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Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : vpr
DDBJ      :vpr          extracellular serine protease
Swiss-Prot:SUBV_BACSU   RecName: Full=Minor extracellular protease vpr;         EC=3.4.21.-;Flags: Precursor;

Homologs  Archaea  19/68 : Bacteria  288/915 : Eukaryota  183/199 : Viruses  0/175   --->[See Alignment]
c.41.1
:806 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   180->578 3eifA PDBj 3e-36 34.8 %
:RPS:PDB   106->142 3bgoP PDBj 5e-04 16.2 %
:RPS:PDB   161->635 3eifA PDBj 1e-41 23.7 %
:RPS:SCOP  168->596 1v6cA  c.41.1.1 * 8e-42 20.3 %
:HMM:SCOP  125->601 1ot5A2 c.41.1.1 * 5e-86 44.9 %
:RPS:PFM   168->346,486->562 PF00082 * Peptidase_S8 5e-25 50.6 %
:RPS:PFM   386->461 PF02225 * PA 2e-07 35.5 %
:HMM:PFM   164->586 PF00082 * Peptidase_S8 1.8e-94 49.4 271/307  
:HMM:PFM   57->142 PF05922 * Inhibitor_I9 5.5e-13 24.7 85/87  
:HMM:PFM   622->689 PF11614 * Bre5 0.00032 24.2 66/120  
:BLT:SWISS 1->806 SUBV_BACSU 0.0 100.0 %
:PROS 185->196|PS00136|SUBTILASE_ASP
:PROS 233->243|PS00137|SUBTILASE_HIS
:PROS 532->542|PS00138|SUBTILASE_SER
:TM
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB15835.1 GT:GENE vpr GT:PRODUCT extracellular serine protease GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION 3907844..3910264 GB:FROM 3907844 GB:TO 3910264 GB:DIRECTION + GB:GENE vpr GB:PRODUCT extracellular serine protease GB:FUNCTION 16.11: Scavenge (Catabolism) GB:NOTE Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034; Product type e: enzyme GB:PROTEIN_ID CAB15835.1 GB:DB_XREF GOA:P29141 HSSP:2SBT InterPro:IPR010259 SubtiList:BG10591 UniProtKB/Swiss-Prot:P29141 GB:GENE:GENE vpr LENGTH 806 SQ:AASEQ MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEVFGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKVNREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQMDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDPKETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAGVERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSPGTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEAKDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPTIKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAPGVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNTAVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFTIENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEGTVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFLVYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVLTEEPFTVE GT:EXON 1|1-806:0| SW:ID SUBV_BACSU SW:DE RecName: Full=Minor extracellular protease vpr; EC=3.4.21.-;Flags: Precursor; SW:GN Name=vpr; OrderedLocusNames=BSU38090; ORFNames=ipa-45r; SW:KW Complete proteome; Direct protein sequencing; Hydrolase; Protease;Secreted; Serine protease; Signal; Zymogen. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->806|SUBV_BACSU|0.0|100.0|806/806| GO:SWS:NREP 4 GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0008233|"GO:peptidase activity"|Protease| GO:SWS GO:0005576|"GO:extracellular region"|Secreted| GO:SWS GO:0008236|"GO:serine-type peptidase activity"|Serine protease| PROS 185->196|PS00136|SUBTILASE_ASP|PDOC00125| PROS 233->243|PS00137|SUBTILASE_HIS|PDOC00125| PROS 532->542|PS00138|SUBTILASE_SER|PDOC00125| TM:NTM 1 TM:REGION 4->26| SEG 8->20|fllvsfvlffals| SEG 61->76|elkekslaeakeages| SEG 88->103|kaknkaikavkngkvn| SEG 661->679|tgkatakvkvntkktkagt| BL:PDB:NREP 1 BL:PDB:REP 180->578|3eifA|3e-36|34.8|385/936| RP:PDB:NREP 2 RP:PDB:REP 106->142|3bgoP|5e-04|16.2|37/71| RP:PDB:REP 161->635|3eifA|1e-41|23.7|469/936| RP:PFM:NREP 