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Bacillus subtilis subsp. subtilis str. 168 (bsub0)
Gene : yhdZ
DDBJ      :yhdZ         putative NAD-dependent deacetylase; sirtuin
Swiss-Prot:NPD_BACSU    RecName: Full=NAD-dependent deacetylase;         EC=3.5.1.-;AltName: Full=Regulatory protein SIR2 homolog;

Homologs  Archaea  35/68 : Bacteria  559/915 : Eukaryota  195/199 : Viruses  1/175   --->[See Alignment]
c.31.1
:247 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   7->238 1s7gE PDBj 4e-39 44.5 %
:RPS:PDB   7->243 3d81A PDBj 2e-26 34.2 %
:RPS:SCOP  2->243 1iciA  c.31.1.5 * 8e-58 33.8 %
:HMM:SCOP  1->243 1j8fA_ c.31.1.5 * 2.1e-72 47.4 %
:RPS:PFM   19->198 PF02146 * SIR2 5e-36 51.5 %
:HMM:PFM   19->198 PF02146 * SIR2 3.8e-56 46.0 176/181  
:BLT:SWISS 1->247 NPD_BACSU e-144 100.0 %

SeqInfo AminoSeq See neighboring genes
Links GIB DAD Abbreviations Back to title page
GT:ID CAB12804.1 GT:GENE yhdZ GT:PRODUCT putative NAD-dependent deacetylase; sirtuin GT:DATABASE GIB00011CH01 GT:ORG bsub0 GB:ACCESSION GIB00011CH01 GB:LOCATION 1040094..1040837 GB:FROM 1040094 GB:TO 1040837 GB:DIRECTION + GB:GENE yhdZ GB:PRODUCT putative NAD-dependent deacetylase; sirtuin GB:FUNCTION 16.3: Control GB:NOTE Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId: 16768447; Product type pe : putative enzyme GB:PROTEIN_ID CAB12804.1 GB:DB_XREF GOA:O07595 HSSP:1MA3 InterPro:IPR003000 SubtiList:BG13032 UniProtKB/Swiss-Prot:O07595 GB:GENE:GENE yhdZ LENGTH 247 SQ:AASEQ METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVLKTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLFDMVIHQKIGEFARSLGMKK GT:EXON 1|1-247:0| SW:ID NPD_BACSU SW:DE RecName: Full=NAD-dependent deacetylase; EC=3.5.1.-;AltName: Full=Regulatory protein SIR2 homolog; SW:GN Name=npdA; Synonyms=yhdZ; OrderedLocusNames=BSU09650; SW:KW Complete proteome; Cytoplasm; Hydrolase; Metal-binding; NAD; Zinc. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->247|NPD_BACSU|e-144|100.0|247/247| GO:SWS:NREP 3 GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| BL:PDB:NREP 1 BL:PDB:REP 7->238|1s7gE|4e-39|44.5|218/248| RP:PDB:NREP 1 RP:PDB:REP 7->243|3d81A|2e-26|34.2|219/235| RP:PFM:NREP 1 RP:PFM:REP 19->198|PF02146|5e-36|51.5|167/178|SIR2| HM:PFM:NREP 1 HM:PFM:REP 19->198|PF02146|3.8e-56|46.0|176/181|SIR2| GO:PFM:NREP 6 GO:PFM GO:0006342|"GO:chromatin silencing"|PF02146|IPR003000| GO:PFM GO:0006476|"GO:protein amino acid deacetylation"|PF02146|IPR003000| GO:PFM GO:0008270|"GO:zinc ion binding"|PF02146|IPR003000| GO:PFM GO:0016811|"GO:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"|PF02146|IPR003000| GO:PFM GO:0045449|"GO:regulation of transcription"|PF02146|IPR003000| GO:PFM GO:0070403|"GO:NAD binding"|PF02146|IPR003000| RP:SCP:NREP 1 RP:SCP:REP 2->243|1iciA|8e-58|33.8|231/256|c.31.1.5| HM:SCP:REP 1->243|1j8fA_|2.1e-72|47.4|230/0|c.31.1.5|1/1|DHS-like NAD/FAD-binding domain| OP:NHOMO 1619 OP:NHOMOORG 790 OP:PATTERN 11---11111111111-12222221--1---11----------------1---11111111---1--1 1-1-22-222211112211-12112211111222222111-1111122-111111121--1221221121111111111-1111-11111111111---11111111111---------------1----1---1-11133---511------------------------------------11111---111111111111111111111111111222-1--111111111111111111111111111111111111111111132-1-111----------1--------------------------1----------1-1111111111111111111-11111111-1---121-11-112-111111-111-----11222---11111------------11111-11--1-------------1111-1-11111111---------11--111------------------------------1111-11-111111122222122122222121122222--1111-22222--1---2----11----------212122111---11----11--1--1211112322-1--11111-2111111111--121--11-121-11-11111111111111111111--1-21-------111111111111111-1-1111111111111111111111111111111111111111111111111111-111111111111-------------1122----11--2-22---11111111-112-2222121211--22323----------111111111111111111111111-------1111111--------1-1----------1--------------1111111111-1- 1111434-83333342321555554554432223432444444333223423642364333333344322354554444444553423-223314333331-253315ADCCA87952143374DA4B3JpA-B7D3534A3674274536416657675566C653744665A82223R1113352212145643343 -------------------1----------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 243 STR:RPRED 98.4 SQ:SECSTR HHHHHHHHHHcccEEEEEcGGGTGGGTccccccTTcHHHHHHHHGGTccHHHHHHcHHHHHHHHHHHTHHGGGGGccccHHHHHHHHHHHTTcccEEEEcccccHHHHHTcccEEETTEEEEEEEETTTccEEEccHHHHHHHGGGccccccTTTcccEEEEEcccTccccHHHHHHHHHHHHccEEEEEccccccTTGGGHHHHHHHTTTcEEEEEcccccTTTTTccEEEcccHHHHHHHH#### DISOP:02AL 246-248| PSIPRED cHHHHHHHHHcccEEEEEcccccHHcccccccccccHHcccccccccccHHHHHHcHHHHHHHHHHHHcccccccccccHHHHHHHHHHHcccEEEEEEcccccHHHHcccccEEEEEccccEEEEccccccccHHHHHHccccccccccccccccccEEcccccccccccccHHHHHHHHHHccEEEEEccccccccHHHHHHHHHHHcccEEEEEcccccccccEEEEEEcccHHHHHHHccccc //