/68 : Bacteria  493/915 : Eukaryota  1/199 : Viruses  2/175   --->[See Alignment]
c.56.5d.58.52
:255 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->178 1jwqA PDBj 3e-20 30.5 %
:BLT:PDB   177->255 1x60A PDBj 4e-39 100.0 %
:RPS:PDB   3->173 3czxA PDBj 2e-36 20.0 %
:RPS:SCOP  1->178 1jwqA  c.56.5.6 * 1e-50 32.2 %
:RPS:SCOP  183->252 1utaA  d.58.52.1 * 1e-15 30.0 %
:HMM:SCOP  1->180 1xovA2 c.56.5.6 * 1.5e-55 43.8 %
:HMM:SCOP  181->253 1utaA_ d.58.52.1 * 1.8e-15 38.4 %
:RPS:PFM   4->171 PF01520 * Amidase_3 3e-29 41.0 %
:RPS:PFM   183->251 PF05036 * SPOR 2e-10 40.6 %
:HMM:PFM   4->172 PF01520 * Amidase_3 1.4e-48 40.7 167/175  
:HMM:PFM   183->252 PF05036 * SPOR 8.7e-21 41.4 70/76  
:BLT:SWISS 1->255 CWLC_BACSU e-143 100.0 %
:REPEAT 2|184->218|220->254

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB13625.2 GT:GENE cwlC GT:PRODUCT N-acetylmuramoyl-L-alanine amidase GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION complement(1872812..1873579) GB:FROM 1872812 GB:TO 1873579 GB:DIRECTION - GB:GENE cwlC GB:PRODUCT N-acetylmuramoyl-L-alanine amidase GB:FUNCTION 16.11: Scavenge (Catabolism) 16.3: Control 16.5: Explore GB:NOTE Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme GB:PROTEIN_ID CAB13625.2 GB:DB_XREF GOA:Q06320 InterPro:IPR007730 PDB:1X60 SubtiList:BG10825 UniProtKB/Swiss-Prot:Q06320 GB:GENE:GENE cwlC LENGTH 255 SQ:AASEQ MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYEGVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTTYQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFIQSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLKDGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES GT:EXON 1|1-255:0| SW:ID CWLC_BACSU SW:DE RecName: Full=Sporulation-specific N-acetylmuramoyl-L-alanine amidase; EC=3.5.1.28;AltName: Full=Cell wall hydrolase;AltName: Full=Autolysin; SW:GN Name=cwlC; OrderedLocusNames=BSU17410; SW:KW 3D-structure; Cell wall; Cell wall biogenesis/degradation; Competence;Complete proteome; Direct protein sequencing; Hydrolase;Metal-binding; Repeat; Secreted; Sporulation; Zinc. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->255|CWLC_BACSU|e-143|100.0|255/255| GO:SWS:NREP 7 GO:SWS GO:0005618|"GO:cell wall"|Cell wall| GO:SWS GO:0007047|"GO:cellular cell wall organization"|Cell wall biogenesis/degradation| GO:SWS GO:0030420|"GO:establishment of competence for transformation"|Competence| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0005576|"GO:extracellular region"|Secreted| GO:SWS GO:0030435|"GO:sporulation resulting in formation of a cellular spore"|Sporulation| NREPEAT 1 REPEAT 2|184->218|220->254| BL:PDB:NREP 2 BL:PDB:REP 1->178|1jwqA|3e-20|30.5|177/179| BL:PDB:REP 177->255|1x60A|4e-39|100.0|79/79| RP:PDB:NREP 1 RP:PDB:REP 3->173|3czxA|2e-36|20.0|160/178| RP:PFM:NREP 2 RP:PFM:REP 4->171|PF01520|3e-29|41.0|166/175|Amidase_3| RP:PFM:REP 183->251|PF05036|2e-10|40.6|69/76|SPOR| HM:PFM:NREP 2 HM:PFM:REP 4->172|PF01520|1.4e-48|40.7|167/175|Amidase_3| HM:PFM:REP 183->252|PF05036|8.7e-21|41.4|70/76|SPOR| GO:PFM:NREP 2 GO:PFM GO:0008745|"GO:N-acetylmuramoyl-L-alanine amidase activity"|PF01520|IPR002508| GO:PFM GO:0009253|"GO:peptidoglycan catabolic process"|PF01520|IPR002508| RP:SCP:NREP 2 RP:SCP:REP 1->178|1jwqA|1e-50|32.2|177/179|c.56.5.6| RP:SCP:REP 183->252|1utaA|1e-15|30.0|70/77|d.58.52.1| HM:SCP:REP 1->180|1xovA2|1.5e-55|43.8|176/0|c.56.5.6|1/1|Zn-dependent exopeptidases| HM:SCP:REP 181->253|1utaA_|1.8e-15|38.4|73/0|d.58.52.1|1/1|Sporulation related repeat| OP:NHOMO 751 OP:NHOMOORG 498 OP:PATTERN ----------------------------------------------------1----1---------- 111-1-----------------------------------1--------------------1---1--------------1-1--111111141111-----221-211-111111111111111111-1-1111-----------222233111221111-123133321-1111111-111212--112-243434432323342326755342343342612222222421111-1111111111-1111--1-11-1---11--11111112--------------------------------------11---1111285-4242242235345222---345--242434458522532111311111--111111-1--1-----1-11-11111111111----------1-----1--------1-1--11-----111--------1-----11------------------------------1-1--11111-111---------11--------1111111--111---1---1-1111--11--------1111-11-1--111111111-1-11-1-1-11111111-11111111111--1-1-1-111121111-111-111------111------1--1---11-1--1----21111111111111111-1111211111111111111222211222222112111222222311111112-222222222222-111111111111-1111111111-11-1-111----------21----1122-11111111------------------------1111111111------1---1111-11--1--1-----------------------------1---1---121 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1---------- --------------------------------------------------------------------------1------------------------------------------------------------------------------1--------------------- STR:NPRED 255 STR:RPRED 100.0 SQ:SECSTR cEcEEEEEcccccccccEETTEEHHHHHHHHHHHHHHHHHHHcccEEEEEEccccccccHHHHHHHHHHHTccEEEEEccccTTccccEEEEcGGGHHGGHHHHHHHHHHHHHHHcccccTcGGcccTTHHHHHTTcEEEEcccTTcHHHHHHHHHHHHHHHHHHHHHHHHHHHHTccccccccEEEEEEEEEccHHHHHHHHHHHHHHTccEEEEEETTEEEEEEEEEccHHHHHHHHHHHHHHTcccEEEEEc DISOP:02AL 255-256| PSIPRED cEEEEEcccccccccccccccccHHHHHHHHHHHHHHHHHHcccccEEEEEccccccccHHHHHHHHHHccccEEEEEEEccccccEEEEEEEccccHHHHHHHHHHHHHHHHHccccccccccccEEEEEcccccEEEEEEEEcccHHHHHHHccHHHHHHHHHHHHHHHHHHHHHccccccccccccccccEEEEEHHHHHHHHHHccccEEEEEcccEEEEEEcccccHHHHHHHHHHHHHccccEEEEEcc //