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Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : ppsA
DDBJ      :ppsA         plipastatin synthetase
Swiss-Prot:PPSA_BACSU   RecName: Full=Plipastatin synthetase subunit A;         EC=2.3.1.-;AltName: Full=Peptide synthetase 1;Includes:  RecName: Full=ATP-dependent glutamate adenylase 1;           Short=GluA 1;  AltName: Full=Glutamate activase 1;Includes:  RecName: Full=ATP-dependent ornithine adenylase;           Short=OrnA;  AltName: Full=Ornithine activase;

Homologs  Archaea  49/68 : Bacteria  780/915 : Eukaryota  190/199 : Viruses  0/175   --->[See Alignment]
a.28.1b.86.1c.43.1e.23.1
:2561 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   6->434 2jgpA PDBj 4e-29 23.3 %
:BLT:PDB   437->950 1amuA PDBj 1e-95 39.7 %
:BLT:PDB   959->1474 2jgpA PDBj e-141 48.0 %
:BLT:PDB   1478->1998 1amuA PDBj 6e-90 35.8 %
:BLT:PDB   2005->2391 2jgpA PDBj 1e-23 26.4 %
:RPS:PDB   3->418 2e1tA PDBj 2e-36 7.5 %
:RPS:PDB   437->951 1amuB PDBj 4e-86 35.9 %
:RPS:PDB   959->1032 1dnyA PDBj 1e-15 48.6 %
:RPS:PDB   1049->1457 3b30A PDBj 3e-80 8.9 %
:RPS:PDB   1498->1997 3e7wA PDBj 7e-63 27.5 %
:RPS:PDB   2000->2091 2dnwA PDBj 2e-13 16.7 %
:RPS:PDB   2095->2521 3b30A PDBj 5e-25 8.9 %
:RPS:SCOP  8->185 1l5aA1  c.43.1.2 * 7e-26 18.5 %
:RPS:SCOP  187->439 1l5aA2  c.43.1.2 * 2e-28 11.5 %
:RPS:SCOP  459->950 1md9A  e.23.1.1 * 5e-88 24.6 %
:RPS:SCOP  959->1032 1dnyA  a.28.1.2 * 9e-25 48.6 %
:RPS:SCOP  1039->1238 1dfaA1  b.86.1.2 * 1e-40 12.2 %
:RPS:SCOP  1225->1478 1l5aA2  c.43.1.2 * 1e-55 15.9 %
:RPS:SCOP  1499->1997 1md9A  e.23.1.1 * 1e-66 19.5 %
:RPS:SCOP  2005->2077 1dnyA  a.28.1.2 * 5e-20 40.5 %
:RPS:SCOP  2095->2280 1l5aA1  c.43.1.2 * 6e-20 13.8 %
:RPS:SCOP  2282->2540 1l5aA2  c.43.1.2 * 3e-10 11.3 %
:HMM:SCOP  8->197 1l5aA1 c.43.1.2 * 1e-31 27.0 %
:HMM:SCOP  186->453 1l5aA2 c.43.1.2 * 1.4e-36 21.8 %
:HMM:SCOP  421->975 1pg4A_ e.23.1.1 * 1.6e-173 39.3 %
:HMM:SCOP  959->1066 1klpA_ a.28.1.1 * 2e-21 30.6 %
:HMM:SCOP  1045->1239 1q9jA1 c.43.1.2 * 1.3e-46 39.9 %
:HMM:SCOP  1223->1492 1l5aA2 c.43.1.2 * 1.4e-60 35.9 %
:HMM:SCOP  1460->2021 1pg4A_ e.23.1.1 * 4.5e-146 32.8 %
:HMM:SCOP  2005->2107 1klpA_ a.28.1.1 * 2.7e-18 33.0 %
:HMM:SCOP  2086->2297 1q9jA1 c.43.1.2 * 4.6e-37 36.4 %
:HMM:SCOP  2281->2547 1l5aA2 c.43.1.2 * 2e-32 26.7 %
:RPS:PFM   6->297 PF00668 * Condensation 4e-31 26.6 %
:RPS:PFM   485->887 PF00501 * AMP-binding 2e-63 40.5 %
:RPS:PFM   970->1032 PF00550 * PP-binding 4e-11 47.6 %
:RPS:PFM   1052->1334 PF00668 * Condensation 1e-69 46.8 %
:RPS:PFM   1546->1931 PF00501 * AMP-binding 2e-42 30.9 %
:RPS:PFM   2019->2077 PF00550 * PP-binding 3e-06 35.5 %
:RPS:PFM   2095->2399 PF00668 * Condensation 6e-28 32.9 %
:HMM:PFM   3->300 PF00668 * Condensation 3.2e-77 29.2 295/301  
:HMM:PFM   1049->1337 PF00668 * Condensation 1.7e-100 43.3 289/301  
:HMM:PFM   2090->2399 PF00668 * Condensation 1.4e-87 39.8 294/301  
:HMM:PFM   485->888 PF00501 * AMP-binding 5.3e-123 39.4 396/418  
:HMM:PFM   1525->1932 PF00501 * AMP-binding 4.8e-106 34.4 398/418  
:HMM:PFM   969->1030 PF00550 * PP-binding 7.5e-16 33.9 62/67  
:HMM:PFM   2018->2077 PF00550 * PP-binding 4e-14 35.0 60/67  
:BLT:SWISS 1->2561 PPSA_BACSU 0.0 100.0 %
:PROS 2037->2052|PS00012|PHOSPHOPANTETHEINE
:PROS 603->614|PS00455|AMP_BINDING
:PROS 1646->1657|PS00455|AMP_BINDING
:REPEAT 3|2->458|1045->1498|2088->2561
:REPEAT 2|459->1028|1499->2073
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB13717.2 GT:GENE ppsA GT:PRODUCT plipastatin synthetase GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION complement(1990272..1997957) GB:FROM 1990272 GB:TO 1997957 GB:DIRECTION - GB:GENE ppsA GB:PRODUCT plipastatin synthetase GB:FUNCTION 16.8: Protect GB:NOTE Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 9889147, 10471562; Product type e: enzyme GB:PROTEIN_ID CAB13717.2 GB:DB_XREF GOA:P39845 HSSP:1DNY InterPro:IPR006162 SubtiList:BG10970 UniProtKB/Swiss-Prot:P39845 GB:GENE:GENE ppsA LENGTH 2561 SQ:AASEQ MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELDTLEGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQDQASIPFKLFNSPLFQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKKKDPLPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQSTSASRDTIILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGNRGSKAEKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNELRNEQKDLHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQLNFDYQNTLFSLEDIKRIQSHLLTILENALKHPHSFIRELDMTNTREKQKLLYEFNKTEAVSPKAFTLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCSAPNFSGETLEVDMTSLASEKAENHEFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAVSFLTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMERAFKELIKRHESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAFIKPFDLSQAPLFRAQIVKISDERHLLLVDMHHIISDGVSVNILIREFGELYNNRNLPALRIQYKDYAVWREGFKTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLDQEVASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQDYPFEELVDKLELTRDMSRNPVFDAMFILQNVEKQDIDLREIKVRPANFAHHISLFDITLIATEISGSICCEMEFSTEVFLKATIERWADHFIEFLHEALSTPETSLAQINILSDKEKQKIVFEFNKTQVEFAQKDIPFHRIFEAKAEENPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKPTVAVLAKRSIDAIVGVLAVMKAGGVYIPIDAHYPKARIEYILRDSGADILLLQRELKHLISNSPESEMSHIFLDDEGSFEESNCNLNLSPAPEEPVYIIYTSGTTGAPKGVIVTYQNFTHAALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVCPDETRLEPAEIYKIIKSQRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFGQSMRIINSYGVTEATIDSSFYETSMGGECTGDNVPIGSPLPNVHMYVLSQTDQIQPIGVAGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGRMDYQVKINGYRIETEEIESVLLQTGLVREAAVAVQHDKNGQAGLAAYIVPSDVNTNALRAALTKELPAYMIPAYLIPLVNMPLTLNGKLDRNALPAPNNVLSRPYTAPVNDLQKTMAYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYSTIQELCGHITPLASQADQGPAEGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNANALHLALRKITEHHDAIRMIFQRDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDEKLAAEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAAYQQALEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKTYWQTILDAHTAFLPKDIENVPDKLQMNSDAAAFVLSGDWTEKLLFETQQAYGTDANELLLTALGMALSEWTGHDQIVISTEGHGREGHVPNIDISRTVGWFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRRVPNKGTGYGLLTHIGELRHKEPEVSFNYLGQFSEEKEVETFQLSYYQPRYEIAGEREREYELDINALITDGRLHVKAVYTQVFSKHSIECFMDRFHRHLIETIEHCSQKKAREKTLSDFSNKELTLSALSSIEDLVKDL GT:EXON 1|1-2561:0| SW:ID PPSA_BACSU SW:DE RecName: Full=Plipastatin synthetase subunit A; EC=2.3.1.-;AltName: Full=Peptide synthetase 1;Includes: RecName: Full=ATP-dependent glutamate adenylase 1; Short=GluA 1; AltName: Full=Glutamate activase 1;Includes: RecName: Full=ATP-dependent ornithine adenylase; Short=OrnA; AltName: Full=Ornithine activase; SW:GN Name=ppsA; Synonyms=pps1; OrderedLocusNames=BSU18340; SW:KW Antibiotic biosynthesis; Complete proteome; Ligase;Multifunctional enzyme; Phosphopantetheine; Repeat; Transferase. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->2561|PPSA_BACSU|0.0|100.0|2561/2561| GO:SWS:NREP 4 GO:SWS GO:0017000|"GO:antibiotic biosynthetic process"|Antibiotic biosynthesis| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| PROS 2037->2052|PS00012|PHOSPHOPANTETHEINE|PDOC00012| PROS 603->614|PS00455|AMP_BINDING|PDOC00427| PROS 1646->1657|PS00455|AMP_BINDING|PDOC00427| NREPEAT 2 REPEAT 3|2->458|1045->1498|2088->2561| REPEAT 2|459->1028|1499->2073| SEG 1527->1540|rllneranrlartl| BL:PDB:NREP 5 BL:PDB:REP 6->434|2jgpA|4e-29|23.3|415/520| BL:PDB:REP 437->950|1amuA|1e-95|39.7|496/509| BL:PDB:REP 959->1474|2jgpA|e-141|48.0|515/520| BL:PDB:REP 1478->1998|1amuA|6e-90|35.8|501/509| BL:PDB:REP 2005->2391|2jgpA|1e-23|26.4|360/520| RP:PDB:NREP 7 RP:PDB:REP 3->418|2e1tA|2e-36|7.5|398/440| RP:PDB:REP 437->951|1amuB|4e-86|35.9|498/508| RP:PDB:REP 959->1032|1dnyA|1e-15|48.6|74/76| RP:PDB:REP 1049->1457|3b30A|3e-80|8.9|403/446| RP:PDB:REP 1498->1997|3e7wA|7e-63|27.5|491/508| RP:PDB:REP 2000->2091|2dnwA|2e-13|16.7|92/99| RP:PDB:REP 2095->2521|3b30A|5e-25|8.9|416/446| RP:PFM:NREP 7 RP:PFM:REP 6->297|PF00668|4e-31|26.6|286/297|Condensation| RP:PFM:REP 485->887|PF00501|2e-63|40.5|388/405|AMP-binding| RP:PFM:REP 970->1032|PF00550|4e-11|47.6|63/67|PP-binding| RP:PFM:REP 1052->1334|PF00668|1e-69|46.8|282/297|Condensation| RP:PFM:REP 1546->1931|PF00501|2e-42|30.9|363/405|AMP-binding| RP:PFM:REP 2019->2077|PF00550|3e-06|35.5|59/67|PP-binding| RP:PFM:REP 2095->2399|PF00668|6e-28|32.9|283/297|Condensation| HM:PFM:NREP 7 HM:PFM:REP 3->300|PF00668|3.2e-77|29.2|295/301|Condensation| HM:PFM:REP 1049->1337|PF00668|1.7e-100|43.3|289/301|Condensation| HM:PFM:REP 2090->2399|PF00668|1.4e-87|39.8|294/301|Condensation| HM:PFM:REP 485->888|PF00501|5.3e-123|39.4|396/418|AMP-binding| HM:PFM:REP 1525->1932|PF00501|4.8e-106|34.4|398/418|AMP-binding| HM:PFM:REP 969->1030|PF00550|7.5e-16|33.9|62/67|PP-binding| HM:PFM:REP 2018->2077|PF00550|4e-14|35.0|60/67|PP-binding| GO:PFM:NREP 6 GO:PFM GO:0003824|"GO:catalytic activity"|PF00501|IPR000873| GO:PFM GO:0008152|"GO:metabolic process"|PF00501|IPR000873| GO:PFM GO:0048037|"GO:cofactor binding"|PF00550|IPR006163| GO:PFM GO:0003824|"GO:catalytic activity"|PF00501|IPR000873| GO:PFM GO:0008152|"GO:metabolic process"|PF00501|IPR000873| GO:PFM GO:0048037|"GO:cofactor binding"|PF00550|IPR006163| RP:SCP:NREP 10 RP:SCP:REP 8->185|1l5aA1|7e-26|18.5|174/174|c.43.1.2| RP:SCP:REP 187->439|1l5aA2|2e-28|11.5|247/250|c.43.1.2| RP:SCP:REP 459->950|1md9A|5e-88|24.6|475/536|e.23.1.1| RP:SCP:REP 959->1032|1dnyA|9e-25|48.6|74/76|a.28.1.2| RP:SCP:REP 1039->1238|1dfaA1|1e-40|12.2|189/202|b.86.1.2| RP:SCP:REP 1225->1478|1l5aA2|1e-55|15.9|245/250|c.43.1.2| RP:SCP:REP 1499->1997|1md9A|1e-66|19.5|484/536|e.23.1.1| RP:SCP:REP 2005->2077|1dnyA|5e-20|40.5|73/76|a.28.1.2| RP:SCP:REP 2095->2280|1l5aA1|6e-20|13.8|171/174|c.43.1.2| RP:SCP:REP 2282->2540|1l5aA2|3e-10|11.3|239/250|c.43.1.2| HM:SCP:REP 8->197|1l5aA1|1e-31|27.0|174/0|c.43.1.2|1/3|CoA-dependent acyltransferases| HM:SCP:REP 186->453|1l5aA2|1.4e-36|21.8|248/0|c.43.1.2|1/3|CoA-dependent acyltransferases| HM:SCP:REP 421->975|1pg4A_|1.6e-173|39.3|547/643|e.23.1.1|1/2|Acetyl-CoA synthetase-like| HM:SCP:REP 959->1066|1klpA_|2e-21|30.6|108/115|a.28.1.1|1/2|ACP-like| HM:SCP:REP 1045->1239|1q9jA1|1.3e-46|39.9|168/175|c.43.1.2|2/3|CoA-dependent acyltransferases| HM:SCP:REP 1223->1492|1l5aA2|1.4e-60|35.9|248/0|c.43.1.2|2/3|CoA-dependent acyltransferases| HM:SCP:REP 1460->2021|1pg4A_|4.5e-146|32.8|552/643|e.23.1.1|2/2|Acetyl-CoA synthetase-like| HM:SCP:REP 2005->2107|1klpA_|2.7e-18|33.0|103/115|a.28.1.1|2/2|ACP-like| HM:SCP:REP 2086->2297|1q9jA1|4.6e-37|36.4|173/175|c.43.1.2|3/3|CoA-dependent acyltransferases| HM:SCP:REP 2281->2547|1l5aA2|2e-32|26.7|243/0|c.43.1.2|3/3|CoA-dependent acyltransferases| OP:NHOMO 9783 OP:NHOMOORG 1019 OP:PATTERN 22-1--5CDEFDCDDA--52442C94431169321---323217576823433--------365---1 3496d874556D9BXsXUU-Tb99zpUUUUUVhcjcWw**1WFU3-14183-B5D77C--VTI2fKeeLf71-------367F1232-4422-2--1--1191-1J13231------11-1111141534313423A99BC11-o5CDD2HHF--221123122-25OEf6121-1113-11164544--3D9QEEFEFKDIFFGGHJE78EEJKEFKBIDFB46333333X43666666666666666554621212212121132222121232222111113116412211111111111111111211111112211121---62222622122J2CC----1-63-8237-CB4252--A31111-11713K99D111118ATLb535WRWOL45554454555-BADDBJCCAKF-8AAF57766CB7AK675ACH3544CAG2222222283113D84----------111111111111111----1BGWC-7HG8HGLNONRTILLFEEJTccdcEYUGaWemU26GGGADGB9QAHMUM23B--42A21112211135C772YG65557775554-5975644476666gJ9822221222212111-11-1111215116A14488243455554B7866557545588--11962------F6LB655777E7EE976-6787779799799776776667CBWY69788979999889889A4556665--577768644464---323131777548S2D2221311121-2112AACEA4B798G4LNHNSOIKAEDFC7HHO5233342322122A566665317667735333332111----1111----------2-------------------------------------2D1 ---1AG6-32--8AEQWVJaUcVloiqKJKJGJSSSPOJNPNMHHKPEMjYbYdOKWQGDBC62232232322113322432221124-AK8WGCA543575CGGC15AAV6L9A9E31125A5ND273KyB1CBL4514H449627612B4-L4E98F98B9WAM86CQLCJMH11-6U33565LOTnVYK54GBE8D ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 2519 STR:RPRED 98.4 SQ:SECSTR ##cccEEccGGGGcHHHHTcEEEEEEEEEEEcccGGGHHHHHHHHHHHHHHHHHHcGGcEEEEEcccTTccccEEEEEEcTTcHHHHHTccGGGccHHHHcccccccccTTccTTcccccEEEEcTEEEEEEEEETTTccHHHHHHHHHHHHHHHHTETccccHHHHHHHTTcccTccccTcccccTTccccGGGTTccccTTccccccEEEEEEEEcHHHHHHHHHHHHTTccTTcccccHHHHHHHHHHHHHHHHHTTTccTTcEEEEEEEEEcHHHHTccccHHHHHHHHTcTGTTccccHHHHHHHHHHHHHHHHHHHHHTTTTTTcccEEEEEcTTccEEcTcEEEHHHHHHHHHHHHHHHTTTcEEEEEETTccccEEccccGGGcccEEEEEEEEEcGGGTTTTccEEEEEEEEEccccccccGGGGccccHHHHHHHHTTcccccccTTccHHHHHHHHHHHcTTcEEEEETTEEEEHHHHHHHHHHHHHHHHHHTccTTcEEEEEccccHHHHHHHHHHHHTTcEEEEccTTccHHHHHHHHHHHcccEEEEcGGGGGccccccEEEEcccccGGGcccccccccccTTcEEEEEEcEEEEEcccEEEEEHHHHHHHHHHHHHTccccTTcEEEEcccTTcTHHHHHHHHHHTTTcEEEEccHHHHTcHHHHHHHHHHTTccEEEEcHHHHTTccTTTTccTTTTcccccEEEEEcccccHHHHHHHTTTcEEEEEEEccGGGccccccEEEEEEcccccccccccccEEcTTEEEEEEcTTcccccTTccEEEEEEETTcccEETTcHHHHHHHEEEccccTTcEEEEEEEEEEEcTTccEEEEEEGGGEEEETTEEEEHHHHHHHHHTcTTEEEEEEEEEEcTTccEEEEEEccccHHHHHHHHHHHccGGGcccEEEEcccccccTTccccGGGcccccTTTcTTTHHHHHHHHHHHHHHHcTTTEEEHHHHTTTcTcEEEEEEEHHHHHHHHHHcGGGccEEEEcHHHHHHHHHcEEEEEEEEEccEEEcTTTcccccEEccGGGGcHHHHTcEEEEEEEEEEEcccGGGHHHHHHHHHHHHHHHHHHcGGGGcEEEEEcccTEEEEEccccccEEEEEEcTTcTTcccHHHccccccTTccTTcccccEEEEcTEEEEEEEEETTTccHHHHHHHHHHHHHHHHTccHHHHHHTTcccTTcccccccHHTTccccGGGTTccccTTcccccccEEEEEEEEcHHHHHHHHHHHHTTccTTcccccHHHHHHHHHHHHHHHHHTTTccTTcEEEEEEEEEcHHHHTccTTcccccEEEEEEEEEHHHccHHHHHHHHHTTccHHHHHHHHHHHHHHHHccccTTccTTTTccTTTcEEEEEcTTccGGGccTTcccccccEEETEEEEccccTTccEEEEEEEEHHHHHHHHHcHHHHTTcEEcccccccccHHHcEEEEcccEEEEEEEEEccHHHHHHHHcHHHHHHHHHHTccccccEEEEEEccccEEEHHHHHHHHHHHHHHHHHTcTTcEEEEEccccHHHHHHHHHHHHTTcEEEEccTTccHHHHHHHHHHHcccEEEEcGGGGGGGcccccEEcEEEEcccccGGGcccccccccccTTcEEEEEEccEEEEcccEEEEEHHHHHHHHHHHHHTccccTTcEEEEEcccTTcTHHHHHHHHHHTTTcEEEEccHHHHTcHHHHHHHHHHTTccEEEEcHHHHTTccTTTcccTTTcTTccEEEEEcccccHHHHHHHHHHHTTTcEEEEEEccGGGccccEEEEcccccccccccccccEEcTTEEEEEEcTTcccccTTccEEEEEEETTcccEETTcHHHHHHHEEEccccTTcEEEEEEEEEEEcTTccEEEEEEGGGEEEETTEEEEHHHHHHHHHTcTTEEEEEEEEEcTTccEEEEEEEEEcccccHHHHHHHHHHHccGGGcccEEEEcccccccTTccccGGGccccTTTcTTTHHHHHHHHHHHHHHTTcEEETTcTTccHHHHHHHHHHHHHHHHHHHcccccEEEEccccHHHHHHHHHHHTTcTEEEEEETTEcccEEEEccGGGGcHHHHTcEEEEEEEEEcccGGGHHHHHHHHHHHHHHHHHHcGGGGcEEEEEcccTEEccccccEEEEEEcTTccHHHHHHHTccGGGccHHHHcccccccccccTTccTTcccccEEEEcTEEEEEEEETTTccHHHHHHHHHHHHHHHHTTETTcccccccHHHHHHTTcccTTcccccTTccccGGGTTccccTTcccccccEEEEEEEEcHHHHHHHHHHHHTTccTHTcccccHHHHHHHHHHHHHHHHHTTTccTTcEEEEEEEEEcHGHHHTccTTcccccEEEEEEEEEHHHHHHccHHHHHHHHHTTccHHHHHHHHHHHHHHHccccTTccTTTccTTTcEEEEEcTTccGGGccTTcccccccEEEccccTTEEEEccccTTccEEEEEEEHHHHHHHHHcHHHHTTcEEc######################################## PSIPRED cccccccccHHHHHHHHHHHHcccccEEEEEEEEEEEccccHHHHHHHHHHHHHHcccccEEEEEcccccEEEEEcccccccEEEEEcccccHHHHHHHHHHHHHcccccccccEEEEEEEEEccccEEEEEEccHHHHcHHHHHHHHHHHHHHHHHHHccccccccccccHHHHHHHHHHHHccHHHHHHHHHHHHHHccccccccccccccccccccccEEEEEEEcHHHHHHHHHHHHHccccHHHHHHHHHHHHHHHHccccEEEEEEEccccccHHHHccHHHccEEEEEEEEEcccccHHHHHHHHHHHHHHHHHHccccHHHHHHHHcccccccccHHHHHHHHcccccccccccccEEEEEccccccccEEEEEEEEccccEEEEEEEEccccccHHHHHHHHHHHHHHHHHHHHccccEEcccccccHHHHHHHHHHcccccccccccccHHHHHHHHHHHccccEEEEccccEEEHHHHHHHHHHHHHHHHHcccccccEEEEEccccHHHHHHHHHHHHHccEEEEccccccHHHHHHHHHHccccEEEEcHHHHcccccccEEEEccHHHcccccccccccccccccEEEEEEcccccccccEEEEEHHHHHHHHHHHHHHcccccccEEEEEccHHHHHHHHHHHHHHHHccEEEEccHHHcccHHHHHHHHHHccccEEEccHHHHHHHHHcccccccccccccEEEEEccccccHHHHHHHHHHccccEEEEcccccHHHHHHEEEEcccccccccccccccEEccccEEEEEccccccccccccEEEEEccccccccccccHHHHHHHHcccccccccEEEEEccEEEEcccccEEEEEEcccEEEEccEEccHHHHHHHHHHcccccEEEEEEEEcccccEEEEEEEcccccHHHHHHHHHccHHHcccEEEEcccccccccccccHHHHHHHHHcccHHcccccccHHHHHHHHHHHHHHccccccccccHHHccccHHHHHHHHHHHHHHHcccccHHHHHccccHHHHHHHHHHHccccccccccccccccccccHHHHHHHHHHHccccccccEEEEEEEEcccccHHHHHHHHHHHHHHccccEEEEEEEccccEEEEEcccccccEEEEEcccccHHHHHHHHHcccccccccEEEEEEEEEccccEEEEEEccHHHHcHHHHHHHHHHHHHHHcccccccccccHHHHHHHHHHHHccHHHHHHHHHHHHHHccccccccccccccccccccccccEEEEEccHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHcccccEEEEEEcccccHHHHHHHHHHHHcEEEEEEEccccccHHHHHHHHHHHHHHHHHHccccHHHHHHHHcccccccccccEEEEEEEEccccccccccccEEEEEEcccccccccEEEEEEEcccEEEEEEEEccccccHHHHHHHHHHHHHHHHHHHccccccccccccccHHHHHHHHHHccccccccccccccHHHHHHHHHHHccccEEEEEccEEEEHHHHHHHHHHHHHHHHHccccccEEEEEccccHHHHHHHHHHHHHccEEEEccccccHHHHHHHHHHccccEEEEcHHHHHHHHHccccccEEEEEccccccccccccccccccccccEEEEEcccccccccEEEEEHHHHHHHHHHHHHHcccccccEEEEEcccHHHHHHHHHHHHHHHHccEEEEccHHHcccHHHHHHHHHHccccEEEccHHHHHHHHHccccccccccccEEEEEccccccHHHHHHHHHHcccccEEEEcccccHHHHEEEEEEcccccccccccccccEEccccEEEEEccccccccccccEEEEEEcccHHccccccHHHHHHHHcccccccccccEEEccEEEEccccEEEEEEEcccEEEEccEEEcHHHHHHHHHHccccEEEEEEEEEcccccEEEEEEEEcccccHHHHHHHHHHcccHHHcccEEEEccccccccccccccHHHHHHHHHcccccccccHHHHHHHHHHHHHHHccccccccccHHHccccHHHHHHHHHHHHHccccccHHHHHHcccHHHHHHHHHHHHHHccccccccccccccHHHHHHHHHccccccccEEEEEEEcccccHHHHHHHHHHHHHHHHHHHEEEEEEccEEEEEEEccccccccccccccccccccccccHHHHHHHHHHHHHHHHcccccccccEEEEEEEEcccccEEEEEEcHHHHHHHHHHHHHHHHHHHHHHHHcccccccccccccHHHHHHHHHHHHccHHHHHHHHHHHHHHcccccccccccccccccccccccEEEEEEcHHHHHHHHHHHHHHHcccHHHHHHHHHHHHHHHHcccccEEEEEEccccccccccccHHHHHHHHHcccEEEEEccccccHHHHHHHHHHHHHHHHHHcccccccHHHHHHHcccccccccEEEEEEccccccccccccccccccccccccccccccccEEEEEEEEccEEEEEEEEcccccHHHHHHHHHHHHHHHHHHHHccccHHcccccccccccccccHHHHHHHHHHcccc 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