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Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : pksJ
DDBJ      :pksJ         polyketide synthase of type I
Swiss-Prot:PKSJ_BACSU   RecName: Full=Polyketide synthase pksJ;         Short=PKS;

Homologs  Archaea  47/68 : Bacteria  875/915 : Eukaryota  195/199 : Viruses  0/175   --->[See Alignment]
a.121.1a.28.1b.178.1c.1.19c.2.1c.43.1c.95.1d.129.7e.23.1
:5043 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   61->663 2vsqA PDBj 4e-25 23.1 %
:BLT:PDB   696->1725 2vsqA PDBj e-125 31.9 %
:BLT:PDB   1761->2186 2qo3B PDBj 1e-56 32.3 %
:BLT:PDB   2314->2351 2hg4F PDBj 1e-04 39.5 %
:BLT:PDB   2391->2623 3el6A PDBj 2e-10 27.1 %
:BLT:PDB   2851->3047 1q7bA PDBj 3e-12 26.9 %
:BLT:PDB   3340->3797 2qo3B PDBj 2e-77 38.1 %
:BLT:PDB   4196->4364 2vz9B PDBj 4e-11 33.5 %
:BLT:PDB   4461->4529 2afdA PDBj 3e-08 33.3 %
:BLT:PDB   4588->5006 2qo3B PDBj 5e-47 28.9 %
:RPS:PDB   30->561 3e7wA PDBj 7e-43 15.7 %
:RPS:PDB   592->666 3ce7A PDBj 4e-09 7.9 %
:RPS:PDB   685->1112 2e1tA PDBj 6e-54 9.2 %
:RPS:PDB   1135->1645 1amuB PDBj 4e-81 40.4 %
:RPS:PDB   1666->1738 2cq8A PDBj 4e-12 24.7 %
:RPS:PDB   1763->2188 2bz4D PDBj 2e-75 19.7 %
:RPS:PDB   2164->2289 3c5oD PDBj 5e-19 14.3 %
:RPS:PDB   2315->2359 1cjaA PDBj 1e-04 15.6 %
:RPS:PDB   2878->3013 2e6gI PDBj 5e-22 17.1 %
:RPS:PDB   3113->3187 1af8A PDBj 5e-11 13.3 %
:RPS:PDB   3213->3282 2cgqA PDBj 5e-09 12.9 %
:RPS:PDB   3334->3778 2c9hA PDBj 3e-93 22.8 %
:RPS:PDB   3750->3866 3c5oA PDBj 5e-22 15.5 %
:RPS:PDB   3885->3953 1cjaA PDBj 3e-05 10.1 %
:RPS:PDB   4231->4398 2ddxA PDBj 3e-13 6.9 %
:RPS:PDB   4462->4532 2afdA PDBj 6e-09 33.8 %
:RPS:PDB   4589->4995 3e60A PDBj 8e-63 19.8 %
:RPS:SCOP  30->555 1md9A  e.23.1.1 * 2e-48 19.7 %
:RPS:SCOP  607->719 1j3mA  d.129.7.1 * 5e-11 7.1 %
:RPS:SCOP  696->872 1l5aA1  c.43.1.2 * 3e-30 18.5 %
:RPS:SCOP  878->1136 1l5aA2  c.43.1.2 * 2e-43 14.0 %
:RPS:SCOP  1142->1642 1md9A  e.23.1.1 * 1e-87 21.5 %
:RPS:SCOP  1673->2268 1e1cA1  c.1.19.1 * 1e-80 8.5 %
:RPS:SCOP  2314->2459 2h1tA1  b.178.1.1 * 2e-19 7.1 %
:RPS:SCOP  2845->3057 2fr0A1  c.2.1.2 * 3e-18 23.3 %
:RPS:SCOP  3113->3187 1af8A  a.28.1.1 * 7e-12 13.3 %
:RPS:SCOP  3230->3863 1e1cA1  c.1.19.1 * 1e-96 9.7 %
:RPS:SCOP  3890->3956 2h1tA1  b.178.1.1 * 4e-07 4.1 %
:RPS:SCOP  3966->4156 2fr0A2  c.2.1.2 * 1e-10 16.0 %
:RPS:SCOP  4188->4364 2fr0A1  c.2.1.2 * 3e-10 25.6 %
:RPS:SCOP  4335->4401 2g7gA2  a.121.1.1 * 8e-10 10.3 %
:RPS:SCOP  4489->5016 1e1cA1  c.1.19.1 * 3e-54 8.4 %
:HMM:SCOP  9->561 1pg4A_ e.23.1.1 * 2.7e-106 28.4 %
:HMM:SCOP  592->666 1klpA_ a.28.1.1 * 2.2e-14 30.7 %
:HMM:SCOP  696->885 1l5aA1 c.43.1.2 * 4.6e-33 32.2 %
:HMM:SCOP  874->1150 1l5aA2 c.43.1.2 * 2.4e-46 28.1 %
:HMM:SCOP  1118->1668 1pg4A_ e.23.1.1 * 2.2e-169 37.1 %
:HMM:SCOP  1652->1777 1klpA_ a.28.1.1 * 2.1e-19 29.5 %
:HMM:SCOP  1752->2189 1tedA_ c.95.1.2 * 4.5e-73 36.2 %
:HMM:SCOP  2843->3091 1gz6A_ c.2.1.2 * 5.1e-39 28.5 %
:HMM:SCOP  3108->3202 1nq4A_ a.28.1.1 * 4.5e-14 27.2 %
:HMM:SCOP  3207->3356 1klpA_ a.28.1.1 * 7.5e-16 33.3 %
:HMM:SCOP  3332->3779 1tedA_ c.95.1.2 * 1.1e-90 40.6 %
:HMM:SCOP  3966->4156 2fr1A2 c.2.1.2 * 8.8e-11 21.3 %
:HMM:SCOP  4170->4405 1zbqA1 c.2.1.2 * 1.5e-30 23.4 %
:HMM:SCOP  4461->4605 1klpA_ a.28.1.1 * 5e-15 27.3 %
:HMM:SCOP  4581->4995 1tedA_ c.95.1.2 * 3.8e-68 36.4 %
:RPS:PFM   71->476 PF00501 * AMP-binding 5e-37 30.1 %
:RPS:PFM   605->663 PF00550 * PP-binding 2e-04 23.7 %
:RPS:PFM   695->989 PF00668 * Condensation 3e-41 30.6 %
:RPS:PFM   1181->1575 PF00501 * AMP-binding 4e-50 35.5 %
:RPS:PFM   1666->1725 PF00550 * PP-binding 6e-08 43.3 %
:RPS:PFM   1763->1997 PF00109 * ketoacyl-synt 5e-36 39.1 %
:RPS:PFM   2019->2136 PF02801 * Ketoacyl-synt_C 2e-22 43.2 %
:RPS:PFM   2850->3036 PF08659 * KR 3e-37 44.2 %
:RPS:PFM   3118->3184 PF00550 * PP-binding 5e-05 29.9 %
:RPS:PFM   3216->3282 PF00550 * PP-binding 6e-05 28.4 %
:RPS:PFM   3342->3589 PF00109 * ketoacyl-synt 1e-60 50.4 %
:RPS:PFM   3599->3722 PF02801 * Ketoacyl-synt_C 7e-27 53.5 %
:RPS:PFM   3814->3909 PF09789 * DUF2353 6e-04 30.9 %
:RPS:PFM   4188->4369 PF08659 * KR 4e-20 35.5 %
:RPS:PFM   4471->4532 PF00550 * PP-binding 8e-05 29.0 %
:RPS:PFM   4591->4802 PF00109 * ketoacyl-synt 4e-31 35.7 %
:RPS:PFM   4830->4943 PF02801 * Ketoacyl-synt_C 5e-20 41.7 %
:HMM:PFM   1761->2010 PF00109 * ketoacyl-synt 1.1e-65 38.5 247/253  
:HMM:PFM   3340->3589 PF00109 * ketoacyl-synt 1.5e-89 50.2 247/253  
:HMM:PFM   4589->4821 PF00109 * ketoacyl-synt 2.7e-62 42.2 232/253  
:HMM:PFM   61->479 PF00501 * AMP-binding 8e-91 32.5 397/418  
:HMM:PFM   1181->1578 PF00501 * AMP-binding 3e-122 39.3 394/418  
:HMM:PFM   2018->2136 PF02801 * Ketoacyl-synt_C 4.3e-41 45.8 118/119  
:HMM:PFM   3597->3724 PF02801 * Ketoacyl-synt_C 2e-44 51.7 118/119  
:HMM:PFM   4829->4943 PF02801 * Ketoacyl-synt_C 3e-32 40.9 115/119  
:HMM:PFM   2850->3035 PF08659 * KR 7.3e-64 46.4 179/181  
:HMM:PFM   4174->4369 PF08659 * KR 6.7e-46 38.4 177/181  
:HMM:PFM   692->988 PF00668 * Condensation 9.5e-78 29.0 293/301  
:HMM:PFM   599->663 PF00550 * PP-binding 1.7e-12 26.2 65/67  
:HMM:PFM   1662->1725 PF00550 * PP-binding 2.4e-18 37.5 64/67  
:HMM:PFM   3119->3184 PF00550 * PP-binding 1.3e-16 30.3 66/67  
:HMM:PFM   3218->3282 PF00550 * PP-binding 7.5e-16 33.8 65/67  
:HMM:PFM   4467->4532 PF00550 * PP-binding 3.9e-12 22.7 66/67  
:BLT:SWISS 1->5043 PKSJ_BACSU 0.0 100.0 %
:PROS 622->637|PS00012|PHOSPHOPANTETHEINE
:PROS 1684->1699|PS00012|PHOSPHOPANTETHEINE
:PROS 4491->4506|PS00012|PHOSPHOPANTETHEINE
:PROS 192->203|PS00455|AMP_BINDING
:PROS 1304->1315|PS00455|AMP_BINDING
:PROS 3502->3518|PS00606|B_KETOACYL_SYNTHASE
:PROS 4734->4750|PS00606|B_KETOACYL_SYNTHASE
:TM
:REPEAT 3|1756->2209|3335->3794|4584->5014
:REPEAT 3|3116->3203|3214->3302|4464->4536
:REPEAT 2|2210->2355|3805->3952
:REPEAT 2|2881->3115|4219->4463
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB13589.3 GT:GENE pksJ GT:PRODUCT polyketide synthase of type I GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION 1792806..1807937 GB:FROM 1792806 GB:TO 1807937 GB:DIRECTION + GB:GENE pksJ GB:PRODUCT polyketide synthase of type I GB:FUNCTION 16.5: Explore 16.8: Protect GB:NOTE Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; PubMedId: 16460000, 16707694; Product type e: enzyme GB:PROTEIN_ID CAB13589.3 GB:DB_XREF GOA:P40806 HSSP:1AMU InterPro:IPR016038 SubtiList:BG10929 UniProtKB/Swiss-Prot:P40806 GB:GENE:GENE pksJ LENGTH 5043 SQ:AASEQ MRNNDNIRILTNPSVSHGEPLHISEKQPATIPEVLYRTATELGDTKGIIYLQPDGTEVYQSYRRLWDDGLRIAKGLRQSGLKAKQSVILQLGDNSQLLPAFWGCVLTGVVPAPLAVPPTYAESSSGTQKLKDAWTLLDKPAVITDRGMHQEMLDWAKEQGLEGFRAIIVEDLLSAEADTDWHQSSPEDLALLLLTSGSTGTPKAVMLNHRNIMSMVKGIIQMQGFTREDITFNWMPFDHVGGIGMLHLRDVYLGCQEINVSSETILMEPLKWLDWIDHYRASVTWAPNFAFGLVTDFAEEIKDKKWDLSSMRYMLNGGEAMVAKVGRRILELLEPHGLPADAIRPAWGMSETSSGVIFSHEFTRAGTSDDDHFVEIGSPIPGFSMRIVNDHNELVEEGEIGRFQVSGLSVTSGYYQRPDLNESVFTEDGWFETGDLGFLRNGRLTITGRTKDAIIINGINYYSHAIESAVEELPEIETSYTAACAVRLGQNSTDQLAIFFVTSAKLNDEQMSQLLRNIQSHVSQVIGVTPEYLLPVQKEEIPKTAIGKIQRTQLKTSFENGEFDHLLHKPNRMNDAVQDEGIQQADQVKRVREEIQKHLLTCLTEELHVSHDWVEPNANIQSLGVNSIKMMKLIRSIEKNYHIKLTAREIHQYPTIERLASYLSEHEDLSSLSADKKGTDTYKTEPERSQATFQPLSEVQKGLWTLQKMSPEKSAYHVPLCFKFSSGLHHETFQQAFGLVLNQHPILKHVIQEKDGVPFLKNEPALSIEIKTENISSLKESDIPAFLRKKVKEPYVKENSPLVRVMSFSRSEQEHFLLVVIHHLIFDGVSSVTFIRSLFDTYQLLLKGQQPEKAVSPAIYHDFAAWEKNMLAGKDGVKHRTYWQKQLSGTLPNLQLPNVSASSVDSQFREDTYTRRLSSGFMNQVRTFAKEHSVNVTTVFLSCYMMLLGRYTGQKEQIVGMPAMVRPEERFDDAIGHFLNMLPIRSELNPADTFSSFISKLQLTILDGLDHAAYPFPKMVRDLNIPRSQAGSPVFQTAFFYQNFLQSGSYQSLLSRYADFFSVDFVEYIHQEGEYELVFELWETEEKMELNIKYNTGLFDAASISAMFDHFVYVTEQAMLNPSQPLKEYSLLPEAEKQMILKTWNATGKTYPYITFHELFEQQAKKTPDRAAVSYEGQTLTYRELDEKSTQLAIYLQAHGVGPDRLAGIYVDRSLDMLVGLLAILKAGGAYVPLDPSYPAERLEYMLEDSEVFITLTTSELVNTLSWNGVTTALLDQDWDEIAQTASDRKVLTRTVTPENLAYVIYTSGSTGKPKGVMIPHKALTNFLVSMGETPGLTAEDKMLAVTTYCFDIAALELFLPLIKGAHCYICQTEHTKDVEKLKRDIRAIKPTVMQATPATWKMLFYSGWENEESVKILCGGEALPETLKRYFLDTGSEAWNMFGPTETTIWSAVQRINVECSHATIGRPIANTQIYITDSQLAPVPAGVPGELCIAGDGVAKGYYKKEELTDSRFIDNPFEPGSKLYRTGDMARWLTGGRIEYIGRIDNQVKIRGFRIELGDIESRLSEHPGILECVVVADMDNLAAYYTAKHANASLTARELRHFVKNALPAYMVPSYFIQLDHMPLTPNGKIDRNSLKNIDLSGEQLKQRQTSPKNIQDTVFTIWQEVLKTSDIEWDDGFFDVGGDSLLAVTVADRIKHELSCEFSVTDLFEYSTIKNISQYITEQRMGDASDHIPTDPAAHIEDQSTEMSDLPDYYDDSVAIIGISCEFPGAKNHDEFWENLRDGKESIAFFNKEELQRFGISKEIAENADYVPAKASIDGKDRFDPSFFQISPKDAEFMDPQLRMLLTHSWKAIEDAGYAARQIPQTSVFMSASNNSYRALLPSDTTESLETPDGYVSWVLAQSGTIPTMISHKLGLRGPSYFVHANCSSSLIGLHSAYKSLLSGESDYALVGGATLHTESNIGYVHQPGLNFSSDGHIKAFDASADGMIGGEGVAVVLLKKAADAVKDGDHIYALLRGIGVNNDGADKVGFYAPSVKGQADVVQQVMNQTKVQPESICYVEAHGTGTKLGDPIELAALTNVYRQYTNKTQFCGIGSVKTNIGHLDTAAGLAGCIKVVMSLYHQELAPSVNYKEPNPNTDLASSPFYVVDQKKTLSREIKTHRAALSSFGLGGTNTHAIFEQFKRDSDKGKIDGTCIVPISAKNKERLQEYAEDILAYLERRGFENSQLPDFAYTLQVGREAMEHRVVFIADHVNELKQRLTDFINGNTAIEGCFQGSKHNAREVSWLTEDEDSAELIRKWMAKGKVNKLAEMWSKGAHIDWMQLYKGERPNRMSLPTYPFAKERYWPSQDDRKPVAQISGNQTGIGSIHPLLHQNTSDFSEQKFSSVFTGDEFFLRDHVVRGKPVLPGVAYLEMAYAAINQAAGSEIGQDVRIRLNHTVWVQPVVVDRHSAQVDISLFPEEDGKITFDIYSTQEDGDDPVIHSQGSAELASAAETPVADLTEMSRRCGKGKMSPDQFYEEGRSRGMFHGPAFQGIKNVNIGNREVLAQLQLPEIVSGTNEQFVLHPSIMDSALQTATICIMQELTDQKLILPFALEELEVIKGCSSSMWAYARLSDSDHSGGVVQKADIDVIDESGTVCVRIKGFSTRVLEGEVHTSKPSTRHERLMLEPVWEKQNEEREDEDLSYTEHIIVLFETERSVTDSIASHMKDARVITLNEAVGHIAERYQCYMQNIFELLQSKVRKLSAGRIIIQAIVPLEKEKQLFAGVSGLFKTAEIEFSKLTAQVIEIEKPEEMIDLHLKLKDDSRRPFDKQIRYEAGYRFVKGWREMVLPSADTLHMPWRDEGVYLITGGAGSLGLLFAKEIANRTGRSTIVLTGRSVLSEDKENELEALRSIGAEVVYREADVSDQHAVRHLLEEIKERYGTLNGIIHGAGSSKDRFIIHKTNEEFQEVLQPKVSGLLHVDECSKDFPLDFFIFFSSVSGCLGNAGQADYAAANSFMDAFAEYRRSLAASKKRFGSTISFNWPLWEEGGMQVGAEDEKRMLKTTGMVPMPTDSGLKAFYQGIVSDKPQVFVMEGQLQKMKQKLLSAGSKAKRNDQRKADQDQGQTRKLEAALIQMVGAILKVNTDDIDVNTELSEYGFDSVTFTVFTNKINEKFQLELTPTIFFEYGSVQSLAEYVVAAYQGEWNQDATAKGKDERTNLVHSLSSLEASLSNMVSAILKVNSEDIDVNTELSEYGFDSVTFTVFTNKINEEFQLELTPTIFFEYGSLHSLAEYLTVEHGDTLVQEREKPEGQEELQTKSSEAPKITSRRKRRFTQPIIAKAERNKKQAADFEPVAIVGISGRFPGAMDIDEFWKNLEEGKDSITEVPKDRWDWREHYGNPDTDVNKTDIKWGGFIDGVAEFDPLFFGISPREADYVDPQQRLLMTYVWKALEDAGCSPQSLSGTGTGIFIGTGNTGYKDLFHRANLPIEGHAATGHMIPSVGPNRMSYFLNIHGPSEPVETACSSSLVAIHRAVTAMQNGDCEMAIAGGVNTILTEEAHISYSKAGMLSTDGRCKTFSADANGYVRGEGVGMVMLKKLEDAERDGNHIYGVIRGTAENHGGRANTLTSPNPKAQADLLVRAYRQADIDPSTVTYIEAHGTGTELGDPIEINGLKAAFKELSNMRGESQPDVPDHRCGIGSVKSNIGHLELAAGISGLIKVLLQMKHKTLVKSLHCETLNPYLQLTDSPFYIVQEKQEWKSVTDRDGNELPRRAGISSFGIGGVNAHIVIEEYMPKANSEHTATEQPNVIVLSAKNKSRLIDRASQLLEVIRNKKYTDQDLHRIAYTLQVGREEMDERLACVAGTMQELEEKLQAFVDGKEETDEFFRGQSHRNKETQTIFTADEDMALALDAWIRKRKYAKLADLWVKGVSIQWNTLYGETKPRLISLPSYPFAKDHYWVPAKEHSERDKKELVNAIEDRAACFLTKQWSLSPIGSAVPGTRTVAILCCQETADLAAEVSSYFPNHLLIDVSRIENDQSDIDWKEFDGLVDVIGCGWDDEGRLDWIEWVQRLVEFGHKEGLRLLCVTKGLESFQNTSVRMAGASRAGLYRMLQCEYSHLISRHMDAEEVTDHRRLAKLIADEFYSDSYDAEVCYRDGLRYQAFLKAHPETGKATEQSAVFPKDHVLLITGGTRGIGLLCARHFAECYGVKKLVLTGREQLPPREEWARFKTSNTSLAEKIQAVRELEAKGVQVEMLSLTLSDDAQVEQTLQHIKRTLGPIGGVIHCAGLTDMDTLAFIRKTSDDIQRVLEPKVSGLTTLYRHVCNEPLQFFVLFSSVSAIIPELSAGQADYAMANSYMDYFAEAHQKHAPIISVQWPNWKETGMGEVTNQAYRDSGLLSITNSEGLRFLDQIVSKKFGPVVLPAMANQTNWEPELLMKRRKPHEGGLQEAALQSPPARDIEEADEVSKCDGLLSETQSWLIDLFTEELRIDREDFEIDGLFQDYGVDSIILAQVLQRINRKLEAALDPSILYEYPTIQRFADWLIGSYSERLSALFGGRISDASAPLENKIEAEASVPGKDRALTPQIQAPAILSPDSHAEGIAVVGLSCRFPGAETLESYWSLLSEGRSSIGPIPAERWGCKTPYYAGVIDGVSYFDPDFFLLHEEDVRAMDPQALLVLEECLKLLYHAGYTPEEIKGKPVGVYIGGRSQHKPDEDSLDHAKNPIVTVGQNYLAANLSQFFDVRGPSVVVDTACSSALVGMNMAIQALRGGDIQSAIVGGVSLLSSDASHRLFDRRGILSKHSSFHVFDERADGVVLGEGVGMVMLKTVKQALEDGDIIYAVVKAASVNNDGRTAGPATPNLEAQKEVMKDALFKSGKKPEDISYLEANGSGSIVTDLLELKAIQSVYRSGHSSPLSLGSIKPNIGHPLCAEGIASFIKVVLMLKERRFVPFLSGEKEMAHFDQQKANITFSRALEKWTDSQPTAAINCFADGGTNAHVIVEAWEKDEKHAIKRSPISPPQLKKRMLSPGEPKLEAETSKMTAANIWDTYEVEV GT:EXON 1|1-5043:0| SW:ID PKSJ_BACSU SW:DE RecName: Full=Polyketide synthase pksJ; Short=PKS; SW:GN Name=pksJ; Synonyms=pksK; OrderedLocusNames=BSU17180; SW:KW Acyltransferase; Antibiotic biosynthesis; Coiled coil;Complete proteome; Cytoplasm; Ligase; Multifunctional enzyme; NADP;Phosphopantetheine; Repeat; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->5043|PKSJ_BACSU|0.0|100.0|5043/5043| GO:SWS:NREP 6 GO:SWS GO:0008415|"GO:acyltransferase activity"|Acyltransferase| GO:SWS GO:0017000|"GO:antibiotic biosynthetic process"|Antibiotic biosynthesis| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 622->637|PS00012|PHOSPHOPANTETHEINE|PDOC00012| PROS 1684->1699|PS00012|PHOSPHOPANTETHEINE|PDOC00012| PROS 4491->4506|PS00012|PHOSPHOPANTETHEINE|PDOC00012| PROS 192->203|PS00455|AMP_BINDING|PDOC00427| PROS 1304->1315|PS00455|AMP_BINDING|PDOC00427| PROS 3502->3518|PS00606|B_KETOACYL_SYNTHASE|PDOC00529| PROS 4734->4750|PS00606|B_KETOACYL_SYNTHASE|PDOC00529| TM:NTM 1 TM:REGION 1344->1366| NREPEAT 4 REPEAT 3|1756->2209|3335->3794|4584->5014| REPEAT 3|3116->3203|3214->3302|4464->4536| REPEAT 2|2210->2355|3805->3952| REPEAT 2|2881->3115|4219->4463| SEG 191->201|lllltsgstgt| SEG 1998->2015|gvavvllkkaadavkdgd| SEG 3451->3464|gtgtgifigtgntg| SEG 4174->4186|llitggtrgigll| SEG 4665->4675|llvleeclkll| SEG 4803->4815|gvvlgegvgmvml| BL:PDB:NREP 10 BL:PDB:REP 61->663|2vsqA|4e-25|23.1|538/1273| BL:PDB:REP 696->1725|2vsqA|e-125|31.9|995/1273| BL:PDB:REP 1761->2186|2qo3B|1e-56|32.3|412/873| BL:PDB:REP 2314->2351|2hg4F|1e-04|39.5|36/859| BL:PDB:REP 2391->2623|3el6A|2e-10|27.1|214/271| BL:PDB:REP 2851->3047|1q7bA|3e-12|26.9|186/243| BL:PDB:REP 3340->3797|2qo3B|2e-77|38.1|436/873| BL:PDB:REP 4196->4364|2vz9B|4e-11|33.5|149/2086| BL:PDB:REP 4461->4529|2afdA|3e-08|33.3|69/88| BL:PDB:REP 4588->5006|2qo3B|5e-47|28.9|418/873| RP:PDB:NREP 17 RP:PDB:REP 30->561|3e7wA|7e-43|15.7|499/508| RP:PDB:REP 592->666|3ce7A|4e-09|7.9|75/90| RP:PDB:REP 685->1112|2e1tA|6e-54|9.2|400/440| RP:PDB:REP 1135->1645|1amuB|4e-81|40.4|500/508| RP:PDB:REP 1666->1738|2cq8A|4e-12|24.7|73/110| RP:PDB:REP 1763->2188|2bz4D|2e-75|19.7|388/402| RP:PDB:REP 2164->2289|3c5oD|5e-19|14.3|118/151| RP:PDB:REP 2315->2359|1cjaA|1e-04|15.6|45/327| RP:PDB:REP 2878->3013|2e6gI|5e-22|17.1|123/227| RP:PDB:REP 3113->3187|1af8A|5e-11|13.3|75/86| RP:PDB:REP 3213->3282|2cgqA|5e-09|12.9|70/74| RP:PDB:REP 3334->3778|2c9hA|3e-93|22.8|408/426| RP:PDB:REP 3750->3866|3c5oA|5e-22|15.5|116/148| RP:PDB:REP 3885->3953|1cjaA|3e-05|10.1|69/327| RP:PDB:REP 4231->4398|2ddxA|3e-13|6.9|144/324| RP:PDB:REP 4462->4532|2afdA|6e-09|33.8|71/88| RP:PDB:REP 4589->4995|3e60A|8e-63|19.8|397/420| RP:PFM:NREP 17 RP:PFM:REP 71->476|PF00501|5e-37|30.1|377/405|AMP-binding| RP:PFM:REP 605->663|PF00550|2e-04|23.7|59/67|PP-binding| RP:PFM:REP 695->989|PF00668|3e-41|30.6|291/297|Condensation| RP:PFM:REP 1181->1575|PF00501|4e-50|35.5|386/405|AMP-binding| RP:PFM:REP 1666->1725|PF00550|6e-08|43.3|60/67|PP-binding| RP:PFM:REP 1763->1997|PF00109|5e-36|39.1|222/245|ketoacyl-synt| RP:PFM:REP 2019->2136|PF02801|2e-22|43.2|116/118|Ketoacyl-synt_C| RP:PFM:REP 2850->3036|PF08659|3e-37|44.2|181/181|KR| RP:PFM:REP 3118->3184|PF00550|5e-05|29.9|67/67|PP-binding| RP:PFM:REP 3216->3282|PF00550|6e-05|28.4|67/67|PP-binding| RP:PFM:REP 3342->3589|PF00109|1e-60|50.4|240/245|ketoacyl-synt| RP:PFM:REP 3599->3722|PF02801|7e-27|53.5|114/118|Ketoacyl-synt_C| RP:PFM:REP 3814->3909|PF09789|6e-04|30.9|94/314|DUF2353| RP:PFM:REP 4188->4369|PF08659|4e-20|35.5|163/181|KR| RP:PFM:REP 4471->4532|PF00550|8e-05|29.0|62/67|PP-binding| RP:PFM:REP 4591->4802|PF00109|4e-31|35.7|212/245|ketoacyl-synt| RP:PFM:REP 4830->4943|PF02801|5e-20|41.7|114/118|Ketoacyl-synt_C| HM:PFM:NREP 16 HM:PFM:REP 1761->2010|PF00109|1.1e-65|38.5|247/253|ketoacyl-synt| HM:PFM:REP 3340->3589|PF00109|1.5e-89|50.2|247/253|ketoacyl-synt| HM:PFM:REP 4589->4821|PF00109|2.7e-62|42.2|232/253|ketoacyl-synt| HM:PFM:REP 61->479|PF00501|8e-91|32.5|397/418|AMP-binding| HM:PFM:REP 1181->1578|PF00501|3e-122|39.3|394/418|AMP-binding| HM:PFM:REP 2018->2136|PF02801|4.3e-41|45.8|118/119|Ketoacyl-synt_C| HM:PFM:REP 3597->3724|PF02801|2e-44|51.7|118/119|Ketoacyl-synt_C| HM:PFM:REP 4829->4943|PF02801|3e-32|40.9|115/119|Ketoacyl-synt_C| HM:PFM:REP 2850->3035|PF08659|7.3e-64|46.4|179/181|KR| HM:PFM:REP 4174->4369|PF08659|6.7e-46|38.4|177/181|KR| HM:PFM:REP 692->988|PF00668|9.5e-78|29.0|293/301|Condensation| HM:PFM:REP 599->663|PF00550|1.7e-12|26.2|65/67|PP-binding| HM:PFM:REP 1662->1725|PF00550|2.4e-18|37.5|64/67|PP-binding| HM:PFM:REP 3119->3184|PF00550|1.3e-16|30.3|66/67|PP-binding| HM:PFM:REP 3218->3282|PF00550|7.5e-16|33.8|65/67|PP-binding| HM:PFM:REP 4467->4532|PF00550|3.9e-12|22.7|66/67|PP-binding| GO:PFM:NREP 9 GO:PFM GO:0003824|"GO:catalytic activity"|PF00501|IPR000873| GO:PFM GO:0008152|"GO:metabolic process"|PF00501|IPR000873| GO:PFM GO:0048037|"GO:cofactor binding"|PF00550|IPR006163| GO:PFM GO:0003824|"GO:catalytic activity"|PF00501|IPR000873| GO:PFM GO:0008152|"GO:metabolic process"|PF00501|IPR000873| GO:PFM GO:0048037|"GO:cofactor binding"|PF00550|IPR006163| GO:PFM GO:0048037|"GO:cofactor binding"|PF00550|IPR006163| GO:PFM GO:0048037|"GO:cofactor binding"|PF00550|IPR006163| GO:PFM GO:0048037|"GO:cofactor binding"|PF00550|IPR006163| RP:SCP:NREP 15 RP:SCP:REP 30->555|1md9A|2e-48|19.7|494/536|e.23.1.1| RP:SCP:REP 607->719|1j3mA|5e-11|7.1|103/127|d.129.7.1| RP:SCP:REP 696->872|1l5aA1|3e-30|18.5|173/174|c.43.1.2| RP:SCP:REP 878->1136|1l5aA2|2e-43|14.0|243/250|c.43.1.2| RP:SCP:REP 1142->1642|1md9A|1e-87|21.5|489/536|e.23.1.1| RP:SCP:REP 1673->2268|1e1cA1|1e-80|8.5|543/559|c.1.19.1| RP:SCP:REP 2314->2459|2h1tA1|2e-19|7.1|140/186|b.178.1.1| RP:SCP:REP 2845->3057|2fr0A1|3e-18|23.3|210/259|c.2.1.2| RP:SCP:REP 3113->3187|1af8A|7e-12|13.3|75/86|a.28.1.1| RP:SCP:REP 3230->3863|1e1cA1|1e-96|9.7|547/559|c.1.19.1| RP:SCP:REP 3890->3956|2h1tA1|4e-07|4.1|67/186|b.178.1.1| RP:SCP:REP 3966->4156|2fr0A2|1e-10|16.0|188/209|c.2.1.2| RP:SCP:REP 4188->4364|2fr0A1|3e-10|25.6|155/259|c.2.1.2| RP:SCP:REP 4335->4401|2g7gA2|8e-10|10.3|66/132|a.121.1.1| RP:SCP:REP 4489->5016|1e1cA1|3e-54|8.4|470/559|c.1.19.1| HM:SCP:REP 9->561|1pg4A_|2.7e-106|28.4|528/643|e.23.1.1|1/2|Acetyl-CoA synthetase-like| HM:SCP:REP 592->666|1klpA_|2.2e-14|30.7|75/115|a.28.1.1|1/5|ACP-like| HM:SCP:REP 696->885|1l5aA1|4.6e-33|32.2|174/0|c.43.1.2|1/1|CoA-dependent acyltransferases| HM:SCP:REP 874->1150|1l5aA2|2.4e-46|28.1|249/0|c.43.1.2|1/1|CoA-dependent acyltransferases| HM:SCP:REP 1118->1668|1pg4A_|2.2e-169|37.1|545/643|e.23.1.1|2/2|Acetyl-CoA synthetase-like| HM:SCP:REP 1652->1777|1klpA_|2.1e-19|29.5|112/115|a.28.1.1|2/5|ACP-like| HM:SCP:REP 1752->2189|1tedA_|4.5e-73|36.2|362/0|c.95.1.2|1/3|Thiolase-like| HM:SCP:REP 2843->3091|1gz6A_|5.1e-39|28.5|235/302|c.2.1.2|1/2|NAD(P)-binding Rossmann-fold domains| HM:SCP:REP 3108->3202|1nq4A_|4.5e-14|27.2|92/95|a.28.1.1|3/5|ACP-like| HM:SCP:REP 3207->3356|1klpA_|7.5e-16|33.3|114/115|a.28.1.1|4/5|ACP-like| HM:SCP:REP 3332->3779|1tedA_|1.1e-90|40.6|360/0|c.95.1.2|2/3|Thiolase-like| HM:SCP:REP 3966->4156|2fr1A2|8.8e-11|21.3|188/0|c.2.1.2|1/1|NAD(P)-binding Rossmann-fold domains| HM:SCP:REP 4170->4405|1zbqA1|1.5e-30|23.4|214/0|c.2.1.2|2/2|NAD(P)-binding Rossmann-fold domains| HM:SCP:REP 4461->4605|1klpA_|5e-15|27.3|110/115|a.28.1.1|5/5|ACP-like| HM:SCP:REP 4581->4995|1tedA_|3.8e-68|36.4|357/0|c.95.1.2|3/3|Thiolase-like| OP:NHOMO 12845 OP:NHOMOORG 1117 OP:PATTERN 33-1--5A98898878--32221D61142225321---222217376923433---------22---- 58D5mA97889E5Bmvmll-lmLL*ynlmmlivlrlcw**3tLj31-61A62A6B56E11igD3*L**V*82122233-486F223216645162221-23E423U572711111112222222221335223514999HG333y9GMH8NOQ3322233312612KdR*B22322223212254455223CBkFFGFGICIEFGHGIE79FFKQEFLCKDHF57444444b84777777777777777565651322224131243322333332333444335339933333333333333333333433333334433343224A4444844243b4EE21211192-75272DC735323B4222213172C999D43333FDUJW767SQQLK56665565667-ECHEFICCALD2EFFM89BBAEEBEO8A6BAJ56669AI2222222275426A78111111111111111111111111111113BCUA27GF8HHNOPQdbRUWNGGIRmoonGlXIWTXdP24EEH79GD8Q9HNTN2491245E33344443559E7A3cI6968887866619C9983F9C7777*Z9A2433122332322212212212226228C467D95679C9888EAA9AAABA989CD1-24B83111111L7UFA978AAJ8KKC98-99A999B8BBABE98899897BJEed89687999999989879C678888721CCCCBDA998B811276A686AAA988c5G222242122223332BBEHB4B788IEMPJOWZNRDJFLEAMNV73333433325AAI79999A69BB77A585566632322213443321-----1--411-------------------------12211111112E1 1152o*9-512-79GaezW*fwk****MMPMKMgncTSTRQSTKJMlWZ*hjdeXQnoONML42322113422223322353333345-8RAeBD7534143FCBD-6UAkAB8A9A52335A5LB483M*C1CCK4723A55B336521F31L5GAAHB7D8dPIEK9RTEJOL434Q*A6MHRNJIotHP88GAD9* ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 4675 STR:RPRED 92.7 SQ:SECSTR #################cccccccccTTccHHHHHHHHHHHcTTcEEEEEEEETTEEEEEccEEEcTTccEEEcccEEcTTccTTTHHHHHHHHHHTTccEEEccGGGTcHHHHHccTTccccGGGcEEEEEEcGGGccHHHHHHHHHTcccccEEEEccccEEccccccccccTTccccEEcccHHHHHHHHHHHHHTTccccEEEEcccHTccccccEEEEEccTTcccHHHHHHHHHHTcEEEEEcTTccTTccccccccccGGGcHHHHHHHHHHTccHEHHHHHHHHHHTTcEEcccEccccccGGGTEEEEEcHHHHHHHTTcccccccccccTcEEEEEEEEEcTTTTcccccHHHHHHHHHHHHHHHTTccccGGGGTcccccccEEEEEEEEccccccccEEEEEEccHHHHEcccEETTEEEEEEEEEcTTccEEEEEEEEEEccETTEEEEHHHHHHHHHTcTTEEETEEEEEEEEEcTTccEEEEEEEEEcccccHHHHHHHHHHHccGGGcccEEEccEEEEcEcccccccTTccccGGGccHHHHHHcTTEEEEEEcGHTTTcTTTHHHHHHHHHHHcccHHHHHHHHHHHHHTccTTTccTTccTTTccccTTHHHHHHHHHHHHTTccccHHHHTTcccHHHHHHHHcHHHHHHHHTTccGGGcEEEETTTcccEEEEEccHHHHcTTTTcccEEEEEEEEccccHHHHHHTHHHHHHHHHHHHHHHcGGGGcEEEEccccccccEEEEcTccGGGTcccccEEGGGcGGGccccEEccccEEEEcEEEEEEEETTTEEEEEEEEcGGGccHHHHHHHHHHHHHHHHEEETTcTTcccHHHHHHccccccccccccHHHHHHHHHHHcHHHHHHHcccccccccccEEEEEEEEcHHHHHHHHHHHHHHHHcTTcccccHHHHHHHHHHHHHHHHHcccEEEEEEEEEcGGGccccccTTcccccEEEEEEEEEGGGTcHHHHHHHHHHHHHHHTTcccccHHHHHccccEEEEEEccTTccGGEEEEcTTEEcTTccGGGcccccccccEEEEGGGGGccEEEEEEcccTccccEEEEEEEEHHHHHHHHHHHHHEEEEEEEccccccccGGGGccccHHHHHHHHTTcccccccTccHHHHHHHHHHHcTTcEEEEETTEEEEHHHHHHHHHHHHHHHHHHTccTTcEEEEEccccHHHHHHHHHHHHTTcEEEEccTTccHHHHHHHHHHHcccEEEEcGGGGGGGccccccEEEEcccccGGGccccccccccccccTTcEEEEEEcccTTccccEEEEEHHHHHHHHHHHHHTccccTTcEEEEcccTTcTHHHHHHHHHHTTTcEEEEccHHHHTcHHHHHHHHHHTTccEEEEcHHHHTTccTTTcccccccEEEEEcccccHHHHHHHTTTTcEEEEEEccGGGccccEEEEcccccccccccEEcTTEEEEEEcTTcccccTTccEEEEEEETTcccEETTcHHHHHHHEEEccccTTcEEEEEEEEEEEcTTccEEEEEEGGGEEEETTEEEEHHHHHHHHHTcTTEEEEEEEEcTTccEEEEEEEEEcccccHHHHHHHHHHHccGGGcccEEEEcccccccTTccccGGGcccccccHHHTccEEEEcGGHHHHHcGGGHHHHHHHHHTcEEEEEEcccEEEHHHHHHHHHHcGGGccEEEEcHHHHHHHHHHHHHTTccGGGcEEEEEETTEEEEEEccccHHTcccHHHcccHHHHHHHHHHHccccccccGGGccTTcccEEEcccGGGTTcccTTcTTccccEEEcccccccTTcccGGGTTccTTHHHHccHHHHHHHHHHHHHHHHHTcccccHHHTEEEEEEEccccHHHHHHHHHHHHHHcGGGccTTHHHHHHHHHHHHHHHTccccEEccccGGHHHHHHHHHHHHHHHHTcccEEEEEEEEccccHHHHHHHHHTTccccTTcccTTcTTccccccccEEEEEEEEEHHHHHHHTccccEEEEEEEEEEccccccccccccTTcEEHHHHHHHHHHTccGGGccEEEEEcGGGGcHHHHHHcEEEEHHHHHTccEEccccTTTHHHHHHHHHHHHTcccccccccEEEEEEcccEEEEEccTTccccEEEEcccccTTEEEcEEEEEEEEEcccEEEEEEccGGGccTTcccEEEEEEEEcccccccHHHHHHHHHHHHcHHccHHHHHHHHHHHGGGcTTcTTccHHHHHHHHHHHHHHHHccccEEEEHHTHHHHHHHHcHHHHHccccHHHHHHHTccEEEEEccEEEccccEEETTcTTTcEEEEcccccccccTTccccEEEETTccEcEEcccEEETTTTEEEEEE##EccEEEEEccGGE###EEEETTTcGGGGGEEETTEEcccHHHHHHHHH#####HHHHHHTccE###EEEEEEcccccccTTcEEEEEEEEEcTTccEEEEEEEEEccccGcccEEEEEEEEEccccccccc#ccccccTTcEEcccTTHHHHHHHTTEEEcGGGccEEEEEEETTEEEEEEE####cccccccccccHHHHHHHHHGGGGcTTccc######cEEEEEEEEEccccccEEEEEEEEccTT#######################################################################################################################################cccTTccccHHHHHEcccccEEEEccTTcccGGGHHHHHHTHHHHHHTTcccccccTTccccccccccccccEEEEEEcccccccGGGGTTcEEEEcccccHHHHHHHHHHHTTTcEEEEEEEccccTTcHHHHHHHHHGGGcEEEEEEEEcccccccEEEEcccccccccccccEEEEEccHHHHHHHHHHHHHHHHHHcccccEEEEEEEEEEccccGGGGGGcHHHHHHHHHHTTcEEEEEEEccccccccHcHHHHHHHHHHHEEEEcccccccEEHHHHHHHHHHHcccccccccHHHHHHHHHHHHHTTccEEcccGGc###################ccccTTcHHHHHHHHHHHHTTccccccccTTTcccTTcTTTTTccTTTHHHHHHHHTTTTcccccTTTTTTcccHHHHHHHHHHHccHcccccccccc##HHHHHHHHHHHHHHHHHHTcGGHHccccccccGGGccccccccTTHTHHHHHHHHHHHTccccEEcTTccEEcccccHHHHHHHTTTccEEHHHHHHHHTcHHHHTTGGGGGTTcccTTccTTcTTcTTccccccccccEEEEEEEEEETTEEcHHHHHHHHHTTcccEEEcccGGGTTcccEETTcTTTGcEEcEcccccccTTcccGGGTTccTTHHHHccHHHHHHHHHHHHHHHHHTcccccHHHHHTEEEEEEEcccHHHHHHHcGGGccTTHHHHHccTTHHHHHHHHHHTccccEEccccGGHHHHHHHHHHHHHHHHTcccEEEEEEEEccccHHHHHHHHHTTccccTTcccTTcTTccccccccEEEEEEEEEHHHHHHHTccccEEEEEEEEEEcccccccccTTcHHHHHHHHHHHHHHTccGGGEEEEEccccccHHHHHHHHHHHHHHHGGHHHcGGHHHHGGGGGTcEEEccHHHHcccGGGHHHHHHHHHHHHHHHTEEcccTTcccccTTccccccccccccccEEcccHcccHHHHHccEEEEEEEETTTEEEEEEEEccccccccccHHHHHHHHHHHHHHHHHHccHHHHHHHHHHHHHHHHcccTTcGGGcHHHHHHHHHHTTccHHHHHHHHHHHHcccccccccccccHHHHTcccHHHHTTccccHHHHHHHHHHHHHHHHHHHTTcccccccccccccGGEEEEcccccGGGccHHHHGGGcccEEGGGTEEcccccccHHHHHHHHHHTTccH#######HHHHHHHHHHHHTTccGGGccTTccc##########################################################################################################################TccccccccccccccEEEEEEEEEGGGGGGccTTccEEEEcccTTcTTHHHHHHHHHTETcEEEEEEEcccTTTTcHHHHccccccTTcccEEccTTHHHHHHHHHHcTTccccHHHHHHHHHHHHHHHHHHTTTEEcHHHHHHHHHHHHHHHTHTTccEEEEEEEEGGGcTTTccTTccccTHHHHHTTTccTHHTTcccEEEEEEcEEEEccccccHHHHHHHHHcccTTTccccEEEEEEEETTccccGGGcTTcEEEEccTTcTTTTHHHHHHTHHHHcccTHHHHHTcc####cccGGGcccccHHHHHHHHHHHHTTTcTTccccHHHHHHHHcEEcTTccEEccccccccccTTTHHHHHHHHHHHHTccccEEcTTccEEcccccGHHH####GGGTTcccTTc####HHHTTTccEEEEEccTTcccTTcTTcTTccccccccccEEEEEEEEEETTEEcHHHHHHHHHTTcccEEEcccGGGcccEEEcccccccTTcccGGGTcccTTHHHHccHHHHHHHHHHHHHHHHHTcccccHHEEEEEEccccHHHHHHHHHcGGGccTTHHHHHHTHHHHHHHHHHTccccEEccccGGHHHHHHHHHHHHHHHHTcccEEEEEEEEccccHHHHHHHHHTTcccccccTcTTcTTccccccccEEEEEEEEEHHHHHHHTccccEEEEEEEEEEcccccccccTTcHHHHHHHHHHHHHHTccGGGEEEEEccccccHHHHHHHHHHHHHHHGGGGGGTcEEEccHHHHcccGGGHHHHHHHHHHHHHHHTEEcccTHHHHHcTTcccccTTcccccccEEccccccEEEEEEEETTTEEEEEEEEccccccccccHHHHHHHHHHHH############################## DISOP:02AL 5043-5044| PSIPRED ccccccccccccHHHcccccccccccccccHHHHHHHHHHHccccEEEEEEcccccEEEEEHHHHHHHHHHHHHHHHHcccccccEEEEEccccHHHHHHHHHHHHHcEEEEEccccccccHHHHHHHHHHHHHHHccccEEEEEHHHHHHHcccccccccccccEEEccccccccccccccccccccEEEEEEcccccccccEEEEEcHHHHHHHHHHHHHcccccccEEEEEccccHHHHHHHHHHHHHHHHccEEEEccHHHHccHHHHHHHHHHHcccEEEccHHHHHHHHHHHHHHHHccccccccEEEEEccccccHHHHHHHHHHHHHccccccEEEEccccHHHHHHHHEEEEEcccccccccccccccEEccccEEEEEccccccccccccEEEEEccccccccccccHHHHHHHHccccccccccEEEcccccEEEEEEcccEEEEccEEEcHHHHHHHHHHcccccEEEEEEEEEEcccccccEEEEEEEEcccccHHHHHHHHHHHHHHHHHHHHccccEEEEEEHHcccccccccccHHHHHccccccccccccccccccccccccccccccccccccHHHHHHHHHHHHHHHHcccHHHccccccHHHcccHHHHHHHHHHHHHHHHcccccHHHHHccccHHHHHHHHHHHHHHcccccccccccccccccccHHHcccccccHHHHHHHHHHHccccccEEEEEEEEEcccccHHHHHHHHHHHHHHccccEEEEEEEccEEEEEEcccccccEEEEEcccccHHHHHHHHHHHHHcccccccccEEEEEEEEEccccEEEEEEccHHHHcHHHHHHHHHHHHHHHHHHHcccccccccccccHHHHHHHHHHHHccHHHHHHHHHHHHHHccccccccccccccccccccccccEEEEEccHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHccccEEEEEEEcccccHHHHHccHHHHHccEEEEEEccccccHHHHHHHHHHHHHHHHcHHcccHHHHHHHHcccccccccccEEEEEEEEccccccHHHHcccccccccEEEEEEcccccccccEEEEEEEcccEEEEEEEEccccccHHHHHHHHHHHHHHHHHHHHcccccHHHccccccHHHHHHHHHccccccccccccHHHHHHHHHHHccccEEEEEcccEEcHHHHHHHHHHHHHHHHHcccccccEEEEEccccHHHHHHHHHHHHHcEEEEcccccccHHHHHHHHHHccccEEEEcHHHHHHcccccccEEEEccccHHccccccccccccccccccccEEEEEcccccccccEEEEEcHHHHHHHHHHHHHcccccccEEEEEcccccHHHHHHHHHHHHHccEEEEccHHHcccHHHHHHHHHHHcccEEEccHHHHHHHHHccccccccEEEEEccccccHHHHHHHHHcccEEEEcccccHHHEEEEEEEcccccccccccccccccEEEEEcHHcccccccccEEEEEccccccccccccHHHHHHHccccccccccEEEEcccccEEcccccEEEEEEEccHHEEccccccHHHHHHHHHHccccHHEEEEEccccccEEEEEccccccccHHHHHHHHHHHccHHHcccEEEEEccccccccccccHHHcccccccccccccccccHHHHHHHHHHHHHHHcccccccccccHHHHccHHHHHHHHHHHHHHHHcccccHHHHHHcccHHHHHHHHHHHHccccccccccccccccHHHHHHccccccccccccccccccccccccccHHHHHHHHHccccEEEEccHHHHHHcccccccccccccccccEEEccHHHccHHHccccHHHHHHccHHHHHHHHHHHHHHHHcccccccccccEEEEEEccccHHHHHcccccccccccccHHHHccccccHHHHHHHHHccccccEEHHHHHHHHHHHHHHHHHHHHHHcccHHHHHccEEEEEccHHHHHHHHcccccccccccccccccccEEEEEEEEEEEEEcHHHHHHcccEEEEEEEEEEEccccccccccccccHHHHHHHHHHHHHHccccHHHccEEEccccccccccHHHHHHHHHHHcccccccccEEEEEEccccccHHHHHHHHHHHHHHHHHHccccccccccccccccccHHHccEEEEcccccccccccEEEEEEEccccccEEEEEEEEccccccccccccccEEEEEEcccHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHcccHHccccEEEEEccHHHHHHHHHHHHcccccccEEEEEccccccEEEEEccccccccccccHHHHHHHHHHHHHHHccccccHHHHccccccccccccccEEccHHHccccccccHHHccccccccccccccccccccccccccEEEEEEccHHHHHHHHHHccEEEccHHHHHHHHHHHHHHHHHHccccccEEEEEEEEEcccEEEcccccEEEEEEEEccccEEEEEEEEEcccccccEEEEEEEEEEcccccccccccccccccccccEEcHHHHHHHHHHHcccccHHHHHHHHHEEcccEEEEEEEEccccccccccccccHHHHHHHHHHHHHHcccccccccEEEEEEEEEEEEEccccccEEEEEEEcccccccccEEEEEEEEEcccccEEEEEEEEEEEccccccccccccccHHHcEEEEcccccccccccccccccccEEEEEcccccHHHHHHHcccccEEEEEccccHHHHHHHHHHHHHHHHHHHHHHHHccccccEEEEEEccccccHHHHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHcccccccEEEEEccEEEEEEEEEEccccccccccccccccEEEEEccccHHHHHHHHHHHHHccccEEEEEccccccHHHHHHHHHHHHcccEEEEEEcccccHHHHHHHHHHHHHHcccEEEEEEccccccccHHHcccHHHHHHHHHHHHHHHHHHHHHcccccccEEEEHHHHHHHHccccHHHHHHHHHHHHHHHHHHHHccccccccccEEEEEcccccccccccccHHHHHHHHHcccccccHHHHHHHHHHHHHccccEEEEEcccHHHHHHHcccccccccccccccccccHHHHHHHHHHHHHHHHHHHcccHHHccccccHHHHcccHHHHHHHHHHHHHHHcccccHHHHHccccHHHHHHHHHHHHHcccccccccccccccccHHHHHHHHHHHHHHHHHHHcccccccccccccHHHcccHHHHHHHHHHHHHHHHcccccHHHHHccccHHHHHHHHHHcccccccccccccccccHHHcccccccccccHHHHHHccHHHHHHHcccccccccccEEEEEEcccccccccHHHHHHHHHccccEEEcccHHHccHHHccccccccccccccccccccccHHHccHHHccccHHHHHHccHHHHHHHHHHHHHHHHccccHHHccccccEEEEEcccccHHHHHHcccccccccEEEccccccHHHHHHHHHccccccEEHHHHHHHHHHHHHHHHHHHHHHcccHHHHHccEEEEEccHHHHHHHHcccccccccccccccccccEEEEEEEEEEEEEEHHHHHHcccEEEEEEEEEEEcccccccccccccHHHHHHHHHHHHHHccccHHHccEEEccccccccccHHHHHHHHHHHcccccccccccccccccEEEEEEEcccccHHHHHHHHHHHHHHHHHHHccccccccccccccccccHHHccEEEEccccccccccccccccccEEEEEEccccccEEEEEEEEccccccccccccccccEEEEEEcccHHHHHHHHHHHHHHHHccccccccHHHHHHHHHcccccccccEEEEEccHHHHHHHHHHHHcccccccEEEEccccccccEEEEEcccccHHHHHccHHHHHHHcccccEEEEEEEEccHHcccccccccccccccHHHHHHHHHcccccccccccccccccccccccccccccEEcccccccccccEEEEEEcccccccHHHHHHcccccEEEEEEEccccHHccccccccccccccccccccHHHHHHHHHHHHHHHcccccccEEEEEccccEEcccccccHHHHHHHHHHHHHHHHccccEEEEEEccccccHHHHHHHHHHHHcccccccEEEEEccEEEEEEcccccccccccccccEEccccEEEEEccccHHHHHHHHHHHHHccccEEEEEcccccccHHHHHHHcccccccHHHHHHHHHHHHcccEEEEEEcccccHHHHHHHHHHHHHHccccEEEEEcccccccccHHHHcccHHHHHHHHHHHHHHHHHHHHHcccccccEEEEHHHHHHHHccccccHHHHHHHHHHHHHHHHHHHccccEEEEEEHHHccccHHHHHHHHHHHcccccccHHHHHHHHHHHHHcccccEEEEEEccHHHHHHHHHHccccHHHHHcccccccccccccccccccccHHHHHHHHHHHHHHHHHHHHHcccHHHccccccHHHHccHHHHHHHHHHHHHHHHcccccHHHHHccccHHHHHHHHHHHcccccccccccccccccccccccccccccccccccccccccccccHHccccccccEEEEEEEEEccccccHHHHHHHHHccccEEEcccHHHccHHHccccEEEccHHHccHHHccccHHHHHHccHHHHHHHHHHHHHHHHccccHHHccccccEEEEEcccccHHHHccccccccEEEcccccHHHHHHHHHcccccccHHHHHHHHHHHHHHHHHHHHHHHcccHHHHHccEEEEEccHHHHHHHHcccccccccccccccccccEEEEEEEEEEEEEEHHHHHHcccEEEEEEEEEEEcccccccccccccHHHHHHHHHHHHHHccccHHHccEEEccccccccccHHHHHHHHHHHcccccccEEEEEEcccccHHHHHHHHHHHHHHHHHHHccccccccccccccccccHHHccEEEEcccccccccccEEEEEccccccEEEEEEEEccccccccccccccccccEEEEEEEcccHHHHHHHHHHHHHHHHHHHccccc 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