2 RP:PFM:REP 168->346,486->562|PF00082|5e-25|50.6|243/285|Peptidase_S8| RP:PFM:REP 386->461|PF02225|2e-07|35.5|76/101|PA| HM:PFM:NREP 3 HM:PFM:REP 164->586|PF00082|1.8e-94|49.4|271/307|Peptidase_S8| HM:PFM:REP 57->142|PF05922|5.5e-13|24.7|85/87|Inhibitor_I9| HM:PFM:REP 622->689|PF11614|0.00032|24.2|66/120|Bre5| GO:PFM:NREP 2 GO:PFM GO:0004252|"GO:serine-type endopeptidase activity"|PF00082|IPR000209| GO:PFM GO:0006508|"GO:proteolysis"|PF00082|IPR000209| RP:SCP:NREP 1 RP:SCP:REP 168->596|1v6cA|8e-42|20.3|404/435|c.41.1.1| HM:SCP:REP 125->601|1ot5A2|5e-86|44.9|314/338|c.41.1.1|1/1|Subtilisin-like| OP:NHOMO 1829 OP:NHOMOORG 490 OP:PATTERN 111-------------1--1-1-2---2--22---------------711-2---2-234-------1 --4-----111-------------1------1-------11-1-2414-221224321--5821B33A7B1-----------3-------------------11-21-12---------------1------112114445-1-91143-11211----1---11-24332----1--2----F4511-----633333444264354659AA774632233844------A41--1-11111---11------1-1231---1----22-------1-22322123--111111111112222222222222122--11211311-2----1------11111222---131111--11--4411323-4--1-------------1--1------1-----------------2---1--------11--11--1--1-1-----1--------------------------------------------------1-1------------------------------1---11----------------------------21-2--7-2------------122112-------73-2---------------------------1--21-6-31-9445462196727533226--2------------------------------------------------------------------------------------------------6---------1-2-----------------------------------1----------1----------1-211111211111232321111--------------------------------------------------3-121-1------ -1-1241-----13642531111111211212211-4----11122119A68B9BAH1223353313212111422323223332322-211261311211D1BGB-1A1A87456622322638A282FiD1C9C4433925642333252474658421898642F3376A62-461F11-58GiW*5tv9255471 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 530 STR:RPRED 65.8 SQ:SECSTR #########################################################################################################EEEEEccccccccGGGTTTEEEETTccccccccccccccccccccccccccccccHHHHccTTcHHHHHHHHcccTTcEEEEEEccccTTcTTcccccGGGcccccHHHHHHHHHEEETTTTcccccHHHHHHHHHHcccccccccTTcEEEEEEccccccHHHHHHHHHHHHHHHHTTccEEEEcccccGGGccHHHHHHHHHHHHTTcEEEEEccccccTTcTTcccTTcccccccccTTEEccEEEEEEEEEETTTEEEEEEEEEEccccTTcEEEEEEcTTcccGGGGTTcTTcEEEEEcccccHHHHHHHHHHTTccEEEEEcccTTcccccccccTTccEEEEcHHHHHHHHTccccEEEEccccEEEEcccccEEcTTccccccTTccccccEEEEcccEEEEEcccccETTTEEEEEccHHHHHHHHHHHHHHHHHHHHHHcTTccHHHHHHHHHHHHHHHccccEHHHHTTccccHHHHHHccEEEEETTcccccEEEEEEccEEEEEEEEEEcccccEEE########################################################################################################################################################################### DISOP:02AL 1-3, 38-51, 65-98| PSIPRED ccHHHHHHHHHHHHHHHHHHHHHHHHHHcccccccccHHHccccccccccccccccEEEEEEccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccEEEEEEEEEEEEEEEccHHHHHHHHHcccEEEEEccEEEEcccccccccccccccccccccccccccccHHHHHcccccccEEEEEEEcccccccHHHHcccccccccccccccccccccccccccccccccHHHHHHHHHHcccEEEEccccEEEEEEEEcccccccHHHHHHHHHHHHccccEEEEEccccccccccHHHHHHHHHHHHcccEEEEEcccccccccccccccccccEEEEccccccccccEEEEcccccEEEEEcccccccccEEcccEEEEccccccccccccccEEEEEEEEcccccHHHHHHHHHHccccEEEEEEcccccccccccccccccEEEEEEccccccHHHHcccccccEEEEEEEcccccccccccccccccccccccccEEcccccEEEEEccccccccccEEEEcccccHHHHHHHHHHHHHHHcccccHHHHHHHHHHHcEEcccccccccccccccccEEcHHHHccccEEEEcccccEEEEEcccccccEEEEEEEEEcccccccEEEEccccccEEEEEcccEEEEcccccEEEEEEEEEccccccccEEEEEEEEccccEEEEEEccEEEEEccccEEEEEEEEEcccccccEEEEEEEccccEEEEEEEEEccccEEEEEEEcccccccccEEEEccEEccccccccccEEEEEEEEEEcccEEEEEcccEEEc //