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Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : dxs
DDBJ      :dxs          1-deoxyxylulose-5-phosphate synthase
Swiss-Prot:DXS_BACSU    RecName: Full=1-deoxy-D-xylulose-5-phosphate synthase;         EC=2.2.1.7;AltName: Full=1-deoxyxylulose-5-phosphate synthase;         Short=DXP synthase;         Short=DXPS;

Homologs  Archaea  41/68 : Bacteria  793/915 : Eukaryota  94/199 : Viruses  0/175   --->[See Alignment]
a.130.1c.23.10c.36.1c.48.1
:633 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   6->610 2o1xB PDBj e-124 44.8 %
:RPS:PDB   17->620 1ay0A PDBj 7e-75 18.8 %
:RPS:SCOP  1->141 1csmA  a.130.1.2 * 7e-28 13.4 %
:RPS:SCOP  247->457 2apjA1  c.23.10.7 * 4e-38 8.7 %
:RPS:SCOP  489->623 1dtwB2  c.48.1.2 * 6e-21 23.7 %
:HMM:SCOP  5->378 1w85A_ c.36.1.11 * 1.4e-76 34.3 %
:HMM:SCOP  287->482 1qgdA1 c.36.1.6 * 3.3e-59 35.1 %
:HMM:SCOP  489->624 1ni4B2 c.48.1.2 * 1.2e-34 37.3 %
:RPS:PFM   113->178 PF00676 * E1_dh 2e-06 34.8 %
:RPS:PFM   359->475 PF02779 * Transket_pyr 1e-11 34.5 %
:RPS:PFM   497->612 PF02780 * Transketolase_C 2e-14 33.3 %
:HMM:PFM   316->477 PF02779 * Transket_pyr 1.9e-38 24.2 161/178  
:HMM:PFM   493->615 PF02780 * Transketolase_C 1.4e-34 37.7 122/124  
:HMM:PFM   36->186 PF00456 * Transketolase_N 2.2e-07 30.7 150/333  
:HMM:PFM   193->232 PF06174 * DUF987 4.1e-05 35.0 40/66  
:BLT:SWISS 1->633 DXS_BACSU 0.0 100.0 %
:PROS 28->47|PS00801|TRANSKETOLASE_1
:PROS 422->438|PS00802|TRANSKETOLASE_2
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB14358.1 GT:GENE dxs GT:PRODUCT 1-deoxyxylulose-5-phosphate synthase GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION complement(2523713..2525614) GB:FROM 2523713 GB:TO 2525614 GB:DIRECTION - GB:GENE dxs GB:PRODUCT 1-deoxyxylulose-5-phosphate synthase GB:FUNCTION 16.2: Construct biomass (Anabolism) GB:NOTE Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; PubMedId: 12682299, 12882400, 15292217, 17458547; Product type e: enzyme GB:PROTEIN_ID CAB14358.1 GB:DB_XREF GOA:P54523 InterPro:IPR005475 SubtiList:BG11715 UniProtKB/Swiss-Prot:P54523 GB:GENE:GENE dxs LENGTH 633 SQ:AASEQ MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGPNLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKRSESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIGDEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKLAATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDGRIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTFLQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKDENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILTFGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEGGFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMPPKTHKGIGS GT:EXON 1|1-633:0| SW:ID DXS_BACSU SW:DE RecName: Full=1-deoxy-D-xylulose-5-phosphate synthase; EC=2.2.1.7;AltName: Full=1-deoxyxylulose-5-phosphate synthase; Short=DXP synthase; Short=DXPS; SW:GN Name=dxs; Synonyms=yqiE; OrderedLocusNames=BSU24270; SW:KW Complete proteome; Isoprene biosynthesis; Thiamine biosynthesis;Thiamine pyrophosphate; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->633|DXS_BACSU|0.0|100.0|633/633| GO:SWS:NREP 3 GO:SWS GO:0008299|"GO:isoprenoid biosynthetic process"|Isoprene biosynthesis| GO:SWS GO:0009228|"GO:thiamin biosynthetic process"|Thiamine biosynthesis| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 28->47|PS00801|TRANSKETOLASE_1|PDOC00635| PROS 422->438|PS00802|TRANSKETOLASE_2|PDOC00635| SEG 370->379|aatmaaamam| SEG 513->522|iemaieaaee| BL:PDB:NREP 1 BL:PDB:REP 6->610|2o1xB|e-124|44.8|551/579| RP:PDB:NREP 1 RP:PDB:REP 17->620|1ay0A|7e-75|18.8|589/678| RP:PFM:NREP 3 RP:PFM:REP 113->178|PF00676|2e-06|34.8|66/298|E1_dh| RP:PFM:REP 359->475|PF02779|1e-11|34.5|110/172|Transket_pyr| RP:PFM:REP 497->612|PF02780|2e-14|33.3|114/122|Transketolase_C| HM:PFM:NREP 4 HM:PFM:REP 316->477|PF02779|1.9e-38|24.2|161/178|Transket_pyr| HM:PFM:REP 493->615|PF02780|1.4e-34|37.7|122/124|Transketolase_C| HM:PFM:REP 36->186|PF00456|2.2e-07|30.7|150/333|Transketolase_N| HM:PFM:REP 193->232|PF06174|4.1e-05|35.0|40/66|DUF987| GO:PFM:NREP 4 GO:PFM GO:0008152|"GO:metabolic process"|PF00676|IPR001017| GO:PFM GO:0016624|"GO:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"|PF00676|IPR001017| GO:PFM GO:0003824|"GO:catalytic activity"|PF02780|IPR005476| GO:PFM GO:0008152|"GO:metabolic process"|PF02780|IPR005476| RP:SCP:NREP 3 RP:SCP:REP 1->141|1csmA|7e-28|13.4|134/253|a.130.1.2| RP:SCP:REP 247->457|2apjA1|4e-38|8.7|195/244|c.23.10.7| RP:SCP:REP 489->623|1dtwB2|6e-21|23.7|131/138|c.48.1.2| HM:SCP:REP 5->378|1w85A_|1.4e-76|34.3|312/0|c.36.1.11|1/1|Thiamin diphosphate-binding fold (THDP-binding)| HM:SCP:REP 287->482|1qgdA1|3.3e-59|35.1|188/195|c.36.1.6|1/1|Thiamin diphosphate-binding fold (THDP-binding)| HM:SCP:REP 489->624|1ni4B2|1.2e-34|37.3|134/138|c.48.1.2|1/1|TK C-terminal domain-like| OP:NHOMO 1556 OP:NHOMOORG 928 OP:PATTERN 11-1--1122222221-111111----1-1-1---11111111-----------11-1111111--11 112131111111-121122-21112321222121113252122521322111423111111131333342111111113222111122222311111122322443341511111111111111122122222242211--111221111112111111111111112211211112111111111111112122222211212122212322221212331-2212221112211111111111111------2-----31-211111--1----221222--11-1111111111111--------------11---2221212243333323435133323331131-2242222322212223222333131211111111123332121211211111111112-3333353322113441232232221411122122332113333333323412212-----------------------------111112211113221222111133221111-1112121122111221112122221111111121111111111131-21211111131111344233322112121121111111111111111111111111111122211211112111112111111111111--21111--11121222311111111111-111111111111111111333321111322222222222222211111111112212222222221111---------1111111122121111111122222111112111111122111221221111111111-11111111111111111111111111111122332244--------111-----------1------1------2222224232211 11--1---311----11---11-1111---111----------111---1--1------1111-----------------------------1----------1----2-2121-211---23133242AU3-43412-13125--1-1231----1-111-11-1-4116--411121S1122366E9-64-1---11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 631 STR:RPRED 99.7 SQ:SECSTR ccccccccGGGcccccccHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHTcccTccEEEEccGGGHHHHHHHTTccccHHHHTcTTccccccccTTcTTcccccccTTHHHHHHHHHHHHHTcccccccEEEEEcHHHHHcHHHHHHHHHHHHTTcTTEEEEEEccEETTEEGGGTccccHHHHHHHHTcEEccTTTcHHHHHHHHHHHTTcTTccEEEEEEccTTTTcTTTTcGGGTcccccHHHHHHHHHHTTccTTccccccHHHHHHHHHHTHHHHHHHHHHHHHccTTGGGGcccccTTcccEEHHHHHHHHHHHHTTTcTTEEEEEcccHHHHTcGGccEETTccEEEccccHHHHHHHHHHHHHHcTTcEEEEEHHHHGGGHHHHHHHHHHTcccEEEEEcccGGGcTTcTTcccccHHHHHTcccccEEEccccHHHHHHHHHHHHHcccccEEEEccccEEcccTTccHHHHTTccEEEEccccccEEEEEcTTHHHHHHHHHHHHHHTTccEEEEEcccHHHHHTccHHHHccTTccEEEEccccHcGGGGGTccEEEcHHHGGGcTccEEEccccccccccHHHHHHHHTccHHHHHHHHHTTccHHHHHHH## DISOP:02AL 625-633| PSIPRED ccccccccHHHHHHccHHHHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHHHHHHHHcccccEEEEEcccHHHHHHHHHHHHHHHHHHHccccccccccccccccEEEccccHHHHHHHHHHHHHHHHHHccccEEEEEEEcccccHHHHHHHHHHHHHHcccEEEEEEcccccccccccccHHHHHHHHHccccEEEEEcHHHHHHHHHHcccHHHHHHHHHHHHHccccccccccHHcccccccccccccHHHHHHHHHHHHHccccEEEHHHHHHHccccHHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHcccEEEEccccccccHHHHHHHHccccEEEcccHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHHHHHccccEEEEEccccccccccccccccHHHHHHHHHcccEEEEEccHHHHHHHHHHHHHcccccEEEEEEccccccccccccccccccccEEEEEccccEEEEEEcHHHHHHHHHHHHHHHccccEEEEEcccccHHHHHHHHHHHHccccEEEEEcccccccHHHHHHHHHHHHccccccEEEEEEEccccccccHHHHHHHHcccHHHHHHHHHHHHHHHccccccc //