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Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : hprK
DDBJ      :hprK         serine/threonine protein kinase/phosphorylase
Swiss-Prot:HPRK_BACSU   RecName: Full=HPr kinase/phosphorylase;         Short=HPrK/P;         EC=2.7.11.-;         EC=2.7.4.-;AltName: Full=HPr(Ser) kinase/phosphorylase;AltName: Full=HPr kinase/phosphatase;

Homologs  Archaea  0/68 : Bacteria  326/915 : Eukaryota  2/199 : Viruses  0/175   --->[See Alignment]
c.91.1c.98.2
:310 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   6->299 1ko7A PDBj 8e-93 59.8 %
:RPS:SCOP  4->132 2iojA1  c.98.2.2 * 2e-19 15.4 %
:RPS:SCOP  134->304 1jb1A  c.91.1.2 * 2e-05 45.9 %
:HMM:SCOP  1->131 1knxA1 c.98.2.1 * 1.2e-39 45.4 %
:HMM:SCOP  132->300 1ko7A2 c.91.1.2 * 2.3e-45 39.6 %
:RPS:PFM   4->127 PF02603 * Hpr_kinase_N 5e-29 47.6 %
:RPS:PFM   133->284 PF07475 * Hpr_kinase_C 2e-55 72.8 %
:HMM:PFM   130->298 PF07475 * Hpr_kinase_C 2.9e-79 65.7 169/171  
:HMM:PFM   3->128 PF02603 * Hpr_kinase_N 5e-50 53.2 126/127  
:BLT:SWISS 1->310 HPRK_BACSU e-174 100.0 %

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB15505.1 GT:GENE hprK GT:PRODUCT serine/threonine protein kinase/phosphorylase GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION complement(3594242..3595174) GB:FROM 3594242 GB:TO 3595174 GB:DIRECTION - GB:GENE hprK GB:PRODUCT serine/threonine protein kinase/phosphorylase GB:FUNCTION 16.3: Control GB:NOTE Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 16267306; Product type e : enzyme GB:PROTEIN_ID CAB15505.1 GB:DB_XREF GOA:O34483 HSSP:1KO7 InterPro:IPR011126 SubtiList:BG14125 UniProtKB/Swiss-Prot:O34483 GB:GENE:GENE hprK LENGTH 310 SQ:AASEQ MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYFTYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDASEKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKSETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAGAVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIEVAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE GT:EXON 1|1-310:0| SW:ID HPRK_BACSU SW:DE RecName: Full=HPr kinase/phosphorylase; Short=HPrK/P; EC=2.7.11.-; EC=2.7.4.-;AltName: Full=HPr(Ser) kinase/phosphorylase;AltName: Full=HPr kinase/phosphatase; SW:GN Name=hprK; Synonyms=ptsK, yvoB; OrderedLocusNames=BSU35000; SW:KW Allosteric enzyme; ATP-binding; Carbohydrate metabolism;Complete proteome; Direct protein sequencing; Kinase; Magnesium;Metal-binding; Multifunctional enzyme; Nucleotide-binding;Serine/threonine-protein kinase; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->310|HPRK_BACSU|e-174|100.0|310/310| GO:SWS:NREP 8 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0005975|"GO:carbohydrate metabolic process"|Carbohydrate metabolism| GO:SWS GO:0016301|"GO:kinase activity"|Kinase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0004674|"GO:protein serine/threonine kinase activity"|Serine/threonine-protein kinase| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| BL:PDB:NREP 1 BL:PDB:REP 6->299|1ko7A|8e-93|59.8|281/285| RP:PFM:NREP 2 RP:PFM:REP 4->127|PF02603|5e-29|47.6|124/127|Hpr_kinase_N| RP:PFM:REP 133->284|PF07475|2e-55|72.8|151/157|Hpr_kinase_C| HM:PFM:NREP 2 HM:PFM:REP 130->298|PF07475|2.9e-79|65.7|169/171|Hpr_kinase_C| HM:PFM:REP 3->128|PF02603|5e-50|53.2|126/127|Hpr_kinase_N| GO:PFM:NREP 10 GO:PFM GO:0000155|"GO:two-component sensor activity"|PF02603|IPR011126| GO:PFM GO:0000160|"GO:two-component signal transduction system (phosphorelay)"|PF02603|IPR011126| GO:PFM GO:0004672|"GO:protein kinase activity"|PF02603|IPR011126| GO:PFM GO:0005524|"GO:ATP binding"|PF02603|IPR011126| GO:PFM GO:0006109|"GO:regulation of carbohydrate metabolic process"|PF02603|IPR011126| GO:PFM GO:0000155|"GO:two-component sensor activity"|PF07475|IPR011104| GO:PFM GO:0000160|"GO:two-component signal transduction system (phosphorelay)"|PF07475|IPR011104| GO:PFM GO:0004672|"GO:protein kinase activity"|PF07475|IPR011104| GO:PFM GO:0005524|"GO:ATP binding"|PF07475|IPR011104| GO:PFM GO:0006109|"GO:regulation of carbohydrate metabolic process"|PF07475|IPR011104| RP:SCP:NREP 2 RP:SCP:REP 4->132|2iojA1|2e-19|15.4|117/120|c.98.2.2| RP:SCP:REP 134->304|1jb1A|2e-05|45.9|159/161|c.91.1.2| HM:SCP:REP 1->131|1knxA1|1.2e-39|45.4|130/132|c.98.2.1|1/1|HPr kinase/phoshatase HprK N-terminal domain| HM:SCP:REP 132->300|1ko7A2|2.3e-45|39.6|169/0|c.91.1.2|1/1|PEP carboxykinase-like| OP:NHOMO 329 OP:NHOMOORG 328 OP:PATTERN -------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------1---------------111111111111------------------------------------------------------111111111111111111111111111111112111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111-1111111111111111111111111-11--------1---1111-1-1--------------------------------------------------------------------1-11111-----------1------------------------------------1--11111111111111111111111111111111111111111111111111111111111111111111111---------------1111111-11111111--------------------------11---------------------------------1-11---------------------------------------------------------------------------------------------11111-----------------------------------------------------------------------------11111111111111---1111111---------11----1-1-1-111---11111-111----------111 -------------1------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1---------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 310 STR:RPRED 100.0 SQ:SECSTR cccccHHHHHHHHTcEEEEcGGGTTcccccccEEccHHHHTTccTTccTTcEEEEcHHHHHHHHHccHHHHTTHHHHHccTTcccEEEcTTccccHHHHHHHHHTTccEEEccccHHHHHHHHHHHHHHHTcEEEEEEcEEEEETTEEEEEEEcTTccHHHHHHHHHHTTcEEEEccEEEEEEcccccEEEEccGGGTTEEEETTTEEEEHHHHHcGGGcccEEEccEEEEEEEccTTccccccccccEEEEETTEEEEEEEEEccccccHHHHHHHHHHHHHHHHTTccHHHHHHHHHHHHHHHHHTcc DISOP:02AL 1-2, 300-310| PSIPRED cccccHHHHHHHHcEEEEEcccccccEEEcccccccHHHHEEHHccccccEEEEEEHHHHHHHHcccHHHHHHHHHHHHcccccEEEEEccccccHHHHHHHHHccccEEEEcccHHHHHHHHHHHHHHHHccEEEEEEEEEEEccEEEEEEccccccHHHHHHHHHHHcccEEEccEEEEEEccccEEEEEccHHHcccEEEccccEEcHHHHHHHHHHccccEEEEEEEEEccccccccccccccccEEEEccccccEEEEEEcccccHHHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHcccccc //