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Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : nrdE
DDBJ      :nrdE         ribonucleoside-diphosphate reductase (major subunit)
Swiss-Prot:RIR1_BACSU   RecName: Full=Ribonucleoside-diphosphate reductase subunit alpha;         EC=1.17.4.1;AltName: Full=Ribonucleotide reductase large subunit;

Homologs  Archaea  49/68 : Bacteria  790/915 : Eukaryota  192/199 : Viruses  17/175   --->[See Alignment]
a.98.1c.7.1
:700 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   31->688 1peuA PDBj e-173 45.4 %
:RPS:PDB   7->689 2bq1F PDBj e-163 43.9 %
:RPS:SCOP  7->166 1pemA1  a.98.1.1 * 3e-39 35.0 %
:RPS:SCOP  167->689 1pemA2  c.7.1.2 * e-133 46.7 %
:HMM:SCOP  6->166 1peqA1 a.98.1.1 * 8.9e-51 43.5 %
:HMM:SCOP  167->690 1peqA2 c.7.1.2 * 3e-165 36.4 %
:RPS:PFM   12->89 PF08343 * RNR_N 2e-15 50.0 %
:RPS:PFM   94->164 PF00317 * Ribonuc_red_lgN 9e-08 40.0 %
:RPS:PFM   169->684 PF02867 * Ribonuc_red_lgC 1e-81 38.3 %
:HMM:PFM   167->684 PF02867 * Ribonuc_red_lgC 3e-151 38.1 491/533  
:HMM:PFM   9->89 PF08343 * RNR_N 1.6e-32 59.3 81/82  
:HMM:PFM   91->163 PF00317 * Ribonuc_red_lgN 1.4e-19 29.2 72/83  
:BLT:SWISS 1->700 RIR1_BACSU 0.0 100.0 %
:PROS 558->580|PS00089|RIBORED_LARGE
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB13622.1 GT:GENE nrdE GT:PRODUCT ribonucleoside-diphosphate reductase (major subunit) GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION 1868969..1871071 GB:FROM 1868969 GB:TO 1871071 GB:DIRECTION + GB:GENE nrdE GB:PRODUCT ribonucleoside-diphosphate reductase (major subunit) GB:FUNCTION 16.2: Construct biomass (Anabolism) GB:NOTE Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719; Product type e: enzyme GB:PROTEIN_ID CAB13622.1 GB:DB_XREF GOA:P50620 InterPro:IPR013554 SubtiList:BG11404 UniProtKB/Swiss-Prot:P50620 GB:GENE:GENE nrdE LENGTH 700 SQ:AASEQ MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQNTVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYNDYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAGRKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVENATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVKTLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKKEKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVSSYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPAVRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAKEKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVAEHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWFFYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTIYYARTKDTGQDSCLSCVV GT:EXON 1|1-700:0| SW:ID RIR1_BACSU SW:DE RecName: Full=Ribonucleoside-diphosphate reductase subunit alpha; EC=1.17.4.1;AltName: Full=Ribonucleotide reductase large subunit; SW:GN Name=nrdE; Synonyms=nrdA; OrderedLocusNames=BSU17380; SW:KW Allosteric enzyme; ATP-binding; Complete proteome; Disulfide bond;DNA replication; Nucleotide-binding; Oxidoreductase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->700|RIR1_BACSU|0.0|100.0|700/700| GO:SWS:NREP 5 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0006260|"GO:DNA replication"|DNA replication| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0016491|"GO:oxidoreductase activity"|Oxidoreductase| GO:SWS GO:0055114|"GO:oxidation reduction"|Oxidoreductase| PROS 558->580|PS00089|RIBORED_LARGE|PDOC00084| SEG 19->30|qkdgkfqfdkdk| BL:PDB:NREP 1 BL:PDB:REP 31->688|1peuA|e-173|45.4|656/692| RP:PDB:NREP 1 RP:PDB:REP 7->689|2bq1F|e-163|43.9|676/684| RP:PFM:NREP 3 RP:PFM:REP 12->89|PF08343|2e-15|50.0|78/81|RNR_N| RP:PFM:REP 94->164|PF00317|9e-08|40.0|70/80|Ribonuc_red_lgN| RP:PFM:REP 169->684|PF02867|1e-81|38.3|483/506|Ribonuc_red_lgC| HM:PFM:NREP 3 HM:PFM:REP 167->684|PF02867|3e-151|38.1|491/533|Ribonuc_red_lgC| HM:PFM:REP 9->89|PF08343|1.6e-32|59.3|81/82|RNR_N| HM:PFM:REP 91->163|PF00317|1.4e-19|29.2|72/83|Ribonuc_red_lgN| GO:PFM:NREP 12 GO:PFM GO:0004748|"GO:ribonucleoside-diphosphate reductase activity"|PF08343|IPR013554| GO:PFM GO:0005515|"GO:protein binding"|PF08343|IPR013554| GO:PFM GO:0005971|"GO:ribonucleoside-diphosphate reductase complex"|PF08343|IPR013554| GO:PFM GO:0006260|"GO:DNA replication"|PF08343|IPR013554| GO:PFM GO:0055114|"GO:oxidation reduction"|PF08343|IPR013554| GO:PFM GO:0004748|"GO:ribonucleoside-diphosphate reductase activity"|PF00317|IPR013509| GO:PFM GO:0005524|"GO:ATP binding"|PF00317|IPR013509| GO:PFM GO:0006260|"GO:DNA replication"|PF00317|IPR013509| GO:PFM GO:0055114|"GO:oxidation reduction"|PF00317|IPR013509| GO:PFM GO:0004748|"GO:ribonucleoside-diphosphate reductase activity"|PF02867|IPR000788| GO:PFM GO:0005971|"GO:ribonucleoside-diphosphate reductase complex"|PF02867|IPR000788| GO:PFM GO:0006260|"GO:DNA replication"|PF02867|IPR000788| RP:SCP:NREP 2 RP:SCP:REP 7->166|1pemA1|3e-39|35.0|160/162|a.98.1.1| RP:SCP:REP 167->689|1pemA2|e-133|46.7|516/520|c.7.1.2| HM:SCP:REP 6->166|1peqA1|8.9e-51|43.5|161/162|a.98.1.1|1/1|R1 subunit of ribonucleotide reductase, N-terminal domain| HM:SCP:REP 167->690|1peqA2|3e-165|36.4|522/525|c.7.1.2|1/1|PFL-like glycyl radical enzymes| OP:NHOMO 1365 OP:NHOMOORG 1048 OP:PATTERN 11---11111111111-11111111111-222--1--------1111-1-111-11111111111-11 11--221111111111122-211112222221222211112--1111211111211111122122122222-111111--1-11122112111-111--21212221221111111111111111---1-------111--32312111-111----------11-------------------111111-111112221122222112111112212121111111111112111111111111111113111-1-11-2-1-11111111111111122221221111111111111122222222222221111111111---1111-111111112--1111111112---111--1-1111111-111231211211111-11--111-1---11111111111---------2131111111-111---1111--21111-2-11111111211111221111111111111111111111111111111111111111111111111111122111111122222211211122222133121111222221111111111111211-111111-1111111121211112111211111111111111111111111111112211211111111111111111111111111-1121111-11122121222222222222-222222222222222222222222222222222222213222222222222112223222332221111111111111112212221211111-111111111111112111211111111111111111111111121121111111211221111111111111111---------1--1-11111111---11-11111-11111---1-111111111-1 1111111-311-1111111111111111121111111111111111111111111111111122222212122222212222222211-111111111111114231131123222111111111-111291-112111111111111-11112111111643111-111111221111H1111121241112241115 ---1-1-1--------1--1-1-11------------1-1--------------------------------------------------------------------------------------1---------------------------------1---1-----1111- STR:NPRED 687 STR:RPRED 98.1 SQ:SECSTR ######ccHHHHHHGGGcccccccccTHHHHHHHHHHHHTTGGGccccccHHHHHHHHHHTTcccHHHHTTccHHHHHHHHHHHHHTccccccHHHHHHHHHHTccccTTcccccccHHHHHHHHHHHHHTTcHHHHHHHHHHHHTTcEEEcHHHHTTcccccccccccEEEEEccccHHHHHHHHHHHHHHHTTTcEEEEEcTTcccTTcccTTccccccccHHHHHHHHHHHHHcTTTTcccccEEEEEETTcTTHHHHTTccccccccTTcccccEEEEEccTHHHHHHHTccEEEEEcHHHHHHHHcccGGGccccTTHHHHHHcccccEEEEEHHHHHHHHHHHHHHHcccEEEcHHHHHHTcHcccccccccccTTccccccccccEEcTTccEEEccccEEccEEEEcHHHHHHcccHHHHHHHHHHHHHHHHTTccccccHHHHHHHHHHcccEEccccHHHHHHHTTccTTcHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTcccccGGGcHHHHTTTTTTTcccccccccHHHHHHHHTcccccTTHHHHHHHHHHHHcccccccccccccccGGGTTTcccccccccccEEEEccTTTcEEEEcTTcccccGGGcccHHHHcHHHHHHHHHHHHHHccccccccEEEcTTccHHHHHHHHHHHHHHTccEEccEEEcccHHH####### PSIPRED ccccHHHHHHHHHHHHHHHccccccHHHHHHHHHHHHHHHccccccccccHHHHHHHHHHcccccHHHHHHccHHHHHHHHHHHcccccccccHHHHHHHHHHHHHcccccccEEccHHHHHHHHHHHHccccHHHHHHHHHHHHccccEEccccccccccccccEEEEEEEEcccccHHHHHHHHHHHHHHHHHcccEEEEccccccccccccccccccccHHHHHHHHHHHHHHHHHcccccccEEEEEEccHHHHHHHHHHccccccccccHHHHHHHccccHHHHHHHHccccEEEEccccccccccccccccHHHHHHHHHHHccccEEEEEEHHHHHHHHHHHHHHHcccEEEEHHHHHHcccccccccEEEEccccccccccccccccccccccHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHHHHHHHccccHHHHHHHHHHHcccEEEEccHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccHHccccHHccccccccccHHHHHHcccccccccHHHHHHHHHHHHHHccccEEEEEEcccHHHHHHHccccccccccccEEEEEEccccEEEccccHHHHHHHHHccHHcccHHHHHHHHHHHHHHHHHHEEEEEEccccccHHHHHHHHHHHHHccccEEEEEccccccccccccccc //