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Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : hemD
DDBJ      :hemD         uroporphyrinogen III cosynthase
Swiss-Prot:HEM4_BACSU   RecName: Full=Uroporphyrinogen-III synthase;         Short=UROS;         EC=4.2.1.75;AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing];AltName: Full=Uroporphyrinogen-III cosynthetase;

Homologs  Archaea  8/68 : Bacteria  147/915 : Eukaryota  0/199 : Viruses  0/175   --->[See Alignment]
c.113.1
:262 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:RPS:PDB   11->253 3d8tB PDBj 3e-11 19.4 %
:RPS:SCOP  28->249 1wd7A  c.113.1.1 * 5e-09 20.2 %
:HMM:SCOP  9->259 1wd7A_ c.113.1.1 * 2.8e-58 34.6 %
:RPS:PFM   64->249 PF02602 * HEM4 7e-13 32.2 %
:HMM:PFM   23->250 PF02602 * HEM4 4.8e-53 33.3 222/229  
:BLT:SWISS 1->262 HEM4_BACSU e-139 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB14774.1 GT:GENE hemD GT:PRODUCT uroporphyrinogen III cosynthase GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION complement(2875173..2875961) GB:FROM 2875173 GB:TO 2875961 GB:DIRECTION - GB:GENE hemD GB:PRODUCT uroporphyrinogen III cosynthase GB:FUNCTION 16.2: Construct biomass (Anabolism) GB:NOTE Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 12029044, 15802251, 2110138; Product type e: enzyme GB:PROTEIN_ID CAB14774.1 GB:DB_XREF GOA:P21248 InterPro:IPR003754 SubtiList:BG10343 UniProtKB/Swiss-Prot:P21248 GB:GENE:GENE hemD LENGTH 262 SQ:AASEQ MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEVKEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTACISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI GT:EXON 1|1-262:0| SW:ID HEM4_BACSU SW:DE RecName: Full=Uroporphyrinogen-III synthase; Short=UROS; EC=4.2.1.75;AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing];AltName: Full=Uroporphyrinogen-III cosynthetase; SW:GN Name=hemD; OrderedLocusNames=BSU28140; SW:KW Complete proteome; Lyase; Porphyrin biosynthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->262|HEM4_BACSU|e-139|100.0|262/262| GO:SWS:NREP 2 GO:SWS GO:0016829|"GO:lyase activity"|Lyase| GO:SWS GO:0006779|"GO:porphyrin biosynthetic process"|Porphyrin biosynthesis| SEG 190->204|vtftssstvhtfmhv| RP:PDB:NREP 1 RP:PDB:REP 11->253|3d8tB|3e-11|19.4|237/249| RP:PFM:NREP 1 RP:PFM:REP 64->249|PF02602|7e-13|32.2|180/228|HEM4| HM:PFM:NREP 1 HM:PFM:REP 23->250|PF02602|4.8e-53|33.3|222/229|HEM4| GO:PFM:NREP 2 GO:PFM GO:0004852|"GO:uroporphyrinogen-III synthase activity"|PF02602|IPR003754| GO:PFM GO:0033014|"GO:tetrapyrrole biosynthetic process"|PF02602|IPR003754| RP:SCP:NREP 1 RP:SCP:REP 28->249|1wd7A|5e-09|20.2|218/254|c.113.1.1| HM:SCP:REP 9->259|1wd7A_|2.8e-58|34.6|246/0|c.113.1.1|1/1|HemD-like| OP:NHOMO 156 OP:NHOMOORG 155 OP:PATTERN ----------------------------------111-1111------1------------------- 111-------------------------------------1--------111---------------------------1-11------------------------------------------11---1--1-1--------1-111-111-1----1-1-11111111--1-1-------11-------1111111111111111111111111111111---1111-11------------------------------------------------------------------------------------------11111111111111111111111111-----11121111-11111-1-11--1----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1111111-111111111111111------11-------------------------11-------------------------------------------------------------------------------------------------------------------------------------------1----------------------------------------------------------------------------------------------------------------------------------------------111 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 238 STR:RPRED 90.8 SQ:SECSTR ##########EEEEccccccHHHHHHHHHHTTcEEEEccccccccEEcTTHHHHHHHHTTcccEEEEccHHHHHHHHHHHHHTTcccHHTcEEEEccHHHHHHHHHTTc#####cccEEcccccGGGGGGccccccEEEEccccccHHHHHHHHHTTcEEEEEccEEccccHHHHHHHHHHHHTTcccEEEEccHHHHHHHHHHcccHHHHHHHTTcEEEEEcHHHHHHHHHTTccccEEccccHHHHHHHHH######### DISOP:02AL 1-3, 261-262| PSIPRED ccccccccccEEEEEccHHHHHHHHHHHHHccccEEEEccEEEEEcccHHHHHHHHHccccccEEEEEcHHHHHHHHHHHHHccccccccccEEEEcHHHHHHHHHccccEEEEcccccHHHHHHHHHHHcccccEEEEEEccccHHHHHHHHHHcccEEEEEEEEccccccccHHHHHHHHHHccccEEEEEcHHHHHHHHHHHcHHHHHHHHcccEEEEEcHHHHHHHHHccccEEccccccHHHHHHHHHHHHHccccc //