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Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : murE
DDBJ      :murE         UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase
Swiss-Prot:MURE_BACSU   RecName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase;         EC=6.3.2.13;AltName: Full=UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase;AltName: Full=Meso-diaminopimelate-adding enzyme;AltName: Full=Meso-A2pm-adding enzyme;AltName: Full=UDP-N-acetylmuramyl-tripeptide synthetase;AltName: Full=UDP-MurNAc-tripeptide synthetase;

Homologs  Archaea  4/68 : Bacteria  872/915 : Eukaryota  18/199 : Viruses  0/175   --->[See Alignment]
c.59.1c.72.2c.98.1
:494 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   29->484 1e8cB PDBj 4e-56 35.2 %
:RPS:PDB   21->491 1e8cB PDBj 1e-93 36.2 %
:RPS:SCOP  21->97 1gg4A3  c.98.1.1 * 6e-25 33.8 %
:RPS:SCOP  98->330 1e8cA3  c.72.2.1 * 4e-56 31.4 %
:RPS:SCOP  333->489 1e8cA2  c.59.1.1 * 6e-33 46.5 %
:HMM:SCOP  1->98 1gg4A3 c.98.1.1 * 1.3e-27 42.9 %
:HMM:SCOP  98->332 1e8cA3 c.72.2.1 * 1.5e-77 42.5 %
:HMM:SCOP  333->491 1e8cA2 c.59.1.1 * 2.7e-48 45.9 %
:RPS:PFM   27->88 PF01225 * Mur_ligase 2e-09 46.8 %
:RPS:PFM   107->311 PF08245 * Mur_ligase_M 5e-27 41.3 %
:RPS:PFM   335->408 PF02875 * Mur_ligase_C 8e-16 47.3 %
:HMM:PFM   107->313 PF08245 * Mur_ligase_M 3.4e-55 42.5 186/188  
:HMM:PFM   333->418 PF02875 * Mur_ligase_C 5.4e-28 38.4 86/91  
:HMM:PFM   23->95 PF01225 * Mur_ligase 3.1e-24 45.2 73/76  
:BLT:SWISS 13->494 MURE_BACSU 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB13391.1 GT:GENE murE GT:PRODUCT UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION 1586330..1587814 GB:FROM 1586330 GB:TO 1587814 GB:DIRECTION + GB:GENE murE GB:PRODUCT UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase GB:FUNCTION 16.13: Shape GB:NOTE Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; PubMedId: 10520745, 12682299; Product type e: enzyme GB:PROTEIN_ID CAB13391.1 GB:DB_XREF GOA:Q03523 HSSP:1E8C InterPro:IPR005761 SubtiList:BG10223 UniProtKB/Swiss-Prot:Q03523 GB:GENE:GENE murE LENGTH 494 SQ:AASEQ MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVKGYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKLQLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQKTFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAKSLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISITAQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVRGRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKMAKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKKGDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS GT:EXON 1|1-494:0| SW:ID MURE_BACSU SW:DE RecName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase; EC=6.3.2.13;AltName: Full=UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase;AltName: Full=Meso-diaminopimelate-adding enzyme;AltName: Full=Meso-A2pm-adding enzyme;AltName: Full=UDP-N-acetylmuramyl-tripeptide synthetase;AltName: Full=UDP-MurNAc-tripeptide synthetase; SW:GN Name=murE; OrderedLocusNames=BSU15180; SW:KW ATP-binding; Cell cycle; Cell division; Cell shape;Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;Ligase; Nucleotide-binding; Peptidoglycan synthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 13->494|MURE_BACSU|0.0|100.0|482/494| GO:SWS:NREP 9 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0007049|"GO:cell cycle"|Cell cycle| GO:SWS GO:0051301|"GO:cell division"|Cell division| GO:SWS GO:0008360|"GO:regulation of cell shape"|Cell shape| GO:SWS GO:0007047|"GO:cellular cell wall organization"|Cell wall biogenesis/degradation| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0009252|"GO:peptidoglycan biosynthetic process"|Peptidoglycan synthesis| SEG 2->12|kltklltyltt| BL:PDB:NREP 1 BL:PDB:REP 29->484|1e8cB|4e-56|35.2|440/484| RP:PDB:NREP 1 RP:PDB:REP 21->491|1e8cB|1e-93|36.2|453/484| RP:PFM:NREP 3 RP:PFM:REP 27->88|PF01225|2e-09|46.8|62/76|Mur_ligase| RP:PFM:REP 107->311|PF08245|5e-27|41.3|184/187|Mur_ligase_M| RP:PFM:REP 335->408|PF02875|8e-16|47.3|74/84|Mur_ligase_C| HM:PFM:NREP 3 HM:PFM:REP 107->313|PF08245|3.4e-55|42.5|186/188|Mur_ligase_M| HM:PFM:REP 333->418|PF02875|5.4e-28|38.4|86/91|Mur_ligase_C| HM:PFM:REP 23->95|PF01225|3.1e-24|45.2|73/76|Mur_ligase| GO:PFM:NREP 7 GO:PFM GO:0005524|"GO:ATP binding"|PF01225|IPR000713| GO:PFM GO:0009058|"GO:biosynthetic process"|PF01225|IPR000713| GO:PFM GO:0005524|"GO:ATP binding"|PF08245|IPR013221| GO:PFM GO:0009058|"GO:biosynthetic process"|PF08245|IPR013221| GO:PFM GO:0005524|"GO:ATP binding"|PF02875|IPR004101| GO:PFM GO:0009058|"GO:biosynthetic process"|PF02875|IPR004101| GO:PFM GO:0016874|"GO:ligase activity"|PF02875|IPR004101| RP:SCP:NREP 3 RP:SCP:REP 21->97|1gg4A3|6e-25|33.8|77/98|c.98.1.1| RP:SCP:REP 98->330|1e8cA3|4e-56|31.4|226/234|c.72.2.1| RP:SCP:REP 333->489|1e8cA2|6e-33|46.5|157/160|c.59.1.1| HM:SCP:REP 1->98|1gg4A3|1.3e-27|42.9|98/98|c.98.1.1|1/1|MurE/MurF N-terminal domain| HM:SCP:REP 98->332|1e8cA3|1.5e-77|42.5|228/0|c.72.2.1|1/1|MurD-like peptide ligases, catalytic domain| HM:SCP:REP 333->491|1e8cA2|2.7e-48|45.9|159/0|c.59.1.1|1/1|MurD-like peptide ligases, peptide-binding domain| OP:NHOMO 2176 OP:NHOMOORG 894 OP:PATTERN --------------------------------211---------------------------1----- 1433321122221111111-11111111111211111122211222122112212111222223112213223332221232233322221233114--534333313231111111111111121221324334411122---3233323333222222322313311132222223232332111132253344747467447644544333465533354543333432334444444444444444443334311333333322113344333224444222233222222222224444443444444244222444427644333333343453442575144433432454433547326644132241422223333222222122212144344434443-111111112323333333324322114423322222322222222221112132222------11224444444444444424313132432221111111122221122222222112243333322111224334323422353344454443445132442242322231213232332322221212321111111111111111121111111332222225332232222312222232422322-42312-3-21222122222222222222-22222222222222222221112222211111111111111112222222222222222222222222322222444312121222323211123333444444421222222222222222222226655465562222222222222222233333333222243221111111111111111--------------------------2631122232213 -------------------------11---------------------------------------------------------------------------------------------------------------------------------------------------1-1119111114122-13------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 472 STR:RPRED 95.5 SQ:SECSTR ###################ccccccccEccGGGccTTcEEEEcccccccGGGGHHHHHHTTccEEEEEcEEETTEEEEEETTHHHHHHHHHHHHTTcGGGccEEEEEEccccHHHHHHHHHHHHHHTTccEcTTccEETTccTcTcccccccccHHHHHHHHHHHHHTTTccEEEEccHHHHHTTTTTTccccEEEEcccccccHHHHccHHHHHHHHHHHcTGGGcccTcccccEEEEETTcHHHHHHHTTcTTcEEEEcccccEEEEEEEEEEccccEEEEEEEETTccEEEEEcccHHHHHHHHHHHHHHHHTTccHHHHHHHGGGccccTTcEEEccTTcTcEEEEEccccHHHHHHHHHHHHHTccccEEEEEccccccccTHHHHHHHHHHHHccEEEEccccccTccHHHHHHHHHTTccTTccEcEccHHHHHHHHHHHccTTcEEEEEccTTccEEEETTEEEEccHHHHHHHHHTcccTTc### DISOP:02AL 485-494| PSIPRED ccHHHHHHHcccEEEEccccccEEEEEEEcccccccccEEEEEccccccHHHHHHHHHHcccEEEEEcccccccccEEEEccHHHHHHHHHHHHHHHHHcccEEEEEEcccccHHHHHHHHHHHHHccccEEEEccccccccccEEEcccccccHHHHHHHHHHHHccccEEEEEEcccccccHHHHccccccEEEEEcccHHHHHHcccHHHHHHHHHHHHHccccccccccccEEEEEcccHHHHHHHHHHcccEEEEEEccccEEEEEEEEEccccEEEEEEEcccEEEEEEccccHHHHHHHHHHHHHHHHccccHHHHHHHHHHcccccccEEEEEccccEEEEEcccccHHHHHHHHHHHHHcccccEEEEEEccccccHHHHHHHHHHHHHHccEEEEEccccccccHHHHHHHHHHHccccEEEEEccHHHHHHHHHHHcccccEEEEEcccccHHHHHccccccccHHHHHHHHHHHHccccccc